Is preoperative physical function testing predictive of length of stay in patients with colorectal cancer? : a retrospective study

La chirurgie est le traitement principal du cancer colorectal (CCR). Une durée d'hospitalisation prolongée peut augmenter le risque de complications et d'inactivité physique, entraînant un déclin de la fonction physique. L'objectif de cette étude est de déterminer si la celle-ci peut prédire l’hospitalisation prolongée chez les patients atteints de CCR. Un total de 459 patients provenant de 7 cohortes a été analysé. Une régression logistique a été utilisée pour déterminer le risque d'hospitalisation prolongée (>3 jours) et une courbe ROC a été tracée pour établir la sensibilité/spécificité. Les variables sélectionnées comprenaient l'âge, le sexe, l'IMC, la présence de comorbidités, le statut ASA, le site tumoral, l'approche chirurgicale, la force de préhension, le test Timed-Up and Go, le test assis-debout de 30 secondes, le test de flexion des coudes de 30 secondes, le test de marche de 6 minutes (6MWT), le questionnaire CHAMPS et le SF-36. Les résultats démontrent que les patients atteints d'une tumeur rectale ont un risque 2,7 fois plus élevé d'appartenir au groupe d'hospitalisation prolongée que ceux atteints d'une tumeur du côlon (O.R. 2,7 ; C.I. 1,3-5,7, p=0,01). Pour chaque augmentation de 20 mètres dans le 6MWT, il y a une diminution de 9% du risque d'être dans le groupe d'hospitalisation prolongée (C.I. 1.03-1.17, p=0.00). Un seuil de 431 m peut prédire 70% des patients dans le groupe d'hospitalisation prolongée (AUC 0,71, C.I. 0,63-0,78, p=0,00). L'utilisation du 6MWT comme outil de dépistage de l'hospitalisation prolongée devrait être intégrée dans le parcours chirurgical préopératoire.Surgery is the primary treatment for colorectal cancer. A prolonged Length of Stay (pLOS) can increase risk of complications and physical inactivity, leading to a decline in physical function. While promising results were seen from preoperative exercise training and post-operative functional recovery, the predictive potential of preoperative physical function has not yet been investigated. The objective of this study is to determine if preoperative physical function can predict pLOS in patients with for colorectal cancer. A total of 459 patients from 7 cohorts were analyzed. Logistic regression was used to determine risk of pLOS (>3 days), and ROC curve was plotted to establish sensitivity/specificity. Selected variables included age, sex, BMI, comorbidity, ASA status, tumor site, surgical approach, handgrip strength, Timed-Up and Go, 30-second Sit-to-Stand, 30-second Arm Curl Test, 6-Minute-Walking Test (6MWT), CHAMPS Physical Activity Questionnaire for Older Adult and 36-Item Short Form Survey. The results showed that patients with rectal tumor are 2.7x more at risk to be in the pLOS group compared to those with colon tumor (O.R. 2.7; C.I. 1.3-5.7, p=0.01). For every increment of 20 meters in 6MWT, there is a decreased risk of 9% of being in pLOS group (C.I. 1.03-1.17, p=0.00). A cut-off of 431m can predict 70% of patients in pLOS group (AUC 0.71 C.I 0.63-0.78, p=0.00). Tumor site (rectal) and 6MWT were significant predictors of pLOS. Using the 6MWT as a screening tool for pLOS with cut-off of 431 m should be implemented in the preoperative surgical pathway

Determining the enzymatic efficiency and thermodynamic stability of BgIB-H223A

Help create and improve an AI program to predict the function of a protein based on the given amino acid sequence. Performing enzyme kinetic and thermal stability assay with BgIB-H223

L’écriture de l’histoire à la fin du Moyen Âge :une étude textuelle et matérielledes Mémoires de Jean de Haynin

Issu de la petite noblesse hennuyère, Jean de Haynin (1423–1495) a combattu à la fin du xve siècle dans les armées des ducs de Bourgogne Philippe le Bon et Charles le Hardi. Il y exerçait un commandement vraisemblablement subalterne et appartenait à la compagnie du duc de Fiennes, Jacques de Luxembourg. Si nous possédons ces quelques renseignements sur sa fonction militaire, l’activité de Jean de Haynin en tant que chroniqueur à la cour de Bourgogne reste en revanche aujourd’hui encore diffic..

« Contre-champs ». Études offertes à Jean-Philippe Genet, éd. Aude Mairey, Solal Abélès et Fanny Madeline

Cet ouvrage collectif est dirigé par Aude Mairey, Solal Abélès et Fanny Madeline, trois anciens étudiants de Jean-Philippe Genet. Il vise à répondre à un double objectif, annoncé clairement par les coordinateurs du volume dans leur « Introduction ». Le premier consiste à rendre hommage au professeur, au chercheur, mais aussi à l’homme. Le second objectif, immanquablement lié au premier, vise à retracer le parcours scientifique de J.-P. Genet, en abordant dans ces quinze contributions les prin..

A Novel Approach to Fine-grained Content-based Access Control for Video Databases

ABSTRAC

GREEN ECONOMY WITH ECONOMIC GROWTH AND PER CAPITA INCOME IN VIETNAM

Objective: The objective of this study is to investigate the green economy with economic growth and per capita income in Vietnam, to analyze the quantitative relationship among those factors, and to improve long-term green economic development in Vietnam towards sustainable national economic growth.   Theoretical Framework: In this topic, the main concepts and theories that underpin the research are presented. The inverted U-shaped model of Kuznets; Green economy concept and regression model stand out, providing a solid basis for understanding the context of the investigation.   Method: The methodology adopted for this research comprises desk research methods to clarify the theoretical basis of green economy, economic growth, and per capita income; qualitative research methods; and quantitative research methods. Data collection was carried out through the collection of time-series data: Real Gross Domestic Product (GDP), Gross Domestic Product per capita (GDPP), and CO2 emissions from 1995 to 2022 from the World Bank website.   Results and Discussion: The results obtained revealed the positive relationship between economic growth, CO2 emissions, and per capita income in the short term; however, in the long term, when GDP as well as per capita income reach a certain threshold. The level of waste gradually decreases and environmental quality improves. In the discussion section, these results are contextualized in light of the theoretical framework, highlighting the implications and relationships identified. Possible discrepancies and limitations of the study are also considered in this section.   Research Implications: The practical and theoretical implications of this research are discussed, providing insights into how the results can be applied or influence practices in the field of development economics. These implications could encompass many sectors, especially the processing industry.   Originality/Value: This study contributes to the literature by Simon Kuznets - economic growth is not a threat, but rather a means to improve the environment in the future. The relevance and value of this research are evidenced by contributing one more case in Vietnam which approves Kuznets curve on the environment and thus is the basis for future research on this urgent problem all over the world

THE RELATIONSHIPS BETWEEN STUDENTS’ SELF-CONFIDENCE AND THEIR ENGLISH-SPEAKING PERFORMANCE: A CASE STUDY OF ENGLISH-MAJORED STUDENTS AT A PRIVATE UNIVERSITY IN VIETNAM

This research aimed to discover the relationships between students' self-confidence and their English-speaking performance. In our research, self-confidence was divided into three components which are affective confidence, behavioral confidence, and cognitive confidence. In addition, speaking performance included eight components which are vocabulary, grammar, pronunciation, fluency, coherence, comprehension, task, and content. A sample of 150 English-majored students at a university in Vietnam was surveyed in this study by using a convenience sampling technique, and then conducting semi-structured interviews to seek for qualitative information from 10 participants out of 150. The result from our study showed that there are significant relationships between the two variables. The more confident the students are, the more accomplished they would be in the presenting procedure since they have superior cognition and understand how to modify their learning methods to build a comprehensive individual in learning English language. We expect that these findings can help students adjust their learning methods to improve their self-confidence as well as English speaking performance and by that way, universities can add more speaking-related subjects so that students can have more opportunities to speak and learn more speaking skills.  Article visualizations

Apple CRISPR-Cas9-A Recipe for Successful Targeting of AGAMOUS-like Genes in Domestic Apple

Fruit trees and other fruiting hardwood perennials are economically valuable, and there is interest in developing improved varieties. Both conventional breeding and biotechnology approaches are being utilized towards the goal of developing advanced cultivars. Increased knowledge of the effectiveness and efficiency of biotechnology approaches can help guide use of the CRISPR gene-editing technology. Here, we examined CRISPR-Cas9-directed genome editing in the valuable commodity fruit tree Malus x domestica (domestic apple). We transformed two cultivars with dual CRISPR-Cas9 constructs designed to target two AGAMOUS-like genes simultaneously. The main goal was to determine the effectiveness of this approach for achieving target gene changes. We obtained 6 Cas9 control and 38 independent CRISPR-Cas9 events. Of the 38 CRISPR-Cas9 events, 34 (89%) had gene edits and 14 (37%) showed changes to all alleles of both target genes. The most common change was large deletions, which were present in 59% of all changed alleles, followed by small deletions (21%), small insertions (12%), and a combination of small insertions and deletions (8%). Overall, a high rate of successful gene alterations was found. Many of these changes are predicted to cause frameshifts and alterations to the predicted peptides. Future work will include monitoring the floral development and floral form

Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease

We integrated lipidomics and genomics to unravel the genetic architecture of lipid metabolism and identify genetic variants associated with lipid species putatively in the mechanistic pathway for coronary artery disease (CAD). We quantified 596 lipid species in serum from 4,492 individuals from the Busselton Health Study. The discovery GWAS identified 3,361 independent lipid-loci associations, involving 667 genomic regions (479 previously unreported), with validation in two independent cohorts. A meta-analysis revealed an additional 70 independent genomic regions associated with lipid species. We identified 134 lipid endophenotypes for CAD associated with 186 genomic loci. Associations between independent lipid-loci with coronary atherosclerosis were assessed in ∼456,000 individuals from the UK Biobank. Of the 53 lipid-loci that showed evidence of association (P \u3c 1 × 10−3), 43 loci were associated with at least one lipid endophenotype. These findings illustrate the value of integrative biology to investigate the aetiology of atherosclerosis and CAD, with implications for other complex diseases