3,599 research outputs found

    Differential equation for four-point correlation function in Liouville field theory and elliptic four-point conformal blocks

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    Liouville field theory on a sphere is considered. We explicitly derive a differential equation for four-point correlation functions with one degenerate field V−mb2V_{-\frac{mb}{2}}. We introduce and study also a class of four-point conformal blocks which can be calculated exactly and represented by finite dimensional integrals of elliptic theta-functions for arbitrary intermediate dimension. We study also the bootstrap equations for these conformal blocks and derive integral representations for corresponding four-point correlation functions. A relation between the one-point correlation function of a primary field on a torus and a special four-point correlation function on a sphere is proposed

    Search for muon neutrinos from gamma-ray bursts with the ANTARES neutrino telescope using 2008 to 2011 data

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    Aims. We search for muon neutrinos in coincidence with GRBs with the ANTARES neutrino detector using data from the end of 2007 to 2011. Methods. Expected neutrino fluxes were calculated for each burst individually. The most recent numerical calculations of the spectra using the NeuCosmA code were employed, which include Monte Carlo simulations of the full underlying photohadronic interaction processes. The discovery probability for a selection of 296 GRBs in the given period was optimised using an extended maximum-likelihood strategy. Results. No significant excess over background is found in the data, and 90% confidence level upper limits are placed on the total expected flux according to the modelPostprint (published version

    Oceans of plenty? Challenges, advancements, and future directions for the provision of evidence-based fisheries management advice

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    Marine population modeling, which underpins the scientific advice to support fisheries interventions, is an active research field with recent advancements to address modern challenges (e.g., climate change) and enduring issues (e.g., data limitations). Based on discussions during the ‘Land of Plenty’ session at the 2021 World Fisheries Congress, we synthesize current challenges, recent advances, and interdisciplinary developments in biological fisheries models (i.e., data-limited, stock assessment, spatial, ecosystem, and climate), management strategy evaluation, and the scientific advice that bridges the science-policy interface. Our review demonstrates that proliferation of interdisciplinary research teams and enhanced data collection protocols have enabled increased integration of spatiotemporal, ecosystem, and socioeconomic dimensions in many fisheries models. However, not all management systems have the resources to implement model-based advice, while protocols for sharing confidential data are lacking and impeding research advances. We recommend that management and modeling frameworks continue to adopt participatory co-management approaches that emphasize wider inclusion of local knowledge and stakeholder input to fill knowledge gaps and promote information sharing. Moreover, fisheries management, by which we mean the end-to-end process of data collection, scientific analysis, and implementation of evidence-informed management actions, must integrate improved communication, engagement, and capacity building, while incorporating feedback loops at each stage. Increasing application of management strategy evaluation is viewed as a critical unifying component, which will bridge fisheries modeling disciplines, aid management decision-making, and better incorporate the array of stakeholders, thereby leading to a more proactive, pragmatic, transparent, and inclusive management framework–ensuring better informed decisions in an uncertain world

    Semantic-Aware Environment Perception for Mobile Human-Robot Interaction

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    Current technological advances open up new opportunities for bringing human-machine interaction to a new level of human-centered cooperation. In this context, a key issue is the semantic understanding of the environment in order to enable mobile robots more complex interactions and a facilitated communication with humans. Prerequisites are the vision-based registration of semantic objects and humans, where the latter are further analyzed for potential interaction partners. Despite significant research achievements, the reliable and fast registration of semantic information still remains a challenging task for mobile robots in real-world scenarios. In this paper, we present a vision-based system for mobile assistive robots to enable a semantic-aware environment perception without additional a-priori knowledge. We deploy our system on a mobile humanoid robot that enables us to test our methods in real-world applications.Comment: ISPA 201

    PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice

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    While Epstein-Barr virus (EBV) establishes a life-long latent infection in apparently healthy human immunocompetent hosts, immunodeficient individuals are at particular risk to develop lymphoproliferative B-cell malignancies caused by EBV. A key EBV protein is the transcription factor EBV nuclear antigen 2 (EBNA2), which initiates B-cell proliferation. Here, we combine biochemical, cellular, and in vivo experiments demonstrating that the mitotic polo-like kinase 1 (PLK1) binds to EBNA2, phosphorylates its transactivation domain, and thereby inhibits its biological activity. EBNA2 mutants that impair PLK1 binding or prevent EBNA2 phosphorylation are gain-of-function mutants. They exhibit enhanced transactivation capacities, accelerate the proliferation of infected B cells, and promote the development of monoclonal B-cell lymphomas in infected mice. Thus, PLK1 coordinates the activity of EBNA2 to attenuate the risk of tumor incidences in favor of the establishment of latency in the infected but healthy host
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