Training of students to standards and fire safety regulations on the basis of the educational platform "Moodle"

This article describes the use of a web-based educational program for teaching students the norms and rules of fire safety. The article describes both the educational program developed by the authors and the advantages of using information technologies in the educational process. Also in the article the first results of the approbation of this approach are given

Testing, Treatment, and Trust: Social Work Professional Development and the Genomics Revolution

Knowledge in the area of human genetics and genomics is expanding at an exponential pace, with significant implications for social work in health, mental health, and other settings. This article identifies some key roles social workers may play in the arena of genetics, discusses social workers responsibility for ongoing professional development in this area, and describes a flexible genetics and genomics social work curriculum developed by the authors. We provide an evaluation of pilot curriculum implementations, discuss ongoing strategies and barriers to dissemination, and make recommendations for future actions to more fully incorporate genetics and genomics content into the social work professional knowledge base

Eating disorders symptoms and excessive internet use in adolescents : the role of internalising and externalising problems

Background: Both eating disorders and excessive internet use represent significant health issues for contemporary adolescents. Yet, the link between them has seldom been investigated. We aim to study this association through their common underlying psychological factors: internalising problems and externalising problems. Methods: A representative sample of 7,083 adolescents (Mage = 13.48 years; SDage = 1.32; 50.3% girls) from Slovakia was obtained from the Health Behaviour in School-aged Children (HBSC) project in 2018. Study variables included the Excessive Internet Use Scale (EIU) and the Strength and Difficulties Questionnaire (SDQ). Eating disorders symptoms (EDS) were assessed by SCOFF and selected items from the Eating Disorder Screen for Primary Care (ESP). Data were analysed separately for boys and girls with Structural Equation Modelling. Results: There was a partial correlation between EDS and EIU (r = 0.36 for boys and r = 0.29 for girls) after controlling for the internalising and externalising of problems. Internalising and externalising problems were positively associated with EDS, while EIU was only associated with externalising problems. The results were comparable for both genders. Conclusion: The study provides evidence that, during adolescence, EDS and EIU are related and have a tendency to occur together. Also, they are related even when controlled for their shared underlying psychological factors, namely the emotional and attentional/behavioural difficulties

Opting for Living-Apart-Together and Cohabitation Relationships in people 50+: A Longitudinal Analysis

Despite a growing body of research on later-life relationships, there are still only a limited number of explorative longitudinal studies that have investigated the factors responsible for the establishment of either a Living-Apart-Together (LAT) arrangement or a cohabitation relationship. Two waves of data collection by the Survey of Health, Ageing and Retirement in Europe (2014/2015-2017; N= 12,155; Mage=71.96; 76.3% women) were analyzed with a special focus on family, dwelling, and financial constraints. Those who were male, younger, and had more children were more likely to enter into a LAT arrangement or a cohabitation relationship than to remain unpartnered. More rooms and fewer years spent in the accommodation raised the odds to partner. LAT persons were slightly older than those in cohabitation relationships. No other factors influenced the form of living arrangement, which indicates that factors other than financial constraints and family responsibilities affect later-life LAT or cohabitation relationship formation.Despite a growing body of research on later-life relationships, there are still only a limited number of explorative longitudinal studies that have investigated the factors responsible for the establishment of either a Living-Apart-Together (LAT) arrangement or a cohabitation relationship. Two waves of data collection by the Survey of Health, Ageing and Retirement in Europe (2014/2015-2017; N= 12,155; Mage=71.96; 76.3% women) were analyzed with a special focus on family, dwelling, and financial constraints. Those who were male, younger, and had more children were more likely to enter into a LAT arrangement or a cohabitation relationship than to remain unpartnered. More rooms and fewer years spent in the accommodation raised the odds to partner. LAT persons were slightly older than those in cohabitation relationships. No other factors influenced the form of living arrangement, which indicates that factors other than financial constraints and family responsibilities affect later-life LAT or cohabitation relationship formation

Severe Disseminated Coagulopathy Caused by Adenocarcinoma with Bone Marrow Metastasis

Background: Patients with mucin-producing adenocarcinoma have an increased risk for venous and arterial thrombosis. When these patients present with thrombocytopenia, disseminated intravascular coagulopathy (DIC) is often the underlying cause. Case Report: We report 2 patients who were admitted due to bleeding symptoms of unknown cause, in whom further workup revealed adenocarcinoma-induced DIC. Conclusion: In elderly patients presenting with signs of DIC, such as reduced fibrinogen levels, elevated prothrombin time, elevated D-dimer, and thrombocytopenia, without any obvious reason (e.g., sepsis), adenocarcinoma-associated coagulopathy should be considered as the underlying cause. Paradoxically, in these patients bleeding symptoms improve when the patient is sufficiently anti-coagulated with low molecular weight heparin. Treatment of the underlying disease is of central importance in controlling acute or chronic DIC associated with malignant diseases and chemotherapy should be started as soon as possible

Exploring challenges in later-life relationships: a qualitative study of the queries posted on counselling websites

IntroductionDivorce rates among individuals aged 50 and above are on the rise. Given the greater life expectancy compared to previous generations, this is an issue that is affecting an increasing number of people. Therefore, it warrants an inquiry into the challenges these individuals encounter in their intimate relationships.MethodsThis study analyzed 225 relationship-related queries posted on Czech counselling websites to identify the strains and stressor patterns that older adults face in their relationships. The queries were limited to those that concerned themes and problems related to partnerships, were posted by one of the partners aged 60 or over, and were analyzed using inductive thematic analysis.ResultsFour main relationship issues were identified: infidelity and jealousy; relationship estrangement and cooling; undesirable changes in personality; and illness and somatic issues. Additionally, three recurring themes were identified that made the problems more demanding and that were specific to older age: lack of norms for relationships in that age group, absence of resources to tackle the issues, and personal calculation for Time Spent and Time Remaining.DiscussionThe research found that the types of problems encountered by older adults were similar to those experienced by younger individuals. However, the way these problems were perceived and processed was influenced by specific aspects of aging, such as societal expectations, available coping resources, and the perception of time. The findings also highlighted the challenges faced by older adults in terms of relationship norms, sexual functioning, and personality changes

Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: integrated analysis of data from Study 10 and ARIEL2

Objective: An integrated analysis was undertaken to characterize the antitumor activity and safety profile of the oral poly(ADP-ribose) polymerase inhibitor rucaparib in patients with relapsed high-grade ovarian carcinoma (HGOC). Methods: Eligible patients from Study 10 (NCT01482715) and ARIEL2 (NCT01891344) who received a starting dose of oral rucaparib 600 mg twice daily (BID) with or without food were included in these analyses. The integrated efficacy population included patients with HGOC and a deleterious germline or somatic BRCA1 or BRCA2 (BRCA1/2) mutation who received at least two prior chemotherapies and were sensitive, resistant, or refractory to platinum-based chemotherapy. The primary endpoint was investigator-assessed confirmed objective response rate (ORR). Secondary endpoints included duration of response (DOR) and progression-free survival (PFS). The integrated safety population included patients with HGOC who received at least one dose of rucaparib 600 mg BID, irrespective of BRCA1/2 mutation status and prior treatments. Results: In the efficacy population (n = 106), ORR was 53.8% (95% confidence interval [CI], 43.8–63.5); 8.5% and 45.3% of patients achieved complete and partial responses, respectively. Median DOR was 9.2 months (95% CI, 6.6–11.6). In the safety population (n = 377), the most frequent treatment-emergent adverse events (AEs) were nausea, asthenia/fatigue, vomiting, and anemia/hemoglobin decreased. The most common grade ≥ 3 treatment-emergent AE was anemia/hemoglobin decreased. Treatment-emergent AEs led to treatment interruption, dose reduction, and treatment discontinuation in 58.6%, 45.9%, and 9.8% of patients, respectively. No treatment-related deaths occurred. Conclusions: Rucaparib has antitumor activity in advanced BRCA1/2-mutated HGOC and a manageable safety profile

Earth Observation Data Mining: A Use Case for Forest Monitoring

The increased number of free and open satellite images has led to new applications of these data. Among them is the systematic classification of land cover/use types based on patterns of settlements or agriculture recorded by satellite imagers, in particular, the identification and quantification of temporal changes. In this paper, we will present guidelines and practical examples of how to obtain reliable image patch classification results based on data mining techniques for detecting possible changes that can appear within a data set. Here, we will focus on a scenario, namely forest monitoring using Earth observation Synthetic Aperture Radar data acquired by Sentinel-1, and multispectral data acquired by Sentinel-2