The discovery of the most UV-Lya luminous star-forming galaxy: a young, dust- and metal-poor starburst with QSO-like luminosities

We report the discovery of BOSS-EUVLG1 at z=2.469, by far the most luminous, almost un-obscured star-forming galaxy known at any redshift. First classified as a QSO within the Baryon Oscillation Spectroscopic Survey, follow-up observations with the Gran Telescopio Canarias reveal that its large luminosity, MUV = -24.40 and log(L_Lya/erg s-1) = 44.0, is due to an intense burst of star-formation, and not to an AGN or gravitational lensing. BOSS-EUVLG1 is a compact (reff = 1.2 kpc), young (4-5 Myr) starburst with a stellar mass log(M*/Msun) = 10.0 +/- 0.1 and a prodigious star formation rate of ~1000 Msun yr-1. However, it is metal- and dust-poor (12+log(O/H) = 8.13 +/- 0.19, E(B-V) = 0.07, log(LIR/LUV) < -1.2), indicating that we are witnessing the very early phase of an intense starburst that has had no time to enrich the ISM. BOSS-EUVLG1 might represent a short-lived (<100 Myrs), yet important phase of star-forming galaxies at high redshift that has been missed in previous surveys. Within a galaxy evolutionary scheme, BOSS-EUVLG1 could likely represent the very initial phases in the evolution of massive quiescent galaxies, even before the dusty star-forming phase.Comment: 6 pages, 3 figures, 1 table. Accepted for publication in MNRAS Letter

Optical polarization and spectral properties of the H-poor superluminous supernovae SN 2021bnw and SN 2021fpl

New optical photometric, spectrocopic and imaging polarimetry data are combined with publicly available data to study some of the physical properties of the two H-poor superluminous supernovae (SLSN) SN 2021bnw and SN 2021fpl. For each SLSN, the best-fit parameters obtained from the magnetar model with \texttt{MOSFiT} do not depart from the range of parameter obtained on other SLSNe discussed in the literature. A spectral analysis with \texttt{SYN++} shows that SN 2021bnw is a W Type, Fast evolver, while SN 2021fpl is a 15bn Type, Slow evolver. The analysis of the polarimetry data obtained on SN 2021fpl at four epochs (+1.8, +20.6, +34.1 and +43.0 days, rest-frame) shows $> 3\sigma$ polarization detections in the range 0.8--1 $\%$. A comparison of the spectroscopy data suggests that SN 2021fpl underwent a spectral transition a bit earlier than SN 2015bn, during which, similarly, it could have underwent a polarization transition. The analysis of the polarimetry data obtained on SN 2021bnw do not show any departure from symmetry of the photosphere at an empirical diffusion timescale of $\approx$ 2 (+81.1 days rest-frame). This result is consistent with those on the sample of W Type SLSN observed at empirical diffusion timescale $\le$ 1 with that technique, even though it is not clear the effect of limited spectral windows varying from one object to the other. Measurements at higher empirical diffusion timescale may be needed to see any departure from symmetry as it is discussed in the literature for SN 2017egm.Comment: 29 pages, 13 Figures, 15 Tables, submitted to the MNRA

An Overview of the Polymorphisms of Circadian Genes Associated With Endocrine Cancer

A major consequence of the world industrialized lifestyle is the increasing period of unnatural light in environments during the day and artificial lighting at night. This major change disrupts endogenous homeostasis with external circadian cues, which has been associated to higher risk of diseases affecting human health, mainly cancer among others. Circadian disruption promotes tumor development and accelerate its fast progression. The dysregulation mechanisms of circadian genes is greatly affected by the genetic variability of these genes. To date, several core circadian genes, also called circadian clock genes, have been identified, comprising the following: ARNTL, CLOCK, CRY1, CRY2, CSNK1E, NPAS2, NR1D1, NR1D2, PER1, PER2, PER3, RORA, and TIMELESS. The polymorphic variants of these circadian genes might contribute to an individual's risk to cancer. In this short review, we focused on clock circadian clock-related genes, major contributors of the susceptibility to endocrine-dependent cancers through affecting circadian clock, most likely affecting hormonal regulation. We examined polymorphisms affecting breast, prostate and ovarian carcinogenesis, in addition to pancreatic and thyroid cancer. Further study of the genetic composition in circadian clock-controlled tumors will be of great importance by establishing the foundation to discover novel genetic biomarkers for cancer prevention, prognosis and target therapies

Developing K-2 Filipino children English language oral proficiency through concrete poetry teaching

The impact of concrete poetry as a strategy to increase word recognition in ten K-2 Filipino children with low oracy/literacy in English was examined in this six-month study utilizing the single-group pre-test/post-test method. Concrete poetry is a distinct form of poetry that comes in a variety of colors, textures, shapes, and even flavors. Either a static or dynamic poem is a concrete poem. These K-2 students, who were chosen at random from the preschools, were taught how to write their own concrete poetry and gained word recognition skills from them. It was believed that concrete poetry could aid increase word recognition by enhancing receptive and expressive oral vocabulary

Neuronal p38α mediates age‐associated neural stem cell exhaustion and cognitive decline

[EN] Neuronal activity regulates cognition and neural stem cell (NSC) function. The molecular pathways limiting neuronal activity during aging remain largely unknown. In this work, we show that p38MAPK activity increases in neurons with age. By using mice expressing p38α-lox and CamkII-Cre alleles (p38α∆-N), we demonstrate that genetic deletion of p38α in neurons suffices to reduce age-associated elevation of p38MAPK activity, neuronal loss and cognitive decline. Moreover, aged p38α∆-N mice present elevated numbers of NSCs in the hippocampus and the subventricular zone. These results reveal novel roles for neuronal p38MAPK in age-associated NSC exhaustion and cognitive decline

An overview of the MILAGRO 2006 Campaign: Mexico City emissions and their transport and transformation

MILAGRO (Megacity Initiative: Local And Global Research Observations) is an international collaborative project to examine the behavior and the export of atmospheric emissions from a megacity. The Mexico City Metropolitan Area (MCMA) – one of the world's largest megacities and North America's most populous city – was selected as the case study to characterize the sources, concentrations, transport, and transformation processes of the gases and fine particles emitted to the MCMA atmosphere and to evaluate the regional and global impacts of these emissions. The findings of this study are relevant to the evolution and impacts of pollution from many other megacities. The measurement phase consisted of a month-long series of carefully coordinated observations of the chemistry and physics of the atmosphere in and near Mexico City during March 2006, using a wide range of instruments at ground sites, on aircraft and satellites, and enlisting over 450 scientists from 150 institutions in 30 countries. Three ground supersites were set up to examine the evolution of the primary emitted gases and fine particles. Additional platforms in or near Mexico City included mobile vans containing scientific laboratories and mobile and stationary upward-looking lidars. Seven instrumented research aircraft provided information about the atmosphere over a large region and at various altitudes. Satellite-based instruments peered down into the atmosphere, providing even larger geographical coverage. The overall campaign was complemented by meteorological forecasting and numerical simulations, satellite observations and surface networks. Together, these research observations have provided the most comprehensive characterization of the MCMA's urban and regional atmospheric composition and chemistry that will take years to analyze and evaluate fully. In this paper we review over 120 papers resulting from the MILAGRO/INTEX-B Campaign that have been published or submitted, as well as relevant papers from the earlier MCMA-2003 Campaign, with the aim of providing a road map for the scientific community interested in understanding the emissions from a megacity such as the MCMA and their impacts on air quality and climate. This paper describes the measurements performed during MILAGRO and the results obtained on MCMA's atmospheric meteorology and dynamics, emissions of gases and fine particles, sources and concentrations of volatile organic compounds, urban and regional photochemistry, ambient particulate matter, aerosol radiative properties, urban plume characterization, and health studies. A summary of key findings from the field study is presented.Mexico. Comisión Ambiental MetropolitanaMexico. Ministry of the EnvironmentConsejo Nacional de Ciencia y Tecnología (Mexico)Petróleos MexicanosNational Science Foundation (U.S.). Atmospheric Chemistry ProgramAtmospheric Sciences Program (U.S.)United States. National Aeronautics and Space Administration. Radiation Science Progra

Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.

Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease manifest with the neuronal accumulation of toxic proteins. Since autophagy upregulation enhances the clearance of such proteins and ameliorates their toxicities in animal models, we and others have sought to re-position/re-profile existing compounds used in humans to identify those that may induce autophagy in the brain. A key challenge with this approach is to assess if any hits identified can induce neuronal autophagy at concentrations that would be seen in humans taking the drug for its conventional indication. Here we report that felodipine, an L-type calcium channel blocker and anti-hypertensive drug, induces autophagy and clears diverse aggregate-prone, neurodegenerative disease-associated proteins. Felodipine can clear mutant α-synuclein in mouse brains at plasma concentrations similar to those that would be seen in humans taking the drug. This is associated with neuroprotection in mice, suggesting the promise of this compound for use in neurodegeneration

Current Advances Research in Nutraceutical Compounds of Legumes, Pseudocereals and Cereals

The increase of the Western-type diet and life-style, with high content of highly processed fats, salt and sugar, as well as sedentary life, is directly linked to an increasing incidence of chronic diseases such as diabetes and obesity, cancer, cardiovascular diseases or stroke, and inflammatory-related diseases, which are a great challenge in global health and are usually associated with negative effects of globalization: rapid urbanization, diet and increased sedentary life worldwide. This has brought new interest and increased research into plant-based diets. In this context, the implementation in the diet of legumes, cereals and pseudo-cereals, due to their nutraceutical properties, which is interesting as well as advisable. These foods, in addition of having a high nutritional value themselves, have synergistic properties as part of a balanced diet. For example, most legumes are rich in lysine which is scarce in cereals, and these are rich in sulphur amino acids, such as methionine, while these amino acids are scarce in legumes and are of great importance for the central nervous system development. These foods or part of a food, due to their qualities, and that they provide health benefits can be classified as nutraceuticals. In addition, due to their health benefits beyond nutritional properties, can be classified as functional foods, promoting prevention and treatment for the above mentioned diseases, among others. This double function is due mainly to the proteins and the presence of various secondary metabolites and bioactive compounds in these foods of plant (grain and seed) origin. Last discovered knowledge and research features will be described in the present book chapter