Design and construction of a prototype ACTS propagation terminal

The launch schedule for the Advanced Communication Technology Satellite (ACTS) spacecraft did not leave sufficient time for completion of the prototype ACTS Propagation Terminals (APT) prior to initiation of the APT production phase. In fact, the approach used was to construct and test all subassemblies of the terminal with special emphasis on the technically challenging portions. These include the RF front end that uses a state-of-the-art down converter which integrates a low noise amplifier, mixer, post amplifier, filter, and local oscillator port frequency doubler into a single small package. In addition, a new digital receiver that uses the latest DSP technology was developed. Both of these subassemblies were thoroughly tested. The highest risk technology in the APT program was the digital receiver. Several candidate algorithms and DSP chips were investigated early on, primarily under JPL sponsorship. A receiver was constructed based on Texas Instruments chip. The final prototype digital receiver was one based on an Analog Devices chip. The design and test results are documented in a report prepared for this grant. A Primary Design Review (PDR) was conducted 30 May 1991, and a Critical Design Review was held 7 Jul. 1992. Final complete documentation of the APT's will appear in the form of three reports: a hardware description report, a report on the data collection code (ACTS VIEW), and a report on the preprocessing code

Food on the go : Delights Bakery / Allyssa Andrew... [et al.]

Food On The Go is a bakery shop located at Sulaman Central, Jalan Sulaman, Sepanggar, Kota Kinabalu Sabah that allow people with busy lifestyle to have their meals instantly and in the most convenient way. This product is suitable for all age ranged between children, teenagers and adults. Food on the Go sells various types of bakery products such as slice cakes, cupcakes and muffins and many more. Our shop is able to serve numbers of people such as entire family in one quick, convenient visit. We realized that there are many other bakery shop like Food on the Go, but we are very confident that we will excel due to its attention to detail regarding customer service. Food on the Go will slowly but surely gain market share as it is potentially for having a long term relationship with the customers, especially the families. Lastly, our advertisement's creativity will attract a lot of walk in traffic. Due to nowadays society's lifestyle, many people will go busy with their works and may not have the luxury for having their meals on crowded shops. But Food on the Go focus on the convenience for the customer to get their food, let alone the delicious healthy food. We have seen this opportunity because a lot of people with long working hours would go for fast food for their lunch and dinner because these shops serves their food in instant manners and efficient ways such as drive through and deliveries. But these foods are not very healthy due to its cooking nature (deep fried food). The strength of our shop is delivering healthy products in instant manners such as drive through and food delivery, and also efficient ways on our walk in services. We, Food on the Go, foresaw that our company has the potential of success provided that it is handled efficiently. Many people should go for healthier food in order to maintain their health and also, save more time to relax rather than lining up at a restaurant to get their food. We also provide services that are customer friendly to ensure return-customers and credibility from our customers. Food on the Go sees this as a way to prosper in this market, by taking advantage of these people's need

Safety of cladribine tablets in the treatment of patients with multiple sclerosis: An integrated analysis.

Abstract Background Treating patients with relapsing multiple sclerosis (MS) with cladribine tablets (two times 4 or 5 days of treatment each year for 2 years) results in long-lasting efficacy, with continued stability in many patients for 4 or more years. Safety and tolerability outcomes from individual clinical studies with cladribine tablets have been reported previously. Objective Report safety data from an integrated analysis of clinical trials and follow-up in patients with MS to further characterize the safety profile of cladribine tablets. Methods Data for patients treated with cladribine tablets 10 mg (MAVENCLAD®; 3.5 mg/kg cumulative dose over 2 years, referred to as cladribine tablets 3.5 mg/kg) as monotherapy (n = 923) or placebo (n = 641) in Phase III clinical trials (CLARITY, CLARITY Extension and ORACLE-MS) and followed up in the PREMIERE registry were aggregated (Monotherapy Oral cohort). To better characterize rare events, additional data from earlier studies which involved the use of parenteral cladribine in patients with MS, and the ONWARD study, in which patients were given cladribine tablets in addition to interferon (IFN)-β or placebo plus IFN-β were included in an All Exposed cohort (cladribine, n = 1926; placebo, n = 802). Adjusted adverse events incidences per 100 patient-years (Adj-AE per 100 PY) were calculated for the integrated analyses. Results The incidence rate of treatment-emergent adverse events (TEAEs) in the Monotherapy Oral cohort was 103.29 vs. 94.26 Adj-AEs per 100 PY for placebo. TEAEs that occurred more frequently with cladribine tablets were mainly driven by the TEAEs of lymphopenia (Adj-AE per 100 PY 7.94 vs. 1.06 for placebo) and lymphocyte count decreased (Adj-AE per 100 PY 0.78 vs. 0.10 for placebo) as anticipated due to the mode of action of cladribine. An increase in TEAE incidence rate was also observed in the cladribine tablets 3.5 mg/kg group vs. placebo for herpes zoster (Adj-AE per 100 PY 0.83 vs. 0.20, respectively). There were no cases of systemic, serious disseminated herpes zoster attributed to treatment with cladribine tablets. In general there was no increase in the risk of infections including opportunistic infections with cladribine tablets versus placebo, except for herpes zoster. Periods of severe lymphopenia ( Conclusion The AE profile for cladribine tablets 3.5 mg/kg as a monotherapy has been well-characterized in a pooled population of patients from early to more advanced relapsing MS. There was no increased risk for infections in general except for a higher incidence of herpes zoster. Lymphopenia was amongst the most frequently observed TEAEs that occurred at a higher incidence with cladribine relative to placebo. There was also no increase in malignancy rates for cladribine relative to placebo

Programmed cell death-1, PD-1, is dysregulated in T cells from children with new onset type 1 diabetes

Programmed death cell 1 (PD-1) is an inhibitor of T cell activation and is also functionally linked to glycolysis. We hypothesized that PD-1 expression is defective in activated T cells from children with type 1 diabetes (T1D), resulting in abnormal T cell glucose metabolism

NSCAT high-resolution surface wind measurements in Typhoon Violet

NASA scatterometer (NSCAT) measurements of the western Pacific Supertyphoon Violet are presented for revolutions 478 and 485 that occurred in September 1996. A tropical cyclone planetary boundary layer numerical, model, which uses conventional meteorological and geostationary cloud data, is used to estimate the winds at 10-m elevation in the cyclone. These model winds are then compared with the winds inferred from the NSCAT backscatter data by means of a novel approach that allows a wind speed to be recovered from each individual backscatter cell. This spatial adaptive (wind vector) retrieval algorithm employs several unique steps. The backscatter values are first regrouped in terms of closest neighbors in sets of four. The maximum likelihood estimates of speed and direction are then used to obtain speeds and directions for each group. Since the cyclonic flow around the tropical cyclone is known, NSCAT wind direction alias selection is easily accomplished. The selected wind directions are then used to convert each individual backscatter value to a wind speed. The results are compared to the winds obtained from the tropical cyclone boundary layer model. The NSCAT project baseline geophysical model function, NSCAT 1, was found to yield wind speeds that were systematically too low, even after editing for suspected rain areas of the cyclone. A new geophysical model function was developed using conventional NSCAT data and airborne Ku band scatterometer measurements in an Atlantic hurricane. This new model uses the neural network method and yields substantially better agreement with the winds obtained from the boundary layer model according to the statistical tests that were used

ARTP statement on cardiopulmonary exercise testing 2021.

Cardiopulmonary exercise testing (CPET) has become an invaluable tool in healthcare, improving the diagnosis of disease and the quality, efficacy, assessment and safety of treatment across a range of pathologies. CPET's superior ability to measure the global exercise response of the respiratory, cardiovascular and skeletal muscle systems simultaneously in a time and cost-efficient manner has led to the application of CPET in a range of settings from diagnosis of disease to preoperative assessment. The Association for Respiratory Technology and Physiology Statement on Cardiopulmonary Exercise Testing 2021 provides the practitioner and scientist with an outstanding resource to support and enhance practice, from equipment to testing to leadership, helping them deliver a quality assured service for the benefit of all patient groups

Longitudinal Secretion of Paramyxovirus RNA in the Urine of Straw-Coloured Fruit Bats (Eidolon helvum).

The straw-coloured fruit bat (Eidolon helvum) is widespread in sub-Saharan Africa and is widely hunted for bushmeat. It is known to harbour a range of paramyxoviruses, including rubuloviruses and henipaviruses, but the zoonotic potential of these is unknown. We previously found a diversity of paramyxoviruses within a small, captive colony of E. helvum after it had been closed to contact with other bats for 5 years. In this study, we used under-roost urine collection to further investigate the paramyxovirus diversity and ecology in this colony, which had been closed to the outside for 10 years at the time of sampling. By sampling urine weekly throughout an entire year, we investigated possible seasonal patterns of shedding of virus or viral RNA. Using a generic paramyxovirus L-gene PCR, we detected eight distinct paramyxovirus RNA sequences. Six distinct sequences were detected using a Henipavirus-specific PCR that targeted a different region of the L-gene. Sequence detection had a bi-annual pattern, with the greatest peak in July, although different RNA sequences appeared to have different shedding patterns. No significant associations were detected between sequence detection and birthing season, environmental temperature or humidity, and no signs of illness were detected in any of the bats in the colony during the period of sample collection

beta-estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBL

<p>Abstract</p> <p>Background</p> <p>Female hormones are known to play an important role in predisposition for many infectious diseases. Recent work suggests there are gender effects in HIV/AIDS progression. Here we ask whether the sex steroid hormone β-estradiol affects the replication of HIV-1 or the efficacy of a common anti-retroviral drug, Stavudine (D4T).</p> <p>Results</p> <p>Human PBL were infected with HIV-1 in the presence or absence of combinations of sex steroid hormones and the anti-retroviral drug, D4T. After seven days in culture, viral supernatants were assayed for HIV-1 p24 protein. β-estradiol resulted in a modest inhibition of HIV-1 replication of ~26%. However, 2 nM β-estradiol increased the amount of HIV-1 replication in the presence of 50 nM D4T from a baseline of 33% (+/- SE = 5.4) to 74% (+/- SE = 5.4) of control virus levels in the absence of drug. Both results were statistically highly significant (p < 0.001). β-estradiol did not increase the replication of a D4T-resistant strain of HIV in the presence of D4T. The effects were unlikely to be due to general cell inhibition or toxicity because these concentrations of drug and hormone cause no cytotoxicity in PBL as measured by trypan blue exclusion.</p> <p>Conclusion</p> <p>β-estradiol inhibited both HIV-1 replication in primary human PBL and the antiretroviral efficacy of D4T in PBL cultures. To optimize antiretroviral drug therapy, it may be necessary to monitor patient hormonal status.</p