AGEs Secreted by Bacteria Are Involved in the Inflammatory Response

Advanced Glycated End Products (AGEs) are formed by non-enzymatic protein glycation and are implicated in several physiological aspects including cell aging and diseases. Recent data indicate that bacteria – although short lived – produce, metabolize and accumulate AGEs. Here we show that Escherichia coli cells secret AGEs by the energy-dependent efflux pump systems. Moreover, we show that in the presence of these AGEs there is an upshift of pro-inflammatory cytokins by mammalian cells. Thus, we propose that secretion of AGEs by bacteria is a novel avenue of bacterial-induced inflammation which is potentially important in the pathophysiology of bacterial infections. Moreover, the sensing of AGEs by the host cells may constitute a warning system for the presence of bacteria

"How Do We Do This at a Distance?!" A Descriptive Study of Remote Undergraduate Research Programs during COVID-19.

The COVID-19 pandemic shut down undergraduate research programs across the United States. A group of 23 colleges, universities, and research institutes hosted remote undergraduate research programs in the life sciences during Summer 2020. Given the unprecedented offering of remote programs, we carried out a study to describe and evaluate them. Using structured templates, we documented how programs were designed and implemented, including who participated. Through focus groups and surveys, we identified programmatic strengths and shortcomings as well as recommendations for improvements from students' perspectives. Strengths included the quality of mentorship, opportunities for learning and professional development, and a feeling of connection with a larger community. Weaknesses included limited cohort building, challenges with insufficient structure, and issues with technology. Although all programs had one or more activities related to diversity, equity, inclusion, and justice, these topics were largely absent from student reports even though programs coincided with a peak in national consciousness about racial inequities and structural racism. Our results provide evidence for designing remote Research Experiences for Undergraduates (REUs) that are experienced favorably by students. Our results also indicate that remote REUs are sufficiently positive to further investigate their affordances and constraints, including the potential to scale up offerings, with minimal concern about disenfranchising students

Laboratories for global space-time: science-fictionality and the World’s Fairs, 1851-1939

This article examines the world’s fair movement between The Great Exhibition of 1851 and The New York World’s Fair of 1939, suggesting that these sites are science-fictional spaces that expose their mass audiences to forms of space-time compression that enable early figurations of globalization. Fair sites embody specific forms of economic transfer and exchange that anticipate dreams of the borderless flows of capital in some current versions of globalization theory. This “sfnal” condition of the world’s-fair site is not just in the futuristic displays of techno-scientific “progress,” which became an insistent form of spectacle in the world’s fair, but also in the spatialization of developmental histories, reading conceptions of modernity remorselessly through hierarchies of racial “progress” or spectacles of anachronistic “arrest” or degenerative “decline.” Long before the famous Futurama of 1939 New York, world’s fairs were one of the first spaces in which large populations experienced deliberate and sustained disadjustment in time within a bounded zone, an early sense of immersion in the “science-fictional.

Walter Deane correspondence.

Sender Bailey, William W., 1888-189