Propuesta de plan de mejoramiento sobre la cultura organizacional y sus factores relacionados en una institución prestadora en salud de mediana complejidad en el departamento de Antioquia, 2023.

Esta investigación realiza un abordaje a la cultura organizacional de una IPS de Antioquia y cómo se ve afectada desde el funcionamiento del sistema de gestión documental en donde se hace énfasis en la formulación de un plan de mejoramiento que atienda las falencias encontradas a nivel institucional tendiente a mitigar los riesgos evidenciados. Así, se estructura un documento que posee una temática definida y justificada, una problemática y una objetividad, seguida de un marco referencial que posibilita una concepción aterrizada de lo que es la cultura organizacional y la gestión documental en las instituciones de salud en la actualidad. Se muestra la contextualización de la Institución y posterior intervención desde la recolección de información frente a la percepción de algunos trabajadores. Así mismo, se detalla la medición de la adherencia a las Guías de Práctica Clínica para las patologías más atendidas verificando las Historias Clínicas. En el apartado del análisis de resultados se evidencian porcentajes coincidentes una mala percepción de los trabajadores frente a los procesos de atención, comunicación y liderazgo denotando afecciones en el clima organizacional. Además, la medición de la adherencia a las guías arroja un resultado de adherencia regular. Según esto, se emiten recomendaciones encaminadas a unas estrategias de intervención frente al clima organizacional demandante de oportunidad en la toma de decisiones gerenciales. Lo anterior permite concluir el estudio, ratificando la necesidad de armonizar la gestión documental para el efecto positivo en el clima laboral de la Institución Prestadora de Salud que fundamenta la presente investigación.EspecializaciónAdministrador(a) de Servicios de Salu

Simultaneous detection of Plasmodium vivax dhfr, dhps, mdr1 and crt-o resistance-associated mutations in the Colombian Amazonian region

Background: Malaria continues being a public health problem worldwide. Plasmodium vivax is the species causing the largest number of cases of malaria in Asia and South America. Due to the lack of a completely effective anti-malarial vaccine, controlling this disease has been based on transmission vector management, rapid diagnosis and suitable treatment. However, parasite resistance to anti-malarial drugs has become a major yet-to-be-overcome challenge. This study was thus aimed at determining pvmdr1, pvdhfr, pvdhps and pvcrt-o gene mutations and haplotypes from field samples obtained from an endemic area in the Colombian Amazonian region. Methods: Fifty samples of parasite DNA infected by a single P. vivax strain from symptomatic patients from the Amazonas department in Colombia were analysed by PCR and the pvdhfr, pvdhps, pvmdr1 and pvcrt-o genes were sequenced. Diversity estimators were calculated from the sequences and the haplotypes circulating in the Colombian Amazonian region were obtained. Conclusion: pvdhfr, pvdhps, pvmdr1 and pvcrt-o genes in the Colombian Amazonian region are characterized by low genetic diversity. Some resistance-associated mutations were found circulating in this population. New variants are also being reported. A selective sweep signal was located in pvdhfr and pvmdr1 genes, suggesting that these mutations (or some of them) could be providing an adaptive advantage. © 2018 The Author(s)

Simultaneous detection of Plasmodium vivax dhfr, dhps, mdr1 and crt-o resistance-associated mutations in the Colombian Amazonian region

Abstract Background Malaria continues being a public health problem worldwide. Plasmodium vivax is the species causing the largest number of cases of malaria in Asia and South America. Due to the lack of a completely effective anti-malarial vaccine, controlling this disease has been based on transmission vector management, rapid diagnosis and suitable treatment. However, parasite resistance to anti-malarial drugs has become a major yet-to-be-overcome challenge. This study was thus aimed at determining pvmdr1, pvdhfr, pvdhps and pvcrt-o gene mutations and haplotypes from field samples obtained from an endemic area in the Colombian Amazonian region. Methods Fifty samples of parasite DNA infected by a single P. vivax strain from symptomatic patients from the Amazonas department in Colombia were analysed by PCR and the pvdhfr, pvdhps, pvmdr1 and pvcrt-o genes were sequenced. Diversity estimators were calculated from the sequences and the haplotypes circulating in the Colombian Amazonian region were obtained. Conclusion pvdhfr, pvdhps, pvmdr1 and pvcrt-o genes in the Colombian Amazonian region are characterized by low genetic diversity. Some resistance-associated mutations were found circulating in this population. New variants are also being reported. A selective sweep signal was located in pvdhfr and pvmdr1 genes, suggesting that these mutations (or some of them) could be providing an adaptive advantage