Development and evaluation of venous oximetry

Photoplethysmography, a technique to measure by optical means volume changes, has been known and applied for many years. One of its most popular applications is pulse oximetry, a non-invasive method to measure oxygen content in arterial blood. It is based on the principle of arterial blood volume changes due to heart contractions, known as systoles. Systolic pulsations appear on the arterial vascular system, while blood flow in veins does not normally present pulsations, especially at remote parts of the peripheral vascular system, such as the fingers. Therefore, pulse oximetry is only applicable to arteries as their pulsations allow for separation of the pulsatile components from the rest of the absorbing components. A novel non-invasive technique permits the measurement of venous oxygen saturation by introducing a series of pulsations in the veins thus allowing the separation of venous signal components for calculation of venous oxygen saturation. This thesis presents a theoretical model describing the mechanical coupling of arteries and veins and its effects in the accuracy of oxygen saturation measurement. [Continues.

A Case for P2P Delivery of Paid Content

P2P file sharing provides a powerful content distribution model by leveraging users' computing and bandwidth resources. However, companies have been reluctant to rely on P2P systems for paid content distribution due to their inability to limit the exploitation of these systems for free file sharing. We present TP2, a system that combines the more cost-effective and scalable distribution capabilities of P2P systems with a level of trust and control over content distribution similar to direct download content delivery networks. TP2 uses two key mechanisms that can be layered on top of existing P2P systems. First, it provides strong authentication to prevent free file sharing in the system. Second, it introduces a new notion of trusted auditors to detect and limit malicious attempts to gain information about participants in the system to facilitate additional out-of-band free file sharing. We analyze TP2 by modeling it as a novel game between malicious users who try to form free file sharing clusters and trusted auditors who curb the growth of such clusters. Our analysis shows that a small fraction of trusted auditors is sufficient to protect the P2P system against unauthorized file sharing. Using a simple economic model, we further show that TP2 provides a more cost-effective content distribution solution, resulting in higher profits for a content provider even in the presence of a large percentage of malicious users. Finally, we implemented TP2 on top of BitTorrent and use PlanetLab to show that our system can provide trusted P2P file sharing with negligible performance overhead

Can P2P Replace Direct Download for Content Distribution

While peer-to-peer (P2P) file-sharing is a powerful and cost-effective content distribution model, most paid-for digital-content providers (CPs) rely on direct download to deliver their content. CPs such as Apple iTunes that command a large base of paying users are hesitant to use a P2P model that could easily degrade their user base into yet another free file-sharing community. We present TP2, a system that makes P2P file sharing a viable delivery mechanism for paid digital content by providing the same security properties as the currently used direct-download model.} introduces the novel notion of trusted auditors (TAs) -- P2P peers that are controlled by the system operator. TAs monitor the behavior of other peers and help detect and prevent formation of illegal file-sharing clusters among the CP's user base. TAs both complement and exploit the strong authentication and authorization mechanisms that are used in TP2 to control access to content. It is important to note that TP2 does not attempt to solve the out-of-band file-sharing or DRM problems, which also exist in the direct-download systems currently in use. We analyze TP2 by modeling it as a novel game between misbehaving users who try to form unauthorized file-sharing clusters and TAs who curb the growth of such clusters. Our analysis shows that a small fraction of TAs is sufficient to protect the P2P system against unauthorized file sharing. In a system with as many as 60\% of misbehaving users, even a small fraction of TAs can detect 99\% of unauthorized cluster formation. We developed a simple economic model to show that even with such a large fraction of malicious nodes, TP2 can improve CP's profits (which could translate to user savings) by 62 to 122\%, even while assuming conservative estimates of content and bandwidth costs. We implemented TP2 as a layer on top of BitTorrent and demonstrated experimentally using PlanetLab that our system provides trusted P2P file sharing with negligible performance overhead

Water on hexagonal boron nitride from diffusion Monte Carlo

Despite a recent flurry of experimental and simulation studies, an accurate estimate of the interaction strength of water molecules with hexagonal boron nitride is lacking. Here we report quantum Monte Carlo results for the adsorption of a water monomer on a periodic hexagonal boron nitride sheet, which yield a water monomer interaction energy of -84 +/- 5 meV. We use the results to evaluate the performance of several widely used density functional theory (DFT) exchange correlation functionals, and find that they all deviate substantially. Differences in interaction energies between different adsorption sites are however better reproduced by DFT

Exploring water adsorption on isoelectronically doped graphene using alchemical derivatives

The design and production of novel 2-dimensional materials has seen great progress in the last decade, prompting further exploration of the chemistry of such materials. Doping and hydrogenating graphene is an experimentally realised method of changing its surface chemistry, but there is still a great deal to be understood on how doping impacts on the adsorption of molecules. Developing this understanding is key to unlocking the potential applications of these materials. High throughput screening methods can provide particularly effective ways to explore vast chemical compositions of materials. Here, alchemical derivatives are used as a method to screen the dissociative adsorption energy of water molecules on various BN doped topologies of hydrogenated graphene. The predictions from alchemical derivatives are assessed by comparison to density functional theory. This screening method is found to predict dissociative adsorption energies that span a range of more than 2 eV, with a mean absolute error $<0.1$ eV. In addition, we show that the quality of such predictions can be readily assessed by examination of the Kohn-Sham highest occupied molecular orbital in the initial states. In this way, the root mean square error in the dissociative adsorption energies of water is reduced by almost an order of magnitude (down to $\sim0.02$ eV) after filtering out poor predictions. The findings point the way towards a reliable use of first order alchemical derivatives for efficient screening procedures

Countering Code Injection Attacks With Instruction Set Randomization

We describe a new, general approach for safeguarding systems against any type of code-injection attack. We apply Kerckhoff's principle, by creating process-specific randomized instruction sets (e.g., machine instructions) of the system executing potentially vulnerable software. An attacker who does not know the key to the randomization algorithm will inject code that is invalid for that randomized processor, causing a runtime exception. To determine the difficulty of integrating support for the proposed mechanism in the operating system, we modified the Linux kernel, the GNU binutils tools, and the bochs-x86 emulator. Although the performance penalty is significant, our prototype demonstrates the feasibility of the approach, and should be directly usable on a suitable-modified processor (e.g., the Transmeta Crusoe).Our approach is equally applicable against code-injecting attacks in scripting and interpreted languages, e.g., web-based SQL injection. We demonstrate this by modifying the Perl interpreter to permit randomized script execution. The performance penalty in this case is minimal. Where our proposed approach is feasible (i.e., in an emulated environment, in the presence of programmable or specialized hardware, or in interpreted languages), it can serve as a low-overhead protection mechanism, and can easily complement other mechanisms

Mitigating the Effect of Free-Riders in BitTorrent using Trusted Agents

Even though Peer-to-Peer (P2P) systems present a cost-effective and scalable solution to content distribution, most entertainment, media and software, content providers continue to rely on expensive, centralized solutions such as Content Delivery Networks. One of the main reasons is that the current P2P systems cannot guarantee reasonable performance as they depend on the willingness of users to contribute bandwidth. Moreover, even systems like BitTorrent, which employ a tit-for-tat protocol to encourage fair bandwidth exchange between users, are prone to free-riding (i.e. peers that do not upload). Our experiments on PlanetLab extend previous research (e.g. LargeViewExploit, BitTyrant) demonstrating that such selfish behavior can seriously degrade the performance of regular users in many more scenarios beyond simple free-riding: we observed an overhead of up to 430% for 80% of free-riding identities easily generated by a small set of selfish users. To mitigate the effects of selfish users, we propose a new P2P architecture that classifies peers with the help of a small number of {\em trusted nodes} that we call Trusted Auditors (TAs). TAs participate in P2P download like regular clients and detect free-riding identities by observing their neighbors' behavior. Using TAs, we can separate compliant users into a separate service pool resulting in better performance. Furthermore, we show that TAs are more effective ensuring the performance of the system than a mere increase in bandwidth capacity: for 80\% of free-riding identities a single-TA system has a 6\% download time overhead while without the TA and three times the bandwidth capacity we measure a 100\% overhead

EC8-based seismic design and assessment of self-centering post-tensioned steel frames with viscous dampers

This paper focuses on seismic design and assessment of steel self-centering moment-resisting frames (SC-MRFs) with viscous dampers within the framework of Eurocode 8 (EC8). Performance levels are defined with respect to drifts, residual drifts and limit states in the post-tensioned (PT) connections. A preliminary pushover analysis is conducted at the early phase of the design process to estimate rotations and axial forces in post-tensioned (PT) connections instead of using approximate formulae. Different designs of an SC-MRF with viscous dampers are considered to investigate all possible scenarios, i.e. use of dampers to achieve drifts significantly lower than the EC8 drift limit; to significantly reduce steel weight without exceeding the EC8 drift limit; or to reduce steel weight and achieve drifts lower than the EC8 drift limit. Nonlinear dynamic analyses using models capable of simulating all structural limit states up to collapse confirm the minimal-damage performance of the SC-MRFs. It is shown that the use of the preliminary pushover analysis makes the design procedure very accurate in predicting structural and non-structural limit states. Supplemental damping along with strict design criteria for the post-tensioned connections are found to significantly improve the seismic performance of the SC-MRFs. Moreover, the paper shows that SC-MRFs with viscous dampers have superior collapse resistance compared to conventional steel MRFs even when the SC-MRF is significantly lighter than the conventional MRF