6,110 research outputs found
From zero to hero: A process mining tutorial
Process mining is an emerging area that synergically combines model-based and data-oriented analysis techniques to obtain useful insights on how business processes are executed within an organization. This tutorial aims at providing an introduction to the key analysis techniques in process mining that allow decision makers to discover process models from data, compare expected and actual behaviors, and enrich models with key information about the actual process executions. In addition, the tutorial will present concrete tools and will provide practical skills for applying process mining in a variety of application domains, including the one of software development
Statistical Field Theory and Effective Action Method for scalar Active Matter
We employ Statistical Field Theory techniques for coarse-graining the
steady-state properties of Active Ornstein-Uhlenbeck particles. The computation
is carried on in the framework of the Unified Colored Noise approximation that
allows an effective equilibrium picture. We thus develop a mean-field theory
that allows to describe in a unified framework the phenomenology of scalar
Active Matter. In particular, we are able to describe through spontaneous
symmetry breaking mechanism two peculiar features of Active Systems that are
(i) The accumulation of active particles at the boundaries of a confining
container, and (ii) Motility-Induced Phase Separation (MIPS).
\textcolor{black}{We develop a mean-field theory for steric interacting active
particles undergoing to MIPS and for Active Lennard-Jones (ALJ) fluids.}
\textcolor{black}{Within this framework}, we discuss the universality class of
MIPS and ALJ \textcolor{black}{showing that it falls into Ising universality
class.} We \textcolor{black}{thus} compute analytically the critical line
for both models. In the case of MIPS, gives rise to a
reentrant phase diagram compatible with an inverse transition from liquid to
gas as the strength of the noise decreases. \textcolor{black}{However, in the
case of particles interacting through anisotropic potentials, } the field
theory acquires a term that, \textcolor{black}{in general, cannot
be canceled performing the expansion around the critical point.} In this case,
the \textcolor{black}{Ising} critical point might \textcolor{black}{be
replaced} by a first-order phase transition \textcolor{black}{region}
Conformance Checking Based on Multi-Perspective Declarative Process Models
Process mining is a family of techniques that aim at analyzing business
process execution data recorded in event logs. Conformance checking is a branch
of this discipline embracing approaches for verifying whether the behavior of a
process, as recorded in a log, is in line with some expected behaviors provided
in the form of a process model. The majority of these approaches require the
input process model to be procedural (e.g., a Petri net). However, in turbulent
environments, characterized by high variability, the process behavior is less
stable and predictable. In these environments, procedural process models are
less suitable to describe a business process. Declarative specifications,
working in an open world assumption, allow the modeler to express several
possible execution paths as a compact set of constraints. Any process execution
that does not contradict these constraints is allowed. One of the open
challenges in the context of conformance checking with declarative models is
the capability of supporting multi-perspective specifications. In this paper,
we close this gap by providing a framework for conformance checking based on
MP-Declare, a multi-perspective version of the declarative process modeling
language Declare. The approach has been implemented in the process mining tool
ProM and has been experimented in three real life case studies
Heat, temperature and Clausius inequality in a model for active brownian particles
Methods of stochastic thermodynamics and hydrodynamics are applied to the a
recently introduced model of active particles. The model consists of an
overdamped particle subject to Gaussian coloured noise. Inspired by stochastic
thermodynamics, we derive from the system's Fokker-Planck equation the average
exchanges of heat and work with the active bath and the associated entropy
production. We show that a Clausius inequality holds, with the local
(non-uniform) temperature of the active bath replacing the uniform temperature
usually encountered in equilibrium systems. Furthermore, by restricting the
dynamical space to the first velocity moments of the local distribution
function we derive a hydrodynamic description where local pressure, kinetic
temperature and internal heat fluxes appear and are consistent with the
previous thermodynamic analysis. The procedure also shows under which
conditions one obtains the unified coloured noise approximation (UCNA): such an
approximation neglects the fast relaxation to the active bath and therefore
yields detailed balance and zero entropy production. In the last part, by using
multiple time-scale analysis, we provide a constructive method (alternative to
UCNA) to determine the solution of the Kramers equation and go beyond the
detailed balance condition determining negative entropy production.Comment: 19 pages, 1 figure. Major changes in the text. 1 figure has been
replace
Saprotrophic soil fungi to improve phosphorus solubilisation and release. In vitro abilities of several species
Modern agriculture is dependent on phosphate rock (PR), which is a nonrenewable resource. Improvement of phosphorus (P) availability for crops in agricultural soils represents a key strategy to slow down the depletion of PR. The aim of this study was to identify potential P biofertilisers among saprotrophic fungal species. We tested 30 fungal strains belonging to 28 taxa (4 Zygomycota and 24 Ascomycota) and with different life strategies. The study showed that many saprotrophic fungi have the ability to mobilise P from insoluble forms according to a variety of mechanisms. Our results expand the pool of P solubilising fungal species, also suggesting a new solubilisation index and shedding light on parameters that could be basic in the selection of efficient soil P-biofertilisers fungi. Rhizopus stolonifer var. stolonifer, Aspergillus niger and Alternaria alternata were found to be the best performing strains in terms of amounts of TCP solubilisation
Endocrinologic Control of Men's Sexual Desire and Arousal/Erection
Several hormones and neurotransmitters orchestrate men's sexual response, including the appetitive (sexual desire) and consummative (arousal and penile erection) phases.
AIM:
To provide an overview and recommendations regarding endocrinologic control of sexual desire and arousal and erection and their disturbances.
METHODS:
Medical literature was reviewed by the subcommittee of the International Consultation of Sexual Medicine, followed by extensive internal discussion, and then public presentation and discussion with other experts. The role of pituitary (prolactin, oxytocin, growth hormone, and α-melanocyte-stimulating hormone), thyroid, and testicular hormones was scrutinized and discussed.
MAIN OUTCOME MEASURES:
Recommendations were based on grading of evidence-based medical literature, followed by interactive discussion.
RESULTS:
Testosterone has a primary role in controlling and synchronizing male sexual desire and arousal, acting at multiple levels. Accordingly, meta-analysis indicates that testosterone therapy for hypogonadal individuals can improve low desire and erectile dysfunction. Hyperprolactinemia is associated with low desire that can be successfully corrected by appropriate treatments. Oxytocin and α-melanocyte-stimulating hormone are important in eliciting sexual arousal; however, use of these peptides, or their analogs, for stimulating sexual arousal is still under investigation. Evaluation and treatment of other endocrine disorders are suggested only in selected cases.
CONCLUSION:
Endocrine abnormalities are common in patients with sexual dysfunction. Their identification and treatment is strongly encouraged in disturbances of sexual desire and arousal
Erratum to "Eosinophils, the IL-5/IL-5Rα axis, and the biologic effects of benralizumab in severe asthma" [Respir. Med. X 1C (2019) 100007]
The Publisher regrets that this article is an accidental duplication of an article that has already been published in , http://dx.doi.org/. The duplicate article has therefore been withdrawn.The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal
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