Effects of Orthotic Intervention during Running among Individuals with Functional Flatfoot

Foot orthotics are commonly prescribed to runners with functional flatfoot (FFF) with the goal of restoring the medial arch of the foot. In addition, treadmills are typically used by both clinicians and researchers in order to measure the lower extremity kinematics associated with running. However the mechanism of orthotic intervention as well as the accuracy of treadmills in representing overground running remains controversial within the literature. This thesis first compared the lower extremity kinematics between treadmill and overground running among individuals with a subtalar neutral foot type. The results indicated no significant differences with respect to rate of rearfoot angle, maximum internal tibial rotation angle and rate of internal tibial rotation between the two running surfaces. However, maximum rearfoot angle was significantly higher during treadmill running. In addition, this thesis compared the lower extremity kinematics during running between individuals with subtalar neutral and FFF foot types. The results indicated similar lower extremity kinematics during running between groups as no significant differences were found between maximum rearfoot angle, rate of rearfoot angle or rate of internal tibial rotation. However, the subtalar neutral group demonstrated significantly higher maximum internal tibial rotation angles when compared to the FFF group. Finally, this thesis investigated the effects of orthotic intervention on the lower extremity kinematics during running among individuals with FFF. The results suggest that orthotics significantly decrease maximum rearfoot angle and maximum internal tibial rotation angle during running among this population. However, rate of rearfoot angle and rate of internal tibial rotation were not affected. These findings suggest that treadmills do accurately represent the lower extremity kinematics associated with overground running, however if clinical decisions are dependent on small changes in maximum rearfoot angle then careful interpretation should be employed when using treadmills. Individuals with FFF did not demonstrate the expected increase in lower extremity kinematics therefore further research is required to better understand the mechanism of running injury among this population. In addition, orthotic intervention may have a mechanical effect on the motion of the lower extremity however the extent and applicability of this effect should be further examined

Assessing phonological awareness in kindergarten children: Issues of task comparability

Ten different phonological awareness tasks were administered to a group of kindergarten children whose reading ability was assessed 1 year later. The extraneous cognitive requirements inherent in the tasks varied widely. The children's performance on three tasks that involved a rhyming response was at ceiling, and these tasks did not correlate with subsequent reading progress. The other seven measures were all moderately related to later reading ability and, employed in sets, were very strong predictors. The relative predictive accuracy of the phonological tasks was equal to or better than more global measures of cognitive skills such as an intelligence test and a reading readiness test. The phonological tasks had a large amount of common variance. Factor analysis revealed only one factor on which all the nonrhyming phonological tasks loaded highly. The results bolster the construct validity of phonological awareness, indicate considerable comparability and interchangeability among the tasks used to measure the construct, and are encouraging as regards the possible use of such tasks in predictive test batteries.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24679/1/0000098.pd

Dataset from "Farzaneh Najafi, Gamaleldin F Elsayed, Robin Cao, Eftychios Pnevmatikakis, Peter E. Latham, John P Cunningham, Anne K Churchland (bioRxiv, 2018); Excitatory and inhibitory subnetworks are equally selective during decision-making and emerge simultaneously during learning.”

This package contains data, in NWB (Neurodata Without Borders) format, from the 4 mice included in "Farzaneh Najafi, Gamaleldin F Elsayed, Robin Cao, Eftychios Pnevmatikakis, Peter E. Latham, John P Cunningham, Anne K Churchland (bioRxiv, 2018); Excitatory and inhibitory subnetworks are equally selective during decision-making and emerge simultaneously during learning.” The "FN_dataSharing/nwb' folder contains NWB files for all recorded sessions for four mice discussed in the paper. Each NWB file represents the data and metadata associated with one recording session. In each NWB file, the metadata related to the session (mouse name, session date/time, lab/institution name, etc.) can be found under "general". Information related to ROI-segmentation such as ROI mask, ROI type (excitatory or inhibitory), poor or good quality, etc. can be found under "modules/Image-Segmentation/pln-seg". Trial information (e.g. start, end times, trial types, trial outcomes, etc.) can be found under "trials". Recorded trial-segmented neuronal responses aligned to different time event (e.g. stimulus start, animal choice, etc.) can be found under "modules/ Trial-based-Segmentation". A jupyter notebook presenting in detail how to work with NWB files is provided at https://github.com/ttngu207/najafi-2018-nwb/blob/master/notebooks/Najafi-2018_example.ipynb

Antibody response to SARS-CoV-2 vaccines in patients with relapsing multiple sclerosis treated with evobrutinib: A Bruton\u27s tyrosine kinase inhibitor

BACKGROUND: Evobrutinib is an oral, central nervous system (CNS)-penetrant and highly selective covalent Bruton\u27s tyrosine kinase inhibitor under clinical development for patients with relapsing multiple sclerosis (RMS). OBJECTIVE: To investigate the effect of evobrutinib on immune responses in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinated patients with RMS from a Phase II trial (NCT02975349). METHODS: A RESULTS: In the vaccinated subgroup, mean/minimum evobrutinib exposure pre-vaccination was 105.2/88.7 weeks. In total, 43 of 45 patients developed/increased S1/S2 IgG antibody levels post-vaccination; one patient\u27s antibody response remained negative post-vaccination and the other had antibody levels above the upper limit of detection, both pre- and post-vaccination. Most patients ( CONCLUSION: These results suggest evobrutinib, an investigational drug with therapeutic potential for patients with RMS, acts as an immunomodulator, that is, it inhibits aberrant immune cell responses in patients with RMS, while responsiveness to foreig

Prevalence and Correlates of Youth Suicidal Ideation and Attempts: Evidence from the 2014 Ontario Child Health Study

Objectives: To present the 12-month prevalence and correlates of suicidal ideation and attempts in a sample of youth in Ontario. Methods: Data come from the 2014 Ontario Child Health Study, a provincially representative survey of families with children in Ontario. Youth aged 14 to 17 y (n = 2,396) completed a computer-assisted, self-administered questionnaire in their home to assess the occurrence of suicidal ideation, suicidal attempts, and associated correlates, including non-suicidal self-injury, mental disorders, substance use, peer victimization and exposure to child maltreatment. Socio-demographic information was collected from the parent. Logistic regression models were used to identify correlates that distinguished between youth reporting: 1) no suicidal ideation or attempts, 2) suicidal ideation but no attempts, and 3) suicidal ideation and attempts. Results: The 12-month prevalence of suicidal ideation and attempts was 8.1% and 4.3%, respectively. All clinical and behavioural correlates were significantly higher among youth reporting suicidal ideation or attempts, as compared with non-suicidal youth. In adjusted models, depression and non-suicidal self-injury were each independently associated with elevated odds of suicidal ideation (OR = 4.84 and 4.19, respectively) and suicidal attempt (OR = 7.84 and 22.72, respectively). Among youth who reported suicidal ideation, the only variable that differentiated youth who attempted suicide v. those who did not, in adjusted models, was non-suicidal self-injury (OR = 3.89). Conclusions: Suicidal ideation and attempts are common among youth in Ontario, often co-occurring with mental disorders and high-risk behaviours. These findings underscore the need for effective prevention and intervention strategies, particularly for youth depression and non-suicidal self-injury

The effectiveness and cost-effectiveness of the ‘Walk with Me’ peer-led walking intervention to increase physical activity in inactive older adults:Study protocol for a randomised controlled trial

Background: The proportion of the population aged 65 years or older is increasing. Typically, physical activity and health decline with age, which is why action to promote active ageing is a major public health priority, particularly due to health inequalities in older adults. The aim of this study is to assess the effectiveness and cost-effectiveness of the Walk with Me peer-led walking intervention for older adults. Methods: This study is a two-arm, assessor-blind, randomised controlled trial. The intervention is a 12-week peer-led walking intervention based on social cognitive theory. Participants in the control group will receive information on active ageing and healthy nutrition. The study will target 348 community-dwelling older adults, aged 60 years or over living in areas of socio-economic disadvantage communities. Trained peer mentors will deliver the intervention. The primary outcome will be a mean between-group change in moderate-to-vigorous physical activity at 12 months from baseline, measured using an Actigraph accelerometer. Secondary outcomes will include quality of life, mental wellbeing, blood pressure, BMI and waist circumference. An embedded process evaluation will involve focus groups and participant diaries. Discussion: Evidence-based, cost-effective interventions to promote physical activity in older adults living in socio-economically disadvantaged communities are needed to address health inequalities

Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers

Peer reviewedPublisher PD

The Ever-Increasing Array of Novel Inborn Errors of Immunity : an Interim Update by the IUIS Committee

The most recent updated classification of inborn errors of immunity/primary immunodeficiencies, compiled by the International Union of Immunological Societies Expert Committee, was published in January 2020. Within days of completing this report, it was already out of date, evidenced by the frequent publication of genetic variants proposed to cause novel inborn errors of immunity. As the next formal report from the IUIS Expert Committee will not be published until 2022, we felt it important to provide the community with a brief update of recent contributions to the field of inborn errors of immunity. Herein, we highlight studies that have identified 26 additional monogenic gene defects that reach the threshold to represent novel causes of immune defects.Peer reviewe