EV with duration forecasting. Case study

EV with duration forecasting. Case stud

Application of the EVM method and its extensions in the implementation of construction objects

Surpassing of the planned budget and delivery time is a common feature during the implementation of building investments in Poland. Only a small number of companies use effective methods of project monitoring during investment performance. One of the popular tools used to control projects with regard to cost and time is the earned value method (EVM). There is, however, no detailed guidance how to deploy the method to the specific characteristics and conditions during the execution of building investments. This fact has contributed to this paper, which presents the results of application and adaptation of the earned value method (EVM) and its further extensions in the control of building projects during their execution (with regard to cost and time), prediction of the final duration and costs, and presentation of the effects resulting from calculations. The analyses were performed in terms of the contractor for 5 selected completed and ongoing building projects in Poland

The eye wipes with polyhexanide (HexaClean) in preoperative prophylaxis of cataract surgery

Background: Progressively increasing number of eye surgeries forces the development of simple-to-use, effective methods to reduce the risk of postoperative endophthalmitis. We wondered whether the eyelid margin wipes containing 0.1% polyhexamethylene biguanide (PHMB) (HexaClean, VERCO, Poland) influence the reduction of bacterial flora localized in the conjunctival sac and whether it can be used for prophylaxis before the cataract surgery. Material and methods: 95 patients before the cataract surgery were included in the study. The conjunctival swab was collected from patients twice — before using eye wipes and after 5 days of eye wipes usage. The swabs were plated on microbiological enriched media and incubated under aerobic and microaerophilic conditions for 24–48 hours at 35°C ± 2°C. Then the identification of microorganisms was carried out using classic microbiological methods and tests. Results: Bacterial strains were isolated from the conjunctival sac in 84% of patients before using the eye wipes. The largest group of isolated pathogens was Gram-positive cocci, and these were mainly methicillin-sensitive and methicillin-resistant coagulase-negative staphylococci, which accounted for 72% of isolated strains. When the eye wipes were used, the bacterial flora was eliminated from the conjunctival sac in 54% of patients. A reduction in isolated strains and decreased variety of bacteria was observed in another 22% of patients. Conclusion: These results indicate that the application of eyelid wipes with polyhexanide reduces a significant amount of the conjunctival sac microbiota, which may prevent inflammation after cataract surgery

Dzieci i młodzież w kręgu oddziaływania mediów i grup rówieśniczych - "w" i "pomimo" czasów ponowoczesnych

Praca recenzowana / peer-reviewed pape

Factor analysis in investigating relation structure in relation marketing

Modern marketing strategies of companies are connected with keeping relations with different market entities, including clients. The knowledge arising from data analysis is of a hidden, specific and unique nature, which makes it difficult for the competition to copy and can thus be used as a basis for preparing the market relation advantage. When describing interactions and market relations multiple variables can be obtained. In order to reveal hidden and emergent characteristics the exploratory factor analysis (EFA) and the confirmatory factor analysis (CFA) can be applied. The aim of the paper is to present the results of factor models as an identification method of hidden characteristics of market relations in factor or construct intersections.Współczesne strategie rynkowe przedsiębiorstw związane są z utrzymaniem relacji z różnymi podmiotami rynku, w tym klientami. Wiedza pochodząca z analizy tych danych ma ukryty, specyficzny i unikalny charakter, trudny do skopiowania przez konkurencję, zatem może stanowić podstawę do konstruowania przewagi rynkowej opartej o relacje rynkowe. Opisując zjawiska interakcji oraz relacji rynkowych można uzyskać wiele zmiennych. Aby wyłonić ukryte i ponadjednostkowe (emergentne) cechy relacji rynkowych, można wykorzystać eksploracyjną analizę czynnikową EFA (ang. exploratory factor analysis), oraz konfirmacyjną analizę czynnikową CFA (ang. confirmatory factor analysis). Celem artykułu jest zaprezentowanie wyników modeli czynnikowych jako metody identyfikacji ukrytych własności relacji rynkowych w przekroju czynników lub konstruktów

Synthesis and Anti-Yeast Evaluation of Novel 2-Alkylthio-4-chloro-5-methyl-N-[imino-(1-oxo-(1H)-phthalazin-2-yl)methyl]benzenesulfonamide Derivatives

Pathogenic fungi are one of the main causes of hospital-related infections. Since conventional antifungals have become less effective because of the increasing fungal resistance to the standard drugs, the need for new agents is becoming urgent. Herein we report a synthesis of a series of novel N-[imino-(1-oxo-(1H)-phthalazin-2-yl)methyl]-benzenesulfonamide derivatives with in vitro activity against yeast-like fungi isolated from the oral cavity and respiratory tract of patients with candidiasis. These compounds were synthesized by the one-step or two-step reactions of 1-(2-alkylthiobenzensulfonyl)-2-aminoguanidines with the appropriate ortho-carbonyl benzoic acids. The biological study revealed that new derivatives have shown significant growth-inhibitory activity, superior or comparable, than those of the reference drug fluconazole. The most promising activities were observed against Candida albicans, with inhibition at least 1–3 (12.5%–37.5%) of the eight tested strains at the low MIC level of ≤6.2–25 µg/mL

Characterization of Multidrug Resistant <i>E</i>. <i>faecalis</i> Strains from Pigs of Local Origin by ADSRRS-Fingerprinting and MALDI -TOF MS; Evaluation of the Compatibility of Methods Employed for Multidrug Resistance Analysis

<div><p>The aim of this study was to characterize multidrug resistant <i>E</i>. <i>faecalis</i> strains from pigs of local origin and to analyse the relationship between resistance and genotypic and proteomic profiles by amplification of DNA fragments surrounding rare restriction sites (ADSRRS-fingerprinting) and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI -TOF MS). From the total pool of <i>Enterococcus</i> spp. isolated from 90 pigs, we selected 36 multidrug resistant <i>E</i>. <i>faecalis</i> strains, which represented three different phenotypic resistance profiles. Phenotypic resistance to tetracycline, macrolides, phenicols, and lincomycin and high-level resistance to aminoglycosides were confirmed by the occurrence of at least one corresponding resistance gene in each strain. Based on the analysis of the genotypic and phenotypic resistance of the strains tested, five distinct resistance profiles were generated. As a complement of this analysis, profiles of virulence genes were determined and these profiles corresponded to the phenotypic resistance profiles. The demonstration of resistance to a wide panel of antimicrobials by the strains tested in this study indicates the need of typing to determine the spread of resistance also at the local level. It seems that in the case of <i>E</i>. <i>faecalis</i>, type and scope of resistance strongly determines the genotypic pattern obtained with the ADSRRS-fingerprinting method. The ADSRRS-fingerprinting analysis showed consistency of the genetic profiles with the resistance profiles, while analysis of data with the use of the MALDI- TOF MS method did not demonstrate direct reproduction of the clustering pattern obtained with this method. Our observations were confirmed by statistical analysis (Simpson’s index of diversity, Rand and Wallace coefficients). Even though the MALDI -TOF MS method showed slightly higher discrimination power than ADSRRS-fingerprinting, only the latter method allowed reproduction of the clustering pattern of isolates based on phenotypic resistance and analysis of resistance and virulence genes (Wallace coefficient 1.0). This feature seems to be the most useful for epidemiological purposes and short-term analysis.</p></div

Dendrogram obtained after NTSYSpc analysis of MALDI-TOF MS data.

<p>Dendrogram obtained after NTSYSpc analysis of MALDI-TOF MS data.</p

Dendrogram of genetic relatedness among <i>E</i>. <i>faecalis</i> strains obtained with the ADSRRS-fingerprinting method.

<p>^a reference strains of <i>E</i>. <i>faecalis</i>: ATCC29212 and ATCC51299 ^b resistance gene profile.</p