Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report

<p>Abstract</p> <p>Background</p> <p>We previously reported a high prevalence (22.3%) of gestational diabetes mellitus (GDM) in a large group of Sardinian women, in contrast with the prevalence of Type 2 diabetes. Sardinia has an unusual distribution of haplotypes and genotypes, with the highest population frequency of HLA DR3 in the world, and after Finland, the highest prevalence of Type 1 diabetes and Autoimmune-related Diseases. In this study we preliminarily tested the prevalence of serological markers of Type 1 diabetes in a group of Sardinian GDM patients.</p> <p>Methods</p> <p>We determined glutamic decarboxylase antibodies (anti-GAD65), protein tyrosine phosphatase ICA 512 (IA2) antibodies (anti-IA2), and IAA in 62 GDM patients, and in 56 controls with matching age, gestational age and parity.</p> <p>Results</p> <p>We found a high prevalence and very unusual distribution of antibodies in GDM patients (38.8%), the anti-IA2 being the most frequent antibody. Out of all our GDM patients, 38.8% (24 of 62) were positive for at least one antibody. Anti-IA2 was present in 29.0 % (18 out of 62) vs. 7.1% (4 out of 56) in the controls (P < 0.001). IAA was present in 14.5% (9 out of 62) of our GDM patients, and absent in the control subjects (P < 0.001). Anti-GAD65 was also present in GDM patients, with a prevalence of 3.2% (2 out of 62) while it was absent in the control group (P = NS). Pre-gestational weight was significantly lower (57.78 ± 9.8 vs 65.9 ± 17.3 <it>P </it>= 0.04) in auto-antibodies- positive GDM patients.</p> <p>Conclusion</p> <p>These results are in contrast with the very low prevalence of all antibodies reported in Italy. If confirmed, they could indicate that a large proportion of GDM patients in Sardinia have an autoimmune origin, in accordance with the high prevalence of Type 1 diabetes.</p

Study of the B−→Λc+Λˉc−K−B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-} decay

The decay $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ is studied in proton-proton collisions at a center-of-mass energy of $\sqrt{s}=13$ TeV using data corresponding to an integrated luminosity of 5 $\mathrm{fb}^{-1}$ collected by the LHCb experiment. In the $\Lambda_{c}^+ K^{-}$ system, the $\Xi_{c}(2930)^{0}$ state observed at the BaBar and Belle experiments is resolved into two narrower states, $\Xi_{c}(2923)^{0}$ and $\Xi_{c}(2939)^{0}$, whose masses and widths are measured to be $$m(\Xi_{c}(2923)^{0}) = 2924.5 \pm 0.4 \pm 1.1 \,\mathrm{MeV}, \\ m(\Xi_{c}(2939)^{0}) = 2938.5 \pm 0.9 \pm 2.3 \,\mathrm{MeV}, \\ \Gamma(\Xi_{c}(2923)^{0}) = \phantom{000}4.8 \pm 0.9 \pm 1.5 \,\mathrm{MeV},\\ \Gamma(\Xi_{c}(2939)^{0}) = \phantom{00}11.0 \pm 1.9 \pm 7.5 \,\mathrm{MeV},$$ where the first uncertainties are statistical and the second systematic. The results are consistent with a previous LHCb measurement using a prompt $\Lambda_{c}^{+} K^{-}$ sample. Evidence of a new $\Xi_{c}(2880)^{0}$ state is found with a local significance of $3.8\,\sigma$, whose mass and width are measured to be $2881.8 \pm 3.1 \pm 8.5\,\mathrm{MeV}$ and $12.4 \pm 5.3 \pm 5.8 \,\mathrm{MeV}$, respectively. In addition, evidence of a new decay mode $\Xi_{c}(2790)^{0} \to \Lambda_{c}^{+} K^{-}$ is found with a significance of $3.7\,\sigma$. The relative branching fraction of $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ with respect to the $B^{-} \to D^{+} D^{-} K^{-}$ decay is measured to be $2.36 \pm 0.11 \pm 0.22 \pm 0.25$, where the first uncertainty is statistical, the second systematic and the third originates from the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb public pages

Measurement of the ratios of branching fractions R(D∗)\mathcal{R}(D^{*}) and R(D0)\mathcal{R}(D^{0})

The ratios of branching fractions $\mathcal{R}(D^{*})\equiv\mathcal{B}(\bar{B}\to D^{*}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(\bar{B}\to D^{*}\mu^{-}\bar{\nu}_{\mu})$ and $\mathcal{R}(D^{0})\equiv\mathcal{B}(B^{-}\to D^{0}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(B^{-}\to D^{0}\mu^{-}\bar{\nu}_{\mu})$ are measured, assuming isospin symmetry, using a sample of proton-proton collision data corresponding to 3.0 fb${ }^{-1}$ of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode $\tau^{-}\to\mu^{-}\nu_{\tau}\bar{\nu}_{\mu}$. The measured values are $\mathcal{R}(D^{*})=0.281\pm0.018\pm0.024$ and $\mathcal{R}(D^{0})=0.441\pm0.060\pm0.066$, where the first uncertainty is statistical and the second is systematic. The correlation between these measurements is $\rho=-0.43$. Results are consistent with the current average of these quantities and are at a combined 1.9 standard deviations from the predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb public pages

Multidifferential study of identified charged hadron distributions in ZZ-tagged jets in proton-proton collisions at s=\sqrt{s}=13 TeV

Jet fragmentation functions are measured for the first time in proton-proton collisions for charged pions, kaons, and protons within jets recoiling against a $Z$ boson. The charged-hadron distributions are studied longitudinally and transversely to the jet direction for jets with transverse momentum 20 $< p_{\textrm{T}} < 100$ GeV and in the pseudorapidity range $2.5 < \eta < 4$. The data sample was collected with the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1.64 fb$^{-1}$. Triple differential distributions as a function of the hadron longitudinal momentum fraction, hadron transverse momentum, and jet transverse momentum are also measured for the first time. This helps constrain transverse-momentum-dependent fragmentation functions. Differences in the shapes and magnitudes of the measured distributions for the different hadron species provide insights into the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb public pages

Mineralogical, petrographic and chemical analysis of geomaterials used in the mortars of Roman Nora theatre (south Sardinia, Italy)

The composition and the origin of raw materials used in the ancient mortars and concrete of the Nora theatre (first century AD) have been analysed to define their provenance and construction technologies of the Roman period. The use of geomaterials in the binder / aggregate mixtures of the mortars vary according to their function in the different sectors (i.e., structure-wall, tribunalia vaults, wall of external niches, foundation of cavea tiers, stage inner wall) but also according to different construction phases of the theatre or the work-steps. The mortars with structural function are mainly hydraulic (e.g., concrete of vaults, jointing and foundation mortars of cavea ashlars), while the lime mortars were used mainly for plasters, and rarely as bedding mortars. As recommended by Vitruvius, in the hydraulic mortars were mainly used volcanic rocks, as coarse and fine pozzolanic aggregate (pulvis puteolanus), and quartz-feldspar sands (present as crystal-clasts with an almost constant ratio of about 2:1, respectively). The cocciopesto is anomalously rare or absent. In the mortars local dacitic volcanic rock were also used, especially in the concrete as caementia. The grey-black volcanic rocks are glasses with characteristics more near to obsidian and less to natural pozzolan normally used in the Roman period. To identify the provenance of these glasses, a geochemical comparison between the samples taken from the theatre mortars and the volcanic outcrops of some probable Sardinian source areas is made by XRF and SEM-EDS / WDS analysis. To verify the quality of the pozzolan (by its chemical reaction with the binder), the edges and inside of volcanic glasses were analysed with an SEM-EDS microprobe, while the compositional characteristics and the hydraulic degree of the binder was analysed with XRPD and TG/DSC methods, respectively. The use of this kind of pozzolanic glass, without local origins, is a novelty because it has never been found in the mortars of the archaeological site of Nora. Given the wide use of Sardinian obsidian in the Neolithic or Calcolithic periods for production of tools and instruments, some considerations about its use, origin and trade are made

Geochemical characterisation of pozzolanic obsidian glasses used in the ancient mortars of Nora Roman theatre (Sardinia, Italy): provenance of raw materials and historical–archaeological implications

The study focused on the volcanic glass used in the production of bedding mortars and concrete of the Roman theatre (I cent. AD) of the Nora site. The volcanic glasses were frequently used as aggregate and with pozzolanic function in all hydraulic mortars of the different sectors of the building (e.g., concretes of tribunalia vaults and external niches, jointing and foundation mortars of cavea tier ashlars, brick bedding), together with mainly quartz-feldspar sands, local Oligo-Miocenic andesitic-dacitic volcanics and Palaeozoic and Tyrrhenian sedimentary rocks. These volcanic glasses show characteristics closer to obsidian than to natural pozzolan normally used in the Roman period. They have definitely not sourced locally, unlike the other components that make up the aggregate. To identify their provenance, a petrochemical comparison between several samples taken from the theatre mortars and the volcanic outcrops of some probable Sardinian source areas is made. The use of the not local pozzolanic glass is a technical innovation in the mortars of the Nora archaeological site, and considering the wide use of obsidians in the prehistoric periods for the production of tools, significant considerations about its origin, procurement and use are made

The stones of the medieval ‘San Mamiliano di Simassi’ church (SW Sardinia, Italy): characterization and state of conservation

The Codex Diplomaticus of Tola indicates that a church dedicated to St. Geminianus, belonging to the Camaldonese monastery of St. Geminianus of the island of Montecristo, existed in the town of Samassi starting from 1119 AD. However, the current form of the church cannot be ascribed to that period and it is thought that it was rebuilt in the late XII century or early XIII century on the ruins of an older Palaeochristian and Vandalic building. The church has a single nave, with the apse directed to the south-east. In the main façade and in those sides, the structural framework consists of a inclined skirting board, wide corner pillars, flat pilasters, and small arches with geometric and moulded decoration. The façade, with arches parallel to the pediment, supports the campanile and contains a portal with lintel on phytomorphic capitals and an arch set on anthropomorphic protomes. The walls are made of medium-sized vulcanite ashlars. These volcanic rocks, with dacitic to rhyo-dacitic composition, belonging to the Oligocene-Miocene volcanism that occurred between 33 and 11 My ago in Sardinia, present a porphyritic structure (porphyritic index 10÷20%) with phenocrysts of opaque minerals (magnetite and/or titanomagnetite), plagioclase, ± orthopyroxene, ± biotite and rare hornblende and quartz. The decay processes are distributed differently in the façades, being concentrated mainly on the basal and top parts where water circulates. There are diverse macroscopic forms of alteration and degradation: exfoliation, pitting, alveolation, decohesion, differential degradation, crypto-florescence (gypsum), etc. Traces of pinkish to honey-yellow Ca-oxalate films were found on the stone surfaces. Preliminary XRD data and polarizing microscope observations revealed at least two types of films. A survey of their distribution on the different architectonic elements is currently in progress in an attempt to clarify their precise roles