Auto-Denoising for EEG Signals Using Generative Adversarial Network.

The brain-computer interface (BCI) has many applications in various fields. In EEG-based research, an essential step is signal denoising. In this paper, a generative adversarial network (GAN)-based denoising method is proposed to denoise the multichannel EEG signal automatically. A new loss function is defined to ensure that the filtered signal can retain as much effective original information and energy as possible. This model can imitate and integrate artificial denoising methods, which reduces processing time; hence it can be used for a large amount of data processing. Compared to other neural network denoising models, the proposed model has one more discriminator, which always judges whether the noise is filtered out. The generator is constantly changing the denoising way. To ensure the GAN model generates EEG signals stably, a new normalization method called sample entropy threshold and energy threshold-based (SETET) normalization is proposed to check the abnormal signals and limit the range of EEG signals. After the denoising system is established, although the denoising model uses the different subjects' data for training, it can still apply to the new subjects' data denoising. The experiments discussed in this paper employ the HaLT public dataset. Correlation and root mean square error (RMSE) are used as evaluation criteria. Results reveal that the proposed automatic GAN denoising network achieves the same performance as the manual hybrid artificial denoising method. Moreover, the GAN network makes the denoising process automatic, representing a significant reduction in time

Inhibition of phage infection in capsule-producing Streptococcus thermophilus using concanavalin A, lysozyme and saccharides

Lactic cultures that produce capsular polysaccharides are widely used in the dairy industry. However, little information is available on their phage-cell interactions. Concanavalin A (Con A), lysozyme, andsaccharides were investigated for their ability to modify phage-cell interactions in such a manner as to inhibit phage infection. The ability of phage to infect cells was determined by measuring acidproduction in Elliker broth. Acid production by capsule-producing Streptococcus thermophilus was inhibited less by bacteriophage when cells were pretreated with Con. A than was acid production by acapsule-free variant. The presence of 0.5 mg/ml lysozyme in Elliker broth significantly reduced phage infection. However, there was no increased effect when lysozyme and Con A were combined in thegrowth medium. The addition of 5 g/L of glucosamine to Elliker broth also inhibited phage infection. The results of this study indicate that it is possible to reduce phage infection of capsule-forming S.thermophilus by blocking or modifying phage adsorption sites

Study of Linkages Between Outward Foreign Direct Investment (OFDI) and Domestic Economic Growth: an Indian Perspective

The inwards and outward FDI movement plays an important role in the economic development and growth of any economy. The OFDI have its impact on the home economy based on scale effect, competition effect and knowledge effect. It helps other domestic companies to expand their business and scale of firms by giving them technological and trade benefits. OFDI help the companies to improve efficiency and upgrade production processes

Lung Nodule Classification using A Novel Two-stage Convolutional Neural Networks Structure'

© 2019 IEEE. Lung cancer is one of the most fatal cancers in the world. If the lung cancer can be diagnosed at an early stage, the survival rate of patients post treatment increases dramatically. Computed Tomography (CT) diagram is an effective tool to detect lung cancer. In this paper, we proposed a novel two-stage convolution neural network (2S-CNN) to classify the lung CT images. The structure is composed of two CNNs. The first CNN is a basic CNN, whose function is to refine the input CT images to extract the ambiguous CT images. The output of first CNN is fed into another inception CNN, a simplified version of GoogLeNet, to enhance the better recognition on complex CT images. The experimental results show that our 2S-CNN structure has achieved an accuracy of 89.6%

Radiographic viewing conditions at Johannesburg Hospital

Purpose: To measure the luminance level of X-ray viewing boxes and ambient lighting levels in reporting rooms as a quality assurance procedure, and to compare the results with those recommended by the Directorate of Radiatio

Antioxidant effects on hypoxia-induced oxidative stress and apoptosis in rat rotator cuff fibroblasts

Most cells, highly sensitive to oxygen levels, undergo apoptosis under hypoxia. Therefore, the involvement of hypoxia in rotator cuff tendon degeneration has been proposed. While previous studies have reported that hypoxia induces apoptosis in rotator cuff fibroblasts (RCFs), little research has investigated whether antioxidants have cytoprotective effects against RCF apoptosis. The present study aimed at determining whether the antioxidant N-acetylcysteine (NAC) exerted cytoprotective effects against hypoxia-induced RCF apoptosis. Third-passage rat RCFs were divided into normoxia, NAC, hypoxia and NAC-hypoxia groups. The hypoxia inducer was 1,000 µmol/L cobalt chloride (CoCl2); the antioxidant was 20 mmol/L NAC. Expressions of hypoxia-inducible factor-1α (HIF-1α) and heme oxygenase-1 (HO-1), cell viability, intracellular reactive oxygen species (ROS) production, apoptosis rates as well as expressions of cleaved caspase-3, cleaved poly ADP-ribose polymerase-1 (PARP-1), vascular endothelial growth factors-β (VEGF-β) and matrix metalloproteinase-2 (MMP-2) were evaluated. Expression of HIF-1α and HO-1 was significantly higher in the hypoxia group than in the normoxia group (p < 0.001). Cell viability was significantly lower in the hypoxia group than in the normoxia group (p < 0.001). Intracellular ROS production, apoptosis rate and expressions of cleaved caspase-3, cleaved PARP-1, VEGF-β and MMP-2 were significantly higher in the hypoxia group than in the normoxia group (p < 0.001). All these responses were significantly attenuated by pre-treatment with NAC (p ≤ 0.001). ROS were involved in hypoxic RCF apoptosis induced by CoCl2; NAC, an ROS scavenger, inhibited hypoxia-induced RCF apoptosis by inhibiting ROS production

Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis.

The successful completion of cytokinesis requires the coordinated activities of diverse cellular components including membranes, cytoskeletal elements and chromosomes that together form partly redundant pathways, depending on the cell type. The biochemical analysis of this process is challenging due to its dynamic and rapid nature. Here, we systematically compared monopolar and bipolar cytokinesis and demonstrated that monopolar cytokinesis is a good surrogate for cytokinesis and it is a well-suited system for global biochemical analysis in mammalian cells. Based on this, we established a phosphoproteomic signature of cytokinesis. More than 10,000 phosphorylation sites were systematically monitored; around 800 of those were up-regulated during cytokinesis. Reconstructing the kinase-substrate interaction network revealed 31 potentially active kinases during cytokinesis. The kinase-substrate network connects proteins between cytoskeleton, membrane and cell cycle machinery. We also found consensus motifs of phosphorylation sites that can serve as biochemical markers specific to cytokinesis. Beyond the kinase-substrate network, our reconstructed signaling network suggests that combination of sumoylation and phosphorylation may regulate monopolar cytokinesis specific signaling pathways. Our analysis provides a systematic approach to the comparison of different cytokinesis types to reveal alternative ways and a global overview, in which conserved genes work together and organize chromatin and cytoplasm during cytokinesis.EMBO (European Molecular Biology Organization) Installation Grant; Young Scientist Award Program BAGEP of the Science Academy (Turkey); TUBITAK-Marie Curie Co-funded Brain Circulation Schem

Impact of generic alendronate cost on the cost-effectiveness of osteoporosis screening and treatment

Introduction: Since alendronate became available in generic form in the Unites States in 2008, its price has been decreasing. The objective of this study was to investigate the impact of alendronate cost on the cost-effectiveness of osteoporosis screening and treatment in postmenopausal women. Methods: Microsimulation cost-effectiveness model of osteoporosis screening and treatment for U.S. women age 65 and older. We assumed screening initiation at age 65 with central dual-energy x-ray absorptiometry (DXA), and alendronate treatment for individuals with osteoporosis; with a comparator of "no screening" and treatment only after fracture occurrence. We evaluated annual alendronate costs of $20 through$800; outcome measures included fractures; nursing home admission; medication adverse events; death; costs; quality-adjusted life-years (QALYs); and incremental cost-effectiveness ratios (ICERs) in 2010 U.S. dollars per QALY gained. A lifetime time horizon was used, and direct costs were included. Base-case and sensitivity analyses were performed. Results: Base-case analysis results showed that at annual alendronate costs of $200 or less, osteoporosis screening followed by treatment was cost-saving, resulting in lower total costs than no screening as well as more QALYs (10.6 additional quality-adjusted life-days). When assuming alendronate costs of$400 through $800, screening and treatment resulted in greater lifetime costs than no screening but was highly cost-effective, with ICERs ranging from$714 per QALY gained through $13,902 per QALY gained. Probabilistic sensitivity analyses revealed that the cost-effectiveness of osteoporosis screening followed by alendronate treatment was robust to joint input parameter estimate variation at a willingness-to-pay threshold of$50,000/QALY at all alendronate costs evaluated. Conclusions: Osteoporosis screening followed by alendronate treatment is effective and highly cost-effective for postmenopausal women across a range of alendronate costs, and may be cost-saving at annual alendronate costs of $200 or less. © 2012 Nayak et al

The effect of transurethral resection of the prostate on erectile and ejaculatory functions in patients with benign prostatic hyperplasia

Introduction: The aim of this study was to investigate the effect of TURP on erectile function (EF) and ejaculatory function (EJF). Methods: A total of 91 patients who underwent TURP were retrospectively assessed. Patients were divided into two groups based on International Index of Erectile Function (IIEF-5): group A included 41 patients with normal EF, and group B included 50 patients with erectile dysfunction (ED). All patients were evaluated for EF and EJF at baseline, 1, 3, and 6 months after TURP by using IIEF-5, Ejaculatory Domain-Male Sexual-Health Inventory (Ej-MSHQ). Results: In group A, there were no significant statistical differences in mean IIEF-5 at baseline and after TURP 22.88 ± 0.81 versus 22.63 ± 2.63 (p = 0.065). However, in group B, there was significant improvement in IIEF-5 after TURP all over the follow-up time points in comparison to the baseline (p = &lt;0.001). The loss of EJF was significant among patients in group A. There was significant improvement of IPSS and Qmax in group A after surgery compared to group B. Conclusion: The results confirmed that TURP has no significant negative influence on EF, and patients with preexisting ED were improved after TURP. On the contrary, the loss of EJF was significant