EFFICACY OF MULTI-MODEL INTERVENTION ON REDUCING PERCEIVED BURDEN AMONG CAREGIVERS OF INDIVIDUAL WITH PSYCHIATRIC ISSUES: A SINGLE GROUP PILOT STUDY

Abstract Background: Despite the crucial role of caregivers in handling psychiatric patients, addressing caregivers burden in the home or hospital setting is remains a significant challenge in the psychiatric nursing. Objective: The purpose of this study is aimed to examine the efficacy of a newly developed Multi-Model Intervention for the caregivers who handling / taking care of psychiatric patients, specifically in Salem District. Methods: This is a single-group pretest-posttest study utilized with randomization. The Zarit Caregiver Burden Scale (ZCBS/CBS) was administered to 261 caregivers of patients with psychiatric illness for early screening. Thirty (30) caregivers were randomly selected who have scored higher in CBS for this study. Results: The results revealed that there is no significant gender difference on burden score on the baseline measure. On comparing pretest-posttest of burden score, it was found that the Multi-Model Intervention program significantly reduced the burden score of caregiver (t-value=6.39).Conclusion: This newly developed Multi-Model Intervention was significantly helped to reduce the burden of the caregivers and gains in handling skills, relaxed mood, reduced stress level, and were found as well. These findings provide promising evidence of the effectiveness of this newly developed Multi-Model Intervention for the caregivers as a strategy to promote caregiver’s personal and psychosocial well-being

Marine fisheries of Orissa

A brief account of marine fish landings in Orissa during 1985 to 1995 is given in this paper. Gearwise, groupwise and districtwise marine fish landings in this state was also discussed together with a critical analysis of marine fishery of the state during the last five decade

Creation of Carbon Nanotube Based BioSensors through Dielectrophoretic Assembly

Due to their excellent electrical, optical, and mechanical properties, nanosized single wall carbon nanotubes (SWNTs) have attracted significant attention as a transducing element in nano-bio sensor research. Controlled assembly, device fabrication, and bio-functionalization of the SWNTs are crucial in creating the sensors. In this study, working biosensor platforms were created using dielectrophoretic assembly of single wall carbon nanotubes (SWNTs) as a bridge between two gold electrodes. SWNTs in a commercial SDS surfactant solution were dispensed in the gap between the two gold electrodes, followed by applying an ac voltage across the two electrodes. The dielectrophoresis aligns the CNTs and forms a bridge between the two electrodes. A copious washing and a subsequent annealing of the devices at 200 ᵒC remove the surfactants and create an excellent semiconducting (p-type) bridge between the two electrodes. A liquid gated field effect transistor (LGFET) was built using DI water as the gate dielectric and the SWNT bridge as the channel. Negative gate voltages of the FET increased the drain current and applying a positive gate voltage of +0.5V depleted the channel of charges and turned the device off. The biosensor was verified using both the two terminal and three terminal devices. Genomic salmon DNA dissolved in DI water was applied on the SWNT bridge in both type of devices. In the two terminal device, the conductance of the bridge dropped by 65x after the binding of the DNA. In the LGFET, the transconductance of the device decreased 2X after the binding of the DNA. The binding of the DNA also suppressed hysteresis in the Drain Current vs Gate Voltage characteristics of the LGFET

Marine fisheries in Gujarat

A brief account of marine fish landings in Gujarat during 1985- 95 is given in this paper. Contribution of different gears along with the CPUE and the regionwise as well as groupwise details are also presented. The status and prospect of marine fisheries ofihe state is discussed with the aid of last 5 decades landing data

Trends in the catch of silverbellies by mechanised boats In Tamil Nadu during 1971-75

Silverbellies form an important demersal fishery of India particularly on the coasts of southern maritime states, the annual average catch amounting to about 3% of the total marine fish CEtoh ia India. In Tamil Nadai, mechanised boats predominantly operate at iRoyapuram (Kasimedai), Cuddflore, Portonovo, Adirampatnarri, Mandapam, Rameswaram and land considerable quantities of silverbellies. The catch trends of silverbellies landed by the mechanised boats in Tamil Nadu during the period 1971 to 1975 and the relation between the index of abundance and the toU'l fishing effort both in respect of total landings and landings of silverbellies are dealt with in the present paper.

Strong Forms of b-Continuous Multifunctions

In this paper we have introduced strong forms of b-continuous multifunctions namely b#-multicontinuity and *b-multicontinuity and studied their properties and characterizations. Also investigate the relationship with other type of functions with suitable examples

Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly

Introduction: Periodontal disease is a chronic, inflammatory bacterial dysbiosis that is associated with both Alzheimer's disease (AD) and Down syndrome. / Methods: A total of 48 elderly cognitively normal subjects were evaluated for differences in subgingival periodontal bacteria (assayed by 16S rRNA sequencing) between cerebrospinal fluid (CSF) biomarker groups of amyloid and neurofibrillary pathology. A dysbiotic index (DI) was defined at the genus level as the abundance ratio of known periodontal bacteria to healthy bacteria. Analysis of variance/analysis of covariance (ANOVA/ANCOVA), linear discriminant effect‐size analyses (LEfSe) were used to determine the bacterial genera and species differences between the CSF biomarker groups. / Results: At genera and species levels, higher subgingival periodontal dysbiosis was associated with reduced CSF amyloid beta (Aβ)42 (P = 0.02 and 0.01) but not with P‐tau. / Discussion: We show a selective relationship between periodontal disease bacterial dysbiosis and CSF biomarkers of amyloidosis, but not for tau. Further modeling is needed to establish the direct link between oral bacteria and Aβ

Estimated marine fish landings (in tonnes)in India during 2002 and 2003

Estimated marine fishing landing in India during 2002 and 2003 is 2.59 and 2.58 millon tonnes respectively. Gear wise landing were also estimated during this period

Experiences of people with dementia and their caregivers during the COVID-19 pandemic in India: a mixed-methods study

Background The COVID-19 pandemic has unprecedented consequences for the management of chronic diseases such as dementia. However, limited evidence exists on the condition of persons with dementia and their caregivers during the pandemic in lower-middle-income countries (LMICs). The study aimed to provide insights into the experiences of persons with dementia and their families during the early phases of the pandemic in India. Methods This study adopted a mixed-method approach. One hundred and four persons with dementia and their caregivers were evaluated via telephone using validated instruments and a semi-structured interview guide. We used the quantitative data collected to establish a baseline, whereas qualitative data were analysed thematically. Results The study revealed that persons with dementia and their caregivers experienced difficulties during the pandemic, which included worsening of behaviour, problems in accessing care, disruptions in functional activities and struggles in enforcing infection prevention contributing to caregiver distress. An important finding that emerged was the unchanging reality of caregiving for families. The relative success of the public health response to the COVID-19 pandemic contrasted with the lack of awareness and formal support for dementia. Conclusions The COVID-19 pandemic has exposed the vulnerabilities of persons with dementia and their caregivers. This calls for a collaborative reframing of medical care and public health policies to address dementia care

Evaluating the In Vitro Activity of Depsidones from Usnea subfloridana Stirton as Key Enzymes Involved in Inflammation and Gout

Background: Traditionally, Usnea genus has significant uses in the treatment of swelling and tumors in Africa and Asia. The aim of the present study was to investigate the chemical constituents present in the acetone extract (AE) of Usnea subfloridana Stirton and also to evaluate their anti-inflammatory and anti-gout effects. Methods: Isolation and characterization of secondary metabolites from AE were evaluated by chromatography and spectral studies. Anti-inflammatory activities were assessed through cyclooxygenase (COX1 and COX2) and 5-lipooxygenase (5-LOX) enzyme inhibition assays, while anti-gout effects were evaluated by xanthine oxidase (XO) inhibition assay. Results: The existence of five known depsidones, identified as galbinic acid (1), conprotocetraricacid (2), constictic acid (3), salazinic acid (4), and lobaric acid (5), were exposed by chemical investigation of AE and confirmed by spectral data. Using in vitro enzyme inhibition assays, it was noticed that all the isolates showed dose-dependent activity against all the tested enzymes. Mainly, compounds 2 and 5 showed better inhibition efficiency on COX2 enzyme with the IC50of 7.17±1.07 and 7.01±0.94 nM, respectively, than the reference drug indomethacin (7.3±0.65nM). Furthermore, all isolates exhibited potent inhibition effects on the XO enzyme. Conclusion: The results indicated that U. subfloridana can be a favorable natural source for thetreatment of inflammation and gout. Compounds 2 and 5 were responsible for these biologicalactions by regulating pro-inflammatory enzymes, namely COXs, 5-LOX, and XO