Association between immune-related adverse events and immunotherapy efficacy in non-small-cell lung cancer: a meta-analysis

Objective: Our study aimed to identify potential correlations between anti-tumor efficacy and immune-related adverse events (irAEs) in non-small-cell lung cancer (NSCLC).Methods: We conducted a comprehensive search of online electronic databases up to March 2023 to identify any correlations between irAEs and immune checkpoint inhibitor (ICI) efficacy in NSCLC. We used meta-analysis RevMan 5.3 software to calculate pooled results.Results: Our meta-analysis of 54 studies revealed that patients who experienced irAEs achieved a significantly higher objective response rate (p < 0.00001) and longer progression-free survival (PFS) (p < 0.00001) and overall survival (OS) (p < 0.00001) than those who did not experience irAEs. Additionally, patients with ≥2 irAEs had better PFS, whereas no significant difference was observed between patients with or without squamous cell carcinoma. Subgroup analysis of irAE types indicated that irAEs (thyroid dysfunction and gastrointestinal, skin, or endocrine irAEs) were associated with better PFS and OS. However, no significant differences were observed between patients with pneumonitis or hepatobiliary irAEs.Conclusion: Our study showed that the occurrence of irAEs was a strong predictor of survival efficacy in patients with NSCLC treated with ICIs. Specifically, patients with ≥2 irAEs and those with thyroid dysfunction and gastrointestinal, skin, or endocrine irAEs achieved a better survival benefit.Systematic Review Registration: Website: https://www.crd.york.ac.uk/prospero/, Identifier: CRD4202342169

Blastic plasmacytoid dendritic cell neoplasm complicated with acute myeloid leukemia: a case report

Blastic plasmacytoid dendritic cell neoplasm （BPDCN） complicated with acute myeloid leukemia （AML） is a rare disease. In this article， we reported the diagnosis and treatment of one patient of BPDCN complicated with AML who presented with fever as the first symptom， aiming to enhance the diagnostic and therapeutic capability of clinicians for this disease. The male patient， aged 69 years old， was admitted to hospital due to fever for 1 week. He had no typical skin lesions. Morphological and cytological observation of bone marrow smear showed extremely active hyperplasia and tumor cells with specific immunophenotype. The diagnosis of BPDCN complicated with AML was confirmed. A low-intensity venetoclax-based chemotherapy regimen was recommended. However， the patient discontinued further treatment

Processing and characterization of cobalt silicide nanoparticle-containing silicon carbide fibers through a colloidal method and their underlying mechanism

National Natural Science Foundation of China [51002127, 51072169]Cobalt-containing silicon carbide (Co-SiC) fibers were synthesized through a colloidal method. Dicobalt octacarbonyl [Co-2(CO)(8)] was employed to react with low-molecular weight liquid polycarbosilane (LPCS) to prepare a stable Co-containing colloid (Co-colloid), which was subsequently added to high-molecular weight solid polycarbosilane to obtain the precursor. FTIR, GPC, XRD, and TEM were employed to further understand and develop the mechanism for the formation of the Co-colloid. Results show that active Co intermediates derived from the incomplete decomposition of Co-2(CO)(8) promoted LPCS cross-linkage. The effects of the Co-colloid on the oxidation-curing nature of the green fiber were also investigated. Under heat treatment at higher temperature, carbonyls in the fibers completely decomposed and further crystallized in the morphology of cobalt silicide (CoSi) domains. The effects of Co on the electrical resistivity, magnetic properties, dielectric properties, microwave absorption properties and tensile strength of SiC fibers were also studied

An egg holders-inspired structure design for large-volume-change anodes with long cycle life

Abstract(#br)Silicon has been considered as a potential alternative of anodes for advanced lithium ion battery as it possesses high capacity and abundance. However, it encounters excessive volume expansion and inferior electoral conductivity, which imposes restrictions on its further development. In order to address these two problems, yolk-shell structure is employed, in which there is a suitable void for the expansion with a shell to protect the core and promote the conductivity. Here, by the inspiration from the egg holders and inverse-opal structure, an egg-stacking-like Si/C composite (ES) anode with spherical air holes was fabricated to gather the yolk-shell particles in a 3D carbon network with abundant channels allowing electrolyte to enter the material, which can facilitate the cycling performance. The half-cell battery assembled with these anodes presents high capacity and good rate performance, with a capacity reduction of only 2–7% per current density. And the cycling performance of ES anode is also praiseworthy that it delivers a high reversible discharge capacity of 2175 mAh g −1 after 300 cycles at 0.5 A g −1 . This kind of structure design is expected to be applicative for most of large-volume-change anodes

The Effect of Temozolomide/Poly(lactide-co-glycolide) (PLGA)/Nano-Hydroxyapatite Microspheres on Glioma U87 Cells Behavior

In this study, we investigated the effects of temozolomide (TMZ)/Poly (lactide-co-glycolide)(PLGA)/nano-hydroxyapatite microspheres on the behavior of U87 glioma cells. The microspheres were fabricated by the “Solid/Water/Oil” method, and they were characterized by using X-Ray diffraction, scanning electron microscopy and differential scanning calorimetry. The proliferation, apoptosis and invasion of glioma cells were evaluated by MTT, flow cytometry assay and Transwell assay. The presence of the key invasive gene, αVβ3 integrin, was detected by the RT-PCR and Western blot method. It was found that the temozolomide/PLGA/nano-hydroxyapatite microspheres have a significantly diminished initial burst of drug release, compared to the TMZ laden PLGA microspheres. Our results suggest they can significantly inhibit the proliferation and invasion of glioma cells, and induce their apoptosis. Additionally, αVβ3 integrin was also reduced by the microspheres. These data suggest that by inhibiting the biological behavior of glioma cells in vitro, the newly designed temozolomide/PLGA/nano-hydroxyapatite microspheres, as controlled drug release carriers, have promising potential in treating glioma

Determination of the Optimal Orientation of Chinese Solar Greenhouses Using 3D Light Environment Simulations

With the continuous use of resources, solar energy is expected to be the most used sustainable energy. To improve the solar energy efficiency in Chinese Solar Greenhouses (CSG), the effect of CSG orientation on intercepted solar radiation was systematically studied. By using a 3D CSG model and a detailed crop canopy model, the light environment within CSG was optimized. Taking the most widely used Liao-Shen type Chinese solar greenhouse (CSG-LS) as the prototype, the simulation was fully verified. The intercepted solar radiation of the maintenance structures and crops was used as the evaluation index. The results showed that the highest amount of solar radiation intercepted by the maintenance structures occurred in the CSG orientations of 4–6° south to west (S-W) in 36.8° N and 38° N areas, 8–10° S-W in 41.8° N areas, and 2–4° south to east (S-E) in 43.6° N areas. The solar radiation intercepted by the crop canopy displayed the highest value at an orientation of 2–4° S-W in 36.8° N, 38° N, 43.6° N areas, and 4–6° S-W in the 41.8° N area. Furthermore, the proposed model could provide scientific guidance for greenhouse crop modelling

Effect of North Wall Materials on the Thermal Environment in Chinese Solar Greenhouse (Part A: Experimental Researches)

In order to clarify the dependence relationship between the heat storage & preservation wall and the thermal environment, and to provide data base and theory foundation for the north wall construction of the Chinese solar greenhouse (CSG), the experimental measures has been employed to investigate the distributions of temperature, humidity and heat transfer of three different wall materials (i.e. perforated brick, fine coal ash brick, common clay brick). The dynamic variations of the heat-storage and heat-release processes were identified, and the thermal response characteristics were discussed. The effect of north wall materials on the thermal environment of the solar greenhouse in northern China was revealed. The results indicated that the daily heat-storage and heat-release of fine coal ash brick wall can reach ϕimput = 34.5~130.6 W·m−2 and ϕoutput = −24.15~-45 W·m−2, respectively. The daily heat-storage time can reach t = 5~8 h, and the wall temperature at night can be 3~4∘C higher than the air temperature. Moreover, the maximum indoor temperature of the fine coal ash brick wall can be maintained at t ≤ 16.7 ≤ 31.1∘C, the minimum humidity can be maintained at 29.75~45%. Fortunately, the construction cost is moderate, while the physical properties are obviously better than those of perforated brick and common clay brick in the CSG. The overall thermal performance of fine coal ash brick is the best of the three north wall materials, and it can make the most advantage of the heat-storage and heat-preservation performances of the CSG. As a consequence, the fine coal ash brick wall of the solar greenhouse has good promotion value in northern China and other high latitude, high altitude and long winter regions