An Investment and Equality-Led Sustainable Development Strategy for Europe

Austerity policies coupled with rising inequality in Europe have resulted in a prolonged stagnation and a vicious circle of chronically low demand, slow down in investment and productivity, and economic, social and political instability. In order to end this vicious cycle, Europe needs directed public investment policies accompanied by industrial policy, higher equality, stimulated demand, and regulation of finance and corporate governance. Our research presents strong empirical evidence that expansionary fiscal policy is sustainable when wage and public investment policies are combined with progressive tax policy; the impact is stronger when these policies are implemented in a coordinated fashion across Europe due to strong positive spill over effects on demand. A strong investment performance also requires a process of de-financialization of the economy and a new approach to corporate governance

The Effect of Pupil Size on Stimulation of the Melanopsin Containing Retinal Ganglion Cells, as Evaluated by Monochromatic Pupillometry

Purpose: To evaluate the influence of the size of the light exposed pupil in one eye on the pupillary light reflex of the other eye. Method: Using a monochromatic pupillometer, the left eye in each of 10 healthy subjects was exposed to 20 s of monochromatic light of luminance 300 cd/m2, first red (660 nm) and in a following session, blue (470 nm) light. The consensual pupillary diameter in the right eye was continuously measured before, during, and after light exposure. Subsequently, Tropicamide 1% or Pilocarpine 2% was instilled into the left eye and when the pupil was either maximally dilated or contracted, the entire sequence of red and blue light exposure repeated. After at least 3 days, when the effect of the eye drop had subsided, the entire experiment was repeated, this time employing the other substance. Results: Prior dilatation of the left pupil augmented the post light contraction to blue (p < 0.0001), but not to red light. The contraction during light exposure did not change. Prior contraction of the left pupil decreased the post-stimulus contraction to blue light (p < 0.04). Conclusion: The size of the light exposed pupil influences the magnitude of the response to blue, but not to red light. Prior dilatation may therefore prove useful, when the response to blue light – as a marker of melanopsin containing retinal ganglion cell function – is of interest, especially when this response is weak

Comparative Genomics Reveals Key Gain-of-Function Events in Foxp3 during Regulatory T Cell Evolution

The immune system has the ability to suppress undesirable responses, such as those against commensal bacteria, food, and paternal antigens in placenta pregnancy. The lineage-specific transcription factor Foxp3 orchestrates the development and function of regulatory T cells underlying this immunological tolerance. Despite the crucial role of Foxp3 in supporting immune homeostasis, little is known about its origin, evolution, and species conservation. We explore these questions using comparative genomics, structural modeling, and functional analyses. Our data reveal that key gain-of-function events occurred during the evolution of Foxp3 in higher vertebrates. We identify key conserved residues in its forkhead domain and show a detailed analysis of the N-terminal region of Foxp3, which is only conserved in mammals. These components are under purifying selection, and our mutational analyses demonstrate that they are essential for Foxp3 function. Our study points to critical functional adaptations in immune tolerance among higher vertebrates, and suggests that Foxp3-mediated transcriptional mechanisms emerged during mammalian evolution as a stepwise gain of functional domains that enabled Foxp3 to interact with a multitude of interaction partners

Reappraising the Spite Lithium Plateau: Extremely Thin and Marginally Consistent with WMAP

The lithium abundance in 62 halo dwarfs is determined from accurate equivalent widths reported in the literature and an improved infrared flux method (IRFM) temperature scale. The Li abundance of 41 plateau stars (those with Teff > 6000 K) is found to be independent of temperature and metallicity, with a star-to-star scatter of only 0.06 dex over a broad range of temperatures (6000 K < Teff < 6800 K) and metallicities (-3.4 < [Fe/H] < -1), thus imposing stringent constraints on depletion by mixing and production by Galactic chemical evolution. We find a mean Li plateau abundance of A(Li) = 2.37 dex (7Li/H = 2.34 X 10^{-10}), which, considering errors of the order of 0.1 dex in the absolute abundance scale, is just in borderline agreement with the constraints imposed by the theory of primordial nucleosynthesis and WMAP data (2.51 < A(Li)[WMAP] < 2.66 dex).Comment: ApJ Letters, in pres