8 research outputs found
Induction of Heme Oxygenase-1 Can Halt and Even Reverse Renal Tubule-Interstitial Fibrosis
Background: The tubule-interstitial fibrosis is the hallmark of progressive renal disease and is strongly associated with inflammation of this compartment. Heme-oxygenase-1 (HO-1) is a cytoprotective molecule that has been shown to be beneficial in various models of renal injury. However, the role of HO-1 in reversing an established renal scar has not yet been addressed. Aim: We explored the ability of HO-1 to halt and reverse the establishment of fibrosis in an experimental model of chronic renal disease. Methods: Sprague-Dawley male rats were subjected to unilateral ureteral obstruction (UUO) and divided into two groups: non-treated and Hemin-treated. To study the prevention of fibrosis, animals were pre-treated with Hemin at days -2 and -1 prior to UUO. To investigate whether HO-1 could reverse established fibrosis, Hemin therapy was given at days 6 and 7 post-surgery. After 7 and/or 14 days, animals were sacrificed and blood, urine and kidney tissue samples were collected for analyses. Renal function was determined by assessing the serum creatinine, inulin clearance, proteinuria/creatininuria ratio and extent of albuminuria. Arterial blood pressure was measured and fibrosis was quantified by Picrosirius staining. Gene and protein expression of pro-inflammatory and pro-fibrotic molecules, as well as HO-1 were performed. Results: Pre-treatment with Hemin upregulated HO-1 expression and significantly reduced proteinuria, albuminuria, inflammation and pro-fibrotic protein and gene expressions in animals subjected to UUO. Interestingly, the delayed treatment with Hemin was also able to reduce renal dysfunction and to decrease the expression of pro-inflammatory molecules, all in association with significantly reduced levels of fibrosis-related molecules and collagen deposition. Finally, TGF-beta protein production was significantly lower in Hemin-treated animals. Conclusion: Treatment with Hemin was able both to prevent the progression of fibrosis and to reverse an established renal scar. Modulation of inflammation appears to be the major mechanism behind HO-1 cytoprotection.Fundacao de Amparo Pesquisa do Estado de Sao Paulo-FAPESP[07/07139-3]Coordenaco de Aperfeioamento de Pessoal de Nivel Superior-CAPESInstituto Nacional de Ciencia e Tecnologia de Complexos Fluidos (INCT)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNP
Conhecimentos e percepção de professores sobre maus-tratos em crianças e adolescentes
Ação social e intersetorialidade: relato de uma experiĂȘncia na interface entre saĂșde, educação e cultura
O planejamento familiar no Brasil no contexto das polĂticas pĂșblicas de saĂșde: determinantes histĂłricos
A RUPTURA SOCIAL INFANTOJUVENIL E SUA INFERĂNCIA NAS REPRESENTAĂĂES DE CONSELHEIROS TUTELARES
ContribuiçÔes da Sociologia na AmĂ©rica Latina Ă imaginação sociolĂłgica: anĂĄlise, crĂtica e compromisso social Sociology's contribution in Latin America to sociological imagination: analysis, critique, and social commitment
O artigo aborda o papel desempenhado pela Sociologia na anĂĄlise dos processos de transformação das sociedades latino-americanas, no acompanhamento do processo de construção do Estado e da Nação, na problematização das questĂ”es sociais na AmĂ©rica Latina. SĂŁo analisados seis perĂodos na Sociologia na AmĂ©rica Latina e no Caribe: I) a herança intelectual da Sociologia ; II) a sociologia da cĂĄtedra; III) O perĂodo da "Sociologia CientĂfica" e a configuração da "Sociologia CrĂtica"; IV) a crise institucional, a consolidação da "Sociologia CrĂtica" e a diversificação da sociologia; V) a sociologia do autoritarismo, da democracia e da exclusĂŁo; VI) a consolidação institucional e a mundialização da sociologia da AmĂ©rica Latina (desde o ano de 2000), podendo-se afirmar que os traços distintivos do saber sociolĂłgico no continente foram: o internacionalismo, o hibridismo, a abordagem crĂtica dos processos e conflitos das sociedades latino-americanas e o compromisso social do sociĂłlogo.<br>The article focuses on the role played by Sociology in the analysis of processes of change in Latin American societies, in the process of construction of Nation and State, in the debate of social issues in Latin America and the Caribbean. Six periods in Sociology in Latin America and the Caribbean are examined: I) sociology's intellectual legacy; II) sociology as a cathedra; III) the period of "Scientific Sociology"; IV) the institutional crisis, the consolidation of "Critical Sociology", and the diversifying of sociology; V) sociology of authoritarianism, democracy and exclusion; VI) institutional consolidation and globalization of Latin American sociology (since 2000). It may be said that the distinctive features of sociological knowledge in the continent were: internationalism, hybridism, the critical approach to processes and conflicts of Latin American societies, and the sociologist social commitment