Energy Demand and Supply Simultaneous Optimization to Design a Nearly Zero-Energy House

The effective design of nearly zero-energy buildings depends on a large set of interdependent variables, which affect both energy demand and supply. Considering them simultaneously is fundamental when searching for optimal design of nearly zero-energy buildings, as encouraged by the EU in the second recast of the Energy Performance of Building Directive (EPBD). This paper presents the application of the new energy demand and supply simultaneous optimization (EDeSSOpt) methodology to optimize the design of a single-family house in the Italian context. Both primary energy optimization and financial optimization are carried out in the context of European regulations. Robustness of the resulting optimal solution is studied through analysis of optimum neighborhoods. The resulting cost-optimized solution relies on a moderately insulated envelope, a highly efficient system, and 34% of coverage from renewables. The energy-optimized solution requires a higher level of insulation and a higher coverage from renewables, demonstrating that there is still a gap between energy and cost optimums. Beyond the results, integrated optimization by means of EDeSSOpt is demonstrated to better minimize cost functions while improving the robustness of results

CEMIP ( HYBID , KIAA1199 ): structure, function and expression in health and disease

CEMIP (cell migration-inducing protein), also known as KIAA1199 or HYBID, is a protein involved in the depolymerisation of hyaluronic acid (HA), a major glycosaminoglycan component of the extracellular matrix. CEMIP was originally described in patients affected by nonsyndromic hearing loss and has subsequently been shown to play a key role in tumour initiation and progression, as well as arthritis, atherosclerosis and idiopathic pulmonary fibrosis. Despite the vast literature associating CEMIP with these diseases, its biology remains elusive. The present review article summarises all the major scientific evidence regarding its structure, function, role and expression, and attempts to cast light on a protein that modulates EMT, fibrosis and tissue inflammation, an unmet key aspect in several inflammatory disease conditions

Feynman diagrams and rooted maps

The rooted maps theory, a branch of the theory of homology, is shown to be a powerful tool for investigating the topological properties of Feynman diagrams, related to the single particle propagator in the quantum many-body systems. The numerical correspondence between the number of this class of Feynman diagrams as a function of perturbative order and the number of rooted maps as a function of the number of edges is studied. A graphical procedure to associate Feynman diagrams and rooted maps is then stated. Finally, starting from rooted maps principles, an original definition of the genus of a Feynman diagram, which totally differs from the usual one, is given

EDeSSOpt – Energy Demand and Supply Simultaneous Optimization for cost-optimized design: Application to a multi-family building

In the context of European efforts to reduce energy consumption and CO2 emissions in the building sector, the second recast of the Energy Performance of Buildings Directive promotes the acceleration of the energy renovation of European building stock. To do this, a cost optimization is necessary to find the best combination of energy efficiency measures which minimize the global cost during the entire life-cycle of the building, as suggested in the first recast of the same Directive. Since a great number of combinations must be analyzed, an automated procedure is necessary to reduce the calculation time. In this work, an iterative input-output process is set, thanks to the coupling of a dynamic energy simulation software (TRNSYS) and a generic optimization software (GenOpt). The cost optimization is applied to a new social housing construction – a multi-family building located in Northern Italy. The methodology that was adopted allows the simultaneous optimization of both the building energy demand (building envelope) and the building energy supply (technical systems and renewable sources). Results are compared with those obtained using a more widespread sequential approach whose purpose is firstly the optimization of one of these two factors, and subsequently the optimization of the other one. This study has demonstrated that an integrated approach allows a larger number of possible combinations of energy efficiency measures to be explored with respect to the sequential approach

Glomerular macrophages in human auto- and allo-immune nephritis

Macrophages are involved in tissue homeostasis. They participate in inflammatory episodes and are involved in tissue repair. Macrophages are characterized by a phenotypic heterogeneity and a profound cell plasticity. In the kidney, and more particularly within glomeruli, macrophages are thought to play a maintenance role that is potentially critical for preserving a normal glomerular structure. Literature on the glomerular macrophage role in human crescentic glomerulonephritis and renal transplantation rejection with glomerulitis, is sparse. Evidence from preclinical models indicates that macrophages profoundly modulate disease progression, both in terms of number—where depletion has resulted in a reduced glomerular lesion—and sub-phenotype—M1 being more profoundly detrimental than M2. This evidence is corroborated by better outcomes in patients with a lower number of glomerular macrophages. However, due to the very limited biopsy sample size, the type and role of macrophage subpopulations involved in human proliferative lesions is more difficult to precisely define and synthesize. Therefore, specific biomarkers of macrophage activation may enhance our ability to assess their role, potentially enabling improved monitoring of drug activity and ultimately allowing the development of novel therapeutic strategies to target these elusive cellular players

Structure Based Modeling of Small Molecules Binding to the TLR7 by Atomistic Level Simulations

Toll-Like Receptors (TLR) are a large family of proteins involved in the immune system response. Both the activation and the inhibition of these receptors can have positive effects on several diseases, including viral pathologies and cancer, therefore prompting the development of new compounds. In order to provide new indications for the design of Toll-Like Receptor 7 (TLR7)-targeting drugs, the mechanism of interaction between the TLR7 and two important classes of agonists (imidazoquinoline and adenine derivatives) was investigated through docking and Molecular Dynamics simulations. To perform the computational analysis, a new model for the dimeric form of the receptors was necessary and therefore created. Qualitative and quantitative differences between agonists and inactive compounds were determined. The in silico results were compared with previous experimental observations and employed to define the ligand binding mechanism of TLR7

Explaining the Microtubule Energy Balance: Contributions Due to Dipole Moments, Charges, van der Waals and Solvation Energy

Microtubules are the main components of mitotic spindles, and are the pillars of the cellular cytoskeleton. They perform most of their cellular functions by virtue of their unique dynamic instability processes which alternate between polymerization and depolymerization phases. This in turn is driven by a precise balance between attraction and repulsion forces between the constituents of microtubules (MTs)—tubulin dimers. Therefore, it is critically important to know what contributions result in a balance of the interaction energy among tubulin dimers that make up microtubules and what interactions may tip this balance toward or away from a stable polymerized state of tubulin. In this paper, we calculate the dipole–dipole interaction energy between tubulin dimers in a microtubule as part of the various contributions to the energy balance. We also compare the remaining contributions to the interaction energies between tubulin dimers and establish a balance between stabilizing and destabilizing components, including the van der Waals, electrostatic, and solvent-accessible surface area energies. The energy balance shows that the GTP-capped tip of the seam at the plus end of microtubules is stabilized only by − 9 kcal/mol, which can be completely reversed by the hydrolysis of a single GTP molecule, which releases + 14 kcal/mol and destabilizes the seam by an excess of + 5 kcal/mol. This triggers the breakdown of microtubules and initiates a disassembly phase which is aptly called a catastrophe

Explaining the microtubule energy balance: contributions due to dipole moments, charges, van der Waals and solvation energy

Microtubules are the main components of mitotic spindles, and are the pillars of the cellular cytoskeleton. They perform most of their cellular functions by virtue of their unique dynamic instability processes which alternate between polymerization and depolymerization phases. This in turn is driven by a precise balance between attraction and repulsion forces between the constituents of microtubules (MTs)—tubulin dimers. Therefore, it is critically important to know what contributions result in a balance of the interaction energy among tubulin dimers that make up microtubules and what interactions may tip this balance toward or away from a stable polymerized state of tubulin. In this paper, we calculate the dipole–dipole interaction energy between tubulin dimers in a microtubule as part of the various contributions to the energy balance. We also compare the remaining contributions to the interaction energies between tubulin dimers and establish a balance between stabilizing and destabilizing components, including the van der Waals, electrostatic, and solvent-accessible surface area energies. The energy balance shows that the GTP-capped tip of the seam at the plus end of microtubules is stabilized only by −9 kcal/mol, which can be completely reversed by the hydrolysis of a single GTP molecule, which releases +14 kcal/mol and destabilizes the seam by an excess of +5 kcal/mol. This triggers the breakdown of microtubules and initiates a disassembly phase which is aptly called a catastrophe