Students’ Perception Related to a Responsible Research and Innovation Demarche

AbstractThe present paper deals with the perception analysis of the importance of the non-formal education, performed as specific activities developed in museums, which promotes Responsible Research and Innovation (RRI) to the primary and secondary school students. A standard research, of theoretical and empiric type, has been achieved. The empirical research aimed both on the quantitative level - the method of structured questionnaire - but also on the qualitative research, based on the focus group method. Some analysis was drawn yielding to the following conclusion: non-formal education performed in museums is reflected like a learning process which stimulates the students’ sensitivity and intellect for RRI

Risks and complications in rhinoplasty. A comparative study in structural vs preservation rhinoplasty

Introduction. Rhinoseptoplasty is considered the most challenging operation because many techniques have to be taken into consideration to achieve an optimal aesthetic and functional results. Rhinoseptoplasty techniques have been perfected over time, following two main surgical approaches: structural rhinoplasty (resection/ reconstruction) and conservative (preservation rhinoplasty). Methods. The authors present the risks and complications in a comparative study of 100 cases with patients in primary rhinoseptoplastyplasty performed between 2019-2021: 50 cases in Structural Rhinoplsty and 50 cases in Preservation Rhinoplasty. The study presents two surgical concepts of rhinoplasty regarding the main advantages, disadvantages and indications of each type of rhinoseptoplasty surgery. Results and conclusions. Complications post-rhinoseptoplasty can be considered as perioperative, functional, anatomic (aesthetic) and psyhological. In this study 10 cases (10%) of primary rhinoplasty required revision surgery. The most frequent postoperative deformity is the “pollybeak” when a deep naso-frontal angle, cartilaginous hump and reduced tip projection are present preoperatively. The pollybeak was the indication in 4 cases (40%) of all revision rhinoplasties. Other frequent postoperative deformities are: wide nasal tip, retractions of the columella base and irregularities of the nasal dorsum. These deformities are very often combined and caused by a loss of septal support. Septorhinoplasy is a difficult procedure and the surgeon must have accurate anatomical knowledge and rich clinical experience. The risks for rhinoplasty-complications can be reduced with increasing experience. It is very important to make distinction between complication and mistake

Plasma miR-19b, miR-34a, and miR-146a expression in patients with type 2 diabetes mellitus and cataract: A pilot study

Cataract is among the most common ocular complications in diabetes mellitus (DM). While microRNA (miRNA) dysregulations in DM have been previously reported, consensus is still lacking concerning miRNA expression in cataract. Furthermore, the miRNA profile in diabetic cataract patients remains largely unexplored, and data on plasma expression levels are limited. Our study aimed to assess the plasma levels of three distinct miRNA species (hsa-miR-19b, hsa-miR-34a, and hsa-miR-146a) implicated in the development of cataract and/or DM.We investigated the circulating miRNA expression in DM patients diagnosed with cataract, compared to a non-DM cataract group. We employed qRT-PCR for relative quantification experiments and subsequently conducted a correlation analysis between miRNA expression levels and clinical characteristics. Our findings reveal that hsa-miR-34a and hsa-miR-146a are differentially expressed in the two cohorts. However, no significant correlation was observed between the clinical variables and miRNA levels. In summary, our results suggest a potential role for hsa-miR-34a and hsa-miR-146a in the biology of diabetic cataract

Study of the management of viral hepatitis C

Abstract. Viral hepatitis C (VHC) is one of the leading causes of chronic liver disease and the overall prevalence of infection in 2019 has been estimated at approximately 1%. The aim of this study was to investigate the efficacy and tolerability of different antiviral drugs in the treatment of VHC. Data on the treatment of VHC in the National Programme for the Control of Viral Hepatitis were analysed. The clinical study was conducted in the Hospital for Infectious Diseases Toma Ciorbă during 2020-2021. The use of treatment with direct-acting antivirals is successful, with a failure rate of less than 0.5%, but also more than 6% among genotype 3. For patients resistant to the treatment regimens used in the National Programme, the use of genotype-specific treatment, as recommended by the European Association for the Study of the Liver (EASL), is required. Based on the study of disease records, the Declatasvir + Sofosbuvir and Sofosbuvir + Ribavirin regimens for chronic VHC show treatment efficacy of about 98% and 87.3 respectively for 12-24 weeks.Rezumat. Hepatita virală C (HVC) este una dintre principalele cauze ale bolilor hepatice cronice, iar prevalenţa generală a infecţiei în 2019 a fost estimată la aproximativ 1%. Scopul studiului este cercetarea eficienţei și tolerabilităţii diferitor preparate antivirale în tratamentul hepatitei virale C. Au fost analizate datele privind tratamentul hepatitei virale C în cadrul Programului Naţional pentru controlul hepatitelor virale. Studiul clinic a fost efectuat în Spitalul Clinic de Boli Infecţioase Toma Ciorbă pe parcursul anilor 2020-2021. Utilizarea tratamentului cu antivirale cu acţiune directă este de succes, rata eșecului fiind mai puţin de 0,5%, dar totodată mai mult de 6% în rândul genotipului 3. Pentru pacienţii rezistenţi la schemele de tratament utilizate în cadrul Programului Naţional este necesar tratamentul genotipic specific, conform recomandărilor Asociaţiei Europene pentru Studiul Ficatului (EASL). În baza studiului fișelor clinice de boală, schemele de terapie cu Declatasvir + Sofosbuvir şi Sofosbuvir + Ribavirină pentru HVC manifestă eficacitate de circa 98% și 87,3 respectiv, timp de 12-24 săptămâni

A Demographic Exploration of Associative Entities in the Local Action Group

Demographic exploration within sustainable local development is pivotal for understanding associative entities in a specific region. This study delves into Romania's demographic views, with a focal point on Local Action Groups (LAGs) in Central Dobrogea. Associative entities encompass political parties, non-governmental associations, agricultural cooperatives, and LAGs, serving as catalysts for positive change, policy influence, and community resilience. This research analyzes 177 respondents' data using SPSS, finding no significant associations between age/gender and participation in associative entities.The work emphasizes the potential influence of demographic characteristics, particularly age and gender, on individuals' perceptions, priorities, and participation in these entities. Age shapes perceptions of socio-economic issues, while gender influences perspectives within the context of sustainable local development. Consequently, this study provides insights into the demographic dynamics of associative entity participation, highlighting their enduring relevance in shaping a more sustainable and resilient local community

Validation of a New Prognostic Score in Patients with Ovarian Adenocarcinoma

Background and Objectives: This study aimed to assess the impact of clinical prognostic factors and propose a prognostic score that aids the clinician’s decision in estimating the risk for patients in clinical practice. Materials and Methods: The study included 195 patients diagnosed with ovarian adenocarcinoma. The therapeutic strategy involved multidisciplinary decisions: surgery followed by adjuvant chemotherapy (80%), neoadjuvant chemotherapy followed by surgery (16.4%), and only chemotherapy in selected cases (3.6%). Results: After a median follow-up of 68 months, in terms of progression-free survival (PFS) and overall survival (OS), Eastern Cooperative Oncology Group (ECOG) performance status of 1 and 2 vs. 0 (hazard ratio—HR = 2.71, 95% confidence interval—CI, 1.96–3.73, p < 0.001 for PFS and HR = 3.19, 95%CI, 2.20–4.64, p < 0.001 for OS), menopausal vs. premenopausal status (HR = 2.02, 95%CI, 1.35–3,0 p < 0.001 and HR = 2.25, 95%CI = 1.41–3.59, p < 0.001), ascites (HR = 1.95, 95%CI 1.35–2.80, p = 0.03, HR = 2.31, 95%CI = 1.52–3.5, p < 0.007), residual disease (HR = 5.12, 95%CI 3.43–7.65, p < 0.0001 and HR = 4.07, 95%CI = 2.59–6.39, p < 0.0001), and thrombocytosis (HR = 2.48 95%CI = 1.72–3.58, p < 0.0001, HR = 3.33, 95%CI = 2.16–5.13, p < 0.0001) were associated with a poor prognosis. An original prognostic score including these characteristics was validated using receiver operating characteristic (ROC) curves (area under the curve—AUC = 0.799 for PFS and AUC = 0.726 for OS, p < 0.001). The median PFS for patients with none, one, two, three, or four (or more) prognostic factors was not reached, 70, 36, 20, and 12 months, respectively. The corresponding median overall survival (OS) was not reached, 108, 77, 60, and 34 months, respectively. Conclusions: Several negative prognostic factors were identified: ECOG performance status ≥ 1, the presence of ascites and residual disease after surgery, thrombocytosis, and menopausal status. These led to the development of an original prognostic score that can be helpful in clinical practice

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to &lt;90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], &gt;300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of &lt;15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P&lt;0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P&lt;0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Perspectives on Ten-to-Twelve Years Old Cognitive Processes Stimulated by Media Messages Reception and Attitudinal Changes Resulting from Gaining Media Competence

Last four decades’ debate on public’s media competencies has been shifting from the model of passive reception of media messages tackled from a behavioral approach “what media do to people”, to the one favoring the active media reception, built on the functionalist way of evaluating, “what people do with media”. Time and media progresses have made it clearer than ever before that aspects regarding the way media have been “insinuating” in our living rooms, bedrooms and last but not least in our everyday life, is an issue involving the family as an “institution” required by society norms and legislation to have a say in the way viewing rules are built and applied when children are around TV

Metamemorie, mobilitate si urbanitate in context de criza industriala. Etnicii germani, o comunitate-patrimoniu la Jimbolia (Roumanie)

International audienc

Metamemorie, mobilitate si urbanitate in context de criza industriala. Etnicii germani, o comunitate-patrimoniu la Jimbolia (Roumanie)

International audienc