DCE-MRI and parametric imaging in monitoring response to neoadjuvant chemotherapy in breast carcinoma : a preliminary report

Purpose: Neoadjuvant chemotherapy is recommended in patients with locally advanced breast cancer. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) enables evaluation of the tumour neovasculature that occurs prior to any volume change, which helps identify early treatment failures and allows prompt implementation of second-line therapy. Material and methods: We conducted a prospective study in 14 patients with histopathologically proven breast cancer. DCE-MRI data were acquired using multisection, T1-weighted, 3D vibe sequences with fat suppression before, during, and after IV bolus injection (0.1 mmol/kg body weight, Gadoversetamide, Optimark). Post-processing of dynamic contrast perfusion data was done with the vendor's Tissue 4D software to generate various dynamic contrast parameters, i.e. Ktrans, Kep, Ve, initial area under the time signal curve (IAUC), apparent diffusion coefficient (ADC), and enhancement curve. Patients underwent MRI examinations at baseline, and then after two cycles, and finally at completion of chemotherapy. Results: Based on Sataloff criteria for pathological responses, four patients out of 14 were responders, and 10 were non-responders. At the 2nd MRI examination, IAUC was significantly smaller in responders than in non-responders (p = 0.023). When the results of the first and second MRI examinations were compared, Kep decreased from baseline to the second MRI (p = 0.03) in non-responders and in responders (p = 0.04). This change was statistically significant in both groups. The ADC values increased significantly in responders from baseline to the third MRI (p = 0.012). Conclusions: In our study, IAUC and ADC were the only parameters that reliably differentiated responders from non-responders after two and three cycles of chemotherapy

Maternal Health Care Awareness Among College Girls of other Backward Class of Central India

Death due to complication related to pregnancy and childbirth are the leading cause of mortality of women in the reproductive ages in developing countries. Health status of Madhya Pradesh in India shows IMR/1000 live births is 90 and < 5 mortality / 1000 is 137.6. [1] India is among "Slow progressing nation” in child and maternal care. Madhya Pradesh is one of the states where maternal mortality rates are as high as 700 or more [2]. Antenatal and postnatal care awareness among youth can certainly reduce the mortality and morbidity rate, as they are future mothers. Objective: The study has been undertaken to find the knowledge and awareness among 250 college girls of other backward class, Jabalpur city, Madhya Pradesh regarding antenatal and postnatal health care. Study Area: India is the seventh biggest country of the world. It has 2.4 percent land area and 16.7 percent population of the whole world. Madhya Pradesh is one of the major state of India located in the central part of India therefore it is named so. It has 6, 03, 85,118 total population out of which 2, 89, 28,245 are female. Jabalpur city is the heart of India, and a Division of Madhya Pradesh The population of Jabalpur is 2,167,469. Sample: 250 randomly selected other backward class category college girls of Jabalpur city, Madhya Pradesh, India are the sample for the present study. Other backward class (OBCS) is one of socially disadvantaged groups. Method: For recording information regarding knowledge & perception towards maternal health care, a detailed structured but simple questionnaire was distributed among 250 randomly selected unmarried college girls of other backward class of Jabalpur city, Madhya Pradesh, India. Sample colleges were selected by stratified random sampling method. The study was conducted in various colleges in Jabalpur. Results: It is found that all 100 percent girls are aware that pregnant women need special care. 60.8 percent girls consider pregnancy as a general physiological process, 74.8 percent accepted that during pregnancy normal daily routine work should be done. 89.6 percent girls have a view for monthly consultation to Doctor during pregnancy. 66.4 percent knew tetanus toxoide injection is necessary in pregnancy.70.4 percent girls have knowledge that folic acid tablets are given to prevent anemia.96 percent girls accepted that in pregnancy extra nutrient should be given. 56.6 percent girls mentioned all the nutrients should be given in extra amount during pregnancy period.15.8 percent girls consider protein 12.0 percent girls iron, 12.0 percent girls calcium and 3.3 percent girls consider Vitamin A should be given in extra amount. 24 percent girls knew that weight of normal neonate is 3 kg. All the girls accepted that mother’s milk should be first feed of new born babies. Only 51.2 percent girls have knowledge regarding colostrums. 28.8 percent girls are aware that 6 months is correct age for infant to introduce semisolid food.17.6 percent girls knew 4 months is correct age for supplementary food. 91.2 percent girls correctly mentioned salt-sugar solution could be given for treatment of diarrhea at home. 97.6 percent students are having knowledge of oral rehydration solution. Conclusion: It has been noticed that girls are quite aware of antenatal and postnatal care. It is suggested regarding important aspects, which are lacking like, colustrum or nutritional requirement of a mother, students should be informed by interpersonal communication. Parents should also pass their knowledge acquired by them through the experience of life realizing that maternal health is a major instrument of social and economic development and plays an important role in the creation of a new world through safe motherhood

Push-out bond strength of different endodontic obturation material at three different sites : in-vitro study

The key to success of any root canal therapy is adequate obturation of the prepared root canal space. Root canal sealers are not dimensionally stable and might dissolve partially over a period of time. The objective of this in vitro study is to evaluate the push-out bond strength to intraradicular dentin of two endodontic obturation materials. Forty extracted single rooted permanent teeth were used. Canals orifice was explored, teeth were instrumented. The samples were divided into two groups each containing twenty specimens obturated with different obturation material (Group1 Epiphany/Resilon and Group 2 Gutta Percha/AH Plus).The obturation systems used in this study was Element Obturation unit (Sybron Endo). Each tooth root was horizontally sectioned in approximately 2-mm thick slices from the coronal 1/3rd, middle 1/3rd and apical 1/3rd. The push-out bond strength of each specimen was calculated using Universal Testing Machine. The statistical analysis was done using two way analysis of variance (ANOVA) and tukey?s test. There was significant difference between push out bond strength of Resilon/Epiphany and AH Plus/Gutta Percha. Gutta percha group was superior with push out bond strength of 2.22 (± 0.16) Mpa in comparison to Resilon/Epiphany group with 1.61 (±0.14) Mpa (p<0.001). The interfacial bond strength achieved with Resilon/Epiphany self-etch (SE) to intraradicular dentine was not superior to that of AH Plus/Gutta Percha

Beneficial Remedies of Ayurvedic Medicines Against Allopathic Drugs In Peptic Ulcer

Ayurveda has long been regarded as the most dependable and secure medical system. The effectiveness of Ayurvedic Remedies becomes evident after a certain period of time. These remedies operate by enhancing the immune response or eliciting antagonistic reactions. Ayurvedic treatments utilize substances derived from plants, marine sources, and minerals. These remedies tend to have minimal to no observed side effects due to their natural origin. Here, we compared the Allopathic therapies with Ayurvedic remedies for Peptic Ulcer disease

Recent approaches to combat various infections in eye

The prevalence of various eye related disorder is increasing rapidly among the global population and the microorganism borne ocular infections are emerging as biggest threat to the healthy functioning of eye during the past few years. Conjunctivitis, keratitis, endophthalmitis, blepharitis, uveitis, cellulitis, and ocular herpes are a few of the more common ocular illnesses. The arrival of novel technologies including nanotechnology and ocular implant are giving a hope to the healthcare sector via improved therapeutic potential and safety profile in the field of ocular infections treatment. This article enlisted major ocular infections, along with the physiology, prevention and treatment methods. The review article also highlighted information related to the available treatments for various ocular infections and recent patent insight of emerging technologies.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp

Energy Conservation in India: Challenges & Achievements

The gap between supply and demand of energy is continuously increasing despite huge outlay for energy sector since independence. Further the brining of fossil fuel is resulting in greenhouse gases which are detrimental to the environment. The gap between supply and demand of energy can be bridged with the help of energy conservation which may be considered as a new source of energy which is environment friendly. The energy conservation is cost effective with a short payback period and modest investment. There is a good scope of energy conservation in various sectors, viz industry agriculture, transport and domestic, This paper will give overview of energy conservation in Indian scenario

Erasmus syndrome: Association of silicosis and systemic sclerosis

Silicosis is an inflammatory disease of the lung characterized by irreversible lung fibrosis which develops from prolonged pulmonary inhalation and retention of crystalline silica and immune reaction. It mainly appears as an occupational hazard in persons involved in stone-quarrying, mining, and sand blasting. Crystalline silica is not only known to be responsible for silicosis but also for other autoimmune diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA)-Caplan syndrome, systemic sclerosis (SSc), and antineutrophil cytoplasmic antibody (ANCA)-related vasculitis. Erasmus syndrome is the association of silica exposure and subsequent development of SSc. The limited numbers of cases reported in the literature were miners and only sporadically involved in other professionals. Here, we report a case of a 52 -year-old stone cutter who developed silicosis and SSc after 25 years of exposure

Malignant intracranial hemangiopericytoma in a 22-year-old male with head injury and implications

We report a case of intracranial hemangiopericytoma of a young male of 22 years who presented with neurological signs of impaired memory, left hemiparesis, headache, and two episodes of focal seizures. A significant history of head trauma 9 years back was given. A space-occupying lesion was identified in the bilateral frontoparietal region. The surgical intervention involved bilateral frontoparietal craniotomy and Simpson Grade II excision of tumor. Postoperative conformal radiotherapy was administered. A marked neurological improvement was subsequently observed. Peak incidence of this disease is in the fourth or fifth decade. However, our case is an exception presenting at an age of 22 years. Associated history of head trauma has only been infrequently reported in the past