Working Together to Build Beacon Centers in San Francisco: Evaluation Findings from 1998-2000

Since 1996, private and public funders in San Francisco have supported a city-wide Beacons Initiative. Eight Beacon Centers, located in public schools, serve 7500 youth and adults each year, providing a rich array of developmental activities in the non-school hours. This report looks at how the centers were created; it describes the centers' operation; and investigates the role of the initiative's "theory of change" in organizing and guiding the effort

Collaboration and Community Change in the Children's Futures Initiative

In 2002, The Robert Wood Johnson Foundation launched Children's Futures (CF), a 10-year community change initiative designed to improve the health and well-being of children from birth to age three throughout Trenton, NJ. CF's strategies included efforts to increase residents' access to prenatal and other health services, provide parenting skills education, improve the quality of available childcare and promote preventive healthcare among medical practices. The Foundation engaged P/PV to evaluate the implementation and outcomes of the initiative and to provide ongoing feedback on its progress.This report, and its forthcoming companion, Early Outcomes in a Community Change Effort to Improve Children's Futures, examine the promise of CF strategies. Collaboration and Community Change in the Children's Futures Initiative focuses on program implementation, participant recruitment and collaborations among Trenton's agencies. The second report examines programmatic improvements and early outcomes for CF families. Major findings from both are compiled in Children's Futures' First Five Years

After-School Pursuits: The Executive Summary

This document summarizes the major findings from P/PV's Examination of Outcomes in the San Francisco Beacon Initiative

After-School Pursuits: An Examination of Outcomes in the San Francisco Beacon Initiative

The San Francisco Beacon Initiative (SFBI) has been in effect in the San Francisco Unified School District since 1996. A collaboration of public and private funders, SFBI operates comprehensive after-school programs in six middle schools, one elementary school and one high school. P/PVs evaluation found that SFBI programs consisted of high quality after-school activities, provided young people with important developmental experiences (such as adult support) and prevented declines in school effort (typical among middle school youth). Although the initiative did not explicitly set out to improve young peoples academic outcomes, these were also examined. Despite the high quality of the centers developmental programs, participants showed no academic gains, and the authors conclude that positive developmental experiences are not sufficient for ensuring academic success among youth who are already struggling in school

Preserving and Enhancing Access to Non-Commercial Sound Recordings at The Harry Ransom Center

The Harry Ransom Center at The University of Texas at Austin requests funds to support a $35,132 one-year project to develop and complete a preservation survey of the Center’s archival sound recordings. This survey will establish, enhance, and document preservation digitization priorities, processes, and standards to ensure future access to a significant collection of primary research materials

Pleistocene glacial refugia across the Appalachian Mountains and coastal plain in the millipede genus Narceus: Evidence from population genetic, phylogeographic, and paleoclimatic data

Background: Species that are widespread throughout historically glaciated and currently nonglaciated areas provide excellent opportunities to investigate the role of Pleistocene climatic change on the distribution of North American biodiversity. Many studies indicate that northern animal populations exhibit low levels of genetic diversity over geographically widespread areas whereas southern populations exhibit relatively high levels. Recently, paleoclimatic data have been combined with niche-based distribution modeling to locate possible refugia during the Last Glacial Maximum. Using phylogeographic, population, and paleoclimatic data, we show that the distribution and mitochondrial data for the millipede genus Narceus are consistent with classical examples of Pleistocene refugia and subsequent post-glacial population expansion seen in other organismal groups. Results: The phylogeographic structure of Narceus reveals a complex evolutionary history with signatures of multiple refugia in southeastern North America followed by two major northern expansions. Evidence for refugial populations were found in the southern Appalachian Mountains and in the coastal plain. The northern expansions appear to have radiated from two separate refugia, one from the Gulf Coastal Plain area and the other from the mid-Atlantic coastal region. Distributional models of Narceus during the Last Glacial Maximum show a dramatic reduction from the current distribution, with suitable ecological zones concentrated along the Gulf and Atlantic coastal plain. We found a strong correlation between these zones of ecological suitability inferred from our paleo-model with levels of genetic diversity derived from phylogenetic and population estimates of genetic structuring. Conclusion: The signature of climatic change, during and after the Pleistocene, on the distribution of the millipede genus Narceus is evident in the genetic data presented. Niche-based historical distribution modeling strengthens the conclusions drawn from the genetic data and proves useful in identifying probable refugia. Such interdisciplinary biogeographic studies provide a comprehensive approach to understanding these processes that generate and maintain biodiversity as well as the framework necessary to explore questions regarding evolutionary diversification of taxa. Originally published BMC Evolutionary Biology, Vol. 9, No. 25, Jan 200

Medication adherence in patients with myotonic dystrophy and facioscapulohumeral muscular dystrophy

Myotonic dystrophy (DM) and facioscapulohumeral muscular dystrophy (FSHD) are the two most common adult muscular dystrophies and have progressive and often disabling manifestations. Higher levels of medication adherence lead to better health outcomes, especially important to patients with DM and FSHD because of their multisystem manifestations and complexity of care. However, medication adherence has not previously been studied in a large cohort of DM type 1 (DM1), DM type 2 (DM2), and FSHD patients. The purpose of our study was to survey medication adherence and disease manifestations in patients enrolled in the NIH-supported National DM and FSHD Registry. The study was completed by 110 DM1, 49 DM2, and 193 FSHD patients. Notable comorbidities were hypertension in FSHD (44 %) and DM2 (37 %), gastroesophageal reflux disease in DM1 (24 %) and DM2 (31 %) and arrhythmias (29 %) and thyroid disease (20 %) in DM1. Each group reported high levels of adherence based on regimen complexity, medication costs, health literacy, side effect profile, and their beliefs about treatment. Only dysphagia in DM1 was reported to significantly impact medication adherence. Approximately 35 % of study patients reported polypharmacy (taking 6 or more medications). Of the patients with polypharmacy, the DM1 cohort was significantly younger (mean 55.0 years) compared to DM2 (59.0 years) and FSHD (63.2 years), and had shorter disease duration (mean 26 years) compared to FSHD (26.8 years) and DM2 (34.8 years). Future research is needed to assess techniques to ease pill swallowing in DM1 and to monitor polypharmacy and potential drug interactions in DM and FSHD

Nitrate loss from fertilized crop fields: does slope steepness matter?

Data used in analysi

CD28 Ligation Increases Macrophage Suppression of T Cell Proliferation

When compared to spleen or lymph node cells, resident peritoneal cavity cells respond poorly to T cell activation in vitro. The greater proportional representation of macrophages in this cell source has been shown to actively suppress the T cell response. Peritoneal macrophages exhibit an immature phenotype $(MHC Class II^{lo}, B7^{lo})$ that reduces their efficacy as antigen presenting cells. Furthermore, these cells readily express inducible nitric oxide synthase (iNOS), an enzyme that promotes T cell tolerance by catabolism of the limiting amino acid arginine. Here, we investigate the ability of exogenous T cell costimulation to recover the peritoneal T cell response. We show that CD28 ligation failed to recover the peritoneal T cell response and actually suppressed responses that had been recovered by inhibiting iNOS. As indicated by cytokine ELISpot and neutralizing mAb treatment, this “co-suppression” response was due to CD28 ligation increasing the number of IFNγ-secreting cells. Our results illustrate that cellular composition and cytokine milieu influence T cell costimulation biology