PI3K/AKT/mTOR Pathway in Angiogenesis

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway is activated in the majority of human cancers. This pathway is known to play a key role in numerous cellular functions including proliferation, adhesion, migration, invasion, metabolism, and survival, but in the current review we focus on its role in angiogenesis. PI3K activation may occur via RAS mutation, loss of phosphatase and tensin homolog (PTEN), or by increased expression of growth factor receptors such as epidermal growth factor receptor. There is a connection between the PI3K pathway and angiogenesis. Hypoxia leads to HIF-1α stabilization and is a major stimulus for increased vascular endothelial growth factor (VEGF) production by tumor cells. However, activation of the PI3K/AKT pathway in tumor cells can also increase VEGF secretion, both by hypoxia-inducible factor 1 (HIF-1) dependent and independent mechanisms. The PI3K/AKT pathway also modulates the expression of other angiogenic factors such as nitric oxide and angiopoietins. Numerous inhibitors targeting the PI3K/AKT/mTOR pathway have been developed, and these agents have been shown to decrease VEGF secretion and angiogenesis. The effect of these inhibitors on tumor vasculature can be difficult to predict. The vasculature of tumors is aberrant, leading to sluggish bloodflow and elevated interstitial blood pressure, which can be perpetuated by the high levels of VEGF. Hence, decreasing VEGF expression can paradoxically lead to vascular normalization and improved bloodflow in some tumors. In addition to its importance in cancer, the PI3K pathway also plays an essential role in the formation of normal blood vessels during development. Embryos with kinase-dead p110α catalytic subunit of PI3K develop vascular defects. Stimulation of endothelial cells by VEGF leads to activation of the PI3K pathway within these cells, which is important for cell migration. Sustained endothelial activation of AKT1 has been shown to induce the formation of structurally abnormal blood vessels that recapitulate the aberrations of tumor vessels. Hence, the PI3K pathway plays an important role in regulating angiogenesis both in normal tissues and in cancers

ROI Based Quality Access Control of Compressed Color Image using DWT via Lifting

Region-of-Interest (ROI) in an image or video signal contains important information and may be used for access control at various qualities using multiresolution analysis (MRA). This paper proposes a novel quality access control method of compressed color image by modulating the coefficients of ROI at various levels. Data modulation causes visual degradation in the original image and plays the key role in access control through reversible process. The modulation information, in the form of a secret key, is embedded in non-ROI part of the chrominance blue (Cb) channel of the color image using quantization index modulation (QIM). Lifting based DWT, rather than conventional DWT, is used to decompose the original image in order to achieve two-fold advantages, namely (1) better flexibility and low loss in image quality due to QIM and (2) better decoding reliability that leads to better access control. Only the authorized users having the full knowledge of the secret key restore the full quality of ROI. Simulation results duly support this claims