Room temperature synthesis of β-NaGdF4:RE3+ (RE = Eu, Er) nanocrystallites and their luminescence

A roomtemperaturesynthesiswasdevelopedforphasepure β-NaGdF4 nanocrystallitesaswellas5,10, and 20%Eu3þ or 5%Er3þ doped material.RareearthacetatesandNaClreactina1:2Mratiowitha variableexcessofNH4F inethyleneglycolwithin24hours.Sincethethermodynamicstabilityofthe hexagonalphasedecreasesalongthelanthanideseries,alargerexcessofNH4F wasrequiredforthe synthesis ofluminescentsamplesdopedwiththesmallerEr3þ ions thanforEu3þ doped orpure β- NaGdF4. ThematerialswerecharacterizedbypowderX-raydiffraction,electronmicroscopy,andlumi- nescence spectroscopy.TheEu3þ-doped samplesshow 5D0-7FJ and 5D1-7FJ luminescence afterEu3þ excitationat394nmorGd3þ excitationat273nmand308nm.Theratioof 5D1 vs. 5D0 luminescence is influenced bytheexcitationwavelengthandtheEu3þ concentration. TheEr3þ-doped samplesshow green andredupconversionluminescence,respectively,fromthe 2H11/2þ4S3/2-4I15/2 and 4F9/2-4I15/2 transitions after970nmexcitation

Magnetic resonance imaging of cerebrospinal fluid outflow after low-rate lateral ventricle infusion in mice.

The anatomical routes for the clearance of cerebrospinal fluid (CSF) remain incompletely understood. However, recent evidence has given strong support for routes leading to lymphatic vessels. A current debate centers upon the routes through which CSF can access lymphatics, with evidence emerging for either direct routes to meningeal lymphatics or along cranial nerves to reach lymphatics outside the skull. Here, a method was established to infuse contrast agent into the ventricles using indwelling cannulae during imaging of mice at 2 and 12 months of age by magnetic resonance imaging. As expected, a significant decline in overall CSF turnover was found with aging. Quantifications demonstrated that the bulk of the contrast agent flowed from the ventricles to the subarachnoid space in the basal cisterns. Comparatively little contrast agent signal was found at the dorsal aspect of the skull. The imaging dynamics from the two cohorts revealed that the contrast agent cleared from the cranium through the cribriform plate to the nasopharyngeal lymphatics. On decalcified sections, we confirmed that fluorescentlylabeled ovalbumin drains through the cribriform plate and can be found within lymphatics surrounding the nasopharynx. In conclusion, routes leading to nasopharyngeal lymphatics appear to be a major efflux pathway for cranial CSF

Energy budgets' formation based on incomplete data

The universal technique of the current energy budget calculation is recommended for several periods of time. Basing on the data of annual energy budget and considering the plant's features, social, climatic and other conditions, correcting factors are calculated to estimate energy resources consumption for the day, week, month and year. Shortterm current energy budget supports important financial, trade, logistic, organizational and other control directions. The developed technique is applicable for subnational entities and industrial enterprises in order to increase level of energy resources consumption planning and forecasting as well as bills' optimization

Ginkgo biloba Extract EGb 761 Improves Vestibular Compensation and Modulates Cerebral Vestibular Networks in the Rat

Unilateral inner ear damage is followed by behavioral recovery due to central vestibular compensation. The dose-dependent therapeutic effect of Ginkgo biloba extract EGb 761 on vestibular compensation was investigated by behavioral testing and serial cerebral [18F]-Fluoro-desoxyglucose ([18F]-FDG)-μPET in a rat model of unilateral labyrinthectomy (UL). Five groups of 8 animals each were treated with EGb 761-supplemented food at doses of 75, 37.5 or 18.75 mg/kg body weight 6 weeks prior and 15 days post UL (groups A,B,C), control food prior and EGb 761-supplemented food (75 mg/kg) for 15 days post UL (group D), or control food throughout (group E). Plasma levels of EGb 761 components bilobalide, ginkgolide A and B were analyzed prior and 15 days post UL. Behavioral testing included clinical scoring of nystagmus, postural asymmetry, head roll tilt, body rotation during sensory perturbation and instrumental registration of mobility in an open field before and 1, 2, 3, 5, 7, 15 days after UL. Whole-brain [18F]-FDG-μPET was recorded before and 1, 3, 7, 15 days after UL. The EGb 761 group A (75 mg/kg prior/post UL) showed a significant reduction of nystagmus scores (day 3 post UL), of postural asymmetry (1, 3, 7 days post UL), and an increased mobility in the open field (day 7 post UL) as compared to controls (group E). Application of EGb 761 at doses of 37.5 and 18.75 mg/kg prior/post UL (groups B,C) resulted in faster recovery of postural asymmetry, but did not influence mobility relative to controls. Locomotor velocity increased with higher plasma levels of ginkgolide A and B. [18F]-FDG-μPET revealed a significant decrease of the regional cerebral glucose metabolism (rCGM) in the vestibular nuclei and cerebellum and an increase in the hippocampal formation with higher plasma levels of ginkgolides and bilobalide 1 and 3 days post UL. Decrease of rCGM in the vestibular nucleus area and increase in the hippocampal formation with higher plasma levels persisted until day 15 post UL. In conclusion, Ginkgo biloba extract EGb 761 improves vestibulo-ocular motor, vestibulo-spinal compensation, and mobility after UL. This rat study supports the translational approach to investigate EGb 761 at higher dosages for acceleration of vestibular compensation in acute vestibular loss

The impact of an hematocrit of 20% during normothermic cardiopulmonary bypass for elective low risk coronary artery bypass graft surgery on oxygen delivery and clinical outcome – a randomized controlled study [ISRCTN35655335]

INTRODUCTION: Cardiopulmonary bypass (CPB) induces hemodilutional anemia, which frequently requires the transfusion of blood products. The objective of this study was to evaluate oxygen delivery and consumption and clinical outcome in low risk patients who were allocated to an hematocrit (Hct) of 20% versus 25% during normothermic CPB for elective coronary artery bypass graft (CABG) surgery. METHODS: This study was a prospective, randomized and controlled trial. Patients were subjected to normothermic CPB (35 to 36°C) and were observed until discharge from the intensive care unit (ICU). Outcome measures were calculated whole body oxygen delivery, oxygen consumption and clinical outcome. A nonparametric multivariate analysis of variance for repeated measurements and small sample sizes was performed. RESULTS: In a total of 54 patients (25% Hct, n = 28; 20% Hct, n = 26), calculated oxygen delivery (p = 0.11), oxygen consumption (p = 0.06) and blood lactate (p = 0.60) were not significantly different between groups. Clinical outcomes were not different between groups. CONCLUSION: These data indicate that an Hct of 20% during normothermic CPB maintained calculated whole body oxygen delivery above a critical level after elective CABG surgery in low risk patients. The question of whether a transfusion trigger in excess of 20% Hct during normothermic CPB is still supported requires a larger prospective and randomized trial

Проект пункта шиномонтажного участка с конструктивной разработкой устройства для измерения биений шин и ободьев колес в условиях ИП Русанова

В разделе объект и методы исследования выполнен аналитический обзор по теме работы и обоснован выбор темы выпускной работы бакалавра. В разделе расчеты и аналитика представлены необходимые инженерные расчеты, связанные с организацией работ по разработке шиномонтажного участка с конструктивной разработкой устройства для измерения биений шин и ободьев колёс.In the object and research methods section, an analytical review is carried out on the topic of work and the choice of the theme of the final work of the bachelor is substantiated. The section of calculations and analytics presents the necessary engineering calculations related to the organization of work on the development of the tire section with the constructive development of a device for measuring the runout of tires and wheel rims

Влияние исходного состава углеродных пресс - композиций на внутреннюю и внешнюю поверхность получаемых из них таблеток

Исследование влияния наличия в исходных для прессования углеродных смесях связующих веществ, их свойств и количества, на размеры внутренней и внешней поверхности получающихся из них таблеток.Investigation of the effect of the presence of binders in the initial compression mixtures of carbon mixtures, their properties and quantities, on the dimensions of the inner and outer surfaces of the tablets obtained from them