Implementación de una estrategia just-in-time en la elaboración de productos de repostería, integrando el servicio al cliente y la gestión de procesos en sabores sorpresa S.A.S. apoyados en herramientas de tecnologías de la información.

This project has been developed in order to respond to a problem identified in the company Sabores Sorpresa S.AS., dedicated to the production and commercialization of pastry products, whose procedure for taking orders and planning production is carried out according to manual way in Excel and physical sheets. A system is not used that allows unifying these processes in the company, which causes delays and delays when providing a timely response to the external client. The aforementioned processes are vital in the operation of the company, as they have a significant impact on the satisfaction of the external client and once they allow a more organized and efficient work dynamic for the internal client. For this reason, it is necessary to analyze in detail the sales processes and production planning to identify the opportunities for improvement that will be addressed through the implementation of methodologies in agile design and innovation frameworks to build solutions that generate value both to clients and the company in a fast and flexible way, in a short time and allowing adjustments during its execution to maximize results. Consequently, the integration of these processes through the design of a tailored digital technological tool will facilitate the management of information in a reliable and timely manner to support the decision-making of the company. In addition, it innovates in the way in which the processes for taking orders and production planning are developed, optimizing the use of resources and reducing times taking into account the capabilities of the company. All this has made it possible to strengthen the culture in the management of innovation as a fundamental axis for the strategic planning of the organization. Through the different tools offered by methodologies in agile design and innovation frameworks, MSMEs such as Sabores Sorpresa S.A.S. They can develop low-cost innovation processes with high-impact results, recognizing the generation of value through business innovation.El presente proyecto se ha elaborado a fin de responder a una problemática identificada en la empresa Sabores Sorpresa S.AS., dedicada a la producción y comercialización de productos de pastelería, cuyo procedimiento para la toma de pedidos y planeación de la producción se realiza de manera manual en Excel y hojas físicas. No se utiliza un sistema que permita unificar estos procesos en la empresa, lo que ocasiona demoras y retrasos al momento de dar respuesta oportuna al cliente externo. Los procesos mencionados, son vitales en la operación de la empresa, pues tienen un impacto significativo en la satisfacción del cliente externo y a su vez permiten una dinámica de trabajo más organizado y eficiente para el cliente interno. Por esta razón, es preciso analizar detalladamente los procesos de venta y la planeación de la producción para lograr identificar las oportunidades de mejora que serán abordadas a través de la implementación de metodologías en marcos ágiles de diseño e innovación para construir soluciones que generen valor tanto a los clientes como a la empresa de una manera rápida y flexible, en corto tiempo y que permita realizar ajustes durante su ejecución para maximizar los resultados. En consecuencia, la integración de estos procesos por medio del diseño de una herramienta tecnológica digital a la medida facilitará el manejo de la información de forma confiable y oportuna para apoyar la toma de decisiones de la empresa. Además, se innova en la forma como se desarrollan los procesos para la toma de pedidos y la planificación de la producción, optimizando el uso de recursos y reducción de tiempos teniendo en cuenta las capacidades de la empresa. Todo esto ha permitido fortalecer la cultura en la gestión de la innovación como un eje fundamental para la planificación estratégica de la organización. A través de las distintas herramientas que ofrecen las metodologías en marcos ágiles de diseño e innovación, Las Mi Pymes como Sabores Sorpresa S.A.S. pueden desarrollar procesos de innovación de bajo costo con resultados de alto impacto reconociendo la generación de valor a través de la innovación empresarial

Analysis of Samples Cleaning Methods Prior to Hydrogen Content Determination in Steel

ABSTRACT: There are multiple references to sample cleaning methods prior to hydrogen content determination, or hydrogen spectroscopy analysis, but there is still no unified criteria; different authors use their own "know-how" to perform this task. The aim of this paper is to solve, or at least clarify, this issue. In this work, the most commonly used sample cleaning methods are compared. Then, five different methodologies are applied on certified hydrogen content calibration pins and on high strength steel concrete-prestressing strands and the three main situations regarding hydrogen content in the microstructural net (non-charged, charged, and charged and uncharged) are studied. It was concluded that the HCl solution C-3.5 cleaning method recommended by ASTM G1 introduces large amounts of hydrogen in the samples; but can be useful for eliminating superficial oxides if necessary. The rest of the methods had similar results; but the more complete ones that involve ultrasounds and last longer than 8 min are not appropriated when important diffusion may occur on the samples during their application. Simple methods that involve acetone or trichloroethylene and last around 1 min are preferable for almost all situations as these are faster, easier, and cheaper. As a final recommendation, as trichloroethylene is toxic, the simple acetone method is, in general, the most convenient one for regular hydrogen content analysis.This research was funded by the UNIVERSITY OF CANTABRIA by means of the “Proyectos Puente 2019” grant program. The APC was funded by papers reviews of the authors for MDPI

Chitosan-hydroxypropyl methylcellulose tioconazole films: A promising alternative dosage form for the treatment of vaginal candidiasis

Vaginal candidiasis is considered a frequent opportunistic mucosal infection and the second most common cause of vaginitis after bacterial vaginosis. In this work, different vaginal films based on chitosan, hydroxypropyl methylcellulose and blends of these polymers containing tioconazole, were developed and thoroughly characterized to improve the conventional therapeutics of vaginal candidiasis. Mechanical properties, swelling, adhesiveness, morphology, antifungal activity, hemocompatibility and cytotoxicity were evaluated. The drug solid state in the films was analyzed by thermal and X-ray diffraction analysis. Films showed homogeneous surfaces and presented similar mechanical properties and adhesiveness. Time-kill studies displayed that films were more active than both tioconazole pure drug and traditional tioconazole ovule against Candida albicans, which is probably related to the fact that tioconazole is in amorphous state inside the films. Although all formulations proved to be hemocompatible, films based only on chitosan exhibited a certain degree of cytotoxicity and therefore they should be avoided. The system based on chitosan-hydroxypropyl methylcellulose with 40% PEG 400 as plasticizer presented fast antimicrobial activity as well as the lowest swelling. Additionally, this formulation did not produce substantial hemolytic and cytotoxic effects, indicating that films based on chitosan-hydroxypropyl methylcellulose could be a promising alternative dosage form for the treatment of vaginal candidiasis.Fil: Calvo, Natalia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Svetaz, Laura Andrea. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; ArgentinaFil: Alvarez, Vera Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Quiroga, Ariel Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Lamas, Maria Celina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Leonardi, Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentin

N-Acetylcysteine Inhibits Lipids Production in Mature Adipocytes through the Inhibition of Peroxisome Proliferator-Activated Receptor

Aims: Reports regarding the effects of antioxidants in obesity have been contradictory. AntioxidantN-acetylcysteine is usually considered a nutritional supplement. Our aim is to evaluate bioactivity ofN-acetylcysteine (NAC) on mature adipocytes, which is a close model to in vivo condition.Study Design: In vitro study.Place and Duration of Study: Department of Basic Science (Universidad Nacional de Lujan),Department of Chemical Biology (Universidad de Buenos Aires), CONICET ? INEDES andCONICET ? IQUIBICEN, between March 2017 and June 2019.Methodology: We evaluated the bioactivity of different concentrations of NAC for 5 days (0.01 mMto 5 mM) on fully differentiated 3T3-L1 cells (mature adipocytes).Results: We demonstrated that NAC treatment was not toxic to mature adipocytes. Only 5mM NACinhibited reactive oxygen species production. 5 mM NAC treatment resulted in a 60% decrease incellular triglycerides content and inhibited 70% cholesterol accumulation. We also determined themRNA and protein expression levels of Peroxisome Proliferator-Activated Receptor as well as,mRNA levels of lipid protein Perilipin in NAC treated adipocytes; we observed that 5mM NACtreatment caused nearly 30% decrease in the expression of these parameters.Conclusion: These results suggest that NAC could avoid lipid accumulation in mature adipocytes;the antioxidant NAC could be beneficial in obesity treatment.Fil: Soto, Daniela. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Martini, Claudia Noemí. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Frontera, Evelyn Micaela. Universidad Nacional de Luján. Departamento de Ciencias Básicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Montaldo, Laura Andrea. Universidad Nacional de Luján. Departamento de Ciencias Básicas; ArgentinaFil: Vila, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Calvo, Juan Carlos. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Guerra, Liliana Noemi. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentin

Development and optimization of a new tioconazole vaginal mucoadhesive film using an experimental design strategy. Physicochemical and biological characterization

A new tioconazole (TCZ) mucoadhesive film, based on a biodegradable chitosan/ hydroxypropyl methylcellulose (CH/HPMC) blend, was developed for treatment of vaginal candidiasis. The formulation was optimized through an I-optimal design (minimizing the integral of the prediction variance across the factor space), where the impact of the proportion of the ingredients and processing variables on the quality of the final product was evaluated. Both, the thickness of the film and the swelling index, which affect patients’ comfort and compliance, were considered. Mechanical testing, such as load at break, elongation at break, and mucoadhesive strength were also included as dependent variables. The optimal mucoadhesive film formulation, which should be obtained at a drying temperature of 30 °C, was found to include the combination of CH and HPMC (forming polymers) at 0.25:0.75 ratio, a mixture of polyethylene glycol 400 and propylene glycol as plasticizers (0.07:0.93, 5% w/w), and TCZ loaded at 15 % w/w. The optimal preparation was subjected to exhaustive characterization studies, which revealed that the drug was entrapped in the polymeric matrix in an amorphous state and that the film exhibited a smooth and uniform surface, demonstrating excellent component compatibility. In vitro tests showed that the formulation has an excellent time to kill value (3 min) and lacks cytotoxicity, suggesting that it should be highly effective and safe.Fil: Calvo, Natalia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Tejada Jacob, Guillermo Ivan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Rosario; ArgentinaFil: Svetaz, Laura Andrea. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Quiroga, Ariel Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Alvarez, Vera Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Lamas, Maria Celina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Leonardi, Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina. Universidad Nacional de Rosario; Argentin

Voices and views : English language issues from different perspectives

The articles in this collection were produced within the framework of the MA program “Maestría en Inglés”, Facultad de Lenguas, Universidad Nacional de Córdoba, Argentina. They are based on selected MA theses and dissertations on Applied Linguistics and Literary Studies. The collection focuses on EFL teacher training, pronunciation assessment, academic writing, Critical Discourse Analysis and Literature

Application of the incremental step loading technique to Small Punch Tests on S420 steel in acid environments

ABSTRACT: The Small Punch test has been recently used to estimate mechanical properties of steels in aggressive environments. This technique, very interesting when there is shortage of material, consists in using a small plane specimen and punch it until it fails. The type of tests normally used are under a constant load in an aggressive environment, with the target to determine the threshold stress. However, this is an inaccurate technique which takes time, as the tests are quite slow. In this paper, the Small Punch tests are combined with the step loading technique collected in the standard ASTM F1624 [1] to obtain the value of threshold stress of an S420 steel in a total time of approximately one week. The ASTM F1624 indicates how to apply constant load steps in hydrogen embrittlement environments, increasing them subsequently and adapting their duration until the specimen fails. The environment is created by means of cathodic polarization of cylindrical tensile specimens in an acid electrolyte. A batch of standard tests are performed to validate the methodology.The present work was performed in the University of Cantabria, through the post-doctoral contracts program (budgetary application 62.0000.64251), and supported by the Government of Cantabria and the University of Cantabria in the framework of “Proyectos Puente 2019” call

La Dominica Potestas en Roma y su proyección actual.

El texto desarrollado está dividido en dos partes, la primera referida a la Dominica Potestas en Roma y la segunda etapa es atinente a la Dominica Potestas y su Proyección Actual, en la cual se exterioriza la abolición de la esclavitud en la Argentina y su ilicitud, a través de la trata de personas la cual se configura por diversas manifestaciones, producidas por hechos a nivel laboral, sexual, religiosos, extracción de órganos, entre otros.AbstractThe text is divided into two parts, the first referring to the Dominica potestas in Rome and the second stage is with regard to the Dominica potestas and its current projection, in which externalises the abolition of slavery in Argentina and its illegality, through trafficking of people, which is configured by various manifestations, produced by facts in the workplace, sexual, religious, removal of organs, among others.Key words: Slavery; Freedom; Abolish; Subjugation; Republic; Life; Death

In vitro effects of endosulfan-based insecticides on mammalian sperm

Endosulfan is an organochloride insecticide extensively used in several countries to protect crops from pests. As several studies indicate that endosulfan can affect human and animal development, the aim of this study was to analyse whether sperm parameters and the process of chromatin decondensation could be altered by endosulfan in mice sperm. Spermatozoa from cauda epididymis were obtained from mature male mice and incubated in the presence of two commercial formulations (CFs) of endosulfan (Master® and Zebra Ciagro®) or the active ingredient (AI) alone. A significant decrease in the percentage motility and viability of spermatozoa with respect to controls was found. In vitro decondensation was performed in the presence of glutathione and heparin. Spermatozoa incubated with the AI, endosulfan Master® and endosulfan Zebra Ciagro® showed an increase in chromatin decondensation. In addition, the TUNEL assay showed that DNA fragmentation was significantly higher when sperm were incubated with either one of the CFs when compared to the AI or controls. The ultrastructure analysis of sperm cells showed evident changes in the structure of the plasma and acrosome membranes of sperm incubated with endosulfan AI or the CFs. These results suggest that endosulfan can affect sperm integrity and in vitro chromatin decondensation as well as DNA fragmentation.Fil: Sánchez, M.C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Alvarez Sedó, C.. Centro de estudios en Genética y Reproducción; ArmeniaFil: Chaufan, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Enzimología, Estrés Oxidativo y Metabolismo; ArgentinaFil: Romanato, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Da Cuña, Rodrigo Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Ecotoxicología Acuática; ArgentinaFil: Lo Nostro, Fabiana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Ecotoxicología Acuática; ArgentinaFil: Calvo, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Quimica Biologica. Laboratorio de Química de Proteoglicanos y Matriz Extracelular; ArgentinaFil: Fontana, Vanina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Quimica Biologica. Laboratorio de Química de Proteoglicanos y Matriz Extracelular; Argentin