Dietary nitrate enhances the contractile properties of human skeletal muscle

Dietary nitrate, a source of nitric oxide (NO), improves the contractile properties of human muscle. We present the hypothesis that this is due to nitrosylation of the ryanodine receptor and increased NO signaling via the soluble guanyl cyclase-cyclic guanosine monophosphate-protein kinase G pathway, which together increase the free intracellular Ca concentration along with the Ca sensitivity of the myofilaments themselves

Themes of drawing and digital context: student engagement with theory and practice using the tool of the integrated learning portfolio

This article presents a reflective visual narrative documenting the learning encounters of BA (Hons) Surface Design undergraduates using the Integrated Learning Portfolio (ILP) tool in Year one. Theoretical themes of drawing, digital drawing design practice, and visual design research experientially blended the physical and the virtual learning tools, environments and collaborative culture through this integrated first year route. Parallel theory and practice on specific themes such as ‘drawing lines within the urban landscape’, ‘creating shadow silhouettes’, ‘using the body as a tool for drawing’, and ‘cultivating fortuitous accidents in drawing practice’, created a conceptual space for students to evaluate the future relevance of these drawing experiences within the context of their design programme