Modelling of network schedule including priority of selected technical resources

The paper presents a method of network planning CPM – Critical Path Method. The author compares models of optimal solutions to design deadlines for individual works, taking various leading technical resources such as is labor and a tower crane into account

Dystonic tics in patients with Gilles de la Tourette syndrome

Clinical rationale for the study. Gilles de la Tourette syndrome (GTS) is a childhood onset disorder characterised by motor and vocal tics. Different types of motor tics may occur in GTS, including dystonic tics (DTs). Although DTs have been recognised as part of GTS symptomatology, little is known about their risk factors or about how often and at what age they appear in affected individuals.Aim of the study. The aim of our study was to investigate lifetime prevalence and clinical correlations of DTs in a Polish cohort of GTS patients.Material and methods. We performed a prospective, one-registration study in a cohort of 207 consecutive ambulatory patients (mean age: 16.5 ± 9.4 years, 131 children, 162 males) with GTS. Duration of GTS was 9.0 ± 8.0 years (range: 1–39 years). DTs were diagnosed during the interview. DTs were defined as slower and lasting longer than typical clonic tics, abnormal dystonia-like movements that led to a sustained, but not fixed, posture.Results. DTs occurred at some point in the lifetime of 73.9% (n = 153) of patients. The prevalence of DTs in adults and children was almost the same (p = 0.963). Age at onset of DTs was 9.9 ± 5.2 years with the most frequent onset in children (7–11 years, 74.4%, n = 64), followed by adolescence (12–18 years; 17.4%, n = 15) and adulthood (≥ 18 years, 8.1%, n = 7). DTs occurred 3.7 ± 4.2 years after tic onset. On average, patients suffered from 1.8 ± 1.7 types of DTs. The most frequent manifestations of DTs were:eyes (tightening resembling blepharospasm 84.3%, n = 129 and oculogyric crisis 45.8%, n = 70), trunk (dystonic postures 59.5%, n = 91), jaw (bruxism 34.6%, n = 53), neck (30.7%, n = 47), upper limb (26.1%, n = 40), and foot (20.9%, n = 32). Multivariate logistic regression analysis showed significant associations of DTs with the total number of simple, and the total number of complex, tics.Conclusions and clinical implications. DTs are early and frequent symptoms of GTS. They tend to localise in the facial area. DTs occur more frequently in individuals with a higher number of tics and probably add to the global impairment caused by tics

Dystonic tics in patients with Gilles de la Tourette syndrome

Clinical rationale for the study. Gilles de la Tourette syndrome (GTS) is a childhood onset disorder characterised by motor and vocal tics. Different types of motor tics may occur in GTS, including dystonic tics (DTs). Although DTs have been recognised as part of GTS symptomatology, little is known about their risk factors or about how often and at what age they appear in affected individuals. Aim of the study. The aim of our study was to investigate lifetime prevalence and clinical correlations of DTs in a Polish cohort of GTS patients. Material and methods. We performed a prospective, one-registration study in a cohort of 207 consecutive ambulatory patients (mean age: 16.5 ± 9.4 years, 131 children, 162 males) with GTS. Duration of GTS was 9.0 ± 8.0 years (range: 1–39 years). DTs were diagnosed during the interview. DTs were defined as slower and lasting longer than typical clonic tics, abnormal dystonia-like movements that led to a sustained, but not fixed, posture. Results. DTs occurred at some point in the lifetime of 73.9% (n = 153) of patients. The prevalence of DTs in adults and children was almost the same (p = 0.963). Age at onset of DTs was 9.9 ± 5.2 years with the most frequent onset in children (7–11 years, 74.4%, n = 64), followed by adolescence (12–18 years; 17.4%, n = 15) and adulthood (≥ 18 years, 8.1%, n = 7). DTs occurred 3.7 ± 4.2 years after tic onset. On average, patients suffered from 1.8 ± 1.7 types of DTs. The most frequent manifestations of DTs were: eyes (tightening resembling blepharospasm 84.3%, n = 129 and oculogyric crisis 45.8%, n = 70), trunk (dystonic postures 59.5%, n = 91), jaw (bruxism 34.6%, n = 53), neck (30.7%, n = 47), upper limb (26.1%, n = 40), and foot (20.9%, n = 32). Multivariate logistic regression analysis showed significant associations of DTs with the total number of simple, and the total number of complex, tics. Conclusions and clinical implications. DTs are early and frequent symptoms of GTS. They tend to localise in the facial area. DTs occur more frequently in individuals with a higher number of tics and probably add to the global impairment caused by tics. Key words: Gilles de la Tourette syndrome, dystonic tics, simple tics, complex tics, dystoni

Influence of structural changes of Co78Si9B13 metallic glass on magnetic properties

The primary crystallization of Co78Si9B13 metallic glass starts at 648 K and as a consequence of this the ε-Co(Si) phase with needle morphology is created. The second stage of crystallization (at 773 K) is the eutectic and as a result of this α-Co(Si) and boron phases: (Co,Si)3B, (Co,Si)2B are formed. The crystallites of these phases have layer morphology. These characteristic morphologies in the first and second stages lead to the increase in coercivity

Vibration testing in buildings and safety of their operation

The paper presents the issue of vibrations in residential buildings located near roads. It describes the measurement methodology and criteria for assessing the impact of vibrations generated by passing trucks. The article specifies a method to establish the impact on the operation of the examined facilities and it promotes the idea of employing a Bayesian network to determine probabilistically the level of risk to single-family houses

HBK-14 and HBK-15 do not influence blood pressure, lipid profile, glucose level, or liver enzymes activity after chronic treatment in rats

Older and even new antidepressants cause adverse effects, such as orthostatic hypotension, hyper- or hypoglycemia, liver injury or lipid disorders. In our previous experiments we showed significant antidepressant- and anxiolytic-like activities of dual 5-HT1A and 5-HT7 antagonists with α1-adrenolitic properties i.e. 1-[(2,6-dimethylphenoxy)ethoxyethyl]-4-(2-methoxyphenyl)piperazine hydrochloride (HBK-14) and 1-[(2-chloro-6-methylphenoxy)ethoxyethyl]-4-(2-methoxyphenyl)piperazine hydrochloride (HBK-15). Here, we evaluated the influence of chronic administration of HBK-14 and HBK-15 on blood pressure (non-invasive blood pressure measurement system for rodents), lipid profile (total cholesterol, low density lipoproteins-LDL, high density lipoproteins-HDL, triglycerides), glucose level, and liver enzymes activity (aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transferase). We determined potential antihistaminic (isolated guinea pig ileum) and antioxidant properties (ferric reducing ability of plasma-FRAP, non-protein thiols-NPSH, stable free radical diphenylpicrylhydrazyl-DPPH) cytotoxicity. Our experiments revealed that HBK-14 and HBK-15 did not influence blood pressure, lipid profile, glucose level or liver enzymes activity in rats after 2-week treatment. We also showed that none of the compounds possessed antioxidant or cytotoxic properties at antidepressant- and anxiolytic-like doses. HBK-14 and HBK-15 very weakly blocked H1 receptors in guinea pig ileum. Positive results of our preliminary experiments on the safety of HBK-14 and HBK-15 encourage further studies concerning their effectiveness in the treatment of depression and/or anxiety disorders

An association between genetic variation in the glutamatergic system and suicide attempts in alcoholâ dependent individuals

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138265/1/ajad12571_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138265/2/ajad12571.pd

Expert systems in assessing the construction process safety taking account of the risk of disturbances

The objective of the paper is to present the issue of safety management during the construction process. Threats in the form of disturbances may occur in the preparatory phase, during the execution of the construction project and also during its operational use. The article presents the concept of applying the methodology based, among others, on Learning Bayesian Networks, Artificial Neural Networks and Support Vector Machine, which can be used for building a system for diagnostic and decision-making support at each stage of the construction process. The use of expert systems when it comes to making choices related to construction issues can bring many benefits to decision-makers, as it reduces the risk of taking a wrong decision, and, thus, increases the construction process safety

Substance use disorder status moderates the association between personality traits and problematic mobile phone/internet use

Background: Associations between personality traits and problematic smartphone use (PSU) among individuals with substance use disorder (SUD) have not been widely investigated. The current study aims to assess whether SUD status moderates the association between personality traits and PSU. Methods: The study group included 151 individuals with SUD and a normative sample (NS) comprised of 554 non-SUD students. The following self-report questionnaires were used: the Mobile Phone Problem Use Scale (MPPUS-10) to assess problematic smartphone use (PSU), the Internet Addiction Test (IAT) to assess intensity of internet use, and the NEO Five-Factor Inventory (NEO-FFI) to assess Personality traits. Results: SUD status moderated the association between neuroticism and openness to new experiences on PSU. That is, greater neuroticism and openness were significantly associated with more excessive PSU among the NS. In the SUD group, greater openness was a significant protective factor against PSU. Moderation results were similar when using the IAT (which was significantly correlated with MPPUS) as an outcome. Conclusions: The presence of SUD may influence how personality traits are associated with problematic mobile phone/internet use. Given that this is among one of the first studies examining this topic, findings should be replicated with additional studies

Używanie telefonów komórkowych i internetu przez osoby uzależnione od substancji psychoaktywnych, pacjentów z zaburzeniami psychicznymi oraz studentów

Introduction: Behavioral disorders involving new technologies are important group of addictions with growing prevalence. This study was designed to assess patterns of mobile phone and internet use among drug addicts, patients diagnosed with mental disorder and medical students. Material and methods: 151 of drug addicts (PU), 183 psychiatric patients (PP) and 613 medical students being control group (GK) were enrolled to the study. Participants were asked to complete questionnaires on mobile phone use (Mobile Phone Problem Use Scale; MPPUS-10 and Mobile Phone Addiction Assessment Questionnaire; MPAAQ) and internet addiction (Internet Addiction Test; IAT). Results: There were no significant differences among the study groups in terms of problem us of mobile phone as measured with MPPUS-10; medians were as follows: PU=31.5 (IQR = 30.2), PP = 33 (IQR = 20.8), GK=35 (IQR = 22). According to MPAAQ, 35.8% of participants met mobile phone addiction criteria, while all other participants were at risk of addiction. MPAAQ medians were: PU=43 (IQR =40), PP=32.5 (IQR = 22.2), GK=31 (IQR = 18) with significant difference between PU and GK, PU and PP (both p < 0.001). Medians of internet addiction measured with IAT were: PU=31 (IQR = 26.5), PP=32 (IQR =10), GK=30 (IQR = 10) with significant difference between PU and PP as well as PP and GK, p = 0.015 and p = 0.012, respectively. Conclusion: Study results suggest high prevalence of mobile phone and internet addiction in Poland. This may indicate common background of substance dependence and behavioral addictions as well as comorbidity of internet addiction with mental disorders.Wstęp: Uzależnienia od nowych technologii stanowią ważną grupę uzależnień behawioralnych, a ich rozpowszechnieniew ostatnich latach wyraźnie wzrasta. Celem badania była ocena używania telefonów komórkowych i internetuwśród osób uzależnionych od substancji psychoaktywnych, pacjentów leczonych z powodu zaburzeń psychicznychoraz studentów medycyny. Materiał i metody: W badaniu wzięło udział 151 osób uzależnionych od substancji psychoaktywnych (PU), 183pacjentów oddziałów psychiatrycznych (PP) oraz 613 studentów uniwersytetu medycznego jako grupa kontrolna (GK).Badanie miało charakter ankietowy; uczestnicy wypełniali kwestionariusze oceniające używanie telefonu komórkowegoi internetu: Mobile Phone Problem Use Scale (MPPUS-10), Kwestionariusz do Badania Uzależnienia od Telefonu Komórkowego(KBUTK) oraz Internet Addiction Test (IAT). Wyniki: Nie stwierdzono różnic między badanymi grupami pod względem problemowego używania telefonu komórkowegoocenianego za pomocą skali MPPUS-10. Mediany skali MPPUS-10 wyniosły: PU = 31,5 (IQR = 30,2),PP = 33 (IQR = 20,8), GK = 35 (IQR = 22). W badanych populacjach, według skali KBUTK uzależnionych od telefonukomórkowego było 35,8% badanych, a pozostali badani byli zagrożeni uzależnieniem. Mediany KBUTK wynosiły:PU = 43 (IQR = 40), PP = 32,5 (IQR = 22,2), GK = 31 (IQR = 18). Istotnie statystycznie różniły się PU i GK oraz PUi PP (p &lt; 0,001). Uzależnienie od internetu oceniano według skali IAT; mediany: PU = 31 (IQR = 26,5), PP = 32 (IQR= 10), GK = 30 (IQR = 10). Istotnie statystycznie różnili się PU i PP oraz PP i GK (odpowiednio p = 0,015 i p = 0,012). Wnioski: Uzyskane wyniki mogą świadczyć o dużym rozpowszechnieniu w Polsce uzależnienia od telefonów komórkowychi internetu. Mogą również udowadniać wspólne podłoże uzależnień od substancji psychoaktywnych i behawioralnych,a także częste współwystępowanie uzależnienia od internetu z zaburzeniami psychicznymi