819 research outputs found
Tunneling transition to the Pomeron regime
We point out that, in some models of small-x hard processes, the transition
to the Pomeron regime occurs through a sudden tunneling effect, rather than a
slow diffusion process. We explain the basis for such a feature and we
illustrate it for the BFKL equation with running coupling by gluon rapidity
versus scale correlation plots.Comment: 17 pages, 5 figures, mpeg animations available from
http://www.lpthe.jussieu.fr/~salam/tunneling/ . v2 includes additional
reference
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Influence of volcanic eruptions on midlatitude upper tropospheric aerosol and consequences for cirrus clouds
The influence of downwelling stratospheric sulfurous aerosol on the UT (upper troposphere) aerosol concentrations and on cirrus clouds is investigated using CARIBIC (Civil Aircraft for Regular Investigation of the Atmosphere Based on an Instrument Container observations) (between 1999â2002 and 2005â2013) and the cirrus reflectance product from Moderate Resolution Imaging Spectroradiometer (MODIS). The initial period, 1999â2002, was volcanically quiescent after which the sulfurous aerosol in the LMS (lowermost stratosphere) (SLMS) became enhanced by several volcanic eruptions starting 2005. From 2005 to 2008 and in 2013, volcanic aerosol from several tropical eruptions increased SLMS. Due to consequent subsidence, the sulfur loading of the upper troposphere (SUT) was increased by a factor of 2.5 compared to background levels. Comparison of SLMS and SUT during the seasons MarchâJuly and AugustâNovember shows a close coupling of the UT and LMS. Finally, the relationship between SLMS and the cirrus cloud reflectance (CR) retrieved from MODIS spectrometer (on board the satellites Terra and Aqua) is studied. SLMS and CR show a strong anticorrelation, with a factor of 3.5 increase in SLMS and decrease of CR by 8â±â2% over the period 2001â2011. We propose that the increase of SLMS due to volcanism has caused the coinciding cirrus CR decrease, which would be associated with a negative radiative forcing in the Northern Hemisphere midlatitudes
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Significant radiative impact of volcanic aerosol in the lowermost stratosphere
Despite their potential to slow global warming, until recently, the radiative forcing associated with volcanic aerosols in the lowermost stratosphere (LMS) had not been considered. Here we study volcanic aerosol changes in the stratosphere using lidar measurements from the NASA CALIPSO satellite and aircraft measurements from the IAGOS-CARIBIC observatory. Between 2008 and 2012 volcanism frequently affected the Northern Hemisphere stratosphere aerosol loadings, whereas the Southern Hemisphere generally had loadings close to background conditions. We show that half of the global stratospheric aerosol optical depth following the Kasatochi, Sarychev and Nabro eruptions is attributable to LMS aerosol. On average, 30% of the global stratospheric aerosol optical depth originated in the LMS during the period 2008â2011. On the basis of the two independent, high-resolution measurement methods, we show that the LMS makes an important contribution to the overall volcanic forcing
Local well-posedness for membranes in the light cone gauge
In this paper we consider the classical initial value problem for the bosonic
membrane in light cone gauge. A Hamiltonian reduction gives a system with one
constraint, the area preserving constraint. The Hamiltonian evolution equations
corresponding to this system, however, fail to be hyperbolic. Making use of the
area preserving constraint, an equivalent system of evolution equations is
found, which is hyperbolic and has a well-posed initial value problem. We are
thus able to solve the initial value problem for the Hamiltonian evolution
equations by means of this equivalent system. We furthermore obtain a blowup
criterion for the membrane evolution equations, and show, making use of the
constraint, that one may achieve improved regularity estimates.Comment: 29 page
Relativistic Heavy--Ion Collisions in the Dynamical String--Parton Model
We develop and extend the dynamical string parton model. This model, which is
based on the salient features of QCD, uses classical Nambu-Got\=o strings with
the endpoints identified as partons, an invariant string breaking model of the
hadronization process, and interactions described as quark-quark interactions.
In this work, the original model is extended to include a phenomenological
quantization of the mass of the strings, an analytical technique for treating
the incident nucleons as a distribution of string configurations determined by
the experimentally measured structure function, the inclusion of the gluonic
content of the nucleon through the introduction of purely gluonic strings, and
the use of a hard parton-parton interaction taken from perturbative QCD
combined with a phenomenological soft interaction. The limited number of
parameters in the model are adjusted to and -- data. Utilizing
these parameters, the first calculations of the model for -- and
-- collisions are presented and found to be in reasonable agreement with
a broad set of data.Comment: 26 pages of text with 23 Postscript figures placed in tex
Connecting Numerical Relativity and Data Analysis of Gravitational Wave Detectors
Gravitational waves deliver information in exquisite detail about
astrophysical phenomena, among them the collision of two black holes, a system
completely invisible to the eyes of electromagnetic telescopes. Models that
predict gravitational wave signals from likely sources are crucial for the
success of this endeavor. Modeling binary black hole sources of gravitational
radiation requires solving the Eintein equations of General Relativity using
powerful computer hardware and sophisticated numerical algorithms. This
proceeding presents where we are in understanding ground-based gravitational
waves resulting from the merger of black holes and the implications of these
sources for the advent of gravitational-wave astronomy.Comment: Appeared in the Proceedings of 2014 Sant Cugat Forum on Astrophysics.
Astrophysics and Space Science Proceedings, ed. C.Sopuerta (Berlin:
Springer-Verlag
Considerations in the preclinical assessment of the safety of antisense oligonucleotides
The nucleic acid therapeutics field has made tremendous progress in the past decades. Continuous advances in chemistry and design have led to many successful clinical applications, eliciting even more interest from researchers including both academic groups and drug development companies. Many preclinical studies in the field focus on improving the delivery of antisense oligonucleotide drugs (ONDs) and/or assessing their efficacy in target tissues, often neglecting the evaluation of toxicity, at least in early phases of development. A series of consensus recommendations regarding regulatory considerations and expectations have been generated by the Oligonucleotide Safety Working Group and the Japanese Research Working Group for the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use S6 and Related Issues (WGS6) in several white papers. However, safety aspects should also be kept in sight in earlier phases while screening and designing OND to avoid subsequent failure in the development phase. Experts and members of the network "DARTER," a COST Action funded by the Cooperation in Science and Technology of the EU, have utilized their collective experience working with OND, as well as their insights into OND-mediated toxicities, to generate a series of consensus recommendations to assess OND toxicity in early stages of preclinical research. In the past few years, several publications have described predictive assays, which can be used to assess OND-mediated toxicity in vitro or ex vivo to filter out potential toxic candidates before moving to in vivo phases of preclinical development, that is, animal toxicity studies. These assays also have the potential to provide translational insight since they allow a safety evaluation in human in vitro systems. Yet, small preliminary in vivo studies should also be considered to complement this early assessment. In this study, we summarize the state of the art and provide guidelines and recommendations on the different tests available for these early stage preclinical assessments.Functional Genomics of Muscle, Nerve and Brain Disorder
Measuring Black Hole Spin using X-ray Reflection Spectroscopy
I review the current status of X-ray reflection (a.k.a. broad iron line)
based black hole spin measurements. This is a powerful technique that allows us
to measure robust black hole spins across the mass range, from the stellar-mass
black holes in X-ray binaries to the supermassive black holes in active
galactic nuclei. After describing the basic assumptions of this approach, I lay
out the detailed methodology focusing on "best practices" that have been found
necessary to obtain robust results. Reflecting my own biases, this review is
slanted towards a discussion of supermassive black hole (SMBH) spin in active
galactic nuclei (AGN). Pulling together all of the available XMM-Newton and
Suzaku results from the literature that satisfy objective quality control
criteria, it is clear that a large fraction of SMBHs are rapidly-spinning,
although there are tentative hints of a more slowly spinning population at high
(M>5*10^7Msun) and low (M<2*10^6Msun) mass. I also engage in a brief review of
the spins of stellar-mass black holes in X-ray binaries. In general,
reflection-based and continuum-fitting based spin measures are in agreement,
although there remain two objects (GROJ1655-40 and 4U1543-475) for which that
is not true. I end this review by discussing the exciting frontier of
relativistic reverberation, particularly the discovery of broad iron line
reverberation in XMM-Newton data for the Seyfert galaxies NGC4151, NGC7314 and
MCG-5-23-16. As well as confirming the basic paradigm of relativistic disk
reflection, this detection of reverberation demonstrates that future large-area
X-ray observatories such as LOFT will make tremendous progress in studies of
strong gravity using relativistic reverberation in AGN.Comment: 19 pages. To appear in proceedings of the ISSI-Bern workshop on "The
Physics of Accretion onto Black Holes" (8-12 Oct 2012). Revised version adds
a missing source to Table 1 and Fig.6 (IRAS13224-3809) and corrects the
referencing of the discovery of soft lags in 1H0707-495 (which were in fact
first reported in Fabian et al. 2009
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