Jet Broadening in Flowing Matter -- Resummation

In this work, we obtain the leading corrections to the jet momentum broadening distribution in a QCD medium arising from the transverse flow of the matter. We first derive the single-particle propagator of a highly energetic parton resumming its multiple interactions with the homogeneous flowing matter, explicitly keeping the leading subeikonal flow terms. Then, we use this propagator to obtain the jet broadening distribution and its leading moments. We show that this distribution becomes anisotropic in the presence of transverse flow, since its odd moments are generally non-zero and proportional to the transverse velocity of the medium. Finally, we evaluate several odd moments, which we compare to the corresponding results at first order in opacity, showing that accounting for multiple in-medium scatterings is essential to describe some observables in dense nuclear matter.Comment: 28 pages, 2 figure

Seeing Beauty in the Quark-Gluon Plasma with Energy Correlators

Heavy quarks created in heavy-ion collisions serve as an excellent probe of the produced quark-gluon plasma (QGP). The radiation pattern of jets formed from heavy quarks as they traverse the QGP exhibits a particularly interesting structure due to the interplay of two competing effects: the suppression of small-angle radiation, also known as the ``dead-cone'' effect, and the enhancement of emitted gluons by medium-induced radiation. In this Letter, we propose a new observable, based on the energy correlator approach to jet substructure, which will allow us to disentangle the two scales associated to these two phenomena and to determine under which conditions the dead-cone is filled by medium-induced radiation. Combined with the forthcoming high-statistics measurements of heavy-flavor jets, this work provides a novel tool to unravel the dynamics of the QGP.Comment: 5 pages, 4 lovely figure

Jet quenching as a probe of the initial stages in heavy-ion collisions

Jet quenching provides a very flexible variety of observables which are sensitive to different energy- and time-scales of the strongly interacting matter created in heavy-ion collisions. Exploiting this versatility would make jet quenching an excellent chronometer of the yoctosecond structure of the evolution process. Here we show, for the first time, that a combination of jet quenching observables is sensitive to the initial stages of heavy-ion collisions, when the approach to local thermal equilibrium is expected to happen. Specifically, we find that in order to reproduce at the same time the inclusive particle production suppression, RAA, and the high-pT azimuthal asymmetries, v2, energy loss must be strongly suppressed for the first ∼0.6 fm. This exploratory analysis shows the potential of jet observables, possibly more sophisticated than the ones studied here, to constrain the dynamics of the initial stages of the evolution.Peer reviewe

Constraining energy loss from high-pt azimuthal asymmetries

Peer reviewe

Medium-induced radiation with vacuum propagation in the pre-hydrodynamics phase

The recent discovery of the potential of jet quenching observables to constrain the initial stages after a heavy-ion collision makes imperative to have a better understanding of the process of medium-induced radiation before the formation of the quark-gluon plasma (QGP) and its impact on observables at high-$p_T$. In this work, we generalize the BDMPS-Z framework for medium-induced radiation to account for additional emissions occurring before the creation of the QGP. For simplicity, we assume that during the pre-hydrodynamics phase the hard parton propagates as in vacuum. This set-up, allows us to isolate the contribution from the additional initial radiation by comparing with the usual scenarios in which the emitter is created inside the medium but with different starting points. Using both a numerical implementation of the fully resummed emission spectrum and the usual analytical approximations, we find that replacing an initial slab of the medium by vacuum yields to a significant reduction of the emission spectrum for low radiated gluon energies, while the high-energy tails remain largely unmodified. Finally, we assess the effect of replacing the initial medium by vacuum propagation on the single-inclusive particle suppression $R_{AA}$ and high-$p_T$ azimuthal asymmetry $v_2$. Our findings indicate that considering vacuum propagation prior to hydrodynamization leads to an increase in the $v_2$, thus corroborating the importance of the treatment of jet quenching in the initial stages for the correct description of both observables.Comment: 25 pages, 9 figures. Matches published version in JHE

Resolving the Scales of the Quark-Gluon Plasma with Energy Correlators

Jets provide us with ideal probes of the quark-gluon plasma (QGP) produced in heavy-ion collisions, since its dynamics at its different scales is imprinted into the multi-scale substructure of the final state jets. We present a new approach to jet substructure in heavy-ion collisions based on the study of correlation functions of energy flow operators. By analysing the two-point correlator of an in-medium quark jet, we demonstrate that the spectra of correlation functions robustly identify the scales defined by the properties of the QGP, particularly those associated with the onset of colour coherence.Comment: 5 pages, 4 lovely figure

Galectin-1 confers resistance to doxorubicin in hepatocellular carcinoma cells through modulation of P-glycoprotein expression

Galectin-1 (GAL1), a β-galactoside-binding protein abundantly expressed in the tumor microenvironment, has emerged as a key mechanism of chemoresistance developed by different tumors. Although increased expression of GAL1 is a hallmark of hepatocellular carcinoma (HCC) progression, aggressiveness and metastasis, limited information is available on the role of this endogenous lectin in HCC resistance to chemotherapy. Moreover, the precise mechanisms underlying this effect are uncertain. HCC has evolved different mechanisms of resistance to chemotherapy including those involving the P-glycoprotein (P-gp), an ATP-dependent drug efflux pump, which controls intracellular drug concentration. Here, we investigated the molecular mechanism underlying GAL1-mediated chemoresistance in HCC cells, particularly the involvement of P-gp in this effect. Our results show that GAL1 protected HepG2 cells from doxorubicin (DOX)- and sorafenib-induced cell death in vitro. Accordingly, GAL1-overexpressing HepG2 cells generated DOX-resistant tumors in vivo. High expression of GAL1 in HepG2 cells reduced intracellular accumulation of DOX likely by increasing P-gp protein expression rather than altering its membrane localization. GAL1-mediated increase of P-gp expression involved activation of the phosphatidylinositol-3 kinase (PI3K) signaling pathway. Moreover, ‘loss-of-function’ experiments revealed that P-gp mediates GAL1-driven resistance to DOX, but not to sorafenib, in HepG2 cells. Conversely, in PLC/PRF/5 cells, P-gp protein expression was undetectable and GAL1 did not control resistance to DOX or sorafenib, supporting the critical role of P-gp in mediating GAL1 effects. Collectively, our findings suggest that GAL1 confers chemoresistance in HCC through mechanisms involving modulation of P-gp, thus emphasizing the role of this lectin as a potential therapeutic target in HCC.Fil: Carabias, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Espelt, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Bacigalupo, Maria Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Rojas, Paola Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Sarrias, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Rubin, Ayelen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Saffioti, Nicolas Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Elola, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Rossi, Juan Pablo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Wolfenstein Todel, Carlota. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Troncoso, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentin