23 research outputs found
Untersuchung der HemisphÀrendominanz wÀhrend mentaler Rotation mittels funktioneller Magnetresonanztomographie und funktioneller transkranieller Dopplersonographie
Die FÀhigkeit zur mentalen Rotation (MR) von Objekten ist eine komplexe kognitive Aufgabe, deren neurale Korrelate bisher kontrovers diskutiert wurden, da es weder in Bezug auf eine hemisphÀrenspezifische Dominanz, noch auf spezifisch aktivierte kortikale Areale oder geschlechterspezifische Unterschiede einheitliche Ergebnisse gibt.
In der vorliegenden Studie wurde die zerebrale HemisphĂ€rendominanz wĂ€hrend mentaler Rotation mittels eines Schlauchfigurenparadigmas mit Hilfe der funktionellen transkraniellen Dopplersonographie (fTCD) und der funktionellen Magnetresonanztomographie (fMRT) untersucht. Anhand der fTCD konnte eine HemisphĂ€rendominanz ĂŒberprĂŒft werden. Die fMRT gab zusĂ€tzlich Hinweise auf aufgabenspezifische kortikale Netzwerke. Von Interesse waren ebenfalls die Untersuchung geschlechterspezifischer Unterschiede und die Korrelation beider Methoden.
Es wurden 22 rechtshĂ€ndige, gesunde Probanden zwischen 20-40 J. untersucht. Die fTCD-Messung wurde mit 2MHz Ultraschallsonden, die fMRT-Messung mit einem 1,5 Tesla Kernspintomographen durchgefĂŒhrt. Die PrĂ€sentation der Stimuli geschah im Block-Design. Die fTCD-Daten wurden anhand des Programms âAverageâ, die fMRT-Daten mit Hilfe des Programms âBrainvoyagerâ ausgewertet. Es wurde eine Gruppenanalyse und eine geschlechterspezifische Analyse wĂ€hrend MR durchgefĂŒhrt. Es wurde mit Hilfe eines Wortgenerierungsparadigmas die sprach-dominante HemisphĂ€re ermittelt. Es wurde ebenfalls die Korrelation beider analysiert.
Die Daten von 10 weiblichen und 10 mĂ€nnlichen Probanden wurden ausgewertet. Der Edinburgh-HĂ€ndigkeitsinventar zeigte bei allen Probanden eine klare RechtshĂ€ndigkeit. 90% der Probanden verfĂŒgten ĂŒber eine linkshemisphĂ€rische Sprachdominanz (fTCD). Die mĂ€nnlichen Probanden zeigten ein tendenziell besseres Resultat. In der fTCD-Gruppenanalyse zeigte sich wĂ€hrend der MR keine statistisch signifikante HemisphĂ€rendominanz. In der geschlechterspezifischen Analyse kam es bei den mĂ€nnlichen Probanden zu einer tendenziell rechtshemisphĂ€rischen Aktivierung. Dies konnte in den fMRT-Ergebnissen bestĂ€tigt werden. In der fMRT-Gruppenanalyse zeigten sich Aktivierungen hauptsĂ€chlich in der parieto-occipitalen Region (insb. im Gyrus parietalis sup. und im parieto-occipitalen Ăbergang). Weitere Aktivierungen bzw. Deaktivierungen wurden im frontalen und temporalen Kortex, in den Basalganglien, der Inselregion, der infratentoriellen Region, im Cuneus, dem Gyrus cinguli und Gyrus angularis lokalisiert. Bei der geschlechterspezifischen Analyse fanden sich bei den mĂ€nnlichen Probanden Aktivierungen im Bereich des frontalen Kortex und der parieto-occipitalen Region. Lediglich im Bereich des Gyrus prĂ€centralis rechts zeigten die mĂ€nnlichen Probanden eine verminderte AktivitĂ€t. BezĂŒglich der Korrelation der Methoden zur Bestimmung der HemisphĂ€rendominanz fĂŒr MR fanden sich im fTCD und in der fMRT bei 14/20 Probanden konkordante Resultate.
Es konnte weder in der fTCD-, noch in der fMRT-Analyse eine eindeutige HemisphĂ€rendominanz wĂ€hrend MR nachgewiesen werden. In der fTCD-Analyse zeigte sich kein signifikanter Einfluss von den integrierten atypisch sprachdominanten Probanden. Im Rahmen dieser Studie wurden vorherige Studien bestĂ€tigt, die von einer bihemisphĂ€rischen Aktivierung ausgehen. Die Ergebnisse der vorliegenden Studie zeigen in der fMRT-Analyse Ă€hnliche beteiligte Areale wie vorherige Studien. Diese Areale waren in der parieto-occipitalen Region (insb. Lobus parietalis sup. und parieto-occipitalen Ăbergang) lokalisiert. Sie waren auch im frontalen (inkl. supplementĂ€r motorischer Areale und frontalem Augenfeld) und primĂ€r visuellen Kortex (auch in visuellen Assoziationsfeldern), im Thalamus und in der Inselregion zu finden. Die mĂ€nnlichen Probanden zeigten eine tendenziell rechtshemisphĂ€rische Dominanz und eine Mehraktivierung im Bereich des parietalen Kortex. Die sehr gute Korrelation beider Methoden in vorherigen Studien konnte nicht repliziert werden (6/20 Probanden keine konkordanten Ergebnisse).
Es sollten weitere Studien folgen, die die MR u.a. bei Patienten mit unilateralen LÀsionen untersuchen. In Bezug auf eine prÀchirurgische Funktionsanalyse bedarf es zur optimalen Charakterisierung dieser am ehesten bihemisphÀrisch prozessierten Funktion multimodale Untersuchungsmethoden
Visual cues combined with treadmill training to improve gait performance in Parkinson's disease: a pilot randomized controlled trial
Objective: To evaluate the effects of visual cues combined with treadmill training on gait performance in patients with Parkinson's disease and to compare the strategy with pure treadmill training. Design: Pilot, exploratory, non-blinded, randomized controlled trial. Setting: University Hospital of Munich, Germany. Subjects: Twenty-three outpatients with Parkinson's disease (Hoehn and Yahr stage II-IV). Interventions: Patients received 12 training sessions within five weeks of either visual cues combined with treadmill training (n = 12) or pure treadmill training (n = 11). Main measures: Outcome measures were gait speed, stride length and cadence recorded on the treadmill. Functional tests included the Timed Up and Go Test, the Unified Parkinson's Disease Rating Scale and the Freezing of gait-questionnaire. Assessments were conducted at baseline, after the training period and at two months follow-up. Results: After the training period (n = 20), gait speed and stride length had increased in both groups (p <= 0.05). Patients receiving the combined training scored better in the Timed Up and Go Test compared with the patients receiving pure treadmill training (p <= 0.05). At two months follow-up (n = 13), patients who underwent the combined training sustained better results in gait speed and stride length (p <= 0.05) and sustained the improvement in the Timed Up and Go Test (p <= 0.05). Conclusions: This pilot study suggests that visual cues combined with treadmill training have more beneficial effects on gait than pure treadmill training in patients with a moderate stage of Parkinson's disease. A large-scale study with longer follow-up is required
Subthalamic oscillatory activity and connectivity during gait in Parkinson's disease
Local field potentials (LFP) of the subthalamic nucleus (STN) recorded during walking may provide clues for determining the function of the STN during gait and also, may be used as biomarker to steer adaptive brain stimulation devices. Here, we present LFP recordings from an implanted sensing neurostimulator (Medtronic Activa PC+S) during walking and rest with and without stimulation in 10 patients with Parkinson's disease and electrodes placed bilaterally in the STN. We also present recordings from two of these patients recorded with externalized leads. We analyzed changes in overall frequency power, bilateral connectivity, high beta frequency oscillatory characteristics and gait-cycle related oscillatory activity. We report that deep brain stimulation improves gait parameters. High beta frequency power (20-30 Hz) and bilateral oscillatory connectivity are reduced during gait, while the attenuation of high beta power is absent during stimulation. Oscillatory characteristics are affected in a similar way. We describe a reduction in overall high beta burst amplitude and burst lifetimes during gait as compared to rest off stimulation. Investigating gait cycle related oscillatory dynamics, we found that alpha, beta and gamma frequency power is modulated in time during gait, locked to the gait cycle. We argue that these changes are related to movement induced artifacts and that these issues have important implications for similar research
Neck Vibration Proprioceptive Postural Response Intact in Progressive Supranuclear Palsy unlike Idiopathic Parkinson's Disease
Progressive supranuclear palsy (PSP) and late-stage idiopathic Parkinson's disease (IPD) are neurodegenerative movement disorders resulting in different postural instability and falling symptoms. IPD falls occur usually forward in late stage, whereas PSP falls happen in early stages, mostly backward, unprovoked, and with high morbidity. Postural responses to sensory anteroposterior tilt illusion by bilateral dorsal neck vibration were probed in both groups versus healthy controls on a static recording posture platform. Three distinct anteroposterior body mass excursion peaks (P1-P3) were observed. 18 IPD subjects exhibited well-known excessive response amplitudes, whereas 21 PSP subjects' responses remained unaltered to 22 control subjects. Neither IPD nor PSP showed response latency deficits, despite brainstem degeneration especially in PSP. The observed response patterns suggest that PSP brainstem pathology might spare the involved proprioceptive pathways and implies viability of neck vibration for possible biofeedback and augmentation therapy in PSP postural instability
Postural Stabilization Differences in Idiopathic Parkinsonâs Disease and Progressive Supranuclear Palsy during Self-Triggered Fast Forward Weight Lifting
Progressive supranuclear palsy (PSP) and late-stage idiopathic Parkinson's disease (IPD) are neurodegenerative movement disorders resulting in different postural instability and falling symptoms. IPD falls occur usually forward in late stage, whereas PSP falls happen in early stages, mostly backward, unprovoked, and with high morbidity. Self-triggered, weighted movements appear to provoke falls in IPD, but not in PSP. Repeated self-triggered lifting of a 0.5-1-kg weight (<2% of body weight) with the dominant hand was performed in 17 PSP, 15 IPD with falling history, and 16 controls on a posturography platform. PSP showed excessive force scaling of weight and body motion with high-frequency multiaxial body sway, whereas IPD presented a delayed-onset forward body displacement. Differences in center of mass displacement apparent at very small weights indicate that both syndromes decompensate postural control already within stability limits. PSP may be subject to specific postural system devolution. IPD are susceptible to delayed forward falling. Differential physiotherapy strategies are suggested
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DNA methylation-based classification of central nervous system tumours.
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology
Typical features of Parkinson disease and diagnostic challenges with microdeletion 22q11.2
Objective: To delineate the natural history, diagnosis, and treatment response of Parkinson disease (PD) in individuals with 22q11.2 deletion syndrome (22q11.2DS), and to determine if these patients differ from those with idiopathic PD.
Methods: In this international observational study, we characterized the clinical and neuroimaging features of 45 individuals with 22q11.2DS and PD (mean follow-up 7.5 ± 4.1 years).
Results: 22q11.2DS PD had a typical male excess (32 male, 71.1%), presentation and progression of hallmark motor symptoms, reduced striatal dopamine transporter binding with molecular imaging, and initial positive response to levodopa (93.3%). Mean age at motor symptom onset was relatively young (39.5 ± 8.5 years); 71.4% of cases had early-onset PD (<45 years). Despite having a similar age at onset, the diagnosis of PD was delayed in patients with a history of antipsychotic treatment compared with antipsychotic-naive patients (median 5 vs 1 year, p = 0.001). Preexisting psychotic disorders (24.5%) and mood or anxiety disorders (31.1%) were common, as were early dystonia (19.4%) and a history of seizures (33.3%).
Conclusions: Major clinical characteristics and response to standard treatments appear comparable in 22q11.2DS-associated PD to those in idiopathic PD, although the average age at onset is earlier. Importantly, treatment of preexisting psychotic illness may delay diagnosis of PD in 22q11.DS patients. An index of suspicion and vigilance for complex comorbidity may assist in identifying patients to prioritize for genetic testing
Human Practice. Digital Ecologies. Our Future. : 14. Internationale Tagung Wirtschaftsinformatik (WI 2019) : Tagungsband
Erschienen bei: universi - UniversitÀtsverlag Siegen. - ISBN: 978-3-96182-063-4Aus dem Inhalt:
Track 1: Produktion & Cyber-Physische Systeme
Requirements and a Meta Model for Exchanging Additive Manufacturing Capacities
Service Systems, Smart Service Systems and Cyber- Physical SystemsâWhatâs the difference? Towards a Unified Terminology
Developing an Industrial IoT Platform â Trade-off between Horizontal and Vertical Approaches
Machine Learning und Complex Event Processing: Effiziente Echtzeitauswertung am Beispiel Smart Factory
Sensor retrofit for a coffee machine as condition monitoring and predictive maintenance use case
Stakeholder-Analyse zum Einsatz IIoT-basierter Frischeinformationen in der Lebensmittelindustrie
Towards a Framework for Predictive Maintenance Strategies in Mechanical Engineering - A Method-Oriented Literature Analysis
Development of a matching platform for the requirement-oriented selection of cyber physical systems for SMEs
Track 2: Logistic Analytics
An Empirical Study of Customersâ Behavioral Intention to Use Ridepooling Services â An Extension of the Technology Acceptance Model
Modeling Delay Propagation and Transmission in Railway Networks
What is the impact of company specific adjustments on the acceptance and diffusion of logistic standards?
Robust Route Planning in Intermodal Urban Traffic
Track 3: Unternehmensmodellierung & Informationssystemgestaltung (Enterprise Modelling & Information Systems Design)
Work System Modeling Method with Different Levels of Specificity and Rigor for Different Stakeholder Purposes
Resolving Inconsistencies in Declarative Process Models based on Culpability Measurement
Strategic Analysis in the Realm of Enterprise Modeling â On the Example of Blockchain-Based Initiatives for the Electricity Sector
Zwischenbetriebliche Integration in der Möbelbranche: Konfigurationen und Einflussfaktoren
Novicesâ Quality Perceptions and the Acceptance of Process Modeling Grammars
Entwicklung einer Definition fĂŒr Social Business Objects (SBO) zur Modellierung von Unternehmensinformationen
Designing a Reference Model for Digital Product Configurators
Terminology for Evolving Design Artifacts
Business Role-Object Specification: A Language for Behavior-aware Structural Modeling of Business Objects
Generating Smart Glasses-based Information Systems with BPMN4SGA: A BPMN Extension for Smart Glasses Applications
Using Blockchain in Peer-to-Peer Carsharing to Build Trust in the Sharing Economy
Testing in Big Data: An Architecture Pattern for a Development Environment for Innovative, Integrated and Robust Applications
Track 4: Lern- und Wissensmanagement (e-Learning and Knowledge Management)
eGovernment Competences revisited â A Literature Review on necessary Competences in a Digitalized Public Sector
Say Hello to Your New Automated Tutor â A Structured Literature Review on Pedagogical Conversational Agents
Teaching the Digital Transformation of Business Processes: Design of a Simulation Game for Information Systems Education
Conceptualizing Immersion for Individual Learning in Virtual Reality
Designing a Flipped Classroom Course â a Process Model
The Influence of Risk-Taking on Knowledge Exchange and Combination
Gamified Feedback durch Avatare im Mobile Learning
Alexa, Can You Help Me Solve That Problem? - Understanding the Value of Smart Personal Assistants as Tutors for Complex Problem Tasks
Track 5: Data Science & Business Analytics
Matching with Bundle Preferences: Tradeoff between Fairness and Truthfulness
Applied image recognition: guidelines for using deep learning models in practice
Yield Prognosis for the Agrarian Management of Vineyards using Deep Learning for Object Counting
Reading Between the Lines of Qualitative Data â How to Detect Hidden Structure Based on Codes
Online Auctions with Dual-Threshold Algorithms: An Experimental Study and Practical Evaluation
Design Features of Non-Financial Reward Programs for Online Reviews: Evaluation based on Google Maps Data
Topic Embeddings â A New Approach to Classify Very Short Documents Based on Predefined Topics
Leveraging Unstructured Image Data for Product Quality Improvement
Decision Support for Real Estate Investors: Improving Real Estate Valuation with 3D City Models and Points of Interest
Knowledge Discovery from CVs: A Topic Modeling Procedure
Online Product Descriptions â Boost for your Sales?
EntscheidungsunterstĂŒtzung durch historienbasierte Dienstreihenfolgeplanung mit Pattern
A Semi-Automated Approach for Generating Online Review Templates
Machine Learning goes Measure Management: Leveraging Anomaly Detection and Parts Search to Improve Product-Cost Optimization
Bedeutung von Predictive Analytics fĂŒr den theoretischen Erkenntnisgewinn in der IS-Forschung
Track 6: Digitale Transformation und Dienstleistungen
Heuristic Theorizing in Software Development: Deriving Design Principles for Smart Glasses-based Systems
Mirroring E-service for Brick and Mortar Retail: An Assessment and Survey
Taxonomy of Digital Platforms: A Platform Architecture Perspective
Value of Star Players in the Digital Age
Local Shopping Platforms â Harnessing Locational Advantages for the Digital Transformation of Local Retail Outlets: A Content Analysis
A Socio-Technical Approach to Manage Analytics-as-a-Service â Results of an Action Design Research Project
Characterizing Approaches to Digital Transformation: Development of a Taxonomy of Digital Units
Expectations vs. Reality â Benefits of Smart Services in the Field of Tension between Industry and Science
Innovation Networks and Digital Innovation: How Organizations Use Innovation Networks in a Digitized Environment
Characterising Social Reading Platformsâ A Taxonomy-Based Approach to Structure the Field
Less Complex than Expected â What Really Drives IT Consulting Value
Modularity Canvas â A Framework for Visualizing Potentials of Service Modularity
Towards a Conceptualization of Capabilities for Innovating Business Models in the Industrial Internet of Things
A Taxonomy of Barriers to Digital Transformation
Ambidexterity in Service Innovation Research: A Systematic Literature Review
Design and success factors of an online solution for cross-pillar pension information
Track 7: IT-Management und -Strategie
A Frugal Support Structure for New Software Implementations in SMEs
How to Structure a Company-wide Adoption of Big Data Analytics
The Changing Roles of Innovation Actors and Organizational Antecedents in the Digital Age
Bewertung des Kundennutzens von Chatbots fĂŒr den Einsatz im Servicedesk
Understanding the Benefits of Agile Software Development in Regulated Environments
Are Employees Following the Rules? On the Effectiveness of IT Consumerization Policies
Agile and Attached: The Impact of Agile Practices on Agile Team Membersâ Affective Organisational Commitment
The Complexity Trap â Limits of IT Flexibility for Supporting Organizational Agility in Decentralized Organizations
Platform Openness: A Systematic Literature Review and Avenues for Future Research
Competence, Fashion and the Case of Blockchain
The Digital Platform Otto.de: A Case Study of Growth, Complexity, and Generativity
Track 8: eHealth & alternde Gesellschaft
Security and Privacy of Personal Health Records in Cloud Computing Environments â An Experimental Exploration of the Impact of Storage Solutions and Data Breaches
Patientenintegration durch Pfadsysteme
Digitalisierung in der StressprĂ€vention â eine qualitative Interviewstudie zu Nutzenpotenzialen
User Dynamics in Mental Health Forums â A Sentiment Analysis Perspective
Intent and the Use of Wearables in the Workplace â A Model Development
Understanding Patient Pathways in the Context of Integrated Health Care Services - Implications from a Scoping Review
Understanding the Habitual Use of Wearable Activity Trackers
On the Fit in Fitness Apps: Studying the Interaction of Motivational Affordances and Usersâ Goal Orientations in Affecting the Benefits Gained
Gamification in Health Behavior Change Support Systems - A Synthesis of Unintended Side Effects
Investigating the Influence of Information Incongruity on Trust-Relations within Trilateral Healthcare Settings
Track 9: Krisen- und KontinuitÀtsmanagement
Potentiale von IKT beim Ausfall kritischer Infrastrukturen: Erwartungen, Informationsgewinnung und Mediennutzung der Zivilbevölkerung in Deutschland
Fake News Perception in Germany: A Representative Study of Peopleâs Attitudes and Approaches to Counteract Disinformation
Analyzing the Potential of Graphical Building Information for Fire Emergency Responses: Findings from a Controlled Experiment
Track 10: Human-Computer Interaction
Towards a Taxonomy of Platforms for Conversational Agent Design
Measuring Service Encounter Satisfaction with Customer Service Chatbots using Sentiment Analysis
Self-Tracking and Gamification: Analyzing the Interplay of Motivations, Usage and Motivation Fulfillment
Erfolgsfaktoren von Augmented-Reality-Applikationen: Analyse von Nutzerrezensionen mit dem Review-Mining-Verfahren
Designing Dynamic Decision Support for Electronic Requirements Negotiations
Who is Stressed by Using ICTs? A Qualitative Comparison Analysis with the Big Five Personality Traits to Understand Technostress
Walking the Middle Path: How Medium Trade-Off Exposure Leads to Higher Consumer Satisfaction in Recommender Agents
Theory-Based Affordances of Utilitarian, Hedonic and Dual-Purposed Technologies: A Literature Review
Eliciting Customer Preferences for Shopping Companion Apps: A Service Quality Approach
The Role of Early User Participation in Discovering Software â A Case Study from the Context of Smart Glasses
The Fluidity of the Self-Concept as a Framework to Explain the Motivation to Play Video Games
Heart over Heels? An Empirical Analysis of the Relationship between Emotions and Review Helpfulness for Experience and Credence Goods
Track 11: Information Security and Information Privacy
Unfolding Concerns about Augmented Reality Technologies: A Qualitative Analysis of User Perceptions
To (Psychologically) Own Data is to Protect Data: How Psychological Ownership Determines Protective Behavior in a Work and Private Context
Understanding Data Protection Regulations from a Data Management Perspective: A Capability-Based Approach to EU-GDPR
On the Difficulties of Incentivizing Online Privacy through Transparency: A Qualitative Survey of the German Health Insurance Market
What is Your Selfie Worth? A Field Study on Individualsâ Valuation of Personal Data
Justification of Mass Surveillance: A Quantitative Study
An Exploratory Study of Risk Perception for Data Disclosure to a Network of Firms
Track 12: Umweltinformatik und nachhaltiges Wirtschaften
KommunikationsfĂ€den im Nadelöhr â Fachliche Prozessmodellierung der Nachhaltigkeitskommunikation am Kapitalmarkt
Potentiale und Herausforderungen der Materialflusskostenrechnung
Computing Incentives for User-Based Relocation in Carsharing
Sustainabilityâs Coming Home: Preliminary Design Principles for the Sustainable Smart District
Substitution of hazardous chemical substances using Deep Learning and t-SNE
A Hierarchy of DSMLs in Support of Product Life-Cycle Assessment
A Survey of Smart Energy Services for Private Households
Door-to-Door Mobility Integrators as Keystone Organizations of Smart Ecosystems: Resources and Value Co-Creation â A Literature Review
Ein EntscheidungsunterstĂŒtzungssystem zur ökonomischen Bewertung von Mieterstrom auf Basis der Clusteranalyse
Discovering Blockchain for Sustainable Product-Service Systems to enhance the Circular Economy
Digitale RĂŒckverfolgbarkeit von Lebensmitteln: Eine verbraucherinformatische Studie
Umweltbewusstsein durch audiovisuelles Content Marketing? Eine experimentelle Untersuchung zur Konsumentenbewertung nachhaltiger Smartphones
Towards Predictive Energy Management in Information Systems: A Research Proposal
A Web Browser-Based Application for Processing and Analyzing Material Flow Models using the MFCA Methodology
Track 13: Digital Work - Social, mobile, smart
On Conversational Agents in Information Systems Research: Analyzing the Past to Guide Future Work
The Potential of Augmented Reality for Improving Occupational First Aid
Prevent a Vicious Circle! The Role of Organizational IT-Capability in Attracting IT-affine Applicants
Good, Bad, or Both? Conceptualization and Measurement of Ambivalent User Attitudes Towards AI
A Case Study on Cross-Hierarchical Communication in Digital Work Environments
âShow Me Your People Skillsâ - Employing CEO Branding for Corporate Reputation Management in Social Media
A Multiorganisational Study of the Drivers and Barriers of Enterprise Collaboration Systems-Enabled Change
The More the Merrier? The Effect of Size of Core Team Subgroups on Success of Open Source Projects
The Impact of Anthropomorphic and Functional Chatbot Design Features in Enterprise Collaboration Systems on User Acceptance
Digital Feedback for Digital Work? Affordances and Constraints of a Feedback App at InsurCorp
The Effect of Marker-less Augmented Reality on Task and Learning Performance
Antecedents for Cyberloafing â A Literature Review
Internal Crowd Work as a Source of Empowerment - An Empirical Analysis of the Perception of Employees in a Crowdtesting Project
Track 14: GeschÀftsmodelle und digitales Unternehmertum
Dividing the ICO Jungle: Extracting and Evaluating Design Archetypes
Capturing Value from Data: Exploring Factors Influencing Revenue Model Design for Data-Driven Services
Understanding the Role of Data for Innovating Business Models: A System Dynamics Perspective
Business Model Innovation and Stakeholder: Exploring Mechanisms and Outcomes of Value Creation and Destruction
Business Models for Internet of Things Platforms: Empirical Development of a Taxonomy and Archetypes
Revitalizing established Industrial Companies: State of the Art and Success Principles of Digital Corporate Incubators
When 1+1 is Greater than 2: Concurrence of Additional Digital and Established Business Models within Companies
Special Track 1: Student Track
Investigating Personalized Price Discrimination of Textile-, Electronics- and General Stores in German Online Retail
From Facets to a Universal Definition â An Analysis of IoT Usage in Retail
Is the Technostress Creators Inventory Still an Up-To-Date Measurement Instrument? Results of a Large-Scale Interview Study
Application of Media Synchronicity Theory to Creative Tasks in Virtual Teams Using the Example of Design Thinking
TrustyTweet: An Indicator-based Browser-Plugin to Assist Users in Dealing with Fake News on Twitter
Application of Process Mining Techniques to Support Maintenance-Related Objectives
How Voice Can Change Customer Satisfaction: A Comparative Analysis between E-Commerce and Voice Commerce
Business Process Compliance and Blockchain: How Does the Ethereum Blockchain Address Challenges of Business Process Compliance?
Improving Business Model Configuration through a Question-based Approach
The Influence of Situational Factors and Gamification on Intrinsic Motivation and Learning
Evaluation von ITSM-Tools fĂŒr Integration und Management von Cloud-Diensten am Beispiel von ServiceNow
How Software Promotes the Integration of Sustainability in Business Process Management
Criteria Catalog for Industrial IoT Platforms from the Perspective of the Machine Tool Industry
Special Track 3: Demos & Prototyping
Privacy-friendly User Location Tracking with Smart Devices: The BeaT Prototype
Application-oriented robotics in nursing homes
Augmented Reality for Set-up Processe
Mixed Reality for supporting Remote-Meetings
Gamification zur Motivationssteigerung von Werkern bei der Betriebsdatenerfassung
Automatically Extracting and Analyzing Customer Needs from Twitter: A âNeedminingâ Prototype
GaNEsHA: Opportunities for Sustainable Transportation in Smart Cities
TUCANA: A platform for using local processing power of edge devices for building data-driven services
Demonstrator zur Beschreibung und Visualisierung einer kritischen Infrastruktur
Entwicklung einer alltagsnahen persuasiven App zur Bewegungsmotivation fĂŒr Ă€ltere Nutzerinnen und Nutzer
A browser-based modeling tool for studying the learning of conceptual modeling based on a multi-modal data collection approach
Exergames & Dementia: An interactive System for People with Dementia and their Care-Network
Workshops
Workshop Ethics and Morality in Business Informatics (Workshop Ethik und Moral in der Wirtschaftsinformatik â EMoWIâ19)
Model-Based Compliance in Information Systems - Foundations, Case Description and Data Set of the MobIS-Challenge for Students and Doctoral Candidates
Report of the Workshop on Concepts and Methods of Identifying Digital Potentials in Information Management
Control of Systemic Risks in Global Networks - A Grand Challenge to Information Systems Research
Die Mitarbeiter von morgen - Kompetenzen kĂŒnftiger Mitarbeiter im Bereich Business Analytics
Digitaler Konsum: Herausforderungen und Chancen der Verbraucherinformati
Untersuchung der HemisphÀrendominanz wÀhrend mentaler Rotation mittels funktioneller Magnetresonanztomographie und funktioneller transkranieller Dopplersonographie
Die FÀhigkeit zur mentalen Rotation (MR) von Objekten ist eine komplexe kognitive Aufgabe, deren neurale Korrelate bisher kontrovers diskutiert wurden, da es weder in Bezug auf eine hemisphÀrenspezifische Dominanz, noch auf spezifisch aktivierte kortikale Areale oder geschlechterspezifische Unterschiede einheitliche Ergebnisse gibt.
In der vorliegenden Studie wurde die zerebrale HemisphĂ€rendominanz wĂ€hrend mentaler Rotation mittels eines Schlauchfigurenparadigmas mit Hilfe der funktionellen transkraniellen Dopplersonographie (fTCD) und der funktionellen Magnetresonanztomographie (fMRT) untersucht. Anhand der fTCD konnte eine HemisphĂ€rendominanz ĂŒberprĂŒft werden. Die fMRT gab zusĂ€tzlich Hinweise auf aufgabenspezifische kortikale Netzwerke. Von Interesse waren ebenfalls die Untersuchung geschlechterspezifischer Unterschiede und die Korrelation beider Methoden.
Es wurden 22 rechtshĂ€ndige, gesunde Probanden zwischen 20-40 J. untersucht. Die fTCD-Messung wurde mit 2MHz Ultraschallsonden, die fMRT-Messung mit einem 1,5 Tesla Kernspintomographen durchgefĂŒhrt. Die PrĂ€sentation der Stimuli geschah im Block-Design. Die fTCD-Daten wurden anhand des Programms âAverageâ, die fMRT-Daten mit Hilfe des Programms âBrainvoyagerâ ausgewertet. Es wurde eine Gruppenanalyse und eine geschlechterspezifische Analyse wĂ€hrend MR durchgefĂŒhrt. Es wurde mit Hilfe eines Wortgenerierungsparadigmas die sprach-dominante HemisphĂ€re ermittelt. Es wurde ebenfalls die Korrelation beider analysiert.
Die Daten von 10 weiblichen und 10 mĂ€nnlichen Probanden wurden ausgewertet. Der Edinburgh-HĂ€ndigkeitsinventar zeigte bei allen Probanden eine klare RechtshĂ€ndigkeit. 90% der Probanden verfĂŒgten ĂŒber eine linkshemisphĂ€rische Sprachdominanz (fTCD). Die mĂ€nnlichen Probanden zeigten ein tendenziell besseres Resultat. In der fTCD-Gruppenanalyse zeigte sich wĂ€hrend der MR keine statistisch signifikante HemisphĂ€rendominanz. In der geschlechterspezifischen Analyse kam es bei den mĂ€nnlichen Probanden zu einer tendenziell rechtshemisphĂ€rischen Aktivierung. Dies konnte in den fMRT-Ergebnissen bestĂ€tigt werden. In der fMRT-Gruppenanalyse zeigten sich Aktivierungen hauptsĂ€chlich in der parieto-occipitalen Region (insb. im Gyrus parietalis sup. und im parieto-occipitalen Ăbergang). Weitere Aktivierungen bzw. Deaktivierungen wurden im frontalen und temporalen Kortex, in den Basalganglien, der Inselregion, der infratentoriellen Region, im Cuneus, dem Gyrus cinguli und Gyrus angularis lokalisiert. Bei der geschlechterspezifischen Analyse fanden sich bei den mĂ€nnlichen Probanden Aktivierungen im Bereich des frontalen Kortex und der parieto-occipitalen Region. Lediglich im Bereich des Gyrus prĂ€centralis rechts zeigten die mĂ€nnlichen Probanden eine verminderte AktivitĂ€t. BezĂŒglich der Korrelation der Methoden zur Bestimmung der HemisphĂ€rendominanz fĂŒr MR fanden sich im fTCD und in der fMRT bei 14/20 Probanden konkordante Resultate.
Es konnte weder in der fTCD-, noch in der fMRT-Analyse eine eindeutige HemisphĂ€rendominanz wĂ€hrend MR nachgewiesen werden. In der fTCD-Analyse zeigte sich kein signifikanter Einfluss von den integrierten atypisch sprachdominanten Probanden. Im Rahmen dieser Studie wurden vorherige Studien bestĂ€tigt, die von einer bihemisphĂ€rischen Aktivierung ausgehen. Die Ergebnisse der vorliegenden Studie zeigen in der fMRT-Analyse Ă€hnliche beteiligte Areale wie vorherige Studien. Diese Areale waren in der parieto-occipitalen Region (insb. Lobus parietalis sup. und parieto-occipitalen Ăbergang) lokalisiert. Sie waren auch im frontalen (inkl. supplementĂ€r motorischer Areale und frontalem Augenfeld) und primĂ€r visuellen Kortex (auch in visuellen Assoziationsfeldern), im Thalamus und in der Inselregion zu finden. Die mĂ€nnlichen Probanden zeigten eine tendenziell rechtshemisphĂ€rische Dominanz und eine Mehraktivierung im Bereich des parietalen Kortex. Die sehr gute Korrelation beider Methoden in vorherigen Studien konnte nicht repliziert werden (6/20 Probanden keine konkordanten Ergebnisse).
Es sollten weitere Studien folgen, die die MR u.a. bei Patienten mit unilateralen LÀsionen untersuchen. In Bezug auf eine prÀchirurgische Funktionsanalyse bedarf es zur optimalen Charakterisierung dieser am ehesten bihemisphÀrisch prozessierten Funktion multimodale Untersuchungsmethoden