Feasibility of Integrating Tripterygium wilfordii into Modern Cancer Therapy for Increased Efficacy with Minimal Toxicity

Cancer is the second leading cause of death in the U.S., and millions of novel cancer cases are being diagnosed each year. While chemotherapy and ionizing radiation are effective treatments against these malignant tumors, the adverse effects that accompany such treatments are devastating. In order to find alternative treatment methods with less side effects, we turn to Eastern herbal medicine. Recent scientific research has found that Tripterygium wilfordii, an herbal medicine traditionally used to treat inflammation in China, contains compounds (triptolide and celastrol) that prevent the growth of solid tumors, induce apoptosis, and prevent metastasis of developed tumors. Investigations on these compounds on various cancer cells lines (in vitro and in vivo) have revealed insight into their mechanism, mode of action, and toxicity. In order to circumvent the potentially fatal side effects of triptolide and celastrol, it was proposed that roots of T. wilfordii, from which the compounds are extracted, be used as a treatment for cancer. Methods for testing the efficacy and toxicity of the roots on the different cell lines previously studied are outlined in this paper. If the results from the proposed experiment conflict with expectation, then future studies on combination drugs using triptolide and celastrol with other non-bioactive compounds within the roots should be done to develop new anti-cancer drugs with low toxicity

Designing for innovation around OER

This paper argues that designing collections of 'closed' educational resources (content and technologies) for use by specific student cohorts and collections of open educational resources for use by any 'learner' require different design approaches. Learning design for formal courses has been a research topic for over 10 years as the ever growing range of digital content and technologies has potentially offered new opportunities for constructing effective learning experiences, primarily through greater sharing and re-use of such content and technologies. While progress in adopting learning design by teaching practitioners has appeared slow so far the advent of open educational resources (OER) has provided a substantive boost to such sharing activity and a subsequent need for employing learning design in practice. Nevertheless there appears to be a paradox in that learning design assumes a reasonably well known and well defined student audience with presumed learning needs and mediating technologies while OER are exposed to a multitude of potential learners, both formal and informal, with unknown learning needs and using diverse technologies. It can be argued that innovative designs for formal courses involve creating structured pathways through a mixture of existing and new content and activities using a mixture of media and technologies in the process. This type of 'configurational' design that blends together given items to meet a particular need, rather than designing something fully de novo is typical in many areas of work and not just teaching. Such designs work very well when there is a small set of users of the innovation or their use of the innovation is narrow. However many innovations in information, communication and computing technologies often have multiple types of users and many more layers of complexity. In these cases, rather than heavily pre-define an innovative solution just to meet certain user requirements, it is necessary to design for greater flexibility so as to allow the users to adapt their use of the innovative solution for their own requirements once it has been deployed. The use of such an 'innofusion' approach for OER is highlighted using the case study of OpenLearn (www.open.ac.uk/openlearn)

The Power and Promise of Community Unionism

[Excerpt] Shaffer\u27s statement portrays an emerging vision of union organizing that represents a dramatic departure from the way most unions have been organizing workers for the past 40 years. Borrowing from the city wide structures of the Knights of Labor in the 19th century, a new breed of union organizers is experimenting with a brand of unionism that may ultimately recast labor as a community-wide movement which tackles workplace issues. Unlike the now defunct Knights, these modern-day champions of community-based union organizing maintain close ties with unions across the country through their affiliation with resourcerich national unions. Many believe that this mixture of community organizing with national union support will spawn a new wave of union growth

Random acts of violins : Oliver Schroer and two British Columbia fiddle communities

Publisher PD

Open Education and the Sustainable Development Goals: Making Change Happen

Education for All has been a concept at the heart of international development since 1990 and has found its latest instantiation within the Sustainable Development Goals (SDGs) as SDG 4, ‘Ensure inclusive and equitable quality education and promote lifelong learning opportunities for all’. Open education, in the form of resources and practices are both seen as contributors to SDG4 as evidenced by the recent 2nd World Open Educational Resources Congress. The ambition for open education to contribute to the SDGs is clear from this and other gatherings but the means to make it happen are not as clear, and many have claimed that little has happened since the SDGs were launched in 2015. To help address this apparent gap, this paper (1) sets out the scale and scope of the SDGs; (2) reviews the potential contribution of open educational resources and practices to support the SDGs, and (3) uses a framing of power and systems thinking to review the way open education activities might be fostered within tertiary education in all local, national and regional contexts in order to support the SDGs, and not just SDG 4. It will also tentatively propose a theory of change that brings together power relationships, systems thinking and open education as key components and provide a case study of how this might work in practice through a newly funded project proposal. It is hoped that this theory of change and proposal will be a starting point for wider debate and discussion on how to make change happen in this important arena

The legend of St Catherine’s well

A short story written from the research of local history sources and produced as an audio work. The piece was commissioned by Nottinghamshire County Council for the development of the successful £1.3m Heritage Lottery bid to renovate historical features within Sconce & Devon Park, Newark, Nottinghamshire