57 research outputs found
Endocrine health conditions in adult survivors of childhood cancer: the need for specialized adult-focused follow-up clinics
Sorafenib treatment of radioiodine-refractory advanced thyroid cancer in daily clinical practice: a cohort study from a single center.
Ultrasound surveillance for radiation-induced thyroid carcinoma in adult survivors of childhood cancer
GH replacement therapy and second neoplasms in adult survivors of childhood cancer: a retrospective study from a single institution.
EARLY SURGERY AND SURVIVAL OF PATIENTS WITH ANAPLASTIC THYROID CARCINOMA: ANALYSIS OF A CASE SERIES REFERRED TO A SINGLE INSTITUTION BETWEEN 1999 - 2012.
Optimized Inhibitors of MDM2 via an Attempted Protein-Templated Reductive Amination
Innovative and efficient hit-identification techniques are required to
accelerate drug discovery. Protein-templated fragment ligations
represent a promising strategy in early drug discovery, enabling the
target to assemble and select its binders from a pool of building
blocks. Development of new protein-templated reactions to access
a larger structural diversity and expansion of the variety of targets
to demonstrate the scope of the technique are of prime interest for
medicinal chemists. Herein, we present our attempts to use a
protein-templated reductive amination to target protein-protein
interactions (PPIs), a challenging class of drug targets. We address a
flexible pocket, which is difficult to achieve by structure-based drug
design. After careful analysis we did not find one of the possible
products in the kinetic target-guided synthesis (KTGS) approach,
however subsequent synthesis and biochemical evaluation of each
library member demonstrated that all the obtained molecules
inhibit MDM2. The most potent library member (Ki=0.095 μm)
identified is almost as active as Nutlin-3, a potent inhibitor of the
p53-MDM2 PPI
Quantum Characterization of a Werner-like Mixture
We introduce a Werner-like mixture [R. F. Werner, Phys. Rev. A {\bf 40}, 4277
(1989)] by considering two correlated but different degrees of freedom, one
with discrete variables and the other with continuous variables. We evaluate
the mixedness of this state, and its degree of entanglement establishing its
usefulness for quantum information processing like quantum teleportation. Then,
we provide its tomographic characterization. Finally, we show how such a
mixture can be generated and measured in a trapped system like one electron in
a Penning trap.Comment: 8 pages ReVTeX, 8 eps figure
AVALIAÇÃO DA IMUNIZAÇÃO COM CATEPSINA L3 FRENTE À FASCIOLOSE EXPERIMENTAL
Fasciolose acomete principalmente bovinos e ovinos e é responsável por importantes perdas econômicas. Objetivou-se testar em ratos e bovinos a proteção do antÃgeno recombinante Catepsina L3 frente à infecção experimental por Fasciola hepatica. Os ratos foram divididos nos grupos: 1) imunizados; 2) adjuvante e 3) controle. Os bovinos foram divididos nos grupos: 4) imunizados e 5) adjuvante. Avaliaram-se ovos por grama nas fezes e contagem parasitária nos ratos, ganho de peso diário e contagem parasitária nos bovinos. Observou-se baixo Ãndice de proteção, não alcançando nÃvel suficiente para utilização comercial do antÃgeno
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