Spot the Difference! Visual plagiarism in the visual arts.

Over recent years there has been considerable investment in the use of technology to identify sources of text-based plagiarism in universities. However, students of the visual arts are also required to complete numerous pieces of visual submissions for assessment, and yet very little similar work has been undertaken in the area of non-text based plagiarism detection. The Spot the Difference! project (2011-2012), funded by JISC and led by the University for the Creative Arts, seeks to address this gap by piloting the use of visual search tools developed by the University of Surrey and testing their application to support learning and teaching in the arts and specifically to the identification of visual plagiarism. Given that most commonly used search technologies rely on text, the identification and evidencing of visual plagiarism is often left to the knowledge and experience of academic staff, which can potentially result in inconsistency of detection, approach, policies and practices. This paper outlines the work of the project team, who sought to investigate the nature, scope and extent of visual plagiarism in the arts education sector

From princess to punk: digitisation in the fashion studio

The Zandra Rhodes Digital Study Collection project was a unique collaborative venture between staff and students at the University for the Creative Arts (UCA) and their Chancellor, the British fashion and textile designer Zandra Rhodes. Working within the designer’s private studio space, this initiative has developed the first digital record of her personal collection of garments and drawings, supported and enriched with behind-the-scenes video interviews and tutorials, for worldwide educational use. This paper examines the benefits and strategies for undertaking the project in situ within the designer’s private studio environment. It outlines the need for a bespoke, flexible approach to digitisation in the visual arts that respects the individuality and creativity of the artist, whilst drawing on established documentation standards and expertise from the library, archive and museum sector

Zandra Rhodes Digital Study Collection

This article details the Zandra Rhodes Digital Study Collection, which was created through a collaborative project between researchers and students at the University for the Creative Arts (UCA) and the team at Zandra Rhodes Studio, with funding from JISC. The collection provides unique online access to 500 garments from the private archive of British fashion designer Zandra Rhodes, as well as fashion drawings, video interviews, and video tutorials that uncover the processes involved in creating a Zandra Rhodes piece

Look-here!: digitisation and collaboration in the visual arts

The Look-Here! project was a collaborative venture that sought to develop skills and strategies for digitisation within libraries, museums and archives in the arts education sector. Led by the Visual Arts Data Service (VADS), with funding from the JISC eContent Programme (2009-11), the project worked with partners in nine specialist arts universities and colleges and art departments in multidisciplinary institutions. Through a series of workshops, case studies and cross-sector activities, the project aimed to share and embed knowledge and expertise in the creation and management of digitised collections in the visual and creative arts. This case study on the project's outputs, outcomes and lessons learnt was published as a chapter within an e-book on the JISC website. The e-book presents case studies from 11 digital projects managing digital resources for higher education

Uncovering hidden treasures in silver trunks: the Zandra Rhodes Digital Study Collection

Hidden away in silver trunks at the Zandra Rhodes Studio are over 5,000 dresses spanning fifty years of British Fashion and including designs worn by clients such as Elizabeth Taylor, Freddie Mercury, and Diana, Princess of Wales. The Zandra Rhodes Digital Study Collection, with an accompanying Open Education Resource (OER), will provide unique online access to images of 500 of the designer’s most iconic garments, for use in study and research by the next generation of fashion and textile designers, and fashion historians

St. Mary\u27s Parish House: Reuse and Rehabilitaion Feasibility Report

Most windows in the structure are historic and in fair condition, consisting of double-hung, six-over-six, divided-light windows throughout most of the building and 12-over-8 divided- light windows in the gymnasium. Windows on the first story of the south façade, in the school addition, are wooden and one-over-one

Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling.

Cells rely on the coordinated regulation of lipid phosphoinositides and Rab GTPases to define membrane compartment fates along distinct trafficking routes. The family of disease-related myotubularin (MTM) phosphoinositide phosphatases includes catalytically inactive members, or pseudophosphatases, with poorly understood functions. We found that Drosophila MTM pseudophosphatase Sbf coordinates both phosphatidylinositol 3-phosphate (PI(3)P) turnover and Rab21 GTPase activation in an endosomal pathway that controls macrophage remodeling. Sbf dynamically interacts with class II phosphatidylinositol 3-kinase and stably recruits Mtm to promote turnover of a PI(3)P subpool essential for endosomal trafficking. Sbf also functions as a guanine nucleotide exchange factor that promotes Rab21 GTPase activation associated with PI(3)P endosomes. Of importance, Sbf, Mtm, and Rab21 function together, along with Rab11-mediated endosomal trafficking, to control macrophage protrusion formation. This identifies Sbf as a critical coordinator of PI(3)P and Rab21 regulation, which specifies an endosomal pathway and cortical control

RNA-seq reveals post-transcriptional regulation of Drosophila insulin-like peptide dilp8 and the neuropeptide-like precursor Nplp2 by the exoribonuclease Pacman/XRN1

Ribonucleases are critically important in many cellular and developmental processes and defects in their expression are associated with human disease. Pacman/XRN1 is a highly conserved cytoplasmic exoribonuclease which degrades RNAs in a 5' - 3' direction. In Drosophila, null mutations in pacman result in small imaginal discs, a delay in onset of pupariation and lethality during the early pupal stage. In this paper, we have used RNA-seq in a genome-wide search for mRNAs misregulated in pacman null wing imaginal discs. Only 4.2% of genes are misregulated ±>2-fold in pacman null mutants compared to controls, in line with previous work showing that Pacman has specificity for particular mRNAs. Further analysis of the most upregulated mRNAs showed that Pacman post-transcriptionally regulates the expression of the secreted insulin-like peptide Dilp8. Dilp8 is related to human IGF-1, and has been shown to co-ordinate tissue growth with developmental timing in Drosophila. The increased expression of Dilp8 is consistent with the developmental delay seen in pacman null mutants. Our analysis, together with our previous results, show that the normal role of this exoribonuclease in imaginal discs is to suppress the expression of transcripts that are crucial in apoptosis and growth control during normal development

Essential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat protein

The pharmacological disruption of the interaction between the HIV Tat protein and its cognate transactivation response RNA (TAR) would generate novel anti-viral drugs with a low susceptibility to drug resistance, but efforts to discover ligands with sufficient potency to warrant pharmaceutical development have been unsuccessful. We have previously described a family of structurally constrained β-hairpin peptides that potently inhibits viral growth in HIV-infected cells. The nuclear magnetic resonance (NMR) structure of an inhibitory complex revealed that the peptide makes intimate contacts with the 3-nt bulge and the upper helix of the RNA hairpin, but that a single residue contacts the apical loop where recruitment of the essential cellular co-factor cyclin T1 occurs. Attempting to extend the peptide to form more interactions with the RNA loop, we examined a library of longer peptides and achieved >6-fold improvement in affinity. The structure of TAR bound to one of the extended peptides reveals that the peptide slides down the major groove of the RNA, relative to our design, in order to maintain critical interactions with TAR. These conserved contacts involve three amino acid side chains and identify critical interaction points required for potent and specific binding to TAR RNA. They constitute a template of essential interactions required for inhibition of this RN