Stability of multifield cosmological solutions in the presence of a fluid

We explore the stability properties of multifield solutions in the presence of a perfect fluid, as appropriate to assisted quintessence scenarios. We show that the stability condition for multiple fields phi(i) in identical potentials V-i is simply d(2)V(i)/d phi(2)(i) > 0, exactly as in the absence of a fluid. A possible new instability associated with the fluid is shown not to arise in situations of cosmological interest

Multifield consequences for D-brane inflation

We analyse the multifield behaviour in D-brane inflation when contributions from the bulk are taken into account. For this purpose, we study a large number of realisations of the potential; we find the nature of the inflationary trajectory to be very consistent despite the complex construction. Inflation is always canonical and occurs in the vicinity of an inflection point. Extending the transport method to non-slow-roll and to calculate the running, we obtain distributions for observables. The spectral index is typically blue and the running positive, putting the model under moderate pressure from WMAP7 constraints. The local f_NL and tensor-to-scalar ratio are typically unobservably small, though we find approximately 0.5% of realisations to give observably large local f_NL. Approximating the potential as sum-separable, we are able to give fully analytic explanations for the trends in observed behaviour. Finally we find the model suffers from the persistence of isocurvature perturbations, which can be expected to cause further evolution of adiabatic perturbations after inflation. We argue this is a typical problem for models of multifield inflation involving inflection points and renders models of this type technically unpredictive without a description of reheating

Effect of reheating on predictions following multiple-field inflation

We study the sensitivity of cosmological observables to the reheating phase following inflation driven by many scalar fields. We describe a method which allows semi-analytic treatment of the impact of perturbative reheating on cosmological perturbations using the sudden decay approximation. Focusing on $\mathcal{N}$-quadratic inflation, we show how the scalar spectral index and tensor-to-scalar ratio are affected by the rates at which the scalar fields decay into radiation. We find that for certain choices of decay rates, reheating following multiple-field inflation can have a significant impact on the prediction of cosmological observables.Comment: Published in PRD. 4 figures, 10 page

Allele-Specific KRT1 Expression Is a Complex Trait

The differential expression of alleles occurs commonly in humans and is likely an important genetic factor underlying heritable differences in phenotypic traits. Understanding the molecular basis of allelic expression differences is thus an important challenge. Although many genes have been shown to display differential allelic expression, this is the first study to examine in detail the cumulative effects of multiple cis-regulatory polymorphisms responsible for allele-specific expression differences. We have used a variety of experimental approaches to identify and characterize cis-regulatory polymorphisms responsible for the extreme allele-specific expression differences of keratin-1 (KRT1) in human white blood cells. The combined data from our analyses provide strong evidence that the KRT1 allelic expression differences result from the haplotypic combinations and interactions of five cis-regulatory single nucleotide polymorphisms (SNPs) whose alleles differ in their affinity to bind transcription factors and modulate KRT1 promoter activity. Two of these cis-regulatory SNPs bind transcriptional activators with the alleles on the high-expressing KRT1 haplotype pattern having a higher affinity than the alleles on the low-expressing haplotype pattern. In contrast, the other three cis-regulatory SNPs bind transcriptional inhibitors with the alleles on the low-expressing haplotype pattern having a higher affinity than the alleles on the high-expressing haplotype pattern. Our study provides important new insights into the degree of complexity that the cis-regulatory sequences responsible for allele-specific transcriptional regulation have. These data suggest that allelic expression differences result from the cumulative contribution of multiple DNA sequence polymorphisms, with each having a small effect, and that allele-specific expression can thus be viewed as a complex trait

Exploring a string-like landscape

We explore inflationary trajectories within randomly-generated two-dimensional potentials, considered as a toy model of the string landscape. Both the background and perturbation equations are solved numerically, the latter using the two-field formalism of Peterson and Tegmark which fully incorporates the effect of isocurvature perturbations. Sufficient inflation is a rare event, occurring for only roughly one in $10^5$ potentials. For models generating sufficient inflation, we find that the majority of runs satisfy current constraints from WMAP. The scalar spectral index is less than 1 in all runs. The tensor-to-scalar ratio is below the current limit, while typically large enough to be detected by next-generation CMB experiments and perhaps also by Planck. In many cases the inflationary consistency equation is broken by the effect of isocurvature modes.Comment: 24 pages with 8 figures incorporated, matches version accepted by JCA

The impact of cooling and pre-heating on the Sunyaev-Zel'dovich effect

We use hydrodynamical simulations to assess the impact of radiative cooling and `pre-heating' on predictions for the Sunyaev--Zel'dovich (SZ) effect. Cooling significantly reduces both the mean SZ signal and its angular power spectrum, while pre-heating can give a higher mean distortion while leaving the angular power spectrum below that found in a simulation without heating or cooling. We study the relative contribution from high and low density gas, and find that in the cooling model about 60 per cent of the mean thermal distortion arises from low overdensity gas. We find that haloes dominate the thermal SZ power spectrum in all models, while in the cooling simulation the kinetic SZ power spectrum originates predominantly in lower overdensity gas.Comment: 4 pages LaTeX file with five figures incorporated. Various clarifications to the discussion. Further colour images and animations at http://astronomy.susx.ac.uk/users/antonio/sz.htm

Sussing merger trees: a proposed merger tree data format

We propose a common terminology for use in describing both temporal merger trees and spatial structure trees for dark-matter halos. We specify a unified data format in HDF5 and provide example I/O routines in C, FORTRAN and PYTHON

A Deep 1.2 mm Map of the Lockman Hole North Field

We present deep 1.2 mm continuum mapping of a 566 arcmin^2 area within the Lockman Hole North field, previously a target of the Spitzer Wide-area Infrared Extragalactic (SWIRE) survey and extremely deep 20 cm mapping with the Very Large Array, which we have obtained using the Max-Planck millimeter bolometer (MAMBO) array on the IRAM 30 m telescope. After filtering, our full map has an RMS sensitivity ranging from 0.45 to 1.5 mJy/beam, with an average of 0.75 mJy/beam. Using the pixel flux distribution in a map made from our best data, we determine the shape, normalization, and approximate flux density cutoff for 1.2 mm number counts well below our nominal sensitivity and confusion limits. After validating our full dataset through comparison with this map, we successfully detect 41 1.2 mm sources with S/N > 4.0 and S(1.2 mm)\simeq 2-5 mJy. We use the most significant of these detections to directly determine the integral number counts down to 1.8 mJy, which are consistent with the results of the pixel flux distribution analysis. 93% of our 41 individual detections have 20 cm counterparts, 49% have Spitzer/MIPS 24 micron counterparts, and one may have a significant Chandra X-ray counterpart. We resolve \simeq 3% of the cosmic infrared background (CIB) at 1.2 mm into significant detections, and directly estimate a 0.05 mJy faint-end cutoff for the counts that is consistent with the full intensity of the 1.2 mm CIB. The median redshift of our 17 detections with spectroscopic or robust photometric redshifts is z(median)=2.3, and rises to z(median)=2.9 when we include redshifts estimated from the radio/far-infrared spectral index. By using a nearest neighbor and angular correlation function analysis, we find evidence that our S/N>4.0 detections are clustered at the 95% confidence level.Comment: 40 pages, 25 figures, accepted for publication in Ap

Impairment of Coronary Arteriolar Endothelium-Dependent Dilation after Multi-Walled Carbon Nanotube Inhalation: A Time-Course Study

Engineered nanomaterials have been developed for widespread applications due to many highly unique and desirable characteristics. The purpose of this study was to assess pulmonary inflammation and subepicardial arteriolar reactivity in response to multi-walled carbon nanotube (MWCNT) inhalation and evaluate the time course of vascular alterations. Rats were exposed to MWCNT aerosols producing pulmonary deposition. Pulmonary inflammation via bronchoalveolar lavage and MWCNT translocation from the lungs to systemic organs was evident 24 h post-inhalation. Coronary arterioles were evaluated 24–168 h post-exposure to determine microvascular response to changes in transmural pressure, endothelium-dependent and -independent reactivity. Myogenic responsiveness, vascular smooth muscle reactivity to nitric oxide, and α-adrenergic responses all remained intact. However, a severe impact on endothelium-dependent dilation was observed within 24 h after MWCNT inhalation, a condition which improved, but did not fully return to control after 168 h. In conclusion, results indicate that MWCNT inhalation not only leads to pulmonary inflammation and cytotoxicity at low lung burdens, but also a low level of particle translocation to systemic organs. MWCNT inhalation also leads to impairments of endothelium-dependent dilation in the coronary microcirculation within 24 h, a condition which does not fully dissipate within 168 h. The innovations within the field of nanotechnology, while exciting and novel, can only reach their full potential if toxicity is first properly assessed