12 research outputs found
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity.
- Author
- Ahern David J
- Ai Zhichao
- Ainsworth Mark
- Allan Chris
- Allcock Alice
- Angus Brian
- Ansari M Azim
- Arancibia-Carcamo Carolina V
- Aschenbrenner Dominik
- Attar Moustafa
- Baillie J Kenneth
- Barnes Eleanor
- Bashford-Rogers Rachael
- Bashyal Archana
- Beer Sally
- Berridge Georgina
- Beveridge Amy
- Bibi Sagida
- Bicanic Tihana
- Blackwell Luke
- Bowness Paul
- Brent Andrew
- Brown Andrew
- Broxholme John
- Buck David
- Burnham Katie L
- Byrne Helen
- Camara Susana
- Charles Philip
- Chen Wentao
- Chen Yi-Ling
- Chong Amanda
- Clutterbuck Elizabeth A
- Coles Mark
- Conlon Christopher P
- Cornall Richard
- Cribbs Adam P
- Curion Fabiola
- Davenport Emma E
- Davidson Neil
- Davis Simon
- Delgado Alberto Santos
- Dendrou Calliope A
- Dequaire Julie
- Dib Lea
- Docker James
- Dold Christina
- Dong Tao
- Downes Damien
- Drakesmith Hal
- Dunachie Susanna J
- Duncan David A
- Eijsbouts Chris
- Esnouf Robert
- Espinosa Alexis
- Etherington Rachel
- Fairfax Benjamin
- Fairhead Rory
- Fang Hai
- Fassih Shayan
- Felle Sally
- Ferreira Ivan Candido
- Ferreira Ricardo
- Fischer Roman
- Foord Thomas
- Forrow Aden
- Frater John
- Fries Anastasia
- Garner Lucy C
- Geeves Clementine
- Georgiou Dominique
- Godfrey Leila
- Golubchik Tanya
- Green Angie
- Harper Hong
- Harrington Heather A
- Heilig Raphael
- Hester Svenja
- Hill Jennifer
- Hinds Charles
- Hird Clare
- Ho Ling-Pei
- Hoekzema Renee
- Hollis Benjamin
- Hughes Jim
- Hutton Paula
- Jackson-Wood Matthew A
- Jainarayanan Ashwin
- James-Bott Anna
- Jansen Kathrin
- Jeffery Katie
- Jones Elizabeth
- Jostins Luke
- Karali Christina Simoglou
- Kerr Georgina
- Kim David
- Klenerman Paul
- Knight Julian C
- Kumar Vinod
- Kurupati Prathiba
- Kwok Andrew
- Lee Angela
- Linder Aline
- Lockett Teresa
- Lonie Lorne
- Lopopolo Maria
- Lukoseviciute Martyna
- Luo Jian
- Marinou Spyridoula
- Marsden Brian
- Martinez Jose
- Matthews Philippa C
- Mazurczyk Michalina
- McGowan Simon
- McKechnie Stuart
- Mead Adam
- Mendoza Maria Fernandez
- Mentzer Alexander J
- Mi Yuxin
- Monaco Claudia
- Montadon Ruddy
- Napolitani Giorgio
- Nassiri Isar
- Novak Alex
- O'Brien Darragh P
- O'Connor Daniel
- O'Donnell Denise
- Ogg Graham
- Overend Lauren
- Park Inhye
- Pavord Ian
- Peng Yanchun
- Penkava Frank
- Peres Raphael Sanches
- Perez Elena
- Pinho Mariana Pereira
- Pollard Andrew J
- Powrie Fiona
- Psaila Bethan
- Quan T Phuong
- Repapi Emmanouela
- Revale Santiago
- Rich-Griffin Charlotte
- Richard Jean-Baptiste
- Ritter Thomas
- Rollier Christine S
- Rowland Matthew
- Ruehle Fabian
- Salio Mariolina
- Sanchez Veronica Gallardo
- Sansom Stephen Nicholas
- Sauka-Spengler Tatjana
- Schwessinger Ron
- Scozzafava Giuseppe
- Screaton Gavin
- Seigal Anna
- Semple Malcolm G
- Sergeant Martin
- Sharma Piyush Kumar
- Silva-Reyes Laura
- Sims David
- Skelly Donal
- Slawinski Hubert
- Sobrinodiaz Alberto
- Sousos Nikolaos
- Stafford Lizzie
- Stockdale Lisa
- Strickland Marie
- Sumray Otto
- Sun Bo
- Taylor Adan
- Taylor Chelsea
- Taylor Stephen
- Thongjuea Supat
- Thraves Hannah
- Todd John A
- Tomic Adriana
- Tong Orion
- Trebes Amy
- Trzupek Dominik
- Tucci Felicia Anna
- Turtle Lance
- Udalova Irina
- Uhlig Holm
- van Grinsven Erinke
- Vazquez Maria Gomez
- Vendrell Iolanda
- Verheul Marije
- Voda Alexandru
- Wang Dapeng
- Wang Guanlin
- Wang Lihui
- Watkinson Peter
- Watson Robert
- Weinberger Michael
- Whalley Justin
- Witty Lorna
- Wray Katherine
- Xue Luzheng
- Yeung Hing Yuen
- Yin Zixi
- Young Rebecca K
- Youngs Jonathan
- Zhang Ping
- Zurke Yasemin-Xiomara
- Publication venue
- Elsevier
- Publication date
- 01/01/2021
- Field of study
Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete description of specific immune biomarkers. We present here a comprehensive multi-omic blood atlas for patients with varying COVID-19 severity in an integrated comparison with influenza and sepsis patients versus healthy volunteers. We identify immune signatures and correlates of host response. Hallmarks of disease severity involved cells, their inflammatory mediators and networks, including progenitor cells and specific myeloid and lymphocyte subsets, features of the immune repertoire, acute phase response, metabolism, and coagulation. Persisting immune activation involving AP-1/p38MAPK was a specific feature of COVID-19. The plasma proteome enabled sub-phenotyping into patient clusters, predictive of severity and outcome. Systems-based integrative analyses including tensor and matrix decomposition of all modalities revealed feature groupings linked with severity and specificity compared to influenza and sepsis. Our approach and blood atlas will support future drug development, clinical trial design, and personalized medicine approaches for COVID-19
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
- Author
- Adeniji Kayode
- Aggleton John P.
- Agranoff Daniel
- Agwuh Ken
- Ahmed Katie A.
- Ail Dhiraj
- Al-Chalabi Ammar
- Aldera Erin L.
- Alegria Ana
- Alex Beatrice
- Allen Christopher M.
- Allen Sam
- Amin Jay
- Andrikopoulos Petros
- Angus Brian
- Armour Cherie
- Armstrong Jane A.
- Ashish Abdul
- Ashworth Milton
- Asiimwe Innocent G.
- Atkinson Dougal
- Bach Benjamin
- Baillie J. Kenneth
- Baillie J. Kenneth
- Baker Mark R.
- Bakshi Siddharth
- Barclay Wendy S.
- Bari Shahedal
- Barlow Gavin
- Barlow Samantha L.
- Barnass Stella
- Barrett Nicholas
- Barrett Suzanne
- Bassford Christopher
- Basu Neil
- Basude Sneha
- Batra Rahul
- Baxter David
- Beadsworth Michael
- Benjamin Laura
- Bernatoniene Jolanta
- Berridge John
- Berry Colin
- Best Nicola
- Bethlehem Richard
- Blackledge Bethan
- Boardman Sarah A.
- Bogaert Debby
- Booth Laura
- Bothma Pieter
- Bradley John R.
- Bradley John R.
- Breen David P.
- Breen Gerome
- Breen Gerome
- Brennan Benjamin
- Breuer Judith
- Brittain-Long Robin
- Broome Matthew R.
- Bullmore Edward
- Bullock Katie
- Bulteel Naomi
- Burden Tom
- Burtenshaw Andrew
- Butler Matthew
- Carlucci Nicola
- Carracedo Alejandra D.
- Carson Alan
- Carson Gail
- Caruth Vikki
- Cass Emily
- Catterall Benjamin W.
- Cavanagh Jonathan
- Cavanagh Jonathan
- Chadwick David
- Chambler Duncan
- Chand Meera
- Chechi Kanta
- Chee Nigel
- Child Jenny
- Chinnery Patrick F.
- Chiollaz Anne-Cecile
- Christmas David
- Christmas David M.
- Chukkambotla Srikanth
- Clark Jordan J.
- Clark Jordan J.
- Clark Richard
- Clark Tom
- Clarke Emily A.
- Clohisey Sara
- Cole Sarah
- Coleman Jonathan R.
- Coles Alaisdair
- Coles Alasdair J.
- Collie Ceryce
- Collie Ceryce
- Collini Paul
- Connor Marie
- Cooke Graham S.
- Cooper Louise
- Cosgrove Catherine
- Cossette Nadine
- Cousins David
- Coutts Audrey
- Cox Helen
- Cupitt Jason
- Cutino-Moguel Maria-Teresa
- da Silva Ana
- Dalton Jo
- Darby Alastair
- Dark Paul
- David Anthony S.
- Davies Nicholas
- Davis Christopher
- Dawson Chris
- de Silva Thushan
- Defres Sylviane
- Dervisevic Samir
- Digby Richard
- Dincarslan Oslem
- Docherty Annemarie B.
- Dodd Katherine C.
- Donegan Cara
- Donnelly Lorna
- Donnison Phil
- Donohue Chloe
- dos Santos Gonçalo
- Douthwaite Sam
- Drake Thomas M.
- Dregan Alex
- Drummond Andrew
- Duff Eugene
- Dumas Marc-Emmanuel
- Dunai Cordelia
- Dunai Cordelia
- Dunn Chris
- Dunning Jake
- DuRand Ingrid
- Dushianthan Ahilanadan
- Dyer Philip
- Dyer Tristan
- Easton Ava
- Ebrahimi Soraya
- Egbe Franklyn N.
- Elliott Angela
- Ellul Mark A.
- Evangelou Nikos
- Evans Anthony
- Evans Cariad
- Eziefula Chi
- Facer Bethany
- Fairfield Cameron J.
- Fawkes Angie
- Fegan Chrisopher
- Fernandes Peter M.
- Finch Lorna
- Finn Adam
- Fisher Lewis W.
- Flaherty Lisa
- Fletcher Tom
- Foster Terry
- Fower Andrew
- Fox Hannah
- Francis Richard
- Fullerton Duncan
- Gamble Carrol
- Garcia-Dorival Isabel
- Garg Atul
- Garg Sanjeev
- Garjani Afagh
- George Lily
- Gilchrist Tammy
- Girvan Michelle
- Gkrania-Klotsas Effrossyni
- Glen Kiran
- Godden Jo
- Goldsmith Arthur
- Graham Clive
- Grammatikopoulos Tassos
- Green Christoper A.
- Greenhalf William
- Gregory Rebecca
- Griffin Julian L.
- Griffiths Fiona
- Griffiths Michael
- Griffiths Michael
- Grimbly Victoria
- Grundmann Alexander
- Grundmann Alexander
- Gunatilake Savini
- Gunning Philip
- Gupta Rishi K.
- Hafezi Katarzyna
- Halpin Sophie
- Hamid Shahd H.
- Hampshire Adam
- Hannah C.
- Hardwick Hayley
- Hardwick Marc
- Hardy Elaine
- Harris Jade D.
- Harrison Ewan
- Harrison Ewen M.
- Harrison Janet
- Harrison Neil
- Harrison Neil A.
- Harrison Paul J.
- Hartley Catherine
- Hartmann Monika
- Hartshorn Stuart
- Harvey Daniel
- Havalda Peter
- Hawcutt Daniel B.
- Held Marie
- Hendry Ross
- Hetherington Claire
- Hiscox Julian
- Hobrok Maria
- Hodel Eva M.
- Hodgson Luke
- Holden Karl
- Holland Angela E.
- Holmes Anthony
- Horby Peter W.
- Hormis Anil
- Hotopf Matthew
- Howard Joanne
- Huang Yun
- Hughes Stella
- Husain Masud
- Ijaz Samreen
- Irani Sarosh
- Irani Sarosh R.
- Jackson Clare
- Jackson Thomas
- Jacobs Michael
- Jain Susan
- Jenkins Thomas M.
- Jennings Paul
- Jensen Rebecca L.
- Jezzard Peter
- Jones Christopher B.
- Jones Trevor R.
- Kaliappan Agilan
- Kasipandian Vidya
- Keating Seán
- Kegg Stephen
- Keller Simon
- Kelsey Michael
- Kendall Jason
- Kerrison Caroline
- Kerslake Ian
- Khandaker Shadia
- Khoo Saye
- King Katharine
- Kingston Nathalie
- Kiy Robyn T.
- Klenerman Paul
- Knight Stephen R.
- Knight Susan
- Koch Oliver
- Koduri Gouri
- Koshy George
- Koukorava Chrysa
- Kyaw Sandar
- Laha Shondipon
- Lahnsteiner Eva
- Laird Steven
- Lake Annette
- Lant Suzannah
- Larkin Susan
- Latawiec Diane
- Lavelle-Langham Lara
- Law Andrew
- Lee James
- Leek Charles
- Leeming Gary
- Lefteri Daniella
- Leibowitz Maya
- Leiner Tamas
- Lett Lauren
- Lewis Gabriella
- Lewis Matthew R.
- Liggi Sonia
- Lilleker James B.
- Lillie Patrick
- Lim Wei S.
- Limb James
- Linnett Vanessa
- Little Jeff
- Livoti Lucia A.
- Lunn Michael P.
- Lyttle Mark
- MacGillivray Louise
- MacIver Claire L.
- Maclean Alan
- MacMahon Michael
- MacNaughton Emily
- Madarshahian Daniel
- Mancini Maria
- Mankregod Ravish
- Mansoori Parisa
- Marsh Laura
- Martin Naomi
- Maslen Lynn
- Massey Hannah
- Masson Huw
- Matovu Elijah
- Maziere Nicole
- McCafferty Sarah
- McCullough Katherine
- McDonald Sarah
- McDonald Sarah E.
- McDonnell Gavin
- McEvoy Laurence
- McEwen Ruth
- McGlinchey Emily
- McIlwaine Ryan
- McIntosh Andrew M.
- McLauchlan John
- Mclean Kenneth A.
- Meda Manjula
- Menon David K.
- Menon David K.
- Mentzer Alexander J.
- Merson Laura
- Metelmann Soeren
- Meynert Alison M.
- Miah Nahida S.
- Michael Benedict D.
- Michael Benedict D.
- Middleton Joanna
- Miller Karla
- Mills Gary
- Minton Jane
- Mitchell Joyce
- Mohandas Kavya
- Mok Quen
- Monssen Dina
- Moon James
- Moore Elinoor
- Moore Shona C.
- Morgan Patrick
- Morrice Kirstie
- Morris Christopher M.
- Morris Craig
- Mortimore Katherine
- Moses Samuel
- Mpenge Mbiye
- Mulholland Ciaran
- Mulla Rohinton
- Murphy Derek
- Murphy Ellen G.
- Murphy Lee
- Murphy Michael
- Nagarajan Thapas
- Nagel Megan
- Nair Akshay
- Needham Edward
- Needham Edward J.
- Nelson Mark
- Newcombe Virginia
- Nicholas Nathalie
- Nicholson Timothy
- Norman Lisa
- Norris Lillian
- Norris Lucy
- Norton Emma
- Noursadeghi Mahdad
- O'Malley Ronan
- O'Shea Matthew K.
- Olanipekun Michael
- Oosthuyzen Wilna
- Openshaw Peter J.
- Openshaw Peter J.
- Osagie Anthonia
- Ostermann Marlies
- Otahal Igor
- Paddick Stella-Maria
- Pais Mark
- Palmarini Massimo
- Palmieri Carlo
- Palmos Alish
- Palmos Alish
- Panchatsharam Selva
- Papakonstantinou Danai
- Papineni Padmasayee
- Paraiso Hassan
- Patel Arvind
- Patel Brij
- Pattison Natalie
- Paxton William A.
- Peacock Sharon
- Pendered Sophie
- Penrice-Randal Rebekah
- Pepperell Justin
- Peters Mark
- Phull Mandeep
- Pilgrim Jack
- Pintus Stefania
- Pius Riinu
- Planche Tim
- Plotkin Daniel
- Pollak Thomas
- Pollakis Georgios
- Pooni Jagtur S.
- Post Frank
- Price David
- Price Nicholas
- Prince Tessa
- Prout Rachel
- Rae Nikolas
- Rambaut Andrew
- Ren Alexander
- Reschreiter Henrik
- Reynolds Tim
- Reynolds Will
- Richardson Neil
- Ridley P. M.
- Roberts Angela
- Roberts Devender
- Roberts Mark
- Roberts Stephanie
- Robertson David L.
- Rogers Henry C.
- Rose Alistair
- Rota Silvia
- Rousseau Guy
- Ruge Bobby
- Russell Clark D.
- Ryan Brendan
- Sales Debby
- Salman Rustam A.
- Saluja Taranprit
- Samuel Merna
- Sanchez Jean-Charles
- Sancho-Shimizu Vanessa
- Sands Caroline J.
- Sargent Brendan
- Saviciute Egle
- Sawcer Stephen J.
- Schmid Matthias L.
- Scott Janet T.
- Scott-Brown James
- Seed Adam W.
- Semple Malcolm G.
- Semple Malcolm G.
- Semple Scott
- Shah Aarti
- Shankar-Hari Manu
- Shanmuga Prad
- Sharma Anil
- Sharma Parul
- Shaw Catherine A.
- Shaw Pamela J.
- Shaw Victoria
- Shaw Victoria E.
- Shawcross Anna
- Shears Rebecca K.
- Sieradzki Adam
- Sigfrid Louise
- Singh Bhagteshwar
- Sizer Jeremy
- Small Benjamin
- Smith Craig J.
- Smith Jacqueline
- Smith Richard
- Smith Stephen
- Snelson Catherine
- Solomon Tom
- Solomon Tom
- Spencer Rebecca G.
- Spittle Nick
- Sriskandan Shiranee
- Staines Nikki
- Stambach Tom
- Stewart James P.
- Stewart Richard
- Stirrups Kathy
- Stuart David
- Subramaniam Krishanthi
- Subramaniam Krishanthi S.
- Subudhi Pradeep
- Summers Charlotte
- Sunderland Geraint
- Swann Olivia V.
- Szakmany Tamas
- Szemiel Agnieska
- Taams Leonie
- Taams Leonie S.
- Taggart Aislynn
- Tait Sarah
- Takats Zoltan
- Takis Panteleimon
- Tamborska Arina
- Tanianis-Hughes Jolanta
- Tatham Kate
- Tato Esteban
- Taylor John-Paul
- Tedder Richard S.
- Tharmaratnam Kukatharmini
- Thomas Jo
- Thomas Jordan
- Thomas Rhys H.
- Thompson A. A. R.
- Thompson Chris
- Thompson Robert
- Thomson Emma
- Thomson Emma C.
- Thwaites Ryan S.
- Tonder Libby v.
- Tridente Ascanio
- Trochu Erwan
- Tupper-Carey Darell
- Turtle Lance C.
- Twagira Mary
- Underwood Jonathan
- Upthegrove Rachel
- Vallotton Nick
- van Daniel J.
- Vancheeswaran Rama
- Veenith Tonny
- Venneri Annalena
- Vincent Angela
- Vincent Angela
- Vincent Rachel
- Vincent-Smith Lisa
- Visuvanathan Shico
- Vuylsteke Alan
- Waddy Sam
- Wai Antonia Y.
- Wake Rachel
- Walden Andrew
- Welters Ingeborg
- Wham Murray
- Whitehouse Tony
- Whittaker Paul
- Whittington Ashley
- Wijesinghe Meme
- Wilcock Eve
- Williams Guy B.
- Williams Martin
- Williams Robyn
- Williams Steven
- Wilson Lawrence
- Winchester Stephen
- Wiselka Martin
- Wolverson Adam
- Wong Sui H.
- Wood Greta K.
- Wood Greta K.
- Wood Nicholas
- Wootton Daniel G.
- Workman Andrew
- Wrobel Nicola
- Yates Bryan
- Young Peter
- Zambon Maria
- Zandi Michael S.
- Zelaya Fernando
- Zhang J. E.
- Publication venue
- Nature Research
- Publication date
- 22/12/2023
- Field of study
To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely
Diversifying the research landscape: Assessing barriers to research for underrepresented populations in an online study of Parkinson’s disease
- Publication venue
- Cambridge University Press
- Publication date
- 01/01/2024
- Field of study
Despite federal regulations mandating the inclusion of underrepresented groups in research, recruiting diverse participants remains challenging. Identifying and implementing solutions to recruitment barriers in real time might increase the participation of underrepresented groups. Hence, the present study created a comprehensive dashboard of barriers to research participation. Barriers to participation were recorded in real time for prospective participants. Overall, 230 prospective participants expressed interest in the study but were unable to join due to one or more barriers. Awareness of the most common obstacles to research in real time will give researchers valuable data to meaningfully modify recruitment methods
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Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL
- Author
- Publication venue
- 'Rockefeller University Press'
- Publication date
- 20/03/2018
- Field of study
Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a neurological syndrome characterized by small vessel disease (SVD), stroke, and vascular cognitive impairment and dementia caused by mutations in NOTCH3. No therapies are available for this condition. Loss of mural cells, which encompass pericytes and vascular smooth muscle cells, is a hallmark of CADASIL and other SVDs, including diabetic retinopathy, resulting in vascular instability. Here, we showed that Notch3 signaling is both necessary and sufficient to support mural cell coverage in arteries using genetic rescue in Notch3 knockout mice. Furthermore, we show that systemic administration of an agonist Notch3 antibody prevents mural cell loss and modifies plasma proteins associated with Notch3 activity, including endostatin/collagen 18α1 and Notch3 extracellular domain in mice with the C455R mutation, a CADASIL variant associated with Notch3 loss of function. These findings open opportunities for the treatment of CADASIL and other SVDs by modulating Notch3 signaling
Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL
- Author
- Alexander A. Bigger-Allen
- Angie V. Sanchez
- Anissa Boutabla
- Arboleda-Velasquez
- Arboleda-Velasquez
- Arboleda-Velasquez
- Arboleda-Velasquez
- Arboleda-Velasquez
- Arboleda-Velasquez
- Armulik
- Arturo I. Machuca-Parra
- Baron-Menguy
- Chabriat
- Choy
- Christian W. Siebel
- Dhanesh Amarnani
- Dotti
- Erro
- Ghosh
- Henshall
- High
- Holtwick
- Jin
- Jonathan Cardona-Vélez
- Joseph F. Arboleda-Velasquez
- Joutel
- Joutel
- Joutel
- Joutel
- Joutel
- Kofler
- Kopan
- Leo A. Kim
- Li
- Louvi
- Magali Saint-Geniez
- Mitchell
- Moccia
- Patricia A. D’Amore
- Pippucci
- Primo
- Robinson
- Roine
- Rufa
- Rutten
- Rutten
- Soriano
- Valdez
- Wallays
- Xu
- Yoon
- Zimber-Strobl
- Publication venue
- 'Rockefeller University Press'
- Publication date
- Field of study
Rivaroxaban with or without aspirin in stable cardiovascular disease
- Author
- Abat M.
- Abatello M.
- Abdul Hafidz M. I.
- Abdul Rahim A. A.
- Abdullah W. M.
- Abe H.
- Abe M.
- Abe S.
- Abe Y.
- Abelson M.
- Abergel H.
- Abib E.
- Abitbul A.
- Abola M.
- Aboyans V.
- Abrantes J.
- Absi F.
- Abu Hassan M. R.
- Abu Kassim Z.
- Accassat S.
- Accini Diaz A.
- Accini Mendoza A.
- Accini Mendoza J.
- Acimic C.
- Acosta G.
- Actis M.
- Adamkova V.
- Adamo M.
- Adams K.
- Adler F.
- Agardi I.
- Agudelo Ramos L.
- Aguirre M.
- Agullo A.
- Ahmad H.
- Ahmed A.
- Ahuad Calvelo A.
- Ahuad Calvelo J.
- Ahuad Guerrero R.
- Aizawa Y.
- Ajax K.
- Akatsuka T.
- Akatsuka Y.
- Akhavuz O.
- Akiyama R.
- Akiyoshi H.
- Ako J.
- Al-Khalili F.
- Al-Qoofi F.
- Alagban C.
- Alarcon J.
- Alarcon V.
- Alarie P.
- Albertijn S.
- Albertsson P.
- Albisu Di Gennero J.
- Alcaraz J.
- Alcaraz L.
- Alcorano J.
- Ali I.
- Alianza M.
- Alings M.
- Alison M.
- Allegrini E.
- Almagro S.
- Almendrales L.
- Almroth H.
- Aloisi A.
- Alvarez D'Amelio A.
- Alvarez Damelio A.
- Alvarez M.
- Alvarez Y.
- Alwi S. M.
- Alzate J.
- Aman S.
- Amemiya H.
- Amemiya Y.
- Amerena J.
- Amir M. A.
- Amiya R.
- Amonchot A.
- Amorin R. C.
- An S.
- Anand S. S.
- Anderson J.
- Anderson T.
- Andersson T.
- Ando K.
- Ando M.
- Andrade G.
- Andrea G.
- Andrei C.
- Andrew G.
- Andrioli V.
- Angel Escobar J.
- Anghel L.
- Angie Lorena A.
- Anonuevo J.
- Antohi L.
- Antropova O.
- Anuschek V.
- Anzules N.
- Aoki S.
- Aotsuka S.
- Apostoie A.
- Appel K.
- Appel S.
- Aquino M. R.
- Aradi D.
- Arai M.
- Araki Y.
- Arantes FBB.
- Araujo V. L.
- Arbis M. G.
- Arciniegas J.
- Arcos Palma E.
- Ardeleanu I.
- Arimie R.
- Aristizabal J.
- Ariz A.
- Armean P.
- Aroca Martinez G.
- Arriagada G.
- Arseneault M. C.
- Arsenescu C.
- Aruachan Vesga S.
- Asahi T.
- Asai J.
- Asayama H.
- Aseycheva O.
- Ashton H.
- Asselman M.
- Assompcao R. P.
- Ata T.
- Atar S.
- Atarashi A.
- Attanasio C.
- Audet M.
- Aukema-Wouda Z.
- Ausheva A.
- Austin D.
- Averkov O.
- Avezum A.
- Aviles A.
- Awater J.
- Axente L.
- Ayano S.
- Azeddine B.
- Azzara G.
- Babapulle M.
- Bacharach J.
- Bachetti C.
- Badings E.
- Badts G.
- Bae J.
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- Yufereva Y.
- Yumiba A.
- Yumoto I.
- Yunis M.
- Yusoff K.
- Yusubova A.
- Yusuf S.
- Yuval R.
- Zabashta S.
- Zabowka M.
- Zadra R.
- Zaidman C.
- Zaidman M.
- Zainal Rashid R.
- Zakharova A.
- Zalewski J.
- Zambonin GEC.
- Zamiti-Smondel A.
- Zamrin D. M.
- Zanateli A.
- Zaprovalna O.
- Zara O.
- Zarate Bernal D.
- Zarka S.
- Zateyshchikov D.
- Zatocil T.
- Zegers E.
- Zelenkova V.
- Zeltser D.
- Zeman P.
- Zeuthen E.
- Zhang B.
- Zhang J.
- Zhang Q.
- Zhang R.
- Zhang S.
- Zhang W.
- Zhao C.
- Zhao Q.
- Zhao Y.
- Zheng Y.
- Zheng Z.
- Zhou X.
- Zhu J.
- Zhu Y.
- Zhuravleva E.
- Zhurina M.
- Zidek M.
- Zidkova E.
- Zillo M.
- Zimlichman R.
- Zimmermann EMB.
- Zimmermann S. L.
- Zoet-Nugteren S.
- Zorzo JAT.
- Zsary A.
- Zsoriova T.
- Zubova E.
- Zuker S.
- Zukermann R.
- Zuleta I.
- Zuleta M.
- Zushi R.
- Zvi R.
- Zvi Y.
- Zwinnen W.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND: We evaluated whether rivaroxaban alone or in combination with aspirin would be more effective than aspirin alone for secondary cardiovascular prevention. METHODS: In this double-blind trial, we randomly assigned 27,395 participants with stable atherosclerotic vascular disease to receive rivaroxaban (2.5 mg twice daily) plus aspirin (100 mg once daily), rivaroxaban (5 mg twice daily), or aspirin (100 mg once daily). The primary outcome was a composite of cardiovascular death, stroke, or myocardial infarction. The study was stopped for superiority of the rivaroxaban-plus-aspirin group after a mean follow-up of 23 months. RESULTS: The primary outcome occurred in fewer patients in the rivaroxaban-plus-aspirin group than in the aspirin-alone group (379 patients [4.1%] vs. 496 patients [5.4%]; hazard ratio, 0.76; 95% confidence interval [CI], 0.66 to 0.86; P<0.001; z=−4.126), but major bleeding events occurred in more patients in the rivaroxaban-plus-aspirin group (288 patients [3.1%] vs. 170 patients [1.9%]; hazard ratio, 1.70; 95% CI, 1.40 to 2.05; P<0.001). There was no significant difference in intracranial or fatal bleeding between these two groups. There were 313 deaths (3.4%) in the rivaroxaban-plus-aspirin group as compared with 378 (4.1%) in the aspirin-alone group (hazard ratio, 0.82; 95% CI, 0.71 to 0.96; P=0.01; threshold P value for significance, 0.0025). The primary outcome did not occur in significantly fewer patients in the rivaroxaban-alone group than in the aspirin-alone group, but major bleeding events occurred in more patients in the rivaroxaban-alone group. CONCLUSIONS: Among patients with stable atherosclerotic vascular disease, those assigned to rivaroxaban (2.5 mg twice daily) plus aspirin had better cardiovascular outcomes and more major bleeding events than those assigned to aspirin alone. Rivaroxaban (5 mg twice daily) alone did not result in better cardiovascular outcomes than aspirin alone and resulted in more major bleeding events
Sugar-sweetened beverage intakes among adults between 1990 and 2018 in 185 countries
- Author
- Abbott Pamela
- Abdollahi Morteza
- Abedi Parvin
- Abumweis Suhad
- Adair Linda
- Agdeppa Imelda Angeles
- Aguero Samuel Duran
- Al-Daghri Nasser
- Al-Hamad Nawal
- Al-Hooti Suad
- Al-Zenki Sameer
- Alam Iftikhar
- Alexy Ute
- Ali Jemal Haidar
- Ali Jennifer
- Alissa Eman
- Aluso Lilian
- Anderson Simon
- Anzid Karim
- Arambepola Carukshi
- Arici Mustafa
- Arlappa Nimmathota
- Arsenault Joanne
- Asayehu Tamene Taye
- Asciak Renzo
- Avula Laxmaiah
- Balfour David
- Barbieri Helene Enghardt
- Barengo Noel
- Barquera Simon
- Bas Murat
- Baykova Donka
- Becker Wulf
- Beer-Borst Sigrid
- Bergman Per
- Biro Lajos
- Boedecker Julia
- Boindala Sesikeran
- Bonaccio Marialaura
- Bovet Pascal
- Bradshaw Debbie
- Brown Ken
- Bukania Zipporah
- Bukhary Noriklil Bukhary Ismail
- Bundhamcharoen Kanitta
- Caballero Mauricio
- Calleja Neville
- Cao Xia
- Capanzana Mario
- Carmikle Jan
- Cash Sean B.
- Castetbon Katia
- Castro Michelle
- Cerdena Corazon
- Chan Mei Fen
- Chang Hsing Yi
- Chen Yu
- Chileshe Justin
- Chiplonkar Shashi
- Cho Yoonsu
- Chuah Khun Aik
- Costanzo Simona
- Cowan Melanie
- Cudhea Frederick
- Damasceno Albertino
- Dastgiri Saeed
- de Brauw Alan
- De Henauw Stefaan
- de Moura Souza Amanda
- Delgado Edna Gamboa
- DeRidder Karin
- Desnacido Josie
- Diba Tshilenge S.
- Ding Eric L.
- Dommarco Juan Rivera
- Don Rokiah
- Douangvichit Daovieng
- Duante Charmaine
- Duleva Vesselka
- Ekbote Veena
- El Ati Jalila
- El-kour Tatyana
- Eldridge Alison
- Eleraky Laila
- Elmadfa Ibrahim
- Erkkola Maijaliisa
- Erndt-Marino Josh
- Ersino Getahun
- Esteghamati Alireza
- Etemad Zohreh
- Fadzil Fariza
- Farzadfar Farshad
- Fernandez Anne
- Fernando Dulitha
- Fisberg Regina
- Freese Riitta
- Garriguet Didier
- Gaspoz Jean Michel
- Gauci Dorothy
- Geleijnse Johanna M.
- Ginnela Brahmam
- Goldsmith Rebecca
- Gravel Ron
- Grosso Giuseppe
- Guessous Idris
- Gulliford Martin
- Gunnarsdottir Ingibjorg
- Hadden Wilbur
- Hadziomeragic Aida
- Haerpfer Christian
- Hakeem Rubina
- Hambidge K. Michael
- Haque Aminul
- Hashemian Maryam
- Hemalatha Rajkumar
- Henjum Sigrun
- Henry Carol
- Hjdaud Zaiton
- Hoffman Daniel
- Hopping Beth
- Hotz Christine
- Houshiar-rad Anahita
- Hsieh Yao Te
- Hung Shu Yi
- Huybrechts Inge
- Hwalla Nahla Chawkat
- Iacoviello Licia
- Ibrahim Hajah Masni
- Ikeda Nayu
- Illescas-Zarate Daniel
- Inoue Manami
- Jan Bin Jan Mohamed Hamid
- Janakiram Chandrashekar
- Janská Veronika
- Jayawardena Ranil
- Jeewon Rajesh
- Jitnarin Nattinee
- Johansson Lars
- Jonsdottir Olof
- Jordan Irmgard
- Kally Ola
- Kandiah Mirnalini
- Karupaiah Tilakavati
- Keding Gudrun B.
- Keinan-Boker Lital
- Kelishadi Roya
- Khadilkar Anuradha
- Khan Umber S.
- Khouw Ilse
- Kim Cho il
- Koksal Eda
- Kombe Yeri
- Korkalo Liisa
- Koster Jeremy
- Kovalskys Irina
- Krebs Nancy F.
- Krishnan Anand
- Kruger Herculina
- Kuriyan-Raj Rebecca
- Kweon Sanghui
- Lachat Carl
- Lai Yuen
- Lanerolle Pulani
- Lara-Castor Laura
- Laxmaiah Avula
- Le Nguyen Bao Khanh
- Leclercq Catherine
- Lee Hae Jeung
- Lee Meei Shyuan
- Lemming Eva Warensjo
- Li Yanping
- Lindroos Anna Karin
- Lindstrom Jaana
- Ling Annie
- Liputo Nur Indrawaty
- Long Julie M.
- Lopes Carla
- Lopez-Jaramillo Patricio
- Luangphaxay Chanthaly
- Luke Amy
- Lukito Widjaja
- Lunet Nuno
- Lupotto Elisabetta
- Ma Guansheng
- Ma Yi
- Maghroun Maryam
- Mahdy Zaleha Abdullah
- Malekzadeh Reza
- Manan Wan
- Manary Mark
- Marchioni Dirce
- Marques Lydia Lera
- Marques-Vidal Pedro
- Martin-Prevel Yves
- Mastiholi Shivanand C.
- Mathee Angie
- Mazumdar Paramita
- Meenakshi J. V.
- Memon Anjum
- Mensink Gert
- Meshram Indrapal
- Meyer Alexa
- Micha Renata
- Miller Victoria
- Mirmiran Parvin
- Mirzaei Masoud
- Misra Anoop
- Misra Puneet
- Mitchell Claudette
- Mohammadi-Nasrabadi Fatemeh
- Mohammadifard Noushin
- Moraeus Lotta
- Moursi Mourad
- Moy Foong Ming
- Mozaffarian Dariush
- Musaiger Abdulrahman
- Mwangi Moses
- Mwaniki Elizabeth
- Mwanza Sydney
- Myhre Jannicke
- Nagalla Balakrishna
- Naska Androniki
- Nelis Keiu
- Ng Shu Wen
- Ng Swee Ai
- Ngoan Le Tran
- Nicolau Anca
- Nikiema Laetitia
- Noshad Sina
- Nsour Mohannad Al
- Nurk Eha
- Nöthlings Ute
- Ochoa Angelica
- Ocke Marga
- Odenkirk Jillian
- Oduor Francis
- Oh Kyungwon
- Oleas Mariana
- Olivares Sonia
- Orfanos Philippos
- Ortiz-Ulloa Johana
- Otero Johanna
- Ovaskainen Marja Leena
- Pakseresht Mohammadreza
- Palacios Cristina
- Palmer Pam
- Pan Wen Harn
- Panagiotakos Demosthenes
- Park Sihyun
- Pekcan Gulden
- Petrova Stefka
- Piaseu Noppawan
- Piccinelli Raffaela
- Pitsavos Christos
- Poh Bee Koon
- Polasa Kalpagam
- Posada Luz
- Pourfarzi Farhad
- Preston Alan Martin
- Rachakulla Harikumar
- Rached Ingrid
- Rahbar Ali Reza
- Rajkumar Hemalatha
- Rangelova Lalka
- Rehm Colin
- Richter Almut
- Riley Leanne
- RodrÃguez-RamÃrez Sonia
- Rojroongwasinkul Nipa
- Roos Eva
- Rovirosa Alicia
- Rybak Constance
- Sabico Shaun
- Salanave Benoit
- Sanchez-Romero Luz Maria
- Sandjaja Sandjaja
- Sarrafzadegan Nizal
- Sawada Norie
- Sekiyama Makiko
- Selamat Rusidah
- Serra-Majem Lluis
- Sette Stefania
- Severo Milton
- Shamsuddin Khadijah
- Sharib Julia R.
- Shariff Zalilah Mohd
- Sharma Sangita
- Shi Peilin
- Shimony Tal
- Siamusantu Ward
- Sibai Abla Mehio
- Siengsounthone Latsamy
- Silva Ivonne Ramirez
- Sinkko Harri
- Sioen Isabelle
- Sipinen Jessica Petrelius
- Skeaff Sheila
- Steingrimsdottir Laufey
- Strand Tor
- Stuetz Wolfgang
- Suarez-Ortegon Milton Fabian
- Sundram Kalyana
- Swaminathan Sumathi
- Swan Gillian
- Sygnowska Elzbieta
- Szabo Maria
- Szponar Lucjan
- Tao Tina
- Tapanainen Heli
- Tayyem Reema
- Tedla Bemnet
- Tedstone Alison
- Tejeda Gabriela
- Templeton Robert
- Termote Celine
- Thanopoulou Anastasia
- Thorsdottir Inga
- Torres Duarte
- Trichopoulos Dimitrios
- Trichopoulou Antonia
- Tsugane Shoichiro
- Tudorie Cornelia
- Turrini Aida
- Vaask Sirje
- van Oosterhout Coline
- Vartiainen Erkki
- Veerman Jacob Lennert
- Virtanen Suvi
- Vollenweider Peter
- Vossenaar Marieke
- Waidyatilaka Indu
- Waskiewicz Anna
- Waswa Lydiah M.
- Wieler Lothar
- Wu Suh
- Yaakub Roseyati
- Yakes-Jimenez Elizabeth
- Yap Mabel
- Yusof Safiah
- Zaghloul Sahar
- Zajkas Gabor
- Zapata MarÃa Elisa
- Zarina Khairul
- Zeba Augustin Nawidimbasba
- Zello Gordon
- Zhang Jianyi
- Zohoori Fatemeh Vida
- Zugravu Corina Aurelia
- Publication venue
- Nature Publishing Group
- Publication date
- 01/12/2023
- Field of study
Sugar-sweetened beverages (SSBs) are associated with cardiometabolic diseases and social inequities. For most nations, recent estimates and trends of intake are not available; nor variation by education or urbanicity. We investigated SSB intakes among adults between 1990 and 2018 in 185 countries, stratified subnationally by age, sex, education, and rural/urban residence, using data from the Global Dietary Database. In 2018, mean global SSB intake was 2.7 (8 oz = 248 grams) servings/week (95% UI 2.5-2.9) (range: 0.7 (0.5-1.1) in South Asia to 7.8 (7.1-8.6) in Latin America/Caribbean). Intakes were higher in male vs. female, younger vs. older, more vs. less educated, and urban vs. rural adults. Variations by education and urbanicity were largest in Sub-Saharan Africa. Between 1990 and 2018, SSB intakes increased by +0.37 (+0.29, +0.47), with the largest increase in Sub-Saharan Africa. These findings inform intervention, surveillance, and policy actions worldwide, highlighting the growing problem of SSBs for public health in Sub-Saharan Africa.Peer reviewe
Clostridium difficile
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- Abdeen S. J.
- Allen C. A.
- Ambrus J. I.
- Angie M. Jarrad
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- Babakhani F.
- Baines E. J.
- Baines S. D.
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- Crowther G. S.
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- Dena Lyras
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- Edwards A. N.
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- Erb W.
- Eyre D. W.
- Feng L.
- Finegold S. M.
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- Grillot A.-L.
- Hamilton M. J.
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- Hong G.
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- Hutton M. L.
- Jadhav A.
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- Jiang Z. D.
- Johnson S.
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- Shoji J.
- Smith M. B.
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- Sorg J. A.
- Stokes N. R.
- Sun X.
- Sunkesula V. C. K.
- Swanson R. N.
- Tanaka K.
- Terasawa T.
- Ternansky R. J.
- Terui Y.
- Tomislav Karoli
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- Ueda C.
- Van Nood E.
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- Villano S. A.
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- Zipursky J. S.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Evolution of genes and genomes on the Drosophila phylogeny
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- Abad J.P. (Jose P.)
- Abdouelleil A. (Amr)
- Abdulkadir J. (Jamal)
- Abebe A. (Adal)
- Abera B. (Brikti)
- Abreu J. (Justin)
- Abt D.N. (Dawn N.)
- Adryan B. (Boris)
- Aftuck L. (Lynne)
- Aguade M. (Montserrat)
- Akashi H. (Hiroshi)
- Alexander A. (Allen)
- Alvarez P. (Pablo)
- An P. (Peter)
- Anderson E. (Erica)
- Anderson S. (Scott)
- Anderson W.W. (Wyatt W.)
- Aquadro C.F. (Charles F.)
- Arachi H. (Harindra)
- Ardell D.H. (David H.)
- Arguello R. (Roman)
- Artieri C.G. (Carlo G.)
- Azer M. (Marc)
- Bachantsang P. (Pasang)
- Baldwin J. (Jennifer)
- Barbash D.A. (Daniel A.)
- Barker D. (Daniel)
- Barry A. (Andrew)
- Barsanti P. (Paolo)
- Batterham P. (Phil)
- Batzoglou S. (Serafim)
- Bayul T. (Tashi)
- Begun D. (Dave)
- Bergman C.M. (Casey M.)
- Berlin A. (Aaron)
- Bernardo De Carvalho A. (A.)
- Bessette D. (Daniel)
- Bhutkar A. (Arjun)
- Blanco E. (Enrico)
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- Brooks A.N. (Angela N.)
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- Doricent M. (Missole)
- Dorje P. (Passang)
- Dorjee K. (Kunsang)
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- Farina A. (Abderrahim)
- Faro S. (Susan)
- Ferguson D. (Diallo)
- Filipski A. (Alan)
- Findeiß S. (Sven)
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- Foley C.D. (Chelsea D.)
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- Friedrich D. (Dennis)
- Fulton L. (Lucinda)
- Fulton R. (Robert)
- Gadbois L. (Loryn)
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- Gardiner A. (Anastasia)
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- Gearin G. (Gary)
- Gelbart W. (William)
- Giannoukos G. (Georgia)
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- Gnerre S. (Sante)
- Godfrey J. (Jennifer)
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- Griffiths-Jones S. (Sam)
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- Guigo R. (Roderic)
- Gustafson E.A. (Erik A.)
- Gyaltsen K. (Kunsang)
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- Han M.V. (Mira V.)
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- Hillier L. (LaDeana)
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- Hollinger A. (Andrew)
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- Honan T. (Tracey)
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- Liu J. (Jinlei)
- Liu S. (Shangtao)
- Liu X. (Xiaohong)
- Llopart A. (Ana)
- Lokyitsang T. (Tashi)
- Lokyitsang Y. (Yeshi)
- Long M. (Manyuan)
- Low L. (Lloyd)
- Lozovsky E. (Elena)
- Lu J. (Jian)
- Lubonja R. (Rakela)
- Lui A. (Annie)
- Luo M. (Meizhong)
- MacCallum I. (Iain)
- MacDonald P. (Pen)
- Machado C.A. (Carlos A.)
- Magnisalis V. (Vasilia)
- Makalowski W. (Wojciech)
- Markiewicz E. (Eva)
- Markow T.A. (Therese A.)
- Maru K. (Kebede)
- Marzo M. (Mar)
- Matsuda M. (Muneo)
- Matthews C. (Charles)
- Matzkin L. (Luciano)
- Mauceli E. (Evan)
- McAllister B. (Bryant)
- McBride C.S. (Carolyn S.)
- McCusker W. (William)
- McDonough S. (Susan)
- McKernan B. (Brendan)
- McKernan K. (Kevin)
- Mehta T. (Teena)
- Meldrim J. (James)
- Mendez-Lago M. (Maria)
- Meneus L. (Louis)
- Mihai O. (Oana)
- Mihalev A. (Atanas)
- Mihova T. (Tanya)
- Minx P. (Patrick)
- Mittelman R. (Rachel)
- Mlenga V. (Valentine)
- Mollenhauer M.U. (Michael U.)
- Montmayeur A. (Anna)
- Montooth K. (Kristi)
- Mount S.M. (Stephen M.)
- Mu X. (Xu)
- Mulrain L. (Leonidas)
- Myers E. (Eugene)
- Navidi A. (Adam)
- Naylor J. (Jerome)
- Negash T. (Tamrat)
- Negre B. (Barbara)
- Newfeld S. (Stuart)
- Nguyen N. (Nga)
- Nguyen T. (Thu)
- Nicol R. (Robert)
- Nielsen R. (Rasmus)
- Noor M.A.F. (Mohamed A. F.)
- Norbu C. (Choe)
- Norbu N. (Nyima)
- Novod N. (Nathaniel)
- O'Grady P. (Patrick)
- O'Neill B. (Barry)
- Oliver B. (Brian)
- Osman S. (Sahal)
- Oyono O.L. (Otero L.)
- Pachter L. (Lior)
- Papaceit M. (Montserrat)
- Parisi M. (Michael)
- Parisi M.J. (Matthew J.)
- Parts L. (Leopold)
- Patti C. (Christopher)
- Pedersen J.S. (Jakob S.)
- Pesole G. (Graziano)
- Phillippy A.M. (Adam M.)
- Phunkhang P. (Pema)
- Pierre F. (Fritz)
- Pollard D.A. (Daniel A.)
- Ponting C.P. (Chris P.)
- Pop M. (Mihai)
- Porcelli D. (Damiano)
- Powell J.R. (Jeffrey R.)
- Priest M. (Margaret)
- Prohaska S. (Sonja)
- Pruitt K. (Kim)
- Puig M. (Marta)
- Quesneville H. (Hadi)
- Raghuraman S. (Sujaa)
- Rand D. (David)
- Rasmussen M.D. (Matthew D.)
- Ravi Ram K. (Kristipati)
- Reed L.K. (Laura K.)
- Reenan R. (Robert)
- Rege F. (Filip)
- Reily A. (Amy)
- Remington K.A. (Karin A.)
- Reyes R. (Rebecca)
- Rieger T.T. (Tania T.)
- Rise C. (Cecil)
- Ritchie M.G. (Michael G.)
- Robin C. (Charles)
- Rogers Y.-H. (Yu-Hui)
- Rogov P. (Peter)
- Rohde C. (Claudia)
- Ross K. (Keenan)
- Rozas J. (Julio)
- Rubenfield M.J. (Marc J.)
- Ruiz A. (Alfredo)
- Russo S. (Susan)
- Ryan E. (Elizabeth)
- Sackton T.B. (Timothy B.)
- Salzberg S.L. (Steven L.)
- Sanchez-Gracia A. (Alejandro)
- Saranga D.J. (David J.)
- Sato H. (Hajime)
- Schaeffer S.W. (Stephen W.)
- Schatz M.C. (Michael C.)
- Schlenke T. (Todd)
- Schwartz R. (Russell)
- Segarra C. (Carmen)
- Settipalli S. (Sampath)
- Shea T. (Terry)
- Sherpa N. (Ngawang)
- Shi L. (Lu)
- Shih D. (Diana)
- Singh N.D. (Nadia D.)
- Singh R.S. (Rama S.)
- Sirot L. (Laura)
- Sirota M. (Marina)
- Sisneros N.B. (Nicholas B.)
- Smith C.D. (Chris D.)
- Smith D.R. (Douglas R.)
- Smith T.F. (Temple F.)
- Sparrow T. (Todd)
- Spaulding J. (Jessica)
- Spieth J. (John)
- Stage D.E. (Deborah E.)
- Stalker J. (John)
- Stange-Thomann N. (Nicole)
- Stark A. (Alexander)
- Stavropoulos S. (Sharon)
- Stephan W. (Wolfgang)
- Stone C. (Catherine)
- Strader C. (Christopher)
- Strausberg R.L. (Robert L.)
- Strempel S. (Sebastian)
- Sturgill D. (David)
- Sutton G. (Granger)
- Sutton G.G. (Granger G.)
- Tao W. (Wei)
- Teichmann S. (Sarah)
- Tesfaye S. (Senait)
- Thomson T. (Talene)
- Thoulutsang D. (Dawa)
- Thoulutsang Y. (Yama)
- Tobari Y.N. (Yoshiko N.)
- Tomimura Y. (Yoshihiko)
- Topham K. (Kerri)
- Topping I. (Ira)
- Tsamla T. (Tsamla)
- Tsolas J.M. (Jason M.)
- Valente V.L.S. (Vera L. S.)
- Vassiliev H. (Helen)
- Venter E. (Eli)
- Vicario S. (Saverio)
- Vieira F.G. (Filipe G.)
- Vilella A.J. (Albert J.)
- Villasante A. (Alfredo)
- Vo A. (Andy)
- Walenz B. (Brian)
- Wang J. (Jun)
- Wangchuk T. (Tsering)
- Wangdi T. (Tsering)
- Wasserman M. (Marvin)
- Watts T. (Thomas)
- Weiand M. (Michael)
- Wilkinson J. (Jane)
- Wilson A. (Adam)
- Wilson D. (Derek)
- Wilson R.K. (Richard K.)
- Wing R.A. (Rod A.)
- Wolfner M.F. (Mariana F.)
- Wong A. (Alex)
- Wu C.-I. (Chung-I)
- Wu G. (Gabriel)
- Yadav S. (Shailendra)
- Yamamoto D. (Daisuke)
- Yang H.-P. (Hsiao-Pei)
- Yang S.-P. (Shiaw-Pyng)
- Yorke J.A. (James A.)
- Yoshida K. (Kiyohito)
- Young G. (Geneva)
- Yu Q. (Qing)
- Zdobnov E. (Evgeny)
- Zembek L. (Lisa)
- Zhang P. (Peili)
- Zhang Y. (Yu)
- Zhong D. (Danni)
- Zimin A.V. (Aleksey V.)
- Zimmer A. (Andrew)
- Zwirko Z. (Zac)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 08/11/2007
- Field of study
Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species
Evolution of genes and genomes on the Drosophila phylogeny
- Author
- Abad Jose P
- Abdouelleil Amr
- Abdulkadir Jamal
- Abebe Adal
- Abera Brikti
- Abreu Justin
- Abt Dawn N
- Acer St Christophe
- Adryan Boris
- Aftuck Lynne
- Aguade Montserrat
- Akashi Hiroshi
- Alexander Allen
- Alvarez Pablo
- An Peter
- Anderson Erica
- Anderson Scott
- Anderson Wyatt W
- Aquadro Charles F
- Arachi Harindra
- Ardell David H
- Arguello Roman
- Artieri Carlo G
- Azer Marc
- Bachantsang Pasang
- Baldwin Jennifer
- Barbash Daniel A
- Barker Daniel
- Barry Andrew
- Barsanti Paolo
- Batterham Phil
- Batzoglou Serafim
- Bayul Tashi
- Begun Dave
- Bergman Casey M
- Berlin Aaron
- Bernardo de Carvalho A
- Bessette Daniel
- Bhutkar Arjun
- Blanco Enrico
- Bloom Toby
- Blye Jason
- Boguslavskiy Leonid
- Bonnet Claude
- Bosak Stephanie A
- Boukhgalter Boris
- Bourzgui Imane
- Bradley Robert K
- Brand Adrianne D
- Brent Michael R
- Brockman Will
- Brooks Angela N
- Brown Adam
- Brown Randall H
- Butler Jonathan
- Butlin Roger K
- Caggese Corrado
- Cahill Patrick
- Calvi Brian R
- Caspi Anat
- Castrezana Sergio
- Celniker Susan E
- Chang Jean L
- Channer Sheridon
- Chapple Charles
- Chatterji Sourav
- Cheshatsang Yama
- Chin CheeWhye
- Chinwalla Asif
- Chuda Lisa
- Citroen Mieke
- Civetta Alberto
- Clark Andrew G
- Clifton Sandra W
- Collymore Alville
- Comeron Josep M
- Cooke Patrick
- Costello James C
- Costello Maura
- Coyne Jerry A
- D'Aco Katie
- Daub Jennifer
- David Robert G
- Daza Riza
- De Haan Georgius
- DeGray Stuart
- Delcher Arthur L
- Delehaunty Kim
- DeMaso Christina
- Dhargay Norbu
- Do Chuong B
- Dooley Erin
- Dooley Kimberly
- Doricent Missole
- Dorje Passang
- Dorjee Kunsang
- Dupes Alan
- Ebling Heather
- Edwards Kevin
- Eickbush Thomas
- Eisen Michael B
- Elong Richard
- Evans Jay D
- Falk Jill
- Farina Abderrahim
- Faro Susan
- Ferguson Diallo
- Filipski Alan
- Findeiss Sven
- Fisher Sheila
- Foley Chelsea D
- Franke Alicia
- Freyhult Eva
- Friedrich Dennis
- Fulton Lucinda
- Fulton Robert
- Gadbois Loryn
- Garcia Ana C L
- Gardiner Anastasia
- Garfield David A
- Garvin Barry E
- Gearin Christina R
- Gearin Gary
- Gelbart William
- Giannoukos Georgia
- Gibson Greg
- Gilbert Don
- Gnerre Sante
- Gnerre Sante
- Godfrey Jennifer
- Good Robert
- Goode Tina
- Gotea Valer
- Grabherr Manfred
- Graham Joseph
- Grandbois Edward
- Gravely Brenton
- Greenberg Anthony J
- Grewal Sharleen
- Griffiths-Jones Sam
- Gross Samuel
- Guigo Roderic
- Gustafson Erik A
- Gyaltsen Kunsang
- Haerty Wilfried
- Hafez Nabil
- Hagos Birhane
- Hahn Matthew W
- Hall Jennifer
- Halligan Daniel L
- Halpern Aaron L
- Halter Gillian M
- Han Mira V
- Heger Andreas
- Henson Charlotte
- Hillier LaDeana
- Hinrichs Angie S
- Hollinger Andrew
- Holmes Ian
- Honan Tracey
- Hoskins Roger A
- Huard Monika D
- Hubisz Melissa J
- Hughes Leanne
- Hultmark Dan
- Huntley Melanie A
- Hurhula Brian
- Husby M Erii
- Iyer Venky N
- Jaffe David B
- Jaffe David B
- Jagadeeshan Santosh
- Jeck William R
- Johnson Justin
- Jones Corbin D
- Jordan William C
- Kamat Asha
- Kanga Ben
- Karpen Gary H
- Kashin Seva
- Kataoka Eiko
- Kaufman Thomas C
- Keightley Peter D
- Kellis Manolis
- Khazanovich Dmitry
- Kheradpour Pouya
- Kirkness Ewen F
- Kisner Peter
- Kleber Michael
- Koerich Leonardo B
- Kristiansen Karsten
- Kudrna Dave
- Kulathinal Rob J
- Kumar Sudhir
- Kwok Roberta
- Lance Krista
- Lander Eric
- Langley Charles H
- Lapoint Richard
- Lara Marcia
- Larracuente Amanda M
- Lazzaro Brian P
- Lee So-Jeong
- Lee William
- Lennon Niall
- Letendre Frances
- Levesque Lisa
- LeVine Rosie
- Li Ruiqiang
- Lin Chiao-Feng
- Lin Michael F
- Lindblad-Toh Kerstin
- Lipovsky Alex
- Liu Jinlei
- Liu Shangtao
- Liu Xiaohong
- Llopart Ana
- Lokyitsang Tashi
- Lokyitsang Yeshi
- Long Manyuan
- Low Lloyd
- Lozovsky Elena
- Lu Jian
- Lubonja Rakela
- Lui Annie
- Luo Meizhong
- MacCallum Iain
- MacDonald Pen
- Machado Carlos A
- Magnisalis Vasilia
- Makalowski Wojciech
- Markiewicz Eva
- Markow Therese A
- Maru Kebede
- Marzo Mar
- Matsuda Muneo
- Matthews Charles
- Matzkin Luciano
- Mauceli Evan
- McAllister Bryant
- McBride Carolyn S
- McCusker William
- McDonough Susan
- McKernan Brendan
- McKernan Kevin
- Mehta Teena
- Meldrim James
- Mendez-Lago Maria
- Meneus Louis
- Mihai Oana
- Mihalev Atanas
- Mihova Tanya
- Minx Patrick
- Mittelman Rachel
- Mlenga Valentine
- Mollenhauer Michael U
- Montmayeur Anna
- Montooth Kristi
- Mount Stephen M
- Mu Xu
- Mulrain Leonidas
- Myers Eugene
- Navidi Adam
- Naylor Jerome
- Negash Tamrat
- Negre Barbara
- Newfeld Stuart
- Nguyen Nga
- Nguyen Thu
- Nicol Robert
- Nielsen Rasmus
- Noor Mohamed A F
- Norbu Choe
- Norbu Nyima
- Novod Nathaniel
- O'Grady Patrick
- O'Neill Barry
- Oliver Brian
- Osman Sahal
- Oyono Otero L
- Pachter Lior
- Papaceit Montserrat
- Parisi Matthew J
- Parisi Michael
- Parts Leopold
- Patti Christopher
- Pedersen Jakob S
- Pesole Graziano
- Phillippy Adam M
- Phunkhang Pema
- Pierre Fritz
- Pollard Daniel A
- Ponting Chris P
- Pop Mihai
- Porcelli Damiano
- Powell Jeffrey R
- Priest Margaret
- Prohaska Sonja
- Pruitt Kim
- Puig Marta
- Quesneville Hadi
- Raghuraman Sujaa
- Ram Kristipati Ravi
- Rand David
- Rasmussen Matthew D
- Reed Laura K
- Reenan Robert
- Rege Filip
- Reily Amy
- Remington Karin A
- Reyes Rebecca
- Rieger Tania T
- Rise Cecil
- Ritchie Michael G
- Robin Charles
- Rogers Yu-Hui
- Rogov Peter
- Rohde Claudia
- Ross Keenan
- Rozas Julio
- Rubenfield Marc J
- Ruiz Alfredo
- Russo Susan
- Ryan Elizabeth
- Sackton Timothy B
- Salzberg Steven L
- Sanchez-Gracia Alejandro
- Saranga David J
- Sato Hajime
- Schaeffer Stephen W
- Schatz Michael C
- Schlenke Todd
- Schwartz Russell
- Segarra Carmen
- Settipalli Sampath
- Shea Terry
- Sherpa Ngawang
- Shi Lu
- Shih Diana
- Singh Nadia D
- Singh Rama S
- Sirot Laura
- Sirota Marina
- Sisneros Nicholas B
- Smith Chris D
- Smith Douglas R
- Smith Temple F
- Sparrow Todd
- Spaulding Jessica
- Spieth John
- Stage Deborah E
- Stalker John
- Stange-Thomann Nicole
- Stark Alexander
- Stavropoulos Sharon
- Stephan Wolfgang
- Stone Catherine
- Strader Christopher
- Strausberg Robert L
- Strempel Sebastian
- Sturgill David
- Sutton Granger
- Sutton Granger G
- Tao Wei
- Teichmann Sarah
- Tesfaye Senait
- Thomson Talene
- Thoulutsang Dawa
- Thoulutsang Yama
- Tobari Yoshiko N
- Tomimura Yoshihiko
- Topham Kerri
- Topping Ira
- Tsamla Tsamla
- Tsolas Jason M
- Valente Vera L S
- Vassiliev Helen
- Venter Eli
- Venter J Craig
- Vicario Saverio
- Vieira Filipe G
- Vilella Albert J
- Villasante Alfredo
- Vo Andy
- Walenz Brian
- Wang Jun
- Wangchuk Tsering
- Wangdi Tsering
- Wasserman Marvin
- Watts Thomas
- Weiand Michael
- Wilkinson Jane
- Wilson Adam
- Wilson Derek
- Wilson Richard K
- Wing Rod A
- Wolfner Mariana F
- Wong Alex
- Wong Gane Ka-Shu
- Wu Chung-I
- Wu Gabriel
- Yadav Shailendra
- Yamamoto Daisuke
- Yang Hsiao-Pei
- Yang Shiaw-Pyng
- Yorke James A
- Yoshida Kiyohito
- Young Geneva
- Yu Qing
- Zdobnov Evgeny
- Zembek Lisa
- Zhang Peili
- Zhang Yu
- Zhong Danni
- Zimin Aleksey V
- Zimmer Andrew
- Zwirko Zac
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study
Affiliations des auteurs : cf page 216 de l'articleInternational audienceComparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species