ibobblyRawDataforDryad

This file contains the raw data collected in interviews on the four measures, DSI-SS, PHQ9, K10, and the BIS-II. There are three time points, baseline, 6 weeks (end of trial for intervention group), and 12 weeks (end of trial for waitlist group). It also includes unidentifiable details such as employment and brief health history

Mental Health Outcomes Variables for mHealth trial

This file contains the means calculated for the ibobbly (intervention) group and the waitlist group for four measures. The measures are suicidal ideation (DSI-SS), the primary outcome, depression (PHQ9), Psychological Distress (K10), and Impulsivity (BIS-II). The analyses and graphs are provided for each measure also

Internet-Delivered Cognitive Behavioural Therapy for Adults with Mild to Moderate Depression and High Cardiovascular Disease Risks: A Randomised Attention-Controlled Trial

<div><p>Background and Aim</p><p>Mild to moderate depression is common in those with cardiovascular disease and undertreated. We aimed to evaluate the effectiveness of internet-delivered Cognitive Behaviour Therapy (iCBT) on depressive symptom severity and adherence to medical advice and lifestyle interventions in adults with mild to moderate depression and high cardiovascular disease (CVD) risks.</p> <p>Methods</p><p>Randomised double-blind, 12 week attention-controlled trial comparing an iCBT programme (<i>E-couch</i>) with an internet-delivered attention control health information package (<i>HealthWatch</i>, n = 282). The primary outcome was depression symptom level on the nine-item Patient Health Questionnaire (PHQ-9) (trial registration: <a href="https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=335062" target="_blank">ACTRN12610000085077</a>).</p> <p>Results</p><p>487/562 (88%) participants completed the endpoint assessment. 383/562 (70%) were currently treated for cardiovascular disease and 314/562 (56%) had at least one other comorbid condition. In ITT analysis of 562 participants iCBT produced a greater decline in the mean PHQ-9 score compared to the attention control of 1.06 (95% CI: 0.23–1.89) points, with differences between the two arms increasing over the intervention period (time by treatment effect interaction p = .012). There were also larger improvements in adherence (2.16 points; 95% CI: 0.33–3.99), reductions in anxiety (0.96 points; 95% CI: 0.19–1.73), and a greater proportion engaging in beneficial physical activity (Odds Ratio 1.91, 95%CI: 1.01–3.61) in the iCBT participants but no effect upon disability, or walking time/day. There were no withdrawals due to study related adverse events.</p> <p>Conclusions</p><p>In people with mild to moderate depression and high levels of CVD risk factors, a freely accessible iCBT programme (<a href="http://www.ecouch.anu.edu.au" target="_blank">http://www.ecouch.anu.edu.au</a>) produced a small, but robust, improvement in depressive symptoms, adherence and some health behaviours.</p> <p>Trial Registration</p><p>Australian and New Zealand Clinical Trials Registry <a href="http://www.anzctr.org.au;ACTRN12610000085077.aspx" target="_blank">ACTRN12610000085077</a></p> </div

Baseline demographic and health characteristics of 562 participants randomised to either iCBT (<i>E-couch</i>) or attention control health information (<i>HealthWatch</i>).

*<p>Scaled 0–100.</p>**<p>Missing data for one participant who did not complete baseline assessment.</p>***<p>Prior Diagnosis of Cardiovascular Disease includes doctor diagnosis of any one of Heart Disease, Stroke or Hypertension.</p>$<p>At least 150 mins of activity over at least 5 sessions each week.</p>#<p>Other comorbid conditions include: cancer (skin, prostate, breast or other cancer), blood clot (thrombosis), asthma, Parkinson’s disease, osteoarthritis, and/or thyroid problems.</p>##<p>Treatment for any Cardiovascular Disease includes: any one of heart attack/angina, other heart disease, hypertension or high blood cholesterol.</p

Observed activity and disability (cutback days) measures for iCBT (<i>E-couch</i>) and active control (<i>HealthWatch</i>) at baseline and post intervention.

*<p>- “sedentary” defined as reporting no physical activity per week.</p><p>- “sufficient activity” defined as at least 150 mins of activity over at least 5 sessions each week.</p>**<p>- cutback days defined as number of days in last month where respondent reported “cutting back or reducing their usual activities or work as a result of a health condition”.</p

Baseline to post-intervention change under iCBT (<i>E-couch</i>) and control (<i>HealthWatch</i>) on depression, adherence, anxiety, disability and activity measures.

<p>All contrasts are scaled so that a positive value indicates improvement.</p><p>Contrast value (95% Confidence Interval).</p

Smoothed means of body mass index [BMI], waist circumference, systolic and diastolic blood pressure by age in men and women with psychosis [red] compared to general population controls [blue].

<p>Shaded areas indicate ±1 standard error of the mean. Dashed lines indicate commonly used community thresholds of risk status [see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0082606#pone-0082606-t001" target="_blank">Table 1</a>].</p

Age at which the mean for measures of obesity, dyslipidemia, diabetes and hypertension first exceeded standard risk thresholds.

<p>Key to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0082606#pone-0082606-t002" target="_blank">Table 2:</a></p>†<p>Estimate outside the age period of observation.</p>v<p>Always below threshold within the period of observation.</p>∧<p>Always above threshold within the period of observation.</p>‡<p>HDL cholesterol is transiently above threshold at the extreme of the age range of observations (18–19·2).</p><p>*Occurs right at the edge of the age period of observation.</p

Measures of obesity, dyslipidemia, diabetes and hypertension and associated risk thresholds.

<p>Key for <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0082606#pone-0082606-t001" target="_blank">Table 1:</a></p><p>M = Male; F = Female; 1 = estimated from fasting blood sample; All differences between the psychosis and the general population samples were significant (p<·001) except overweight BMI in females (p<·01) and fasting blood glucose in females (p = 0·39).</p

Smoothed means of fasting blood total, LDL and HDL cholesterol, triglycerides and glucose by age in men and women with psychosis [red] compared to general population controls [blue].

<p>Shaded areas indicate ±1 standard error of the mean. Dashed lines indicate commonly used community thresholds of risk status [see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0082606#pone-0082606-t001" target="_blank">Table 1</a>].</p