Comparative aspects of treatment of endometrial hyperplasia in women of reproductive age with overweight

The aim. Minimization of the frequency of recurrence of endometrial hyperplasia (EH) in women of reproductive age with overweight (OW) depending on the tactics of treatment. Materials and methods. 90 women of reproductive age with endometrial hyperplasia and OW were selected. They, in turn, were divided into three groups: group 1 – 30 women who took a gonadotropin-releasing hormone agonist (GnRH agonist), namely at a dose of 3.75 mg intramuscularly once every 28 days; group 2 – 30 women who used progestin (norethisterone) at a dose of 10 mg per day from day 16 to 25 of the cycle, group 3 – 30 women who took combined oral contraception (COC) (30 mcg ethinyl estradiol and 150 mcg desogestrel) in a cyclic mode 21/7. Evaluation of the effectiveness of therapy included a clinical picture of the disease 6 months after the start of treatment, assessment of the variability of the average values of endometrial thickness and uterine size on ultrasound (US) of the pelvis 6 months after treatment. Also analyzed the effectiveness of therapy based on the results of morphological examination of the endometrium in a biopsy of the uterine mucosa, performed 6 months after the start of treatment. In addition, a general analysis of the frequency of EH recurrence was performed 6–24 months after treatment. Results. The results showed that in the group in which women were prescribed GnRH agonist, there was a significantly higher effectiveness of treatment, in particular the absence of uterine bleeding and menstrual disorders (MD). At the same time, in the other norethisterone group, 53.3 % (16) of women had intermenstrual uterine bleeding. In patients in the group in which women received COC, uterine bleeding was observed in 30.0 % (i.e. 9) of patients (p <0.05). Immediately after treatment, the average values of endometrial thickness in patients of group 1, according to ultrasound, was 3.59±0.47 mm, which was significantly less than in women of groups 2 and 3 – 6.81±0.59 mm (p<0.001) and 7.58±0.69 mm (p<0.001). In addition, patients in group 1 at 3, 6, 12, 24 months after the end of hormone therapy were registered significantly lower average values of endometrial thickness, compared with patients receiving norethisterone and estrogen-progestogen drugs. Conclusions. In a comparative evaluation of the effectiveness of treatment of endometrial hyperplastic processes in overweight women, it was found that the recurrence rate after 6–24 months occurs in 6.7 % (i.e. 2) of patients after GnRH agonist therapy, in 33.3 % (i.e. in 10) patients receiving norethisterone (p<0.001), and in 50 % (i.e. 15) of women treated with COC (p<0.001)

Bidirectional path planning

This bachelor thesis deals with path planning of a mobile robot using artificial intelligence algorithms. The theoretical part describes different approaches to path planning with a focus on their bidirectional modifications. Furthermore, attention is paid to selected algorithms. In the practical part of the thesis, the emphasis is on the comparison of the selected algorithms by carrying out experiments in a self-developed simulation environment

Effect of localisation and climate change on operation of data centres in Ukraine towards 2050

Data centres (DCs) are large electricity consumers, estimated to account for around 1% of worldwide electricity usage. They release excess heat (EH) during the operation, which can be recovered in district heating (DH) networks. DCs are expected to satisfy the rising demand for digital services.The electricity usage for cooling and available EH from the operation of DCs depends on the air temperature that changes with geographical location. The changes are not uniform and global warming pathways will influence them. Here lays the contribution of the present article. We use an existing thermodynamic model of a hyper-scale DC for different locations in Ukraine to analyse the electricity usage for cooling and EH availability for two climate scenarios (RCP2.6 and RCP 4.5) in 2010–2050.The results show that the electricity consumption for cooling and available EH can vary greatly within Ukraine. The electricity consumption for cooling is over two times higher in the hottest compared to the coldest location in the country, while the emitted EH is around 80% higher on average. The global climate pathway has a minor influence — the electricity use for cooling and EH availability are 4% higher in RCP4.5 than in RCP2.6. Finally, one hyper-scale DC of 150 MW could cover the demand for space heating and domestic hot water for roughly 100 thousand people. This assessment is an important input to consider when developing plans to rebuild Ukraine