40 research outputs found
Transition of young people with chronic conditions: a cross-sectional study of patient perceptions before and after transfer from pediatric to adult health care
The aim of this study was to compare perceived barriers to and the most preferred age for successful transition to adult health care between young people with chronic disorders who had not yet transferred from pediatric to adult health care (pre-transfer) and those who had already transferred (post-transfer). In a cross-sectional study, we compared 283 pre-transfer with 89 post-transfer young people, using a 28-item questionnaire that focused on perceived barriers to transition and beliefs about the most preferred age to transfer. Feeling at ease with the pediatrician was the most important barrier to successful transition in both groups, but was rated significantly higher in the pre-transfer compared to the post-transfer group (OR = 2.03, 95%CI 1.12-3.71). Anxiety and lack of information were the next most important barriers, rated equally highly by the two groups (OR = 0.67, 95%CI 0.35-1.28 and OR = 0.71, 95%CI 0.36-1.38, respectively). More than 80% of the respondents in both groups reported that 16-19years was the most preferred age to transfer; more than half of all the respondents reported 18-19years and older as the most preferred age. Conclusion: Better transition planning through the provision of regular and more detailed information about adult health-care providers and the transition process could reduce anxiety and contribute to a more positive attitude to overcome perceived barriers to transition from young people's perspective. Young people's preferences about transferring to adult health care provide a challenge to those children's hospitalsthat transfer to adult health care at a younger age
www.fevertravel.ch: an online study prototype to evaluate the safety and feasibility of computerized guidelines for fever in returning travellers and migrants
Following the paper publication of practice guidelines for the management of febrile patients returning from the tropics, we constructed a consultation website that comprises a decision chart and specific diagnostic features providing medical diagnostic assistance to primary care physicians. We then integrated a research component to evaluate the implementation of these computerized guidelines. This study website has the same interface as the consultation website. In addition, one is able to record: (i) the pathway followed by the physician through the decision chart, (ii) the diagnostic tests performed, (iii) the initial and final diagnoses as well as outcome and (iv) reasons for non-adherence when the physician diverges from the proposed attitude. We believe that Internet technology is a powerful medium to reach physicians of different horizons in their own environment, and could prove to be an effective research tool to disseminate practice guidelines and evaluate their appropriateness. Here we describe the design, content, architecture and system implementation of this interactive study prototype aimed at integrating operational research in primary care practice. [Authors]]]>
Emigration and Immigration; Fever; Guidelines as Topic; Internet; Travel
eng
oai:serval.unil.ch:BIB_4BBC99034368
2022-05-07T01:17:24Z
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documents
phdthesis
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https://serval.unil.ch/notice/serval:BIB_4BBC99034368
Usage conditionnel et inconditionnel des droits humains dans la vie quotidienne
Anex, Emmanuelle
Université de Lausanne, Faculté des sciences sociales et politiques
info:eu-repo/semantics/doctoralThesis
phdthesis
2018
fre
https://serval.unil.ch/resource/serval:BIB_4BBC99034368.P001/REF.pdf
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_4BBC990343683
info:eu-repo/semantics/openAccess
Copying allowed only for non-profit organizations
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oai:serval.unil.ch:BIB_4BA5F44A285D
2022-05-07T01:17:24Z
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https://serval.unil.ch/notice/serval:BIB_4BA5F44A285D
A double-blind, placebo-controlled study of citalopram with and without lithium in the treatment of therapy-resistant depressive patients: a clinical, pharmacokinetic, and pharmacogenetic investigation
Baumann, Pierre
Nil, Rico
Souche, Alain
Montaldi, Stefano
Baettig, Dominique
Lambert, Susanne
Uehlinger, Claude
Kasas, Anton
Amey, Marlyse
Jonzier-Perey, Michèle
info:eu-repo/semantics/article
article
1996
Journal of Clinical Psychopharmacology, vol. 16, pp. 307-314
one$; TBOK
eng
oai:serval.unil.ch:BIB_4BA60F08CDFC
2022-05-07T01:17:24Z
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https://serval.unil.ch/notice/serval:BIB_4BA60F08CDFC
Busulfan Pharmacokinetics in Adenosine Deaminase-Deficient Severe Combined Immunodeficiency Gene Therapy.
info:doi:10.1016/j.bbmt.2020.07.004
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbmt.2020.07.004
info:eu-repo/semantics/altIdentifier/pmid/32653625
Bradford, K.L.
Liu, S.
Krajinovic, M.
Ansari, M.
Garabedian, E.
Tse, J.
Wang, X.
Shaw, K.L.
Gaspar, H.B.
Candotti, F.
Kohn, D.B.
info:eu-repo/semantics/article
article
2020-10
Biology of blood and marrow transplantation, vol. 26, no. 10, pp. 1819-1827
info:eu-repo/semantics/altIdentifier/eissn/1523-6536
urn:issn:1083-8791
<![CDATA[The pharmacokinetics of low-dose busulfan (BU) were investigated as a nonmyeloablative conditioning regimen for autologous gene therapy (GT) in pediatric subjects with adenosine deaminase-deficient severe combined immunodeficiency disease (ADA SCID). In 3 successive clinical trials, which included either γ-retroviral (γ-RV) or lentiviral (LV) vectors, subjects were conditioned with BU using different dosing nomograms. The first cohort received BU doses based on body surface area (BSA), the second cohort received doses based on actual body weight (ABW), and in the third cohort, therapeutic drug monitoring (TDM) was used to target a specific area under the concentration-time curve (AUC). Neither BSA-based nor ABW-based dosing achieved a consistent cumulative BU AUC; in contrast, TDM-based dosing led to more consistent AUC. BU clearance increased as subject age increased from birth to 18 months. However, weight and age alone were insufficient to accurately predict the dose that would consistently achieve a target AUC. Furthermore, various clinical, laboratory, and genetic factors (eg, genotypes for glutathione-S-transferase isozymes known to participate in BU metabolism) were analyzed, but no single finding predicted subjects with rapid versus slow clearance. Analysis of BU AUC and the postengraftment vector copy number (VCN) in granulocytes, a surrogate marker of the level of engrafted gene-modified hematopoietic stem and progenitor cells (HSPCs), demonstrated gene marking at levels sufficient for therapeutic benefit in the subjects who had achieved the target BU AUC. Although many factors determine the ultimate engraftment following GT, this work demonstrates that the BU AUC correlated with the eventual level of engrafted gene-modified HSPCs within a vector group (γ-RV versus LV), with significantly higher levels of granulocyte VCN in the recipients of LV-modified grafts compared to recipients of γ-RV-transduced grafts. Taken together, these findings provide insight into low-dose BU pharmacokinetics in the unique setting of autologous GT for ADA SCID, and these dosing principles may be applied to future GT trials using low-dose BU to open the bone marrow niche
How to approach and take care of minor adolescents whose situations raise ethical dilemmas? a position paper of the European academy of pediatrics
In the care of adolescents, health care providers often face situations raising ethical concerns or dilemmas, such as refusal of a treatment or hospitalization, or request of confidentiality while engaging in risky behaviors or facing unplanned pregnancy. This position paper provides concrete avenues as how to assess the adolescent's capacity for autonomous decision making, e.g. the patient's competence in a specific situation, and how to elicit informed choice or consent. To do so, professionals need to be sensitized and trained as how to assess the cognitive and socio-psychological development of the young patient. Another challenge for the health professionals is to balance the needs to support patient's autonomy while offering secure guidance and protection if needed. To optimize such a process, they establish a climate of trust and empathy that will allow the patient to participate freely in the decision. In addition, especially when the decisions have potentially important consequences on the health and life, the professionals include, with the adolescent's permission, parents, caregivers or other significant adults, as well as they may request the opinion of other members of the health care team or expert colleagues such as ethicists
Transition of young people with chronic conditions: a cross-sectional study of patient perceptions before and after transfer from pediatric to adult health care
UNLABELLED The aim of this study was to compare perceived barriers to and the most preferred age for successful transition to adult health care between young people with chronic disorders who had not yet transferred from pediatric to adult health care (pre-transfer) and those who had already transferred (post-transfer). In a cross-sectional study, we compared 283 pre-transfer with 89 post-transfer young people, using a 28-item questionnaire that focused on perceived barriers to transition and beliefs about the most preferred age to transfer. Feeling at ease with the pediatrician was the most important barrier to successful transition in both groups, but was rated significantly higher in the pre-transfer compared to the post-transfer group (OR = 2.03, 95 %CI 1.12-3.71). Anxiety and lack of information were the next most important barriers, rated equally highly by the two groups (OR = 0.67, 95 %CI 0.35-1.28 and OR = 0.71, 95 %CI 0.36-1.38, respectively). More than 80 % of the respondents in both groups reported that 16-19 years was the most preferred age to transfer; more than half of all the respondents reported 18-19 years and older as the most preferred age.
CONCLUSION Better transition planning through the provision of regular and more detailed information about adult health-care providers and the transition process could reduce anxiety and contribute to a more positive attitude to overcome perceived barriers to transition from young people's perspective. Young people's preferences about transferring to adult health care provide a challenge to those children's hospitals that transfer to adult health care at a younger age
L’adolescence : une métamorphose porte-parole de notre société
L’adolescence est une période de métamorphoses qui se définit par l’émergence pubertaire induisant des changements physiques, psychiques, cognitifs et sociaux. Ces derniers sont responsables du remaniement de l’économie pulsionnelle et des processus identificatoires. L’adolescence se retrouve au défi de donner sens à ces métamorphoses
Chapitre 10. Les adolescents et leur santé
La vision que les adultes peuvent avoir de la santé des adolescents oscille souvent entre deux extrêmes. D’un côté, les adolescents sont vus comme des individus jouissant d’une bonne santé physique, d’un autre côté, les médias de masse et la rumeur publique leur attribuent nombre de comportements problématiques et une réputation d’individus à haut risque. En fait, les adolescents ne constituent pas une population homogène, et leur conduite, pour la majorité d’entre eux, peut évoluer rapidemen..
Services "amis des jeunes" : promouvoir des soins adaptés aux adolescents
Many young people have difficulties requesting medical or psychosocial support, although some badly need it. This difficulty is related to the fact that, as part of their search for autonomy, young people prefer to solve their problems by themselves. To improve the quality of care, the World Health Organization, UNICEF and allied organizations have developed the concept of "Youth friendly health services". This concept includes policies and strategies to improve the accessibility and flexibility, staff's competence and communication skills, etc. Such an approach should not be limited to specialized centers for adolescent health. It should be adopted by all health care institutions dealing with young people
Transactional sex and HIV risks – evidence from a cross-sectional national survey among young people in Uganda
Background: Transactional sex is associated with the HIV epidemic among young people in Uganda. Few quantitative studies based on nationally representative survey data explored the relationship between sexual behaviors, HIV infection, and transactional sex. Objective: This study aimed to determine the associations between risky sexual behaviors, participation in transactional sex, and HIV sero-status among men and women aged 15–24 in Uganda. Design: The study uses data from the Uganda AIDS Indicator Survey, a cross-sectional national HIV serological study conducted in 2011. We analyzed data on 1,516 men and 2,824 women aged 15–24 who had been sexually active in the 12 months preceding the survey. Private, face-to-face interviews were also conducted to record the sociodemographics, sexual history, and experiences of sexual coercion. Logistic regression analysis was performed to measure associations between sexual behaviors and transactional sex, and associations between HIV sero-status and transactional sex. Results: Among young people who had been sexually active in the 12 months prior to the survey, 5.2% of young men reported paying for sex while 3.7% of young women reported receiving gifts, favors, or money for sex. Lower educational attainment (ORadjusted 3.25, CI 1.10–9.60) and experience of sexual coercion (ORadjusted 2.83, CI 1.07–7.47) were significantly associated with paying for sex among men. Multiple concurrent sexual relationships were significantly associated with paying for sex among young men (ORadjusted 5.60, CI 2.08–14.95) and receiving something for sex among young women (ORadjusted 8.04, CI 2.55–25.37). Paying for sex among young men and having three to five lifetime sexual partners among young women were associated with increased odds of testing positive for HIV. Conclusions: Transactional sex is associated with sexual coercion and HIV risk behaviors such as multiple concurrent sexual partnerships among young people in Uganda. In addition, transactional sex appears to place young men at increased risk for HIV in Uganda. Both sexes appear equally vulnerable to risks associated with transactional sex, and therefore should be targeted in intervention programs. In addition, strengthening universal education policy and improving school retention programs may be beneficial in reducing risky sexual behaviors and transactional sex