The Arches Cluster: Extended Structure and Tidal Radius

At a projected distance of ~26 pc from Sgr A*, the Arches cluster provides insight to star formation in the extreme Galactic Center (GC) environment. Despite its importance, many key properties such as the cluster's internal structure and orbital history are not well known. We present an astrometric and photometric study of the outer region of the Arches cluster (R > 6.25") using HST WFC3IR. Using proper motions we calculate membership probabilities for stars down to F153M = 20 mag (~2.5 M_sun) over a 120" x 120" field of view, an area 144 times larger than previous astrometric studies of the cluster. We construct the radial profile of the Arches to a radius of 75" (~3 pc at 8 kpc), which can be well described by a single power law. From this profile we place a 3-sigma lower limit of 2.8 pc on the observed tidal radius, which is larger than the predicted tidal radius (1 - 2.5 pc). Evidence of mass segregation is observed throughout the cluster and no tidal tail structures are apparent along the orbital path. The absence of breaks in the profile suggests that the Arches has not likely experienced its closest approach to the GC between ~0.2 - 1 Myr ago. If accurate, this constraint indicates that the cluster is on a prograde orbit and is located front of the sky plane that intersects Sgr A*. However, further simulations of clusters in the GC potential are required to interpret the observed profile with more confidence.Comment: 24 pages (17-page main text, 7-page appendix), 24 figures, accepted to Ap

Effects of Speed of Visual Processing Training upon Non-Visual Attention in "At-Risk" Older Drivers

Reduction in a measure known as the Useful Field of View (UFOV) is a risk factor for car crash involvement in older drivers (Owsley et al, 1991; Ball et al, 1993). This measure depends on aspects of visual attention (divided attention [DA], selective attention [SA]) and speed of processing (Owsley et al, 1991; Ball et al., 1993). UFOV scores can be improved through speed of processing training (Ball, Beard, et al., 1988a,b), and this improvement may transfer to enhanced driving performance (Roenker et al, submitted). This preliminary analysis addresses the hypothesis that training of visual speed of processing can improve performance in attentiondemanding tasks that are processed outside the visual domain

Automobile Driving with Severe Amnesia

Automobile Driving with Severe Amnesi

Effects of Speed of Visual Processing Training upon Non-Visual Attention in At-Risk Older Drivers

Reduction in a measure known as the Useful Field of View (UFOV) is a risk factor for car crash involvement in older drivers (Owsley et al, 1991; Ball et al, 1993). This measure depends on aspects of visual attention (divided attention [DA], selective attention [SA]) and speed of processing (Owsley et al, 1991; Ball et al., 1993). UFOV scores can be improved through speed of processing training (Ball, Beard, et al., 1988a,b), and this improvement may transfer to enhanced driving performance (Roenker et al, submitted). This preliminary analysis addresses the hypothesis that training of visual speed of processing can improve performance in attentiondemanding tasks that are processed outside the visual domain

Partitioned Bayesian Analyses, Partition Choice, and the Phylogenetic Relationships of Scincid Lizards

Partitioned Bayesian analyses of ∼ 2.2 kb of nucleotide sequence data (mtDNA) were used to elucidate phylogenetic relationships among 30 scincid lizard genera. Few partitioned Bayesian analyses exist in the literature, resulting in a lack of methods to determine the appropriate number of and identity of partitions. Thus, a criterion, based on the Bayes factor, for selecting among competing partitioning strategies is proposed and tested. Improvements in both mean-lnL and estimated posterior probabilities were observed when specific models and parameter estimates were assumed for partitions of the total data set. This result is expected given that the 95% credible intervals of model parameter estimates for numerous partitions do not overlap and it reveals that different data partitions may evolve quite differently. We further demonstrate that how one partitions the data (by gene, codon position, etc.) is shown to be a greater concern than simply the overall number of partitions. Using the criterion of the 2ln Bayes factor > 10, the phylogenetic analysis employing the largest number of partitions was decisively better than all other strategies. Strategies that partitioned the ND1 gene by codon position performed better than other partition strategies, regardless of the overall number of partitions. Scincidae, Acontinae, Lygosominae, east Asian and North American "Eumeces” + Neoseps; North African Eumeces, Scincus, and Scincopus, and a large group primarily from sub-Saharan Africa, Madagascar, and neighboring islands are monophyletic. Feylinia, a limbless group of previously uncertain relationships, is nested within a "scincine” clade from sub-Saharan Africa. We reject the hypothesis that the nearly limbless dibamids are derived from within the Scincidae, but cannot reject the hypothesis that they represent the sister taxon to skinks. Amphiglossus, Chalcides, the acontines Acontias and Typhlosaurus, and Scincinae are paraphyletic. The globally widespread "Eumeces” is polyphyletic and we make necessary taxonomic change

Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice.

IntroductionPrevious studies in animal models of osteoarthritis suggest that alendronate (ALN) has antiresorptive and chondroprotective effects, and can reduce osteophyte formation. However, these studies used non-physiologic injury methods, and did not investigate early time points during which bone is rapidly remodeled prior to cartilage degeneration. The current study utilized a non-invasive model of knee injury in mice to investigate the effect of ALN treatment on subchondral bone changes, articular cartilage degeneration, and osteophyte formation following injury.MethodsNon-invasive knee injury via tibial compression overload or sham injury was performed on a total of 90 mice. Mice were treated with twice weekly subcutaneous injections of low-dose ALN (40 μg/kg/dose), high-dose ALN (1,000 μg/kg/dose), or vehicle, starting immediately after injury until sacrifice at 7, 14 or 56 days. Trabecular bone of the femoral epiphysis, subchondral cortical bone, and osteophyte volume were quantified using micro-computed tomography (μCT). Whole-joint histology was performed at all time points to analyze articular cartilage and joint degeneration. Blood was collected at sacrifice, and serum was analyzed for biomarkers of bone formation and resorption.ResultsμCT analysis revealed significant loss of trabecular bone from the femoral epiphysis 7 and 14 days post-injury, which was effectively prevented by high-dose ALN treatment. High-dose ALN treatment was also able to reduce subchondral bone thickening 56 days post-injury, and was able to partially preserve articular cartilage 14 days post-injury. However, ALN treatment was not able to reduce osteophyte formation at 56 days post-injury, nor was it able to prevent articular cartilage and joint degeneration at this time point. Analysis of serum biomarkers revealed an increase in bone resorption at 7 and 14 days post-injury, with no change in bone formation at any time points.ConclusionsHigh-dose ALN treatment was able to prevent early trabecular bone loss and cartilage degeneration following non-invasive knee injury, but was not able to mitigate long-term joint degeneration. These data contribute to understanding the effect of bisphosphonates on the development of osteoarthritis, and may support the use of anti-resorptive drugs to prevent joint degeneration following injury, although further investigation is warranted

The Quintuplet Cluster: Extended Structure and Tidal Radius

The Quintuplet star cluster is one of only three known young ($<10$ Myr) massive (M $>10^4$ M$_\odot$) clusters within $\sim100$ pc of the Galactic Center. In order to explore star cluster formation and evolution in this extreme environment, we analyze the Quintuplet's dynamical structure. Using the HST WFC3-IR instrument, we take astrometric and photometric observations of the Quintuplet covering a $120''\times120''$ field-of-view, which is $19$ times larger than those of previous proper motion studies of the Quintuplet. We generate a catalog of the Quintuplet region with multi-band, near-infrared photometry, proper motions, and cluster membership probabilities for $10,543$ stars. We present the radial density profile of $715$ candidate Quintuplet cluster members with $M\gtrsim4.7$ M$_\odot$ out to $3.2$ pc from the cluster center. A $3\sigma$ lower limit of $3$ pc is placed on the tidal radius, indicating the lack of a tidal truncation within this radius range. Only weak evidence for mass segregation is found, in contrast to the strong mass segregation found in the Arches cluster, a second and slightly younger massive cluster near the Galactic Center. It is possible that tidal stripping hampers a mass segregation signature, though we find no evidence of spatial asymmetry. Assuming that the Arches and Quintuplet formed with comparable extent, our measurement of the Quintuplet's comparatively large core radius of $0.62^{+0.10}_{-0.10}$ pc provides strong empirical evidence that young massive clusters in the Galactic Center dissolve on a several Myr timescale.Comment: 25 pages (21-page main text, 4-page appendix), 18 figures, submitted to Ap

Fractionalization and confinement in the U(1) and Z2Z_2 gauge theories of strongly correlated systems

Recently, we have elucidated the physics of electron fractionalization in strongly interacting electron systems using a $Z_2$ gauge theory formulation. Here we discuss the connection with the earlier U(1) gauge theory approaches based on the slave boson mean field theory. In particular, we identify the relationship between the holons and Spinons of the slave-boson theory and the true physical excitations of the fractionalized phases that are readily described in the $Z_2$ approach.Comment: 4 page