Uterine leiomyosarcoma and disseminated peritoneal leiomyomatosis in the surgical treatment of uterine myoma: a retrospective analysis

Aim. To analyze the incidence and types of adverse outcomes and complications of laparoscopic myomectomies. Materials and methods. This work is a retrospective study based on data from the Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology. We analyzed 711 case histories of patients diagnosed with uterine myoma who received surgical treatment in the Department of Innovative Oncology and Gynecology from 2015 to 2019. The frequency of malignant neoplasms, verified by pathomorphological examination, and the characteristics of surgical interventions performed in these patients were comparatively evaluated. Results. Surgical interventions for uterine myoma are leading in gynecology due to the high prevalence of such disorders. Conservative myomectomy remains the "gold standard" in organ-sparing surgery. However, during surgeries for suspected benign neoplasms, there is a risk of morcellation of the malignant tumor, significantly worsening patient survival outcomes. In our study, the incidence of uterine leiomyosarcoma in suspected benign neoplasms was 0.98%. The probability of parasitic myomas or disseminated perineal leiomyomatosis after myomatous nodule morcellation is 0.19%. Conclusion. No reliable information about the malignant potential of the tumor and its proliferative activity can be obtained until a definitive pathomorphological examination. The above considerations warrant the routine use of prophylactic measures to prevent tumor cell dissemination

Actively Open-Minded Thinking, Bullshit Receptivity, and Susceptibility to Framing: Evaluating the Dual-Process Account in North America and Bulgaria (2021)

The framing effect occurs when different presentations of the same problem lead to predictably different preferences. The dual-process framework of higher cognition assumes that the effect violates rational principles, but alternative accounts and recent evidence have contested this interpretation. Contributing to this debate, we tested the dual-process assumption by investigating associations between susceptibility to framing and the willingness and ability to think in line with rational norms, conceptualized as actively open-minded thinking and pseudo-profound bullshit receptivity, or the tendency to uncritically accept meaningless statements as profound. We conducted two online studies among North American (N = 259) and Bulgarian (N = 248) university students and administered several framing problems within subjects, presumably a necessary condition for the associations to appear. Confirmatory factor analyses showed that susceptibility to framing was associated with decreased actively open-minded thinking and increased bullshit receptivity in both sites. Exploratory multi-group analyses demonstrated partial strong invariance and showed that the negative association between actively open-minded thinking and susceptibility to framing was stronger among Bulgarians than North Americans. These results support the dual-process account of the framing effect. Our study further contributes to adapting existing measures to a novel setting and expanding the findings across borders and populations

Training of Professional Pedagogues in Modern Socio-Economic Conditions of Higher Education

The article presents the actualization of the methodological base for the design and realization of educational programs for professional training of pedagogues under the socio-economic conditions of the higher education system. The study objective is to identify and describe the principles of the design and realization of educational programs for professional training of pedagogues in modern socio-economic conditions. The main methods of the study include a comparative analysis of scientific literature and modeling. Based on the interdisciplinary comparative theoretical analysis of economical concepts and education system phenomena, the principles of the design and realization of educational programs in modern socio-economic conditions are defined as the result of the study through the means of modeling the processes of professional pedagogues’ training

Does myofascial and trigger point treatment reduce pain and analgesic intake in patients undergoing OnabotulinumtoxinA injection due to chronic intractable migraine? A pilot, single-blind randomized controlled trial

BACKGROUND: Chronic migraine is a disabling disorder associated with myofascial and trigger point disorders in the neck. Pharmacological management is the first line of treatment; however, rehabilitation procedures aimed at lessening symptoms of myofascial and trigger point disorders may add value in the management of headache symptoms. AIM: To evaluate the feasibility of myofascial and trigger point treatment in chronic migraine patients receiving prophylactic treatment with onabotulinumtoxinA. To evaluate the treatment effects on headache frequency and intensity, analgesic consumption, cervical range of motion, trigger point pressure pain threshold, quality of life, and disability. DESIGN: Pilot, single-blind randomized controlled trial with two parallel groups. SETTING: Neurorehabilitation unit. POPULATION: 22 outpatients with chronic migraine. METHODS: Patients were randomly assigned to receive either cervicothoracic manipulative treatment (n=12) or transcutaneous electrical nerve stimulation (TENS) in the upper trapezius (n=10). Treatment consisted of 4 sessions (30 min/session, 1 session/week for 4 weeks). A rater blinded to treatment allocation evaluated outcomes before treatment, during treatment, and 1 month after the end of treatment. Consistent with the pilot nature of the study, feasibility was considered the primary outcome and efficacy the secondary outcome. RESULTS: All patients completed the study. No adverse events were reported. No significant between-group differences in pain intensity were observed during the study period. At post-treatment evaluation, the total consumption of analgesics (p=.02) and non-steroidal anti-inflammatory (p=.02) drugs was significantly lower in the manipulative treatment group than in the TENS group. These effects paralleled significant improvements in trigger point sensitivity and cervical active range of motion. CONCLUSIONS: Manipulative techniques aimed at reducing peripheral nociceptive triggers might add value in the management of chronic migraine symptoms and lower acute medication use. CLINICAL REHABILITATION IMPACT: An interdisciplinary approach comprising pharmacological and non- pharmacological strategies can reduce analgesic consumption and myofascial dysfunction symptoms in chronic migraine patients

Harmonizacja przepisów o zaskarżaniu i bezskuteczności czynności dłużnika

Książka jest wynikiem międzynarodowego projektu naukowego, którego celem było sformułowanie propozycji zharmonizowanych przepisów dotyczących bezskuteczności i zaskarżania czynności dłużnika w Unii Europejskiej. Projekt opiera się na 25 raportach krajowych (w tym dotyczącym prawa polskiego), na podstawie których sformułowano podstawowe zasady prawa w tym zakresie, a następnie sporządzono ustawę modelową będącą propozycją zharmonizowanych przepisów, które mogłyby zostać wprowadzone w drodze rozporządzenia albo dyrektywy UE. Projekt wpisuje się w długoterminowe plany legislacyjne UE w dziedzinie prawa upadłościowego i może zostać wzięty pod uwagę w pracach legislacyjnych.This book is the result of an intensive research project on transactions avoidance laws in the EU, comprising national reports and input from 25 jurisdictions and analysing the relevant topics from a principle-based perspective. The authors elaborate on the principles supporting and shaping transactions avoidance law, identifying the topics to be addressed from a principle-based perspective, and weighing and balancing the relevant principles to find adequate solutions for every single topic. The final result is a Model Law, comprising nine sections, which the authors recommend implementing into all national insolvency laws of the EU Member States in order to provide for legal certainty as to which transactions should (or should not) be challengeable in all Member States under the same conditions