Public spending and outcomes : does governance matter?

The authors examine the role of governance-measured by level of corruption and quality of bureaucracy-and ask how it affects the relationship between public spending and outcomes. Their main innovation is to see if differences in efficacy of public spending can be explained by quality of governance. The authors find that public health spending lowers child and infantmortality rates in countries with good governance. The results also indicate that as countries improve their governance, public spending on primary education becomes effective in increasing primary education attainment. These findings have important implications for enhancing the development effectiveness of public spending. The lessons are particularly relevant for developing countries, where public spending on education and health is relatively low, and the state of governance is often poor.Health Systems Development&Reform,Public Health Promotion,Public Sector Economics&Finance,Decentralization,Health Monitoring&Evaluation,Health Economics&Finance,National Governance,Governance Indicators,Health Monitoring&Evaluation,Public Sector Economics&Finance

Novel Molecules for Intra-Oral Delivery of Antimicrobials to Prevent and Treat Oral Infectious Diseases

New molecules were designed for efficient intra-oral delivery of antimicrobials to prevent and treat oral infection. The salivary statherin fragment, which has high affinity for the tooth enamel, was used as a carrier peptide. This was linked through the side chain of the N-terminal residue to the C-terminus of a defensin-like 12-residue peptide to generate two bifunctional hybrid molecules, one with an ester linkage and the other with an anhydride bond between the carrier and the antimicrobial components. They were examined for their affinity to a HAP (hydroxyapatite) surface. The extent of the antimicrobial release in human whole saliva was determined using 13C-NMR spectroscopy. The candidacidal activity of the molecules was determined as a function of the antimicrobial release from the carrier peptide in human saliva. The hybrid-adsorbed HAP surface was examined against Candida albicans and Aggregatibacter actinomycetemcomitans using the fluorescence technique. The bifunctional molecules were tested on human erythrocytes, GECs (gingival epithelial cells) and GFCs (gingival fibroblast cells) for cytotoxicity. They were found to possess high affinity for the HAP mineral. In human whole saliva, a sustained antimicrobial release over a period of more than 40–60 h, and candidacidal activity consistent with the extent of hybrid dissociation were observed. Moreover, the bifunctional peptide-bound HAP surface was found to exhibit antimicrobial activity when suspended in clarified human saliva. The hybrid peptides did not show any toxic influence on human erythrocytes, GECs and GFCs. These novel hybrids could be safely used to deliver therapeutic agents intra-orally for the treatment and prevention of oral infectious diseases

What does aid to Africa finance?

If a donor gives aid for a project that the recipient government would have undertaken anyway, the aid finances expenditures other than the intended project. The notion that aid in this sense may be"fungible"has recently received empirical support. The authors look at why aid isfungible or nonfungible, and the extent to which it is fungible in Sub-Saharan Africa. Their results suggest that aid may be partially fungible in Africa and suggests some reasons. They find relatively little evidence that aid leads to greater tax relief in Africa. Every dollar of aid leads to a 90-cent increase in government spending. The implications of this result are by no means clear. If the marginal cost of taxation is exceptionally high - which it might be in African countries - using aid for tax relief may be the best use of foreign resources. Aid's effect on the composition of current and capital spending? They increase equally. Even if all aid were intended to finance capital spending, the reallocation to current spending might not necessarily be harmful. The fungible of loans to specific sectors generally mirrors patterns found in a broader sample of countries. Aid to energy, transport, and communication sectors increase public spending in those sectors somewhat but by no means one for one. (By contrast, in the worldwide sample, aid to transport and communications was almost fully nonfungible). Aid to the education sector - which had no discernible effect on education spending in the global sample - had an almost one-for-one effect on education spending in Africa. Even in these partially fungible sectors, governments spend more out of aid resources than they do out of their own resources, at the margin. Governments do not spend all sectoral aid in that sector - nor do they treat such aid as merely budgetary support. The more donors to a country, the more likely aids is to be fungible. If the number of donors represents a proxy for monitoring costs, it is not surprising that most aid is partly fungible.Economic Adjustment and Lending,Development Economics&Aid Effectiveness,Gender and Development,Payment Systems&Infrastructure,School Health,School Health,Public Sector Economics&Finance,Economic Adjustment and Lending,Urban Economics,Development Economics&Aid Effectiveness

The political economy of health services provision and access in Brazil

The authors examine the impact of local politics and government structure on the allocation of publicly subsidized (SUS) health services across municipios (counties) in Brazil, and on the probability that uninsured individuals who require medical attention actually receive access to those health services. Using data from the 1998 PNAD survey they demonstrate that higher per capita levels of SUS doctors, nurses, and clinic rooms increase the probability that an uninsured individual gains access to health services when he, or she seeks it. The authors find that an increase in income inequality, an increase in the percentage of the population that votes, and an increase in the percentage of votes going to left-leaning candidates are each associated with higher levels of public health services. The per capita provision of doctors, nurses, and clinics is also greater in counties with a popular local leader, and in counties where the county mayor and state governor are politically aligned. Administrative decentralization of health services to the county decreases provision levels, and reduces access to services by the uninsured, unless it is accompanied by good local governance.Health Systems Development&Reform,Health Monitoring&Evaluation,Public Health Promotion,Regional Rural Development,Gender and Health,Health Economics&Finance,Health Monitoring&Evaluation,Health Systems Development&Reform,Regional Rural Development,Gender and Health

The adoption and use of Through-life Engineering Services within UK Manufacturing Organisations

Manufacturing organisations seek ever more innovative approaches in order to maintain and improve their competitive position within the global market. One such initiative that is gaining significance is ‘through-life engineering services’. These seek to adopt ‘whole life’ service support through the greater understanding of component and system performance driven by knowledge gained from maintenance, repair and overhaul activities. This research presents the findings of exploratory research based on a survey of UK manufacturers who provide through-life engineering services. The survey findings illustrate significant issues to be addressed within the field before the concept becomes widely accepted. These include a more proactive approach to maintenance activities based on real-time responses; standardisation of data content, structure, collection, storage and retrieval protocols in support of maintenance; the development of clear definitions, ontologies and a taxonomy of through-life engineering services in support of the service delivery system; lack of understanding of component and system performance due to the presence of ‘No Fault Found’ events that skew maintenance metrics and the increased use of radio-frequency identification technology in support of maintenance data acquisition

Individuals' Donations to Charities and their Use of Tax Relief

The study investigated the extent British people gave money to charity over the last 12 months: how much they gave, how they gave it, what proportion of these donations were of the kind that attract tax relief and how much of this relief was actually taken up. It also investigated people's awareness of tax relief, how they saw the connection between giving to charity and the use of tax relief and how this might have influenced the pattern or scale of their giving

Data mining and knowledge reuse for the initial systems design and manufacturing: Aero-engine service risk drivers

Service providers of civil aero engines are typically confronted with a high cost of maintenance, replacement and refurbishment of the service damaged components. In such context, service experience becomes a key issue for determining the service risk drivers for operational disruptions and maintenance burden. This paper presents an industrial case study to produce new knowledge on the relationships between degradation and component design to manufacture. The study applied semantic data mining as a methodology for an efficient and the consistent data capture, representation, and analysis. The paper aims at identifying the service risk drivers based on service experience and event data. The analysis shows that the 3 top mechanisms accounting for 32% of the mechanism references have a strong Pareto effect. The paper concludes with missing information links and future research directions

Pericytes display increased CCN2 expression upon culturing

By providing a source of α-smooth muscle actin (α-SMA)-expressing myofibroblasts, microvascular pericytes contribute to the matrix remodeling that occurs during tissue repair. However, the extent to which pericytes may contribute to the fibroblast phenotype post-repair is unknown. In this report, we test whether pericytes isolated from human placenta can in principle become fibroblast-like. Pericytes were cultured in vitro for 11 passages. The Affymetrix mRNA expression profile of passage 2 and passage 11 pericytes was compared. The expression of type I collagen, thrombospondin and fibronectin mRNAs was induced by passaging pericytes in culture. This induction of a fibroblast phenotype was paralleled by induction of connective tissue growth factor (CTGF/CCN2) and type I collagen protein expression and the fibroblast marker ASO2. These results indicate that, in principle, pericytes have the capacity to become fibroblast-like and that pericytes may contribute to the population of fibroblasts in a healed wound

Haemogenic endocardium contributes to transient definitive haematopoiesis.

Haematopoietic cells arise from spatiotemporally restricted domains in the developing embryo. Although studies of non-mammalian animal and in vitro embryonic stem cell models suggest a close relationship among cardiac, endocardial and haematopoietic lineages, it remains unknown whether the mammalian heart tube serves as a haemogenic organ akin to the dorsal aorta. Here we examine the haemogenic activity of the developing endocardium. Mouse heart explants generate myeloid and erythroid colonies in the absence of circulation. Haemogenic activity arises from a subset of endocardial cells in the outflow cushion and atria earlier than in the aorta-gonad-mesonephros region, and is transient and definitive in nature. Interestingly, key cardiac transcription factors, Nkx2-5 and Isl1, are expressed in and required for the haemogenic population of the endocardium. Together, these data suggest that a subset of endocardial/endothelial cells serve as a de novo source for transient definitive haematopoietic progenitors