Doentes oncológicos críticos admitidos em Unidade de Cuidados Intensivos - preditores de mortalidade

O objectivo principal deste estudo consiste em identificar potenciais factores preditivos de mortalidade nos doentes oncológicos críticos admitidos em UCI. Pretende-se ainda avaliar a mortalidade na UCI, hospitalar e 30-dias após a alta; os índices de gravidade à admissão; as causas de admissão; as características da doença oncológica e o subgrupo de doentes admitidos por causa médica.info:eu-repo/semantics/publishedVersio

Safety of Thrombolysis in a Patient with an Intracranial Dural Arteriovenous Fistula

Intracranial dural arteriovenous fistula is an abnormal connection between an artery and a vein that has an increased risk of bleeding. This case report presents a 53-year-old man diagnosed with a dural arteriovenous malformation fistula in occipital topography, lacking therapeutic indication because of an extension. He was admitted to an intensive care unit due to a high-risk pulmonary thromboembolism with indication for thrombolysis. Taking into account the hemorrhagic risk associated with arteriovenous malformation, the authors discuss the therapeutic options and the inherent risks

Landscape of Current Targeted Therapies for Advanced Colorectal Cancer

Colorectal cancer (CRC) is one of the most frequent and lethal cancer types worldwide. While surgery with chemotherapy and radiotherapy remains the only curative approach for localized CRC, for metastatic disease the therapeutic landscape has significantly evolved over the last years. Development and approval of novel targeted therapies, such as monoclonal antibodies against EGFR and VEGF, have significantly increased the median survival of patients with metastatic disease, with some trials reporting a benefit over 40 months. Increasing accessibility of high throughput sequencing has unraveled several new therapeutic targets. Actionable alterations, such as HER2 overexpression, BRAF mutations, and NTRK fusions, are currently available in metastatic disease, providing significant therapeutic opportunities for these patients, while new emerging agents, as immune checkpoint inhibitors, promise better treatment options in the near future. In this chapter, an overview of established and future CRC targeted therapies in the clinical setting is provided, as well as their mechanism of action, limitations, and future applicability

Cross Species Analysis and Comparison of Tumors in Dogs and Cats, by Age, Sex, Topography and Main Morphologies. Data from Vet-OncoNet

The animal cancer burden is essential for the translational value of companion animals in comparative oncology. The present work aims to describe, analyze, and compare frequencies and associations of tumors in dogs and cats based on the Animal Cancer Registry created by Vet-OncoNet. With 9079 registries, regarding 2019 and 2020, 81% (n = 7355) belonged to dogs. In comparison, cats have a general one-year right advance in the mean age of cancer diagnosis compared to dogs. The multivariate topography group analysis shows a distinct pattern between the two species: dogs have higher odds of cancer in the genito-urinary system, spleen, soft tissue tumors and skin, while cats show higher odds for tumors in the eyes, digestive organs, nasal cavity, lymph nodes, bones and mammary glands. Regarding morphologies, dogs are overrepresented in mast cell tumors (MCT), melanomas, and hemangiosarcomas. While cats are overrepresented in fibrosarcomas, lymphomas (T and B-cell), in malignant mammary tumors, and squamous cell carcinoma (SCC). Females have greater odds only in the mammary gland, with males having greater odds in six of twelve topographies. This study is the first outcome of continuous animal cancer registration studies in Portugal

Abiotic Stress Upregulates the Expression of Genes Involved in PSV and Autophagy Routes

Adverse conditions caused by abiotic stress modulate plant development and growth by altering morphological and cellular mechanisms. To face this problem, plants, along with physiological adaptations, developed intracellular mechanisms, including changes in protein production and trafficking or modifications of the endomembrane system. It is known that stress situations can alter protein sorting to the vacuole, changing their routes via a Golgi-independent pathway. Our goal is to evaluate the expression levels of different aspartic proteinases and well-characterized genes involved in the vacuolar pathway, in plants submitted to different abiotic stresses (osmotic, oxidative, saline and heavy metals). The results obtained point to a different response of the three aspartic proteinases under study, indicating that different, yet related, genes respond differently to different types of stress, resulting in a fine-tuned regulation. Furthermore, our results regarding the endomembrane system effectors show that AtEXO70, AtRMR1, AtSYP51, AtSYP121 and AtVTI12 are up-regulated, while AtVAMP, AtSYP23 and AtBP80 are downregulated in the same situations. This demonstrates that adverse conditions caused by abiotic stress can alter the expression of key proteins involved in the protein trafficking machinery, which can be related to the activation/deactivation of certain pathways

Quiero vivir en mi casa: un desafío para las comunidades del interior en el contexto del ageing in place

O objetivo do presente estudo é identificar as preferências de residência futura das pessoas idosas. O local de residência é um importante fator na manutenção das vivências na comunidade. Em Portugal as alternativas à institucionalização são escassas e pouco conhecidas e o conceito de Ageing in Place está pouco explorado. Quando, por razões de saúde ou sociais, permanecer na habitação depende de respostas individualizadas adequadas, desenvolver novas políticas e serviços alternativos à institucionalização é hoje uma tarefa urgente, que responda às preferências de residência. Apresenta-se um estudo descritivo e exploratório com dados do projeto Persoparage, com 484 sujeitos dos 55 aos 99 anos a viver na comunidade. É feita uma análise de variáveis sociodemográficas e de perguntas relacionadas com as preferências de residência no futuro. As opções de resposta foram organizadas em 3 categorias (na própria residência/noutra residência/em instituição) e as respostas permitiam a escolha ordenada de 3 opções. As primeiras opções de residência foram na própria casa para 95,8% da amostra. Independentemente da idade, sexo, estado civil ou outras variáveis sociodemográficas esta opção foi escolhida pelos sujeitos em valores entre um mínimo de 92,4% (para os sujeitos viúvos) e de 100% (solteiros). As preferências enunciadas pelos sujeitos do estudo apontam indiscutivelmente para o desejo de se manterem na sua casa e na sua comunidade, revelando um claro alinhamento com o conceito de Ageing in Place.The objective of this study was to identify the preferences of future residence of elderly people. The place of residence of the elderly is an important factor in maintaining community experiences. In Portugal the alternatives to institutionalization are few and unknown and the concept of Ageing in Place is little explored. When staying in housing depends on adequate individualized responses for health or social reasons, developing new policies and services alternative to institutionalization is an urgent challenge today. Descriptive and exploratory study from the data obtained by interview in the persoparage project, with 484 individuals aged 55 to 99 years living in the community. Analysis of sociodemographic variables and questions related to future residence preferences. The answer options were organized into 3 categories (at home / in another home / institution) and the answers allowed the orderly choice of 3 options. The first residence options are a common ground in 95.8% of the sample. Regardless of age, gender, marital status or other sociodemographic variables, this option is chosen by individuals in percentages ranging from a minimum of 92.4% ( for widowed people) and 100% (for single people). The preferences revealed by the study show that people undoubtedly point to the desire to stay at home and in their community, revealing a clear alignment with the concept of Ageing in Place.El objetivo de este estudio fue identificar las preferencias de futura residencia de ancianos. El lugar de residencia de las personas mayores es un factor importante para mantener las experiencias colectivas. En Portugal, las alternativas a la institucionalización son escasas y poco conocidas y el concepto de Ageing in Place está poco explorado. Cuando por razones de salud o sociales quedarse en su casa depende del análisis de cada situación particular, desarrollar nuevas políticas y servicios alternativos a la institucionalización es un desafío realmente urgente en la actualidad. Estudio descriptivo y exploratorio de los datos obtenidos en las entrevistas en el proyecto Persoparage, con 484 sujetos de 55 a 99 años viviendo en la comunidad. Análisis de variables sociodemográficas y preguntas relacionadas con preferencias de residencia futura. Las opciones de respuesta se organizaron en 3 categorías: en casa / en otra casa / institución. Cabe referir que las respuestas permitían la elección ordenada de 3 opciones. Las primeras opciones de residencia son siempre la casa propia para el 95.8% de la muestra., independientemente de la edad, el género, el estado civil u otras variables sociodemográficas, esta opción es eligida por los sujetos en una porcentaje de un mínimo del 92.4% (por los viudos) y 100% (por los solteros). Las preferencias reveladas en el estudio muestran indudablemente el deseo de las personas mayores de quedarse en su casa y en su comunidad, revelando estos resultados una clara correspondencia con las líneas de actuación del concepto de ageing in place.info:eu-repo/semantics/publishedVersio