Continuous Glucose Monitoring in Preterm Infants: The Role of Nutritional Management in Minimizing Glycemic Variability

Glycemic variability (GV) is common in preterm infants. In the premature population, GV is a risk factor for morbidity and mortality. Both hypo- and hyperglycemia can impair neurodevelopment. We investigated the impact of continuous versus intermittent tube enteral feeding on GV. In our prospective observational study, 20 preterm infants with a gestational age ≤ 34 weeks at either continuous or intermittent bolus full enteral feeding. For five days, continuous glucose monitoring (CGM) was utilized, which was achieved through the subcutaneous insertion of a sensor. A total of 27,532 measurements of blood glucose were taken. The mean amplitude of glycemic excursions did not differ between the two cohorts statistically. Continuous feeding resulted in higher positive values, increasing the risk of hypo- and hyperglycemia. Subjects who were small for their gestational age had a higher standard deviation during continuous feeding (p = 0.001). Data suggest that intermittent bolus nutrition is better for glycemic control than continuous nutrition. Nutritional management optimization of preterm infants appears to be critical for long-term health. In the future, CGM may provide a better understanding of the optimal glucose targets for various clinical conditions, allowing for a more personalized approach to management

Análise prospectiva da patente ?Processo para a Aplicação da Biomineralização na Melhoria de Solos? ? PI 1001279-6: estudo de viabilidade de patente brasileira por meio de informetria.

Desenvolvimento sustentável é um tema estratégico e consiste em ações de crescimento econômico preservando o meio ambiente. O mercado de construção civil é um dos que tendem a crescer sob essa ótica e, neste sentido, a patente ?Processo para a aplicação da biomineralização na melhoria de solos?, cuja titular é a Universidade de Brasília (UnB), é uma tecnologia que se apresenta como alternativa ambiental para melhorias na mecânica de solos de forma sustentável. Assim o objetivo deste estudo foi apresentar uma análise prospectiva da patente por meio de informetria para indicação do grau de maturidade tecnológica e de competitividade da patente no mercado pretendido, a fim de proceder à avaliação da viabilidade patentária. A análise demonstrou que as tecnologias neste mercado estão maduras, que a patente da UnB tem grau baixo de maturidade e, portanto, baixo caráter estratégico, embora possua um caráter inovador e um alto grau de sustentabilidade ambiental

Bivalirudin anticoagulation to overcome heparin resistance in a neonate with cerebral sinovenus thrombosis

Anticoagulation in a neonate is a challenge and the availability of anticoagulant options is extremely limited. Here we describe the use of a direct thrombin inhibitor, bivalirudin, in a full-term neonate with symptomatic cerebral sinovenous thrombosis complicated by bilateral thalamic hemorrhagic stroke and intraventricular hemorrhage, who could not be effectively treated with sodium heparin due to heparin resistance (HR) and showed thrombosis regression after start of bivalirudin treatment, without worsening of the hemorrhage. While the use of bivalirudin in neonates has been previously described, the indication of cerebral sinovenous thrombosis and the setting of HR are unique

Effects of Photobiomodulation on High-Intensity Intermittent Anaerobic Performance of Lower Limbs in Brazilian Jiu-Jitsu Athletes: a Randomized, Crossover, Double-Blind Clinical Trial.

International Journal of Exercise Science 16(6): 1165-1181, 2023. Photobiomodulation (PBM) has ergogenic effects on aerobic and anaerobic efforts and may improve sports performance. As Brazilian jiu-jitsu (BJJ) fighting requires both aerobic and anaerobic metabolism, so PBM may be effective in increasing the physical performance of BJJ athletes. Thus, this study aimed to verify the effects of PBM with different energy doses (6 or 12 J per point) on high-intensity intermittent anaerobic performance in BJJ athletes. Methods: Eleven male athletes performed three lower limb Wingate testing sessions. At the beginning of each session, in a randomized, crossover, double-blind fashion, the athletes received PBM with a dose of 6 J (4.5 J/cm2) or 12 J (9.1 J/cm2), or placebo (PLA) at 17 points in each lower limb. In each session, the squat jump (SJ) and three Wingate test series were performed, with a 3-minute interval between series. Heart rate (HR) was collected immediately before, after each Wingate test, and at 1, 3, and 5 minutes after the last test. The rate of perceived exertion (RPE) was reported after each Wingate test. Differences between Wingate tests and treatment sessions were set at p\u3c0.05. Results: No differences were observed between treatments in SJ height, Wingate performance, HR, and RPE (p\u3e0.05; for all comparisons). The Wingate test session promoted a reduction in anaerobic capacity in the second and third sets in all conditions, indicating fatigue (p\u3c0.05). Conclusion: Treatment with PBM did not produce a dose-dependent ergogenic response in high-intensity intermittent performance in BJJ athletes