Vibrational Raman optical activity of peptides and proteins

Vibrational Raman optical activity spectra in the range 1100–1500 cm–1 of aqueous solutions of L-alanyl-L-alanine, D-alanyl-D-alanine, lysozyme, and α-chymotrypsin show features originating in coupled Cα–H and N–H deformations of the peptide backbone and appear to be sensitive to the details of the secondary conformation

Vibrational Raman optical activity of carbohydrates

Vibrational Raman optical activity (R.o.a.) spectra of a range of carbohydrates in aqueous solution, measured in back-scattering between 700 and 1500 cm−1, are presented. Features were revealed that appear to be characteristic of details of the stereochemistry. Effects associated with the glycosidic linkage in di- and oligo-saccharides are prominent

Vibrational Raman optical activity of cyclodextrins

Vibrational Raman optical activity spectra of aqueous solutions of α−, β− and γ-D-cyclodextrin in the range 700–1500 cm−1 are reported. As well as showing features characteristics of D-glucose, the ROA spectra all show remarkably intense features between 890 and 960 cm−1 originating in coupled C(1)-H deformations and glycosidic C-O stretches delocalized around the cyclodextrin ring and which reflect the stereochemistry of the glycosidic links