The creation of a new literary experience to the digital world.

Este trabalho foi inteiramente produzido em ambiente acadêmico, tendo como objetivo ser um exercício didático e de Conclusão de Curso, deste modo seu intuito não é voltado à comercialização.The creation of the work was based on experimentation, strictly saying, the odd. Based on the assimilated premises, such as the demands of the target audience, another narrative was constructed based on the layout and also with the content of the story of Deborah Ellis, which guided the design decisions. The approach taken from the concepts of Artist’s Book, Randomly Produces Design and Emotional Design, seeks to build an eBook that stimulates creativity, critical thinking and the search for knowledge beyond what they are used to read.Pesquisa sem auxílio de agências de fomentoTrabalho de Conclusão de Curso (Graduação)A criação do trabalho baseou-se na experimentação, mais propriamente dito, o acaso. A partir das premissas assimiladas, como as demandas do público alvo, foi feita a construção de uma outra narrativa a partir da diagramação e também com o próprio conteúdo da história de Deborah Ellis, que norteou as decisões projetuais. A abordagem feita a partir dos conceitos de Livro de Artista, Design do Acaso e Design Emocional, compõe a tentativa da construção de um eBook que estimula em jovens leitores à criatividade, o senso crítico e à busca pelo conhecimento além do que estão acostumados a ler

Psicopedagogy in literacy of children with learning difficulties

The main purpose of this article is to investigate learning difficulties as limiting the literacy process. In this context, it was used for the investigation of several theoretical references to clarify the importance of the psychoeducator, its intervention and preventive work and its role in the school environment and the educating, from its context Social, cognitive, psychic and organic. It was used as a methodology for this study a revision of literature, analyzing several bibliographies, based on renowned authors who studied deeply the topic addressed. After analyzing, it is reaffirmed that the psychopedagogy contributes to the education broadening the possibilities of search and reflections on the learning process

A psicopedagogia na alfabetização de crianças com dificuldades de aprendizagem

The main purpose of this article is to investigate learning difficulties as limiting the literacy process. In this context, it was used for the investigation of several theoretical references to clarify the importance of the psychoeducator, its intervention and preventive work and its role in the school environment and the educating, from its context Social, cognitive, psychic and organic. It was used as a methodology for this study a revision of literature, analyzing several bibliographies, based on renowned authors who studied deeply the topic addressed. After analyzing, it is reaffirmed that the psychopedagogy contributes to the education broadening the possibilities of search and reflections on the learning process.El objetivo principal de este artículo es investigar las dificultades de aprendizaje como la limitación del proceso de alfabetización. En este contexto, se utilizó para la investigación de varias referencias teóricas para clarificar la importancia del psicoeducador, su intervención y trabajo preventivo y su papel en el entorno escolar y la educación, desde su contexto Social, cognitiva, psíquica y orgánica. Se utilizó como metodología para este estudio una revisión de la literatura, analizando varias bibliografías, basadas en reconocidos autores que estudiaron profundamente el tema abordado. Después de analizar, se reafirma que la psicopedagogía contribuye a la educación ampliando las posibilidades de búsqueda y reflexiones sobre el proceso de aprendizaje.O presente artigo tem como objetivo principal investigar as dificuldades de aprendizagem enquanto limitadoras do processo de alfabetização. Nesse contexto, utilizou-se para a investigação de diversos referenciais teóricos voltados para o esclarecimento da importância do psicopedagogo, seu trabalho interventivo e preventivo e seu papel no ambiente escolar e ao educando, a partir do seu contexto social, cognitivo, psíquico e orgânico. Utilizou-se como metodologia para esse estudo uma revisão de literatura, analisando diversas bibliografias, baseada em autores renomados que estudaram profundamente a temática abordada. Após analisar, reafirma-se que a Psicopedagogia contribui para a Educação ampliando as possibilidades de buscas e reflexões sobre o processo de aprendizagem

EFFECT OF SEXING ON THE PERFORMANCE AND CARCASS CHARACTERISTICS OF ROSS® 308 AP BROILERS

The study aimed to evaluate the effect of sexing on performance, carcass characteristics, bone development, and profitability of Ross® 308 AP broilers. Six hundred chicks, one day old, reared by sex separation, were used. The experimental design used was completely randomized, with three treatments composed of lots separated by sex (males, females, and mixed) and five replications. Live weight, weight gain, feed intake and conversion, carcass weight and yield, commercial cuts, edible offal, and abdominal fat were evaluated. The length, thickness, weight, and Seedor index of the long bones (tibiotarsus and femur) were measured to assess bone development. An analysis of viability (VB), productive efficiency index (PEI), and profitability was carried out. The productive performance of broilers raised in male and mixed lots was higher from 1 to 21 days compared to the productive performance of females. The broilers from the mixed lots had greater femur length than the female lot, not differing from the males. Ross® 308 AP male broilers had better performance, carcass characteristics, and most parameters related to bone development than the mixed and female lots. However, mixed lots showed higher profitability than male and female lots.Objetivou-se avaliar o efeito da sexagem no desempenho, características de carcaça, desenvolvimento ósseo e lucratividade de frangos de corte Ross 308. Foram utilizados 600 pintinhos, com um dia de idade, criados por separação do sexo. O delineamento experimental utilizado foi o inteiramente casualizado, com três tratamentos que foram lotes separados por sexo (machos, fêmeas e mistos) e cinco repetições. Avaliou-se o peso vivo, ganho de peso, consumo de ração e conversão alimentar, o peso e rendimento de carcaça, cortes comerciais, miúdos comestíveis e da gordura abdominal. Para avaliação do desenvolvimento ósseo foram mensurados o comprimento, espessura, peso e índice de Seedor dos ossos longos (tíbia e fêmur). Fizeram-se análises de viabilidade criatória (VC), índice de eficiência produtiva (IEP) e lucratividade. O desempenho produtivo dos frangos criados em lotes de machos e mistos foram maiores a partir do período de 1 a 21 dias quando comparado ao desempenho produtivo de fêmeas. O lote de frangos mistos teve comprimento de fêmur superior aos de machos e fêmeas. O lote misto foi mais lucrativo do que o lote de machos e fêmeas. Frangos de cortes machos, da linhagem Ross 308® apresentaram melhores desempenho produtivo, características de carcaça e a maioria dos parâmetros relacionados ao desenvolvimento ósseo do que os lotes de mistos e os de fêmeas. Porém, lotes mistos apresentaram maior lucratividade do que os lotes de machos e fêmeas

The creation of a new literary experience to the digital world

The creation of the work was based on experimentation, strictly saying, the odd. Based on the assimilated premises, such as the demands of the target audience, another narrative was constructed based on the layout and also with the content of the story of Deborah Ellis, which guided the design decisions. The approach taken from the concepts of Artist’s Book, Randomly Produces Design and Emotional Design, seeks to build an eBook that stimulates creativity, critical thinking and the search for knowledge beyond what they are used to read.Pesquisa sem auxílio de agências de fomentoTrabalho de Conclusão de Curso (Graduação)A criação do trabalho baseou-se na experimentação, mais propriamente dito, o acaso. A partir das premissas assimiladas, como as demandas do público alvo, foi feita a construção de uma outra narrativa a partir da diagramação e também com o próprio conteúdo da história de Deborah Ellis, que norteou as decisões projetuais. A abordagem feita a partir dos conceitos de Livro de Artista, Design do Acaso e Design Emocional, compõe a tentativa da construção de um eBook que estimula em jovens leitores à criatividade, o senso crítico e à busca pelo conhecimento além do que estão acostumados a ler

The Role of Cell Metabolism in Innate Immune Memory

Immunological memory is classically attributed to adaptive immune responses, but recent studies have shown that challenged innate immune cells can display long-term functional changes that increase nonspecific responsiveness to subsequent infections. This phenomenon, coined trained immunity or innate immune memory, is based on the epigenetic reprogramming and the rewiring of intracellular metabolic pathways. Here, we review the different metabolic pathways that are modulated in trained immunity. Glycolysis, oxidative phosphorylation, the tricarboxylic acid cycle, amino acid, and lipid metabolism are interplaying pathways that are crucial for the establishment of innate immune memory. Unraveling this metabolic wiring allows for a better understanding of innate immune contribution to health and disease. These insights may open avenues for the development of future therapies that aim to harness or dampen the power of the innate immune response

Glutathione Metabolism Contributes to the Induction of Trained Immunity

The innate immune system displays heterologous memory characteristics, which are characterized by stronger responses to a secondary challenge. This phenomenon termed trained immunity relies on epigenetic and metabolic rewiring of innate immune cells. As reactive oxygen species (ROS) production has been associated with the trained immunity phenotype, we hypothesized that the increased ROS levels and the main intracellular redox molecule glutathione play a role in the induction of trained immunity. Here we show that pharmacological inhibition of ROS in an in vitro model of trained immunity did not influence cell responsiveness; the modulation of glutathione levels reduced pro-inflammatory cytokine production in human monocytes. Single nucleotide polymorphisms (SNPs) in genes involved in glutathione metabolism were found to be associated with changes in pro-inflammatory cytokine production capacity upon trained immunity. Also, plasma glutathione concentrations were positively associated with ex vivo IL-1β production, a biomarker of trained immunity, produced by monocytes of BCG-vaccinated individuals. In conclusion, glutathione metabolism is involved in the induction of trained immunity, and future studies are warranted to explore its functional consequences in human diseases

Glutathione Metabolism Contributes to the Induction of Trained Immunity.

The innate immune system displays heterologous memory characteristics, which are characterized by stronger responses to a secondary challenge. This phenomenon termed trained immunity relies on epigenetic and metabolic rewiring of innate immune cells. As reactive oxygen species (ROS) production has been associated with the trained immunity phenotype, we hypothesized that the increased ROS levels and the main intracellular redox molecule glutathione play a role in the induction of trained immunity. Here we show that pharmacological inhibition of ROS in an in vitro model of trained immunity did not influence cell responsiveness; the modulation of glutathione levels reduced pro-inflammatory cytokine production in human monocytes. Single nucleotide polymorphisms (SNPs) in genes involved in glutathione metabolism were found to be associated with changes in pro-inflammatory cytokine production capacity upon trained immunity. Also, plasma glutathione concentrations were positively associated with ex vivo IL-1β production, a biomarker of trained immunity, produced by monocytes of BCG-vaccinated individuals. In conclusion, glutathione metabolism is involved in the induction of trained immunity, and future studies are warranted to explore its functional consequences in human diseases