Finite mixtures of matrix-variate Poisson-log normal distributions for three-way count data

Three-way data structures, characterized by three entities, the units, the variables and the occasions, are frequent in biological studies. In RNA sequencing, three-way data structures are obtained when high-throughput transcriptome sequencing data are collected for n genes across p conditions at r occasions. Matrix-variate distributions offer a natural way to model three-way data and mixtures of matrix-variate distributions can be used to cluster three-way data. Clustering of gene expression data is carried out as means to discovering gene co-expression networks. In this work, a mixture of matrix-variate Poisson-log normal distributions is proposed for clustering read counts from RNA sequencing. By considering the matrix-variate structure, full information on the conditions and occasions of the RNA sequencing dataset is simultaneously considered, and the number of covariance parameters to be estimated is reduced. A Markov chain Monte Carlo expectation-maximization algorithm is used for parameter estimation and information criteria are used for model selection. The models are applied to both real and simulated data, giving favourable clustering results

Mirror neurons and their role in communication

Actions done by others are probably the most important stimuli of our lives. Most of others’ actions do not convey intentional information to the observer. From them, however, we understand   what others are doing and we can infer why they are doing it. This involuntary communication is fundamental for interpersonal relations, and is at the basis of social life. What is the mechanism underlying our capacity to understand others’ actions? The traditional view is that actions done by others are understood in the same way as other visual stimuli. Thus, action understanding is based on the visual analysis of the different elements that form an action. For example, when we observe a girl picking up a flower, the analyzed elements would be her hand, the flower, and the movement of the hand towards the flower. The association of these elements and inferences about their interaction enables the observer to understand the witnessed action. The discovery of neurons that code selectively biological motion has better specified the neural basis of this   recognition mechanism. These theoretical considerations received strong support from the discovery that in the motor cortex of the macaque monkey there is a particular set of neurons that discharge both when the monkey observes a given motor act and when it does the same act. These neurons called “mirror neurons,” represent a system that directly matches observed and executed actions

Raman anomalies as signatures of pressure induced electronic topological and structural transitions in black phosphorus: Experiments and Theory

We report high pressure Raman experiments of Black phosphorus up to 24 GPa. The line widths of first order Raman modes A$^1_g$, B$_{2g}$ and A$^2_g$ of the orthorhombic phase show a minimum at 1.1 GPa. Our first-principles density functional analysis reveals that this is associated with the anomalies in electron-phonon coupling at the semiconductor to topological insulator transition through inversion of valence and conduction bands marking a change from trivial to nontrivial electronic topology. The frequencies of B$_{2g}$ and A$^2_g$ modes become anomalous in the rhombohedral phase at 7.4 GPa, and new modes appearing in the rhombohedral phase show anomalous softening with pressure. This is shown to originate from unusual structural evolution of black phosphorous with pressure, based on first-principles theoretical analysis.Comment: 13pages, 12figure

Oral Health Status of Institutionalized Orphans and Non-Orphans Aged 6-12 Years in a Central Indian City: A Comparative Study

INTRODUCTION: Oral Health, like general health, is a basic fundamental right for all, and even more so for the underprivileged. AIM: To evaluate the oral health status of Institutionalized orphans aged 6-12 years and non-orphans in Indore, Madhya PradeshMATERIALS AND METHODS: The present descriptive cross-sectional study was conducted among various registered orphanages in Indore, Madhya Pradesh. Oral Examination was done by two standardized examiners (ADA type III examination) and data was entered using a pre-tested and pre-validated proforma. Data was transferred into MS excel and after application of descriptive statistics, the independent samples t-test and multiple logistic regression were applied (p value significant at ≤ 0.5). RESULTS: Of the total 263 study subjects, there were 132(50.2%) orphans and 131(49.8%) school children aged 6-12 years. Among orphans, males (62.9%) formed the majority; use of toothbrush with toothpaste was observed among 69.7% of orphans, while 6.1% did not use any oral hygiene aid. The most common observed hard lesion was dental caries (31.8%) as compared to 20.6% in school children and its presence revealed a significant association (p=0.02). CONCLUSION: It is recommended that a special emphasis should be made to promote oral health among the children residing in orphanages

DESIGN, SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME MANNICH BASE DERIVATIVE OF 2-(SUBTITUTED)-5-AMINO-THIADIAZOLES

Objective: The major objective of the present study was to design, synthesize some Mannich base derivative of 2-substituted-5-amino thiadiazoles with primary amines/phthalimide and formaldehyde anticipating effective as antimicrobial agents.Methods: The efficient syntheses of substituted thiadiazole were done simply by reaction of substituted benzoic acid with thiosemicarbazide in presence of only conc. sulphuric acid. The isolated products were further subjected for Mannich reaction and evaluated for antibacterial activity.Results: Three substituted thiadiazoles (BA-1 to BA-3) were synthesized by solvent less efficient synthesis and their Mannich base derivates were also prepared with phthalimide, p-nitro/methyl/chloro-aniline. All characterized products were screened for antibacterial and antifungal activities. Among these compounds having nitro group (3,7,13) showed maximum activity followed by phthalimide, chloro and methyl groups.Conclusion: Thiadiazole-Mannich bases derivatives exhibited better antimicrobial activities then their starting components (BA-1 to BA-3) indicated joining different pharmacophore in the same molecule have increased activity.Â

A Case Study on Small Town Big Player – Enjay IT Solutions Ltd., Bhilad

Adequately trained Manpower is a problem that affects the IT industry as a whole, but it is particularly acute for Enjay IT Solution. Enjay's location in a semi-urban or rural area makes it even more difficult to find a talented employee with the right skills. As the competition for skilled workers grows, it becomes more difficult to attract and keep those workers who have the requisite training and experience