Incidental sun exposure in North Queensland: an application of the prototype willingness (PW) model

Objective: The prevalence of skin cancer in North Queensland is among the highest in the world (Buettner & Rasch, 1998), yet comparably few individuals report deliberately sunbathing to get a tan. This might suggest that skin damage in this region is due to incidental exposure that is not planned or deliberate. While the theoretical frameworks which have been adopted in past research can account for planned behaviours such as deliberate tanning, such models may not be suited to predicting unplanned behaviour such as incidental sun exposure. Therefore, alternative frameworks need to be explored. The prototype willingness (PW) model is a dual-process model which has been useful in the prediction of behaviours that are considered unplanned or spontaneous such as binge drinking and drug abuse. The current study aims to explore whether the dual pathways of the PW model differentially predict deliberate and incidental sun exposing behaviours. Methods: Community participants (n=218) from the North Queensland region completed a survey about their sun-related behaviours. Participants also responded to items that assessed standing on the PW model variables. Predictive modelling techniques were used to determine which of the model's proximal antecedents in each pathway was a better predictor of each type of exposure behaviour. Results: When controlling for age, skin sensitivity and gender; behavioural intention was the sole predictor of deliberate sun exposure (p<.05). Incidental sun exposure was predicted by both behavioural intention and behavioural willingness (p's<.05). This indicates that while engaging in deliberate sun exposure may be a deliberative process, there may be a number of cognitive mechanisms influencing incidental sun exposure. Conclusions: The current research provides support for the use of the PW model to explain variance across a range of sun-related behaviours, particularly incidental sun exposure. To date, skin cancer prevention efforts have focused on decreasing deliberate sun exposure. In North Queensland though, where the ambient ultra-violet radiation is high to extreme all year, incidental sun exposure may need to be targeted in order to reduce the prevalence of skin cancer. The current findings suggest that the PW model may be able to provide possible avenues for future health promotion activities to reduce incidental sun exposure in high risk regions

Characterising the tumour morphological response to therapeutic intervention:an ex vivo model

In cancer, morphological assessment of histological tissue samples is a fundamental part of both diagnosis and prognosis. Image analysis offers opportunities to support that assessment through quantitative metrics of morphology. Generally, morphometric analysis is carried out on two dimensional tissue section data and so only represents a small fraction of any tumour. We present a novel application of three-dimensional (3D) morphometrics for 3D imaging data obtained from tumours grown in a culture model. Minkowski functionals, a set of measures that characterise geometry and topology in n-dimensional space, are used to quantify tumour topology in the absence of and in response to therapeutic intervention. These measures are used to stratify the morphological response of tumours to therapeutic intervention. Breast tumours are characterised by estrogen receptor (ER) status, human epidermal growth factor receptor (HER)2 status and tumour grade. Previously, we have shown that ER status is associated with tumour volume in response to tamoxifen treatment ex vivo. Here, HER2 status is found to predict the changes in morphology other than volume as a result of tamoxifen treatment ex vivo. Finally, we show the extent to which Minkowski functionals might be used to predict tumour grade.Minkowski functionals are generalisable to any 3D data set, including in vivo and cellular systems. This quantitative topological analysis can provide a valuable link among biomarkers, drug intervention and tumour morphology that is complementary to existing, non-morphological measures of tumour response to intervention and could ultimately inform patient treatment

Identifying prognostic structural features in tissue sections of colon cancer patients using point pattern analysis

Diagnosis and prognosis of cancer is informed by the architecture inherent in cancer patient tissue sections. This architecture is typically identified by pathologists, yet advances in computational image analysis facilitate quantitative assessment of this structure. In this article we develop a spatial point process approach in order to describe patterns in cell distribution within tissue samples taken from colorectal cancer (CRC) patients. In particular, our approach is centered on the Palm intensity function. This leads to taking an approximate-likelihood technique in fitting point processes models. We consider two Neyman-Scott point processes and a void process, fitting these point process models to the CRC patient data. We find that the parameter estimates of these models may be used to quantify the spatial arrangement of cells. Importantly, we observe characteristic differences in the spatial arrangement of cells between patients who died from CRC and those alive at follow-up

INFLUENCE OF JUMPING MEASURES AND SQUAT 1RM ON SPRINT SPEED IN RUGBY UNION PLAYERS

This study examined the relationship of countermovement (CMJ), squat (SJ), and rebound jumps (RBJ), estimated 1RM back squat (SQ), contact time (CT) and Reactive Strength Index (RSI) for the RBJ to 30 m sprint time of sub-elite, semi-professional Rugby Union players. The results show that with the exception of SQ and CT, all variables were significantly (p .575). The best determinant of predicting 30 m sprint time was RSI. The relationships of SJ, CMJ, and RBJ jump height and RSI to 30 m sprint time suggest that these rapid movements are all common in Rugby Union players. The results show that estimated 1 RM back squat has little influence on sprint performance

RELIABILITY OF JUMP AND PERFORMANCE MEASURES IN RUGBY UNION PLAYERS

The current study examined the reliability of countermovement (CMJ), squat (SJ), and rebound jumps (RBJ) to sprint and estimated 1RM back squat (SQ) of sub-elite Rugby Union players drawn from two teams of similar competitive level. Comparisons of mean performance on all tests were made via Student t-tests. The three trial reliability of jump height for the SJ, CMJ, RBJ, contact time (CT) and Reactive Strength Index for the RBJ, T-Test agility run (TA-Test), 30 and 36.58 m (40 yd) sprint times were estimated via ICC and ReANOVA. All variables displayed Average measures ICC &#8805; .900; and except for the TA-Test, the three trials did not differ from each other. The performance of the two teams was found to be similar on all tests except the 30 m and 40 yd sprint tests. All the studied performance measures could be reliably assessed with one trial, except the TA-test

Cortical tau deposition follows patterns of entorhinal functional connectivity in aging.

Tau pathology first appears in the transentorhinal and anterolateral entorhinal cortex (alEC) in the aging brain. The transition to Alzheimer's disease (AD) is hypothesized to involve amyloid-β (Aβ) facilitated tau spread through neural connections. We contrasted functional connectivity (FC) of alEC and posteromedial EC (pmEC), subregions of EC that differ in functional specialization and cortical connectivity, with the hypothesis that alEC-connected cortex would show greater tau deposition than pmEC-connected cortex. We used resting state fMRI to measure FC, and PET to measure tau and Aβ in cognitively normal older adults. Tau preferentially deposited in alEC-connected cortex compared to pmEC-connected or non-connected cortex, and stronger connectivity was associated with increased tau deposition. FC-tau relationships were present regardless of Aβ, although strengthened with Aβ. These results provide an explanation for the anatomic specificity of neocortical tau deposition in the aging brain and reveal relationships between normal aging and the evolution of AD

Living with Traumatic Brain Injury in a Rural Setting: Supports and Barriers Across the Continuum of Care

Purpose: Traumatic brain injury (TBI) is prevalent in Kentucky and comes with a high cost in care and quality of life for individuals and caregivers affected. Many people living with the condition of TBI have unmet needs. Research among people living with TBI in rural areas is limited. The purposes of this study were to (1) increase understanding of the lived experience of people with TBI and caregivers in rural regions of Kentucky across the continuum of their care and (2) provide their perspectives on barriers and facilitators of optimal function and well-being. Methods: A qualitative descriptive interview study was conducted by a multidisciplinary team. Content analysis was completed with data-derived coding and iterative modifications to analysis, coalescing codes into categories and themes. Results: Thirteen people with TBI and six caregivers participated in the interview. Categories that emerged in analysis included the experiences under each locus of care; themes included relationships, functional competence, and participation in meaningful activity. Conclusion: Relationships represented both barriers and facilitators of well-being. Major unmet needs persisted in terms of medical problems, support for caregivers, community linkages, and participation in meaningful activities. Recommendations are made regarding avenues for addressing unmet needs

Tau deposition is associated with functional isolation of the hippocampus in aging.

The tau protein aggregates in aging and Alzheimer disease and may lead to memory loss through disruption of medial temporal lobe (MTL)-dependent memory systems. Here, we investigated tau-mediated mechanisms of hippocampal dysfunction that underlie the expression of episodic memory decline using fMRI measures of hippocampal local coherence (regional homogeneity; ReHo), distant functional connectivity and tau-PET. We show that age and tau pathology are related to higher hippocampal ReHo. Functional disconnection between the hippocampus and other components of the MTL memory system, particularly an anterior-temporal network specialized for object memory, is also associated with higher hippocampal ReHo and greater tau burden in anterior-temporal regions. These associations are not observed in the posteromedial network, specialized for context/spatial information. Higher hippocampal ReHo predicts worse memory performance. These findings suggest that tau pathology plays a role in disconnecting the hippocampus from specific MTL memory systems leading to increased local coherence and memory decline

The unseen and unacceptable face of digital libraries

The social and organizational aspects of digital libraries are often overlooked but this paper reviews how they can affect users' awareness and acceptance of digital libraries. An analysis of research conducted within two contrasting domains (Clinical and Academic) is presented which highlights issues of user interactions, work practices and the organizational social structures. The combined study comprises an analysis of 98 in-depth interviews and focus groups with lecturers, librarians and hospital clinicians. The importance of current and past roles of the library, and how users interacted with it, are revealed. Web-based digital libraries, while alleviating most library resource and interaction problems, require a change in librarians' and DL designers' roles and interaction patterns if they are to be implemented acceptably and effectively. Without this role change, users will at best be unaware of these digital resources and at worst feel threatened by them. The findings of this paper highlight the importance on DL design and implementation of the social context and supporting user communication (i.e. collaboration and consultation) in their information search and usage activities