Whiplash associated disorders: a comprehensive review

This report is a compendium of papers on aspects of whiplash associated disorders (WAD). The aim of the report is to provide an overview of WAD from different perspectives: epidemiological, engineering, biomechanical, biopsychosocial, and treatment. Two recent studies on WAD in South Australia are also reported. The findings from studies published up until August 2005 are included in this report. Whiplash associated disorders are a complex phenomenon, triggered by a mechanical event but whose prognosis is affected by many factors including clinical and psychosocial factors. A thorough understanding of these factors provides a basis for dealing with the prevalence of WAD in the community and reducing the incidence of WAD.R.W.G. Andersonhttp://casr.adelaide.edu.au/publications/researchreports

Using crash information to improve the treatment of crash injuries

This report examines whether there is evidence for the proposition that knowledge of the nature of a road crash aids in the treatment of injuries that arise from the crash. We reviewed published reports in which the utility of crash reports for triage was examined. We also reviewed the evidence in relation to chronic injury and whiplash injury in particular. There is some evidence that crash reports and information about the crash can assist in triage decisions and, in one study, steering wheel deformation was a good predictor of abdominal injury (which is hard to diagnose in some cases). There was very little direct evidence in relation to the treatment of chronic injury, but indirect evidence suggests that crash parameters that can be established, such as the change in velocity, are a poor predictor of chronic complaints. Any perceived benefit of crash reports in the treatment of chronic symptoms may arise as a result of their use in counselling the patient.S.L. Versteegh and R.W.G. Andersonhttp://casr.adelaide.edu.au/publications/researchreports

A study on the biomechanics of axonal injury

The current focus of research efforts in the area of the biomechanics of traumatic brain injury is the development of numerical (finite element) models of the human head. A validated numerical model of the human head may lead to better head injury criteria than those used currently in crashworthiness studies. A critical step in constructing a validated finite element model of the head is determining the mechanical threshold, should it exist, for various types of injury to brain tissue. This thesis describes a biomechanical study of axonal injury in the anaesthetised sheep. The study used the measurements of the mechanics of an impact to the living sheep, and a finite element model of the sheep skull and brain, to investigate the mechanics of the resulting axonal injury. Sheep were subjected to an impact to the left lateral region of the skull and were allowed to survive for four hours after the impact. The experiments were designed specifically with the numerical model in mind; sufficient data were collected to allow the mechanics of the impact to be faithfully reproduced in the numerical model. The axonal injury was identified using immunohistological methods and the injury was mapped and quantified. Axonal injury was produced consistently in all animals. Commonly injured regions included the sub-cortical and deep white matter, the hippocampi and the margins of the lateral ventricles. The degree of injury was closely related to the peak impact force and to kinematic measurements, particularly the peak change in linear and angular velocity. There was significantly more injury in animals receiving fractures. A three-dimensional finite element model of the sheep skull and brain was constructed to simulate the dynamics of the brain during the impact. The model was used to investigate different regimes of material properties and boundary conditions, in an effort to produce a realistic model of the skull and brain. Model validation was attempted by comparing pressure measurements in the experiment with those calculated by the model. The distribution of axonal injury was then compared with the output of the finite element model. The finite element model was able to account for approximately thirty per cent of the variation in the distribution and extent of axonal injury, using von Mises stress as the predictive variable. Logistic regression techniques were used to construct sets of curves which related the extent of injury, to the predictions of the finite element model, on a regional basis. The amount of observable axonal injury in the brains of the sheep was clearly related to the severity of the impact, and was related to the predictions of a finite element model of the impact. Future improvements to the fidelity of the finite element model may improve the degree to which the model can explain the variation in injury throughout the brain of the animal and variations between animals. This thesis presents results, and a methodological framework, that may be used to further our understanding of the limits of human endurance, in the tolerance of the brain to head impact. All experiments reported herein conformed with the Australian Code of Practice for the Care and Use of Animals for Scientific Purposes.Thesis (Ph.D.)--Mechanical Engineering, 2000

A survey of drivers' child restraint choice and knowledge in South Australia

This study investigated the frequency of child restraint choices in a sample consisting of 357 drivers in the Adelaide metropolitan area, who were transporting to school 586 children aged up to 10 years. The main survey result was that the rate of appropriate restraint was between 64% and 72% on such trips, (according to weight criteria in the Australian and New Zealand Standard on child restraints for motor vehicles). Only 1% are completely unrestrained. Most of those who were not restrained appropriately had prematurely progressed to an adult seatbelt. Appropriate child restraint use is lowest for children in the age range 5 - <7. Inappropriate restraint choice is strongly related to the child’s age, their seating location (children seated in the rear being more likely to be restrained appropriately), and possibly the child’s entry into primary school. Female drivers were more likely than male drivers to know what restraints were suitable for children in their carriage. However, it did not appear to be the case than good knowledge of child restraints is predictive of appropriate restraint use. Barriers to booster seat use included the child’s attitudes to using a booster seat. This effect may be lessened if the child’s age were able to used to guide restraint selection, as peer cues (for child and parent) would be more consistent. Drivers almost never mentioned cost as a barrier to child restraint use. Encouraging parents to become better informed may also help, but recommendations should be reviewed. Further developemnt of the Australian and New Zealand Standard for child restraints may enable age to be used as a criterion, thus simplifying advice to parents.S.A. Edwards, R.W.G. Anderson and T.P. Hutchinsonhttp://casr.adelaide.edu.au/publications/researchreports

Trends in traffic casualties in South Australia, 1981-2003

There has been a reduction in traffic fatalities in South Australia between 1981 and 2003, but this has not been accompanied by a fall in the total number of traffic casualties, and even the number of fatalities has declined very little since about 1992. This report throws light on these and related observations. The main data source is TARS, the database of crashes reported to the police; in addition, some use is made of statistics of death registration and of casualties hospitalised. Among the findings are the following. (a) Although the number of fatalities has not fallen much since about 1992, this has been a result of a continued decline in fatality rate and an increase in vehicle kilometres. (b) The increase in total casualties over the period 1992-2000 was largely confined to the minor categories of injury. (c) An increase in minor rear-end crashes was part of this, but not all of it. (d) In the metropolitan area of Adelaide, hospital-admitted casualties have been falling faster than fatalities over the period 1981-2003. (The evidence is less clear for country areas.) (e) There are numerous other features of the data that are not fully understood. In some cases, a more elaborate tabulation of subcategory numbers might resolve the issue, but in other cases, it is difficult to imagine doing so with mass accident data.T.P. Hutchinson, R.W.G Anderson, A.J. McLean and C.N. Kloede

South Australian primary schools bicycle helmet usage survey

This was a school-based survey that was conducted to assess bicycle helmet compliance rates amongst South Australian primary school students riding to school. 32% of South Australian primary schools chose to participate in the survey. The total number of students surveyed in the participating schools accounted for approximately 42% of all primary school children. It was estimated that 4% of primary school children ride their bicycle to school. Of the students riding a bicycle to school, 92% wore a helmet. The highest rate of helmet-compliance was reported in Catholic and independent primary schools (100%). Geographically, the lowest rate was reported in the metropolitan Adelaide region (89%).H Thomas, R.L. Somers and R.W.G. Anderso

Performance of bull bars in pedestrian impact tests

Thirteen bull bars and the five models of vehicle were tested to measure their performance in pedestrian impact tests. Three tests were used in the assessment: two tests using an impactor representing the upper leg of an adult pedestrian, and a test with an impactor representing the head of a child. The headform impact and one of the upper legform impacts were with the top rail of the bull bar, and the second upper legform impact was with the bumper section of the bull bar. Equivalent locations on the vehicle that the bull bars were attached to were also tested. The tests were conducted at 30 km/h. Two rating systems were developed to summarise the results. The first rates the performance of the bull bars and the fronts of the vehicles according to the New Car Assessment Program consumer rating system used in Europe and Australia. The second system rates the performance of the bull bars relative to the front of the vehicle to which they are attached. Overall, steel bull bars are significantly more hazardous for a pedestrian in the event of a collision than the front of the vehicle, as are the aluminium/alloy bull bars, but to a lesser extent than the steel bull bars. Overall, the polymer bull bars slightly improve the safety of the front of the vehicle.. This study demonstrates the practicability of reporting the performance of bull bars in pedestrian impact tests. The system developed herein could form the basis of a consumer-oriented bull bar testing program.R.W.G. Anderson, A.L. van den Berg, G. Ponte, L.D. Streeter and A.J. McLeanhttp://casr.adelaide.edu.au/publications/researchreports

UBVRIz Light Curves of 51 Type II Supernovae

We present a compilation of UBV RIz light curves of 51 type II supernovae discovered during the course of four different surveys during 1986 to 2003: the Cerro Tololo Supernova Survey, the Calan/Tololo Supernova Program (C&T), the Supernova Optical and Infrared Survey (SOIRS), and the Carnegie Type II Supernova Survey (CATS). The photometry is based on template-subtracted images to eliminate any potential host galaxy light contamination, and calibrated from foreground stars. This work presents these photometric data, studies the color evolution using different bands, and explores the relation between the magnitude at maximum brightness and the brightness decline parameter (s) from maximum light through the end of the recombination phase. This parameter is found to be shallower for redder bands and appears to have the best correlation in the B band. In addition, it also correlates with the plateau duration, being thus shorter (longer) for larger (smaller) s values.Comment: 110 pages, 9 Figures, 6 Tables, accepted in A

Different paths to the modern state in Europe: the interaction between domestic political economy and interstate competition

Theoretical work on state formation and capacity has focused mostly on early modern Europe and on the experience of western European states during this period. While a number of European states monopolized domestic tax collection and achieved gains in state capacity during the early modern era, for others revenues stagnated or even declined, and these variations motivated alternative hypotheses for determinants of fiscal and state capacity. In this study we test the basic hypotheses in the existing literature making use of the large date set we have compiled for all of the leading states across the continent. We find strong empirical support for two prevailing threads in the literature, arguing respectively that interstate wars and changes in economic structure towards an urbanized economy had positive fiscal impact. Regarding the main point of contention in the theoretical literature, whether it was representative or authoritarian political regimes that facilitated the gains in fiscal capacity, we do not find conclusive evidence that one performed better than the other. Instead, the empirical evidence we have gathered lends supports to the hypothesis that when under pressure of war, the fiscal performance of representative regimes was better in the more urbanized-commercial economies and the fiscal performance of authoritarian regimes was better in rural-agrarian economie

The Pediatric Cell Atlas:Defining the Growth Phase of Human Development at Single-Cell Resolution

Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan