Structured Review of the Evidence on the Intersection of Housing and Health Policy in the WHO European Region

A central challenge in promoting good health is to ensure access to adequate housing for all. The United Nations Committee on Economic, Social and Cultural Rights defines adequate housing as not only simple shelter, but a secure, affordable, accessible and fully equipped home. While there is potential for the housing sector to promote, or to harm, people’s health, housing policies are often made with little regard to their potential health impact. To better promote joined-up intersectoral action across health and housing policy, this paper reports a structured and thematic review of literature relevant to the WHO European Region. Eighty documents met the study inclusion criteria. The paper summarizes the impacts on health of physical housing quality, affordability and stability, and location, as well as the role of health in achieving desirable housing outcomes. Individuals who are especially vulnerable to housing impacts on health are those who spend greater quantities of time in their household, including self-employed persons who work at home, older persons, carers, children and persons with disabilities. The paper concludes with directions for future research and policy, with a view towards joined-up intersectoral action, such as policies that establish minimum housing standards and ensure housing affordability

The Effects of Schooling and Education Policy on the Subjective Well-Being of Children: A Comparative Study

There has been increasing interest in subjective well-being, including child subjective well-being, in recent years. However there has been comparatively little work considering the impact of school and education policies on children’s subjective well-being, despite the important roles these areas play in children’s lives. This thesis aims to reduce this gap in the literature by investigating the relationship between schools and children’s subjective well-being through the quantitative analysis of a range of secondary datasets from England and the USA. The thesis first presents analysis demonstrating a generally positive relationship between subjective well-being and school performance reiterating evidence from elsewhere that subjective well-being is important to objective outcomes. The remainder of the thesis presents analyses investigating the extent and nature of the influence of the school a child attends on their overall subjective well-being. It is the results of these analyses that provide the original contribution to literature of this thesis. This analysis both quantifies the amount of variance in subjective well-being explained by the school a child is attending and demonstrates which areas of children’s lives are influenced by schools. It finds that schools play an important social and supportive role in children’s lives, explaining considerable proportions of the variance in subjective well-being. The comparison between England and the US in this regard demonstrates that schools play an important role in children’s lives in both nations, but in different forms. Results for England emphasise a more emotional and supportive role for schools, while in the US the social role of school appears more critical for children’s subjective well-being. The results of this thesis therefore support calls for a change in approach to education policy in England and the US from an almost exclusive focus on attainment towards a more holistic approach, considering the impact of schools on the whole child, as well as highlighting schools as an important area of research for those concerned with children’s well-being

The effect of Local Housing Allowance reductions on overcrowding in the Private Rented Sector in England

Ensuring housing affordability while controlling government expenditure is a concern in many countries. In the UK support for private renters is delivered via an income-related housing benefit calculated using the Local Housing Allowance. As part of a programme to reduce government spending the support provided by the Local Housing Allowance was significantly reduced in 2011, and ongoing changes to its uprating have further reduced its value. These changes have raised concerns about the suitability of homes people receiving the allowance can afford. Using a natural experiment approach by applying matching and difference-in-difference methods to housing stock data from the English Housing Survey, this research finds a statistically significant 5% increase in overcrowding for housing benefit recipients following the changes to the Local Housing Allowance, equivalent to approximately 75,000 additional households living in overcrowded conditions. Longer-term results show that overcrowding continued to increase as changes to the uprating system further reduced the value of housing benefit. The decision to reduce the Local Housing Allowance and sever its relationship with actual rents has therefore reduced the ability of recipients to access suitable housing which will have had important implications for health and well-being, particularly during the COVID-19 pandemic

Reeves et al. Respond to “Harnessing Housing Natural Experiments”: Table 1.

We appreciate the interest our paper has generated, which takes advantage of a natural experiment design to better ascertain causality than conventional observational studies. In the accompanying commentary, Bentley, Baker, and Blakely suggest that misclassification of depression symptoms (e.g., if someone with depression reports that they are not depressed) may explain our findings if misclassification rates changed due to the reduction in the Local Housing Allowance, one component of Housing Benefit in the UK for people in the private renter sector

Housing and Health: New Evidence Using Biomarker Data

Background The link between housing and health is well established and long-standing, however much of the evidence relies on self-reported health measures. While these are useful, the availability of biomarker data allows us to add to this evidence using objective indicators of health. Methods In this paper, we use C-reactive protein (CRP), a biomarker associated with infection and stress, alongside information relating to housing details, demographic characteristics and health behaviours taken from the UK Household Longitudinal Study. Hierarchical linear regression models estimate CRP for individual housing characteristics, and all available housing characteristics, controlling for confounders. Results Results indicate that housing tenure, type, cost burden and desire to stay in current home are associated with CRP. Private renters have significantly higher (worse) CRP than owners with a mortgage. In terms of housing type, respondents living in detached homes had lower CRP than those in semidetached or terraced houses, or those living in flats. Housing cost burden is associated with lower CRP, although further analysis indicates that this is the case only for low-income renters. Desire to stay in current home is significantly associated with higher CRP. Conclusions A number of housing characteristics were associated with CRP. These results further support an important role for housing in health

Reductions in the United Kingdom's Government Housing Benefit and Symptoms of Depression in Low-Income Households

Housing security is an important determinant of mental ill health. We used a quasinatural experiment to evaluate this association, comparing the prevalence of mental ill health in the United Kingdom before and after the government's April 2011 reduction in financial support for low-income persons who rent private-sector housing (mean reduction of approximately £1,220 ($2,315) per year). Data came from the United Kingdom's Annual Population Survey, a repeated quarterly cross-sectional survey. We focused our analysis on renters in the private sector, disaggregating data between an intervention group receiving the government's Housing Benefit (n = 36,859) and a control group not receiving the Housing Benefit (n = 142,205). The main outcome was a binary measure of self-reported mental health problems. After controlling for preexisting time trends, we observed that between April 2011 and March 2013, the prevalence of depressive symptoms among private renters receiving the Housing Benefit increased by 1.8 percentage points (95% confidence interval: 1.0, 2.7) compared with those not receiving the Housing Benefit. Our models estimated that approximately 26,000 (95% confidence interval: 14,000, 38,000) people newly experienced depressive symptoms in association with the cuts to the Housing Benefit. We conclude that reducing housing support to low-income persons in the private rental sector increased the prevalence of depressive symptoms in the United Kingdom

The Effects of Vagus Nerve Stimulation on Neuroinflammation in Epilepsy

Epilepsy is a neurological disorder characterized by chronic, unexplainable seizures. Recurring epileptic seizures are associated with long-term structural damage and cognitive deficits, and can even lead to sudden, unexplainable death. Approximately 30% of epilepsy cases are not responsive to medication. Epileptic seizures often induce inflammation in the brain and may increase the frequency of future seizures, resulting in a detrimental cycle. Vagus nerve stimulation (VNS) is a non-pharmaceutical treatment method for epilepsy that has been shown to reduce inflammation in peripheral pathways. The role of VNS in the modulation of neuroinflammation has yet to be demonstrated experimentally. To explore this, several cuff electrodes were attached to the left vagus nerve in an epileptic rodent model. The electrodes will deliver a biphasic square waveform continuously for up to two weeks and record the resulting action potentials from the nerve. Immunohistochemistry will be used to evaluate microglial activation in the hippocampus, an indicator of neuroinflammation. The anticipated results will show whether continuous stimulation of the left vagus nerve effectively reduces microglial activation in the hippocampus of the epileptic rodents. If so, these results would suggest that inflammation in the brain can be effectively modulated using VNS, thereby reducing structural and cognitive damage as well as seizure recurrence. In this way, VNS could be an effective and reliable treatment method for epileptic patients who are not responsive to medication

Intensive Cultural Resources Survey of the Proposed Galveston County Project, Texas City, Galveston County, Texas

On behalf of Florida Gas Transmission Company, LLC (FGT), EDGE Engineering and Science, LLC (EDGE) has selected Horizon Environmental Services, Inc. (Horizon) to conduct a cultural resources survey and assessment for the proposed Galveston County Project. The project includes a proposed pipeline that will allow the delivery of natural gas to a new delivery point off the FGT mainline. The facilities to be installed include approximately 4.0 kilometers ([km] 2.5 miles) of 30.5-centimeter ([cm]12.0-inch) and 50.8-cm (20.0-inch) lateral piping as well as a measurement and regulation (M&R) station located at the southwest end of the new pipeline, referred to as the Attwater-Topaz M&R station. This portion of the proposed project is located approximately 2.9 km (1.8 miles) northwest of Texas City and crosses State Highway (SH) 146 in Galveston County, Texas. As part of the Galveston County Project, FGT will also be uprating a unit at their existing CS 4 compressor station in Matagorda County, Texas to maintain a sufficient delivery pressure to the proposed Attwater-Topaz M&R station. In accordance with Section 7(b) of the Natural Gas Act, the project requires Prior Notice authorization to the Federal Energy Regulatory Commission (FERC), which will serve as the lead federal agency for the undertaking. Because the undertaking is regulated by FERC, the undertaking falls under the regulations of Section 106 of the National Historic Preservation Act (NHPA) of 1966, as amended. The Antiquities Code of Texas (ACT) governs proposed undertakings by political subdivisions of the State of Texas and/or projects located on publicly owned lands. Approximately 11.3 hectares (27.8 acres) of the project area are owned by the Gulf Coast Water Authority (GCWA). Since the GCWA is a public entity, this portion of the project falls under the jurisdiction of the ACT. Survey of the GCWA property was carried out under Antiquities Permit No. 9449. Less than 0.1 hectare (0.2 acres) of additional temporary workspace (ATWS) falls within the State Highway (SH) 146 ROW, which is controlled by the Texas Department of Transportation (TxDOT). Since TxDOT is a State agency, survey of this area would also require an Antiquities Permit. However, this area has already been disturbed from road construction and underground utilities. Horizon therefore recommends no additional survey or shovel testing in this ATWS. Horizon sent a letter with this recommendation to the Texas Historical Commission (THC) on June 30, 2020. Originally, FGT did not define the actual limits of the proposed right-of-way (ROW) for the project. Rather, they elected to wait until after the environmental assessments on larger overall parcels were complete in order to select a route with the least amount of environmental impacts. As such, the cultural resources survey initially consisted of 100% survey of the entire 203.2 hectares (502.0 acres) that comprise the parcels traversed by the proposed pipeline. After FGT selected a proposed route, Horizon archeologists conducted additional fieldwork to ensure adequate survey coverage within the proposed ROW. From May 12 to 15, and June 17, 2020, Horizon archeologists Charles E. Bludau, Jr. and Luis Gonzales performed an intensive cultural resources survey of the project area to locate any cultural resources that would potentially be impacted by the proposed undertaking. Horizon’s archeologists traversed the project area on foot and thoroughly inspected the modern ground surface for aboriginal and historic-age cultural resources. The project area consists of an extensive, largely featureless coastal flat. An existing FGT pipeline corridor passes from northeast to southwest through the northern portion of the project area. In addition to pedestrian walkover, the recently revised 2020 Texas State Minimum Archeological Survey Standards (TSMASS) require at least 50 shovel tests for the first 10.1 hectares (25.0 acres) of a project plus at least one shovel test for every 2.0 hectares (5.0 acres) over the original 10.1 hectares (25.0 acres). This equates to a minimum of 145 shovel tests within the original 203.2-hectare (502.0-acre) project area. Horizon excavated156 shovel tests within this area, thereby exceeding the TSMASS for a project area of this size. The TSMASS require a minimum of 16 shovel tests per mile for projects measuring 30.0 m (98.4 feet) or less in width; this equates to a minimum of 40 shovel tests within the proposed ROW. Horizon exceeded this minimum by excavating 46 shovel tests within the proposed ROW. Shovel testing typically revealed shallow deposits of hydric, dark gray clay extending from the modern ground surface to depths ranging from 5.0 to 60.0 cm (2.0 to 23.6 inches) below surface, though most shovel tests were terminated at depths of 30.0 to 50.0 cm (11.8 to 19.7 inches) below surface. Shovel testing was capable of penetrating Holocene-age soils with the potential to contain subsurface archeological resources. No archeological sites or historic-aged structures were recorded within the project area during the survey. A modern cattle corral, constructed with modern lumber, is present in the northeast corner of the project area, south of Skyline Drive. The corral does not appear on any historical topographic maps. It is first visible in a 1981 aerial image, which indicates the corral is not of historic age. Based on the results of the survey-level investigations documented in this report, no significant cultural resources would be affected by the proposed undertaking. In accordance with 36 CFR 800.4, Horizon has made a reasonable and good faith effort to identify historic properties within the project area. No cultural resources were identified within the project area that meet the criteria for inclusion in the National Register of Historic Places (NRHP) under 36 CFR 60.4. Horizon recommends a finding of “no historic properties affected,” and no further archeological work is recommended in connection with the proposed undertaking. However, human burials, both prehistoric and historic, are protected under the Texas Health and Safety Code. In the event that any human remains or burial objects are inadvertently discovered at any point during construction, use, or ongoing maintenance in the project area, even in previously surveyed areas, all work should cease immediately in the vicinity of the inadvertent discovery, and the THC should be notified immediately

The impact of the housing crisis on self-reported health in Europe: multilevel longitudinal modelling of 27 EU countries

Background: Many EU nations experienced a significant housing crisis during the Great Recession of 2008–10. We evaluated the consequences of housing payment problems for people’s self-reported overall health. Methods: We used longitudinal data from the EU Statistics on Income and Living Conditions survey covering 27 countries from 2008 to 2010 to follow a baseline sample of persons who did not have housing debt and who were employed (45 457 persons, 136 371 person–years). Multivariate linear regression and multilevel models were used to evaluate the impact of transitions into housing arrears on self-reported health, correcting for the presence of chronic illness, health limitations, and other potential socio-demographic confounders. Results: Persons who transitioned into housing arrears experienced a significant deterioration in self-reported overall health by − 0.03 U (95% CI − 0.01 to − 0.04), even after correcting for chronic illness, disposable income and employment status, and individual fixed effects. This association was independent and similar in magnitude to that for job loss (−0.02, 95% CI: −0.01 to − 0.04). We also found that the impact of housing arrears was significantly worse among renters, corresponding to a mean 0.11 unit additional drop in health as compared with owner-occupiers. These adverse associations were only evident in persons below the 75th percentile of disposable income. Discussion: Our analysis demonstrates that persons who suffer housing arrears experience increased risk of worsening self-reported health, especially among those who rent. Future research is needed to understand the role of alternative housing support systems and available strategies for preventing the health consequences of housing insecurity

Remobilization of Tol2 transposons in Xenopus tropicalis

<p>Abstract</p> <p>Background</p> <p>The Class II DNA transposons are mobile genetic elements that move DNA sequence from one position in the genome to another. We have previously demonstrated that the naturally occurring <it>Tol2 </it>element from <it>Oryzias latipes </it>efficiently integrates its corresponding non-autonomous transposable element into the genome of the diploid frog, <it>Xenopus tropicalis. Tol2 </it>transposons are stable in the frog genome and are transmitted to the offspring at the expected Mendelian frequency.</p> <p>Results</p> <p>To test whether <it>Tol2 </it>transposons integrated in the <it>Xenopus tropicalis </it>genome are substrates for remobilization, we injected <it>in vitro </it>transcribed <it>Tol2 </it>mRNA into one-cell embryos harbouring a single copy of a <it>Tol2 </it>transposon. Integration site analysis of injected embryos from two founder lines showed at least one somatic remobilization event per embryo. We also demonstrate that the remobilized transposons are transmitted through the germline and re-integration can result in the generation of novel GFP expression patterns in the developing tadpole. Although the parental line contained a single <it>Tol2 </it>transposon, the resulting remobilized tadpoles frequently inherit multiple copies of the transposon. This is likely to be due to the <it>Tol2 </it>transposase acting in discrete blastomeres of the developing injected embryo during the cell cycle after DNA synthesis but prior to mitosis.</p> <p>Conclusions</p> <p>In this study, we demonstrate that single copy <it>Tol2 </it>transposons integrated into the <it>Xenopus tropicalis </it>genome are effective substrates for excision and random re-integration and that the remobilized transposons are transmitted through the germline. This is an important step in the development of 'transposon hopping' strategies for insertional mutagenesis, gene trap and enhancer trap screens in this highly tractable developmental model organism.</p