Swimming capabilities of stoats and the threat to inshore sanctuaries

Stoats (Mustela erminea) are small carnivorous mammals which were introduced into New Zealand in the late 19th century, and have now become widespread invasive pests. Stoats have long been known to be capable of swimming to islands 1-1.5 km offshore. Islands further out have usually been assumed to be safe from invasion, therefore routine stoat monitoring on them has been considered un-necessary. Recent incursions, including a stoat found on Rangitoto Island (3 km offshore) in 2010, and another which was deduced to have reached Kapiti (5 km offshore) in 2009, along with distribution modelling and genetic studies, strongly support the proposition that stoats can swim much further than 1.5 km. Acceptance of this hypothesis depends on estimating the probability that such small animals could indeed swim so far unaided. This paper reports the results of a project designed to assist this debate by recording the paddling action, speed and minimal endurance of nine stoats observed (once each) swimming against an endless current in a flume at the Aquatic Research Centre, University of Waikato. Four of the five males and two of the four females could hold a position for at least five minutes against the maximum current available, averaging 1.36 ± 0.336 km/h. In steady swimming against a current of c. 1 km/hr, they all used a rapid quadripedal paddling action (averaging 250 strokes/min, stronger with the spread forepaws). Four of the nine swam strongly for >1 h, including one female who covered 1.8 km in nearly 2 h non- stop. Results from such artificial conditions cannot be conclusive, but support suggestions that wild stoats could indeed swim much further than 1.5 km, hence we conclude that the “risk zone” for stoat reinvasions of inshore islands has been seriously under-estimated

The AGN-starburst connection, Galactic superwinds, and M_BH - sigma

Recent observations of young galaxies at redshifts z ~ 3 have revealed simultaneous AGN and starburst activity, as well as galaxy-wide superwinds. I show that there is probably a close connection between these phenomena by extending an earlier treatment of the M_BH - sigma relation (King, 2003). As the black hole grows, an outflow drives a shell into the surrounding gas. This stalls after a dynamical time at a size determined by the hole's current mass and thereafter grows on the Salpeter timescale. The gas trapped inside this bubble cools and forms stars and is recycled as accretion and outflow. The consequent high metallicity agrees with that commonly observed in AGN accretion. Once the hole reaches a critical mass this region attains a size such that the gas can no longer cool efficiently. The resulting energy-driven flow expels the remaining gas as a superwind, fixing both the M_BH - sigma relation and the total stellar bulge mass at values in good agreement with observation. Black hole growth thus produces starbursts and ultimately a superwind.Comment: ApJ, in press, 4 page

Daily Scheduled High Fat Meals Moderately Entrain Behavioral Anticipatory Activity, Body Temperature, and Hypothalamic c-Fos Activation

When fed in restricted amounts, rodents show robust activity in the hours preceding expected meal delivery. This process, termed food anticipatory activity (FAA), is independent of the light-entrained clock, the suprachiasmatic nucleus, yet beyond this basic observation there is little agreement on the neuronal underpinnings of FAA. One complication in studying FAA using a calorie restriction model is that much of the brain is activated in response to this strong hunger signal. Thus, daily timed access to palatable meals in the presence of continuous access to standard chow has been employed as a model to study FAA in rats. In order to exploit the extensive genetic resources available in the murine system we extended this model to mice, which will anticipate rodent high fat diet but not chocolate or other sweet daily meals (Hsu, Patton, Mistlberger, and Steele; 2010, PLoS ONE e12903). In this study we test additional fatty meals, including peanut butter and cheese, both of which induced modest FAA. Measurement of core body temperature revealed a moderate preprandial increase in temperature in mice fed high fat diet but entrainment due to handling complicated interpretation of these results. Finally, we examined activation patterns of neurons by immunostaining for the immediate early gene c-Fos and observed a modest amount of entrainment of gene expression in the hypothalamus of mice fed a daily fatty palatable meal

Automated classification of three-dimensional reconstructions of coral reefs using convolutional neural networks

© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Hopkinson, B. M., King, A. C., Owen, D. P., Johnson-Roberson, M., Long, M. H., & Bhandarkar, S. M. Automated classification of three-dimensional reconstructions of coral reefs using convolutional neural networks. PLoS One, 15(3), (2020): e0230671, doi: 10.1371/journal.pone.0230671.Coral reefs are biologically diverse and structurally complex ecosystems, which have been severally affected by human actions. Consequently, there is a need for rapid ecological assessment of coral reefs, but current approaches require time consuming manual analysis, either during a dive survey or on images collected during a survey. Reef structural complexity is essential for ecological function but is challenging to measure and often relegated to simple metrics such as rugosity. Recent advances in computer vision and machine learning offer the potential to alleviate some of these limitations. We developed an approach to automatically classify 3D reconstructions of reef sections and assessed the accuracy of this approach. 3D reconstructions of reef sections were generated using commercial Structure-from-Motion software with images extracted from video surveys. To generate a 3D classified map, locations on the 3D reconstruction were mapped back into the original images to extract multiple views of the location. Several approaches were tested to merge information from multiple views of a point into a single classification, all of which used convolutional neural networks to classify or extract features from the images, but differ in the strategy employed for merging information. Approaches to merging information entailed voting, probability averaging, and a learned neural-network layer. All approaches performed similarly achieving overall classification accuracies of ~96% and >90% accuracy on most classes. With this high classification accuracy, these approaches are suitable for many ecological applications.This study was funded by grants from the Alfred P. Sloan Foundation (BMH, BR2014-049; https://sloan.org), and the National Science Foundation (MHL, OCE-1657727; https://www.nsf.gov). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript

Radiatively-Driven Outflows and Avoidance of Common-Envelope Evolution in Close Binaries

Recent work on Cygnus X-2 suggests that neutron-star or black-hole binaries survive highly super-Eddington mass transfer rates without undergoing common-envelope evolution. We suggest here that the accretion flows in such cases are radiation pressure-dominated versions of the "ADIOS" picture proposed by Blandford and Begelman (1999), in which almost all the mass is expelled from large radii in the accretion disk. We estimate the maximum radius from which mass loss is likely to occur, and show that common-envelope evolution is probably avoided in any binary in which a main-sequence donor transfers mass on a thermal timescale to a neutron star or black hole, even though the mass transfer rate may reach values of 0.001 solar masses per year. This conclusion probably applies also to donors expanding across the Hertzsprung gap, provided that their envelopes are radiative. SS433 may be an example of a system in this state.Comment: 4 pages, submitted to Astrophysical Journal Letters, 26 March 199

Role of angiopoietin-like protein 3 in sugar-induced dyslipidemia in rhesus macaques: suppression by fish oil or RNAi.

Angiopoietin-like protein 3 (ANGPTL3) inhibits lipid clearance and is a promising target for managing cardiovascular disease. Here we investigated the effects of a high-sugar (high-fructose) diet on circulating ANGPTL3 concentrations in rhesus macaques. Plasma ANGPTL3 concentrations increased ∼30% to 40% after 1 and 3 months of a high-fructose diet (both P < 0.001 vs. baseline). During fructose-induced metabolic dysregulation, plasma ANGPTL3 concentrations were positively correlated with circulating indices of insulin resistance [assessed with fasting insulin and the homeostatic model assessment of insulin resistance (HOMA-IR)], hypertriglyceridemia, adiposity (assessed as leptin), and systemic inflammation [C-reactive peptide (CRP)] and negatively correlated with plasma levels of the insulin-sensitizing hormone adropin. Multiple regression analyses identified a strong association between circulating APOC3 and ANGPTL3 concentrations. Higher baseline plasma levels of both ANGPTL3 and APOC3 were associated with an increased risk for fructose-induced insulin resistance. Fish oil previously shown to prevent insulin resistance and hypertriglyceridemia in this model prevented increases of ANGPTL3 without affecting systemic inflammation (increased plasma CRP and interleukin-6 concentrations). ANGPTL3 RNAi lowered plasma concentrations of ANGPTL3, triglycerides (TGs), VLDL-C, APOC3, and APOE. These decreases were consistent with a reduced risk of atherosclerosis. In summary, dietary sugar-induced increases of circulating ANGPTL3 concentrations after metabolic dysregulation correlated positively with leptin levels, HOMA-IR, and dyslipidemia. Targeting ANGPTL3 expression with RNAi inhibited dyslipidemia by lowering plasma TGs, VLDL-C, APOC3, and APOE levels in rhesus macaques

Magnetic structures of NaLMnWO_6 perovskites (L=La,Nd,Tb)

The magnetic structures of the perovskites NaLaMnWO_6, NaNdMnWO_6, and NaTbMnWO_6, with rocksalt ordering of the Mn/W ions and layered ordering of Na and the rare-earth ions, have been determined by neutron powder diffraction. The manganese moments in NaLaMnWO_6 order below 10 K with a propagation vector of k_14=(1/2,0,1/2) and a moment of 3.99μB per Mn^2+ ion. The Mn^2+ and Nd^3+ ions order simultaneously in NaNdMnWO_6 at 11 K. The resulting magnetic structure is incommensurate with the underlying crystal structure and has the propagation vector of k_5=(0,0.48,1/2). NaTbMnWO_6 undergoes two magnetic phase transitions at 15 and 9 K. The structure determined at 11 K is based on two propagation vectors of k_14=(1/2,0,1/2) and k_5=(0,0.427,1/2). Upon cooling at 6 K the incommensurate vector is no longer present and the moments order only according to k_14. The moments of the Nd and Tb ions are found to remain within the planes of the A-site cations, and in NaTbMnWO_6 the Mn moments also lie within the xy plane. This study not only reveals magnetic structures with previously unexplored topologies but it also sheds light on the intricate coupling between the two magnetic sublattices

Establishing and Evaluating Climate Change Heuristics of Multi-Actor Professional Leadership in the New York Metropolitan Region

This article sets out to evaluate the existing range of heuristics and preferences for the concepts of adaptation, resilience, mitigation and coping of a variety of actors in the metropolitan region of New York City who are undertaking professional leadership positions in developing policies and practices which address a multitude of risks associated with climate change. Prior interviews and observations have suggested that the inconsistent usage of these concepts—including, the rhetorical application of resilience as a leading framework—are thwarting the development of planning instruments and decision tools. This article positions a normative set of meanings for each of the aforementioned concepts based on a review of existing literature. Then, utilizing a survey, these normative meanings are evaluated by and between the: (i) concepts and meanings; (ii) concepts and applications; and, (iii) applications and preferences, as applied to various risk based scenarios ranging from sea level rise to heat waves. This survey tests the hypotheses that the respondents: (a) are unable to consistently match the concept of resiliency with the normative meanings or applications: and, (b) will not consistently show a preference for resilience applications or outcomes ahead of other concepts. The results of the survey confirm both hypotheses, which is demonstrative of the inadequacy of the current framework dominated by resilience in its rhetorical form. It is anticipated that the results of this article will advance an argument for the necessity to develop consistent meanings for concepts which bridge the scientific, policy and popular domains

What is on Tap? The Role of Spin in Compact Objects and Relativistic Jets

We examine the role of spin in launching jets from compact objects across the mass scale. Our work includes a total of 37 Seyferts, 11 stellar-mass black holes, and 13 neutron stars. We find that when the Seyfert reflection lines are modeled with Gaussian line features (a crude proxy for inner disk radius and therefore spin), only a slight inverse correlation is found between the Doppler-corrected radio luminosity at 5 GHz (a proxy for jet power) and line width. When the Seyfert reflection features are fit with relativistically-blurred disk reflection models that measure spin, there is a tentative positive correlation between the Doppler-corrected radio luminosity and the spin measurement. Further, when we include stellar-mass black holes in the sample, to examine the effects across the mass scale, we find a slightly stronger correlation with radio luminosity per unit mass and spin, at a marginal significance (2.3 sigma confidence level). Finally, when we include neutron stars, in order to probe lower spin values, we find a positive correlation (3.3 sigma confidence level) between radio luminosity per unit mass and spin. Although tentative, these results suggest that spin may have a role in determining the jet luminosity. In addition, we find a slightly more significant correlation (4.4 sigma confidence level) between radio luminosity per Bolometric luminosity and spin, using our entire sample of black holes and neutrons stars. Again, although tentative, these relations point to the possibility that the mass accretion rate, i.e. Bolometric luminosity, is also important in determining the jet luminosity, in addition to spin. Our analysis suggests that mass accretion rate and disk or coronal magnetic field strength may be the "throttle" in these compact systems, to which the Eddington limit and spin may set the maximum jet luminosity that can be achieved.Comment: 14 pages, 13 Figures, ApJ Accepte

Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase

ERK5 is a mitogen-activated protein (MAP) kinase regulated in human cells by diverse mitogens and stresses but also suspected of mediating the effects of a number of oncogenes. Its expression in the slt2Delta Saccharomyces cerevisiae mutant rescued several of the phenotypes caused by the lack of Slt2p (Mpk1p) cell integrity MAP kinase. ERK5 is able to provide this cell integrity MAP kinase function in yeast, as it is activated by the cell integrity signaling cascade that normally activates Slt2p and, in its active form, able to stimulate at least one key Slt2p target (Rlm1p, the major transcriptional regulator of cell wall genes). In vitro ERK5 kinase activity was abolished by Hsp90 inhibition. ERK5 activity in vivo was also lost in a strain that expresses a mutant Hsp90 chaperone. Therefore, human ERK5 expressed in yeast is an Hsp90 client, despite the widely held belief that the protein kinases of the MAP kinase class are non-Hsp90-dependent activities. Two-hybrid and protein binding studies revealed that strong association of Hsp90 with ERK5 requires the dual phosphorylation of the TEY motif in the MAP kinase activation loop. These phosphorylations, at positions adjacent to the Hsp90-binding surface recently identified for a number of protein kinases, may cause a localized rearrangement of this MAP kinase region that leads to creation of the Hsp90-binding surface. Complementation of the slt2Delta yeast defect by ERK5 expression establishes a new tool with which to screen for novel agonists and antagonists of ERK5 signaling as well as for isolating mutant forms of ERK5