Pursuing innovative actions during Covid-19 crisis: a qualitative analysis of family firms’ resilience

Purpose: The study aims to broaden and refine the extant theory in the area of resilience in family firms during a grand challenge such as Covid-19. More specifically, the study aims to explore how characteristics that normally contribute to the resilience of family businesses also influence their innovative actions when facing a grand challenge Design/methodology/approach. This study reviews what has been written on resilience in family firms and their innovative actions in the exceptional context of Covid-19. Then, through an inductive approach based on multiple case studies, qualitative data (primary and secondary sources of information) collected from five Italian family businesses that have demonstrated success in responding to Covid-19 are triangulated. Findings. The findings seem to reveal that, during Covid-19, some features that normally contribute to the resilience of family firms (i.e. trust, long-term orientation, centralized and personalized authority structures, and patient capital) also contribute to their resilience, through innovative actions, to react to the Covid-19 grand challenge. Originality of the study. The study reveals that a further element (namely purpose driven orientation) not previously discussed in family business literature allowed the firms analyzed to be resilient during the Covid-19. Drawing on these findings, our paper aims to enrich the current understanding of family firms’ resilience for both academics and managers

Identifying entrepreneurial opportunities during crises: a qualitative study of Italian firms

Purpose – Recognizing novel entrepreneurial opportunities arising from a crisis is of paramount importance for firms. Hence, understanding the pivotal factors that facilitate firms in this endeavor holds significant value. This study delves into such factors within a representative empirical context impacted by a crisis, drawing insights from existing literature on opportunity recognition during such tumultuous periods. Design/methodology/approach – The authors conducted a qualitative inspection of 14 Italian firms during the COVID-19 pandemic crisis. The authors collected a rich body of multi-source qualitative data, including 34 interviews (with senior managers and entrepreneurs) and secondary data (press releases, videos, web interviews, newspapers, reports and academic articles) in two phases (March–August 2020 and September– December 2020). Findings – The results suggest the existence of a process model of opportunity recognition during crises based on five entrepreneurial influencing factors (entrepreneurial knowledge, entrepreneurial alertness, entrepreneurial proclivity, entrepreneurial personality and entrepreneurial purpose). Originality/value – Various scholars have highlighted that, in times of crises, it is not easy and indeed very challenging for entrepreneurs to identify novel entrepreneurial opportunities. However, recent research has shown that crises can also positively impact entrepreneurs and their capacity to identify new entrepreneurial opportunities. Given these findings, not much research has analyzed the process by which entrepreneurs identify novel entrepreneurial opportunities during crises. This study shows that some entrepreneurial influencing factors are very important to identify new entrepreneurial opportunities during crises

Not just numbers! Improving TTO performance by balancing the soft sides of the TQM

Purpose: This study investigates the role of “soft” factors of total quality management – in terms of empowerment and engagement of employees – in facilitating or hindering organizational performance of the university technology transfer offices. Design/methodology/approach: The authors developed an Ordinary Least Squares (OLS), multiple regression model to test if empowerment and engagement affect organizational performance of the university technology transfer offices. Findings: The authors found that “soft” factors of total quality management – in terms of empowerment and engagement – facilitate the improvement of organizational performance in university technology transfer offices. Practical implications: The authors’ analysis shows that soft total quality management practices create the conditions for improving organizational performance. This study provides practical implications by showing that, in the evaluation of the technology transfer office, not only the “hard” variables (e.g. number of employees and employee experience) but also the “soft” one (e.g. empowerment and engagement) matter. Therefore, university technology transfer managers or university technology transfer delegates should take actions to promote not only empowering employees but also create a climate conducive to employees' engagement in the university technology transfer offices. Originality/value: With regards to the differences in organizational performances of university technology transfer offices, several studies have focused their attention on technology transfer professionals in technology transfer offices, but only a few of them have examined the “soft side” of total quality management. Thus, this study examines the organizational goals of technology transfer offices through “soft” factors of total quality management in terms of empowerment and engagement employees

Clinical characterization of gingival type of burning mouth syndrome:a cross-sectional study

The aim of this study is to investigate the prevalence of localized intraoral neuropathic pain in a cluster of patients who reported the involvement of gingival site as only clinical manifestation of dysesthesia, analysing type and distribution of symptoms. Burning mouth syndrome (BMS) patients were enrolled in the study. Patients were screened through laboratory test and a conventional oral examination with periodontal chart. A questionnaire to collect data on symptoms, oral site involved, quality of sleep, anxiety was submitted to all the patients. A total of 236 patients were recruited. Seventy-six patients (32.2%) presented generalized type, whereas 160 (67.8%) had localized type. In the localized BMS group, the gingiva was involved in 70 patients and in 33 of these it was the only site involved. In the gingival subgroup, 35 patients reported burning, 29 pain and 24 xerostomia. To best our knowledge, this study is the first that analyses gingival involvement as the only site in BMS and it could encourage further investigations to understand the etiopathogenesis of gingival BMS

Hip joint centre position estimation using a dual unscented Kalman filter for computer-assisted orthopaedic surgery

In computer-assisted knee surgery, the accuracy of the localization of the femur centre of rotation relative to the hip-bone (hip joint centre) is affected by the unavoidable and untracked pelvic movements because only the femoral pose is acquired during passive pivoting manoeuvres. We present a dual unscented Kalman filter algorithm that allows the estimation of the hip joint centre also using as input the position of a pelvic reference point that can be acquired with a skin marker placed on the hip, without increasing the invasiveness of the surgical procedure. A comparative assessment of the algorithm was carried out using data provided by in vitro experiments mimicking in vivo surgical conditions. Soft tissue artefacts were simulated and superimposed onto the position of a pelvic landmark. Femoral pivoting made of a sequence of star-like quasi-planar movements followed by a circumduction was performed. The dual unscented Kalman filter method proved to be less sensitive to pelvic displacements, which were shown to be larger during the manoeuvres in which the femur was more adducted. Comparable accuracy between all the analysed methods resulted for hip joint centre displacements smaller than 1 mm (error: 2.2 ± [0.2; 0.3] mm, median ± [inter-quartile range 25%; inter-quartile range 75%]) and between 1 and 6 mm (error: 4.8 ± [0.5; 0.8] mm) during planar movements. When the hip joint centre displacement exceeded 6 mm, the dual unscented Kalman filter proved to be more accurate than the other methods by 30% during multi-planar movements (error: 5.2 ± [1.2; 1] mm)

Deep neural network approach in human-like redundancy optimization for anthropomorphic manipulators

© 2013 IEEE. Human-like behavior has emerged in the robotics area for improving the quality of Human-Robot Interaction (HRI). For the human-like behavior imitation, the kinematic mapping between a human arm and robot manipulator is one of the popular solutions. To fulfill this requirement, a reconstruction method called swivel motion was adopted to achieve human-like imitation. This approach aims at modeling the regression relationship between robot pose and swivel motion angle. Then it reaches the human-like swivel motion using its redundant degrees of the manipulator. This characteristic holds for most of the redundant anthropomorphic robots. Although artificial neural network (ANN) based approaches show moderate robustness, the predictive performance is limited. In this paper, we propose a novel deep convolutional neural network (DCNN) structure for reconstruction enhancement and reducing online prediction time. Finally, we utilized the trained DCNN model for managing redundancy control a 7 DoFs anthropomorphic robot arm (LWR4+, KUKA, Germany) for validation. A demonstration is presented to show the human-like behavior on the anthropomorphic manipulator. The proposed approach can also be applied to control other anthropomorphic robot manipulators in industry area or biomedical engineering

Highly Structured Wind in Vela X-1

We present an in-depth analysis of the spectral and temporal behavior of a long almost uninterrupted INTEGRAL observation of Vela X-1 in Nov/Dec 2003. In addition to an already high activity level, Vela X-1 exhibited several very intense flares with a maximum intensity of more than 5 Crab in the 20 40 keV band. Furthermore Vela X-1 exhibited several off states where the source became undetectable with ISGRI. We interpret flares and off states as being due to the strongly structured wind of the optical companion: when Vela X-1 encounters a cavity in the wind with strongly reduced density, the flux will drop, thus potentially triggering the onset of the propeller effect which inhibits further accretion, thus giving rise to the off states. The required drop in density to trigger the propeller effect in Vela X-1 is of the same order as predicted by theoretical papers for the densities in the OB star winds. The same structured wind can give rise to the giant flares when Vela X-1 encounters a dense blob in the wind. Further temporal analysis revealed that a short lived QPO with a period of 6800 sec is present. The part of the light curve during which the QPO is present is very close to the off states and just following a high intensity state, thus showing that all these phenomena are related

Lung Matrix Metalloproteinase Activation following Partial Hepatic Ischemia/Reperfusion Injury in Rats

Purpose. Warm hepatic ischemia-reperfusion (I/R) injury can lead to multiorgan dysfunction. The aim of the present study was to investigate whether acute liver I/R does affect the function and/or structure of remote organs such as lung, kidney, and heart via modulation of extracellular matrix remodelling. Methods. Male Sprague-Dawley rats were subjected to 30 min partial hepatic ischemia by clamping the hepatic artery and the portal vein. After a 60 min reperfusion, liver, lung, kidney, and heart biopsies and blood samples were collected. Serum hepatic enzymes, creatinine, urea, Troponin I and TNF-alpha, and tissue matrix metalloproteinases (MMP-2, MMP-9), myeloperoxidase (MPO), malondialdehyde (MDA), and morphology were monitored. Results. Serum levels of hepatic enzymes and TNF-alpha were concomitantly increased during hepatic I/R. An increase in hepatic MMP-2 and MMP-9 activities was substantiated by tissue morphology alterations. Notably, acute hepatic I/R affect the lung inasmuch as MMP-9 activity and MPO levels were increased. No difference in MMPs and MPO was observed in kidney and heart. Conclusions. Although the underlying mechanism needs further investigation, this is the first study in which the MMP activation in a distant organ is reported; this event is probably TNF-alpha-mediated and the lung appears as the first remote organ to be involved in hepatic I/R injury

High variability in Vela X-1: giant flares and off states

We investigate the spectral and temporal behavior of the high mass X-ray binary Vela X-1 during a phase of high activity, with special focus on the observed giant flares and off states. INTEGRAL observed Vela X-1 in a long almost uninterrupted observation for two weeks in 2003 Nov/Dec. The data were analyzed with OSA 7.0 and FTOOLS 6.2. We derive the pulse period, light curves, spectra, hardness ratios, and hardness intensity diagrams, and study the eclipse. In addition to an already high activity level, Vela X-1 exhibited several intense flares, the brightest ones reaching a maximum intensity of more than 5 Crab in the 20-40 keV band and several off states where the source was no longer detected by INTEGRAL. We determine the pulse period to be 283.5320+/-0.0002 s, which is stable throughout the entire observation. Analyzing the eclipses provided an improvement in the ephemeris. Spectral analysis of the flares indicates that there appear to be two types of flares: relatively brief flares, which can be extremely intense and show spectral softening, in contrast to high intensity states, which are longer and show no softening. Both flares and off states are interpreted as being due to a strongly structured wind of the optical companion. When Vela X-1 encounters a cavity with strongly reduced density, the flux will drop triggering the onset of the propeller effect, which inhibits further accretion, giving rise to off states. The sudden decrease in the density of the material required to trigger the propeller effect in Vela X-1 is of the same order as predicted by theoretical papers about the densities in OB star winds. A similarly structured wind can produce giant flares when Vela X-1 encounters a dense blob in the wind.Comment: 15 pages, 11 figures, accepted for publication in Astronomy and Astrophysics as of August 2, 200

Oxidative stress and pro-apoptotic conditions in a rodent model of Wilson's disease.

Wilson's disease (WD) is an inherited disorder, characterized by selective copper deposition in liver and brain, chronic hepatitis and extrapyramidal signs. In this study, we investigated changes of biochemical markers of oxidative stress and apoptosis in liver, striatum and cerebral cortex homogenates from Long-Evans Cinnamon (LEC) rats, a mutant strain isolated from Long Evans (LE) rats, in whom spontaneous hepatitis develops shortly after birth. LEC and control (LE) rats at I I and 14 weeks of age were used. We determined tissue levels of glutathione (GSH/GSSG ratio), lipid peroxides, protein-thiols (P-SH), nitric oxide metabolites, activities of caspase-3 and total superoxide-dismutase (SOD), striatal levels of monoamines and serum levels of hepatic amino-transferases. We observed a decrease of protein-thiols, GSH/GSSG ratio and nitrogen species associated to increased lipid peroxidation in the liver and striatum - but not in the cerebral cortex - of LEC rats, accompanied by dramatic increase in serum amino-transferases and decrease of striatal catecholamines. Conversely, SOD and caspase-3 activity increased consistently only in the cortex of LEC rats. Hence, we assume that enhanced oxidative stress may play a central role in the cell degeneration in WD, at the main sites of copper deposition, with discrete pro-apoptotic conditions developing in distal areas